UY27647A1 - Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios - Google Patents

Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios

Info

Publication number
UY27647A1
UY27647A1 UY27647A UY27647A UY27647A1 UY 27647 A1 UY27647 A1 UY 27647A1 UY 27647 A UY27647 A UY 27647A UY 27647 A UY27647 A UY 27647A UY 27647 A1 UY27647 A1 UY 27647A1
Authority
UY
Uruguay
Prior art keywords
amino
treatment
thyrosine
kinase inhibitors
inflammatory processes
Prior art date
Application number
UY27647A
Other languages
English (en)
Inventor
Jung Birgit
Puschner Hubert
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY27647A1 publication Critical patent/UY27647A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Utilización de quinazolinas de fórmula general en que A, B, C, D, X, Ra, Rb, Rc, y n están definidos según reivindicaciones 1, o de los compuestos (1) 4-( (3-cloro-4-fluorofenil) amino) -6- (4-dimetilamino- ciclohexil) amino) pirimido (5,4-d) pirimidina, (2) 4-( (R) -(1- feniletil)amino - 6- (4- hidroxifenil) -7H- pirrolo (2,3-d) pirimidina, (3) 4- (3- cloro-4- (3- fluoro- 4 benciloxi) - fenil) amino) -6-(5-( 2-metanosulfonil-etil) -furan-2-il) -quinazolina o de los anticuerpos Cetuximab C225, Trastuzumab, ABX- EGF, acn ICR- 62 o EGFR - antisentido, sus tautómeros, estereoisómeros y sales, en particular sus sales fisiológicamente compartibles con ácidos o bases inorgánicos u orgánicos, para preparar un medicamento de prevención o tratamiento de enfermedades de vías respiratorias o pulmones.
UY27647A 2002-02-05 2003-02-04 Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios UY27647A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10204462A DE10204462A1 (de) 2002-02-05 2002-02-05 Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse

Publications (1)

Publication Number Publication Date
UY27647A1 true UY27647A1 (es) 2003-08-29

Family

ID=7713648

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27647A UY27647A1 (es) 2002-02-05 2003-02-04 Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios

Country Status (11)

Country Link
US (2) US20030149062A1 (es)
EP (1) EP1474149A2 (es)
JP (1) JP2005525328A (es)
AR (1) AR038392A1 (es)
AU (1) AU2003206785A1 (es)
CA (1) CA2472293C (es)
DE (1) DE10204462A1 (es)
PE (1) PE20030866A1 (es)
TW (1) TW200404547A (es)
UY (1) UY27647A1 (es)
WO (1) WO2003066060A2 (es)

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EP1660479A1 (en) * 2003-07-29 2006-05-31 Astrazeneca AB Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
SI1667991T1 (sl) * 2003-09-16 2008-10-31 Astrazeneca Ab Kinazolinski derivati kot inhibitorji tirozin kinaze
ES2279441T3 (es) * 2003-09-19 2007-08-16 Astrazeneca Ab Derivados de quinazolina.
DE602004004811T2 (de) * 2003-09-19 2007-11-22 Astrazeneca Ab Chinazolinderivate
WO2005030757A1 (en) * 2003-09-25 2005-04-07 Astrazeneca Ab Quinazoline derivatives
CA2537812C (en) 2003-09-26 2013-01-22 Exelixis, Inc. C-met modulators and method of use
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DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
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DE102004001607A1 (de) * 2004-01-09 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen auf der Basis von Scopin- oder Tropensäureestern mit EGFR-Kinase-Hemmern
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US20060032853A1 (en) * 2004-07-27 2006-02-16 Freeman Jimmy L Pressure vessel door
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US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
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AU2006210175A1 (en) * 2005-02-04 2006-08-10 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of chronic rhinosinusitis
EP1856095B1 (en) * 2005-02-26 2011-08-24 AstraZeneca AB Quinazoline derivatives as tyrosine kinase inhibitors
KR100832593B1 (ko) * 2005-11-08 2008-05-27 한미약품 주식회사 신호전달 저해제로서의 퀴나졸린 유도체 및 이의 제조방법
US8404697B2 (en) 2005-11-11 2013-03-26 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
CA2663599A1 (en) * 2006-09-18 2008-03-27 Boehringer Ingelheim International Gmbh Method for treating cancer harboring egfr mutations
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Also Published As

Publication number Publication date
EP1474149A2 (de) 2004-11-10
US20030149062A1 (en) 2003-08-07
TW200404547A (en) 2004-04-01
PE20030866A1 (es) 2003-11-28
WO2003066060A2 (de) 2003-08-14
AU2003206785A1 (en) 2003-09-02
WO2003066060A3 (de) 2004-01-15
CA2472293C (en) 2011-08-30
AR038392A1 (es) 2005-01-12
US20090306072A1 (en) 2009-12-10
DE10204462A1 (de) 2003-08-07
CA2472293A1 (en) 2003-08-14
JP2005525328A (ja) 2005-08-25

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