UY27647A1 - Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios - Google Patents

Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios

Info

Publication number
UY27647A1
UY27647A1 UY27647A UY27647A UY27647A1 UY 27647 A1 UY27647 A1 UY 27647A1 UY 27647 A UY27647 A UY 27647A UY 27647 A UY27647 A UY 27647A UY 27647 A1 UY27647 A1 UY 27647A1
Authority
UY
Uruguay
Prior art keywords
amino
treatment
thyrosine
kinase inhibitors
inflammatory processes
Prior art date
Application number
UY27647A
Other languages
English (en)
Inventor
Jung Birgit
Puschner Hubert
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY27647A1 publication Critical patent/UY27647A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Utilización de quinazolinas de fórmula general en que A, B, C, D, X, Ra, Rb, Rc, y n están definidos según reivindicaciones 1, o de los compuestos (1) 4-( (3-cloro-4-fluorofenil) amino) -6- (4-dimetilamino- ciclohexil) amino) pirimido (5,4-d) pirimidina, (2) 4-( (R) -(1- feniletil)amino - 6- (4- hidroxifenil) -7H- pirrolo (2,3-d) pirimidina, (3) 4- (3- cloro-4- (3- fluoro- 4 benciloxi) - fenil) amino) -6-(5-( 2-metanosulfonil-etil) -furan-2-il) -quinazolina o de los anticuerpos Cetuximab C225, Trastuzumab, ABX- EGF, acn ICR- 62 o EGFR - antisentido, sus tautómeros, estereoisómeros y sales, en particular sus sales fisiológicamente compartibles con ácidos o bases inorgánicos u orgánicos, para preparar un medicamento de prevención o tratamiento de enfermedades de vías respiratorias o pulmones.
UY27647A 2002-02-05 2003-02-04 Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios UY27647A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10204462A DE10204462A1 (de) 2002-02-05 2002-02-05 Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse

Publications (1)

Publication Number Publication Date
UY27647A1 true UY27647A1 (es) 2003-08-29

Family

ID=7713648

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27647A UY27647A1 (es) 2002-02-05 2003-02-04 Utilización de inhibidores de tirosina-quinasa para el tratamiento de procesos inflamatorios

Country Status (11)

Country Link
US (2) US20030149062A1 (es)
EP (1) EP1474149A2 (es)
JP (1) JP2005525328A (es)
AR (1) AR038392A1 (es)
AU (1) AU2003206785A1 (es)
CA (1) CA2472293C (es)
DE (1) DE10204462A1 (es)
PE (1) PE20030866A1 (es)
TW (1) TW200404547A (es)
UY (1) UY27647A1 (es)
WO (1) WO2003066060A2 (es)

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US20050096332A1 (en) * 2003-10-30 2005-05-05 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
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US20060088533A1 (en) * 2004-10-08 2006-04-27 Charalabos Pothoulakis Methods of treating inflammatory bowel disease
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
DOP2006000016A (es) * 2005-01-26 2006-07-31 Aventis Pharma Inc 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2.
WO2006082129A1 (de) * 2005-02-04 2006-08-10 Boehringer Ingelheim International Gmbh Verwendung von tyrosinkinase-inhibitoren zur behandlung der chronischen rhinosinusitis
AR055564A1 (es) * 2005-02-26 2007-08-22 Astrazeneca Ab Derivados de quinazolina
KR100832594B1 (ko) * 2005-11-08 2008-05-27 한미약품 주식회사 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법
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Also Published As

Publication number Publication date
US20030149062A1 (en) 2003-08-07
AR038392A1 (es) 2005-01-12
TW200404547A (en) 2004-04-01
JP2005525328A (ja) 2005-08-25
AU2003206785A1 (en) 2003-09-02
WO2003066060A3 (de) 2004-01-15
DE10204462A1 (de) 2003-08-07
EP1474149A2 (de) 2004-11-10
WO2003066060A2 (de) 2003-08-14
CA2472293A1 (en) 2003-08-14
CA2472293C (en) 2011-08-30
PE20030866A1 (es) 2003-11-28
US20090306072A1 (en) 2009-12-10

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Effective date: 20150126