WO2003066060A3 - Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse - Google Patents

Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse Download PDF

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Publication number
WO2003066060A3
WO2003066060A3 PCT/EP2003/000814 EP0300814W WO03066060A3 WO 2003066060 A3 WO2003066060 A3 WO 2003066060A3 EP 0300814 W EP0300814 W EP 0300814W WO 03066060 A3 WO03066060 A3 WO 03066060A3
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WO
WIPO (PCT)
Prior art keywords
amino
treatment
tyrosine kinase
kinase inhibitors
inflammatory processes
Prior art date
Application number
PCT/EP2003/000814
Other languages
English (en)
French (fr)
Other versions
WO2003066060A2 (de
Inventor
Birgit Jung
Hubert Pueschner
Original Assignee
Boehringer Ingelheim Pharma
Birgit Jung
Hubert Pueschner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Birgit Jung, Hubert Pueschner filed Critical Boehringer Ingelheim Pharma
Priority to EP03704477A priority Critical patent/EP1474149A2/de
Priority to AU2003206785A priority patent/AU2003206785A1/en
Priority to CA2472293A priority patent/CA2472293C/en
Priority to JP2003565484A priority patent/JP2005525328A/ja
Publication of WO2003066060A2 publication Critical patent/WO2003066060A2/de
Publication of WO2003066060A3 publication Critical patent/WO2003066060A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die vorliegende Erfindung bezieht sich auf die Verwendung von Chinazolinen der allgemeinen Formel in der A, B, C, D, X, Ra, Rb, Rc und n wie in Anspruch 1 definiert sind, oder der Verbindungen (1) 4-[(3-Chlor-4-fluorphenyl)amino]-6-[(4-dimethylamino-cyclohexyl)amino]-pyrimido[5,4-d]pyrimidin, (2) 4-[(R)-(1-Phenylethyl)amino]-6-(4-hydroxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin, (3) 4-{[3-Chlor-4-(3-fluor-4-benzyloxy)-phenyl]amino}-6-(5-{[(2-methansulfonylethyl)amino]methyl}-furan-2-yl)chinazolin oder der Antikörper Cetuximab C225, Trastuzumab, ABX-EGF, Mab ICR-62 und EGFR-antisense, deren Tautomere, deren Stereoisomere und deren Salze, insbesondere derenphysiologisch verrägliche Salze mit anorganischen oder organischen Säuren oder Basen, zur Herstellung eines Arzneimittels zur Vorbeugung oder Behandlung von Erkrankungen der Atemwege oder der Lunge.
PCT/EP2003/000814 2002-02-05 2003-01-28 Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse WO2003066060A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03704477A EP1474149A2 (de) 2002-02-05 2003-01-28 Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse
AU2003206785A AU2003206785A1 (en) 2002-02-05 2003-01-28 Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
CA2472293A CA2472293C (en) 2002-02-05 2003-01-28 Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
JP2003565484A JP2005525328A (ja) 2002-02-05 2003-01-28 炎症プロセスの治療のためのチロシンキナーゼインヒビターの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10204462.7 2002-02-05
DE10204462A DE10204462A1 (de) 2002-02-05 2002-02-05 Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse

Publications (2)

Publication Number Publication Date
WO2003066060A2 WO2003066060A2 (de) 2003-08-14
WO2003066060A3 true WO2003066060A3 (de) 2004-01-15

Family

ID=7713648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000814 WO2003066060A2 (de) 2002-02-05 2003-01-28 Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse

Country Status (11)

Country Link
US (2) US20030149062A1 (de)
EP (1) EP1474149A2 (de)
JP (1) JP2005525328A (de)
AR (1) AR038392A1 (de)
AU (1) AU2003206785A1 (de)
CA (1) CA2472293C (de)
DE (1) DE10204462A1 (de)
PE (1) PE20030866A1 (de)
TW (1) TW200404547A (de)
UY (1) UY27647A1 (de)
WO (1) WO2003066060A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877776B2 (en) 2009-01-16 2014-11-04 Exelixis, Inc. (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
US9359332B2 (en) 2002-07-15 2016-06-07 Symphony Evolution, Inc. Processes for the preparation of substituted quinazolines

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WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
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US20050096332A1 (en) * 2003-10-30 2005-05-05 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
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US9359332B2 (en) 2002-07-15 2016-06-07 Symphony Evolution, Inc. Processes for the preparation of substituted quinazolines
US8877776B2 (en) 2009-01-16 2014-11-04 Exelixis, Inc. (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Also Published As

Publication number Publication date
DE10204462A1 (de) 2003-08-07
TW200404547A (en) 2004-04-01
PE20030866A1 (es) 2003-11-28
JP2005525328A (ja) 2005-08-25
US20030149062A1 (en) 2003-08-07
AU2003206785A1 (en) 2003-09-02
EP1474149A2 (de) 2004-11-10
UY27647A1 (es) 2003-08-29
US20090306072A1 (en) 2009-12-10
WO2003066060A2 (de) 2003-08-14
CA2472293C (en) 2011-08-30
AR038392A1 (es) 2005-01-12
CA2472293A1 (en) 2003-08-14

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