UY26038A1 - Difenilureas w-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa - Google Patents

Difenilureas w-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa

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Publication number
UY26038A1
UY26038A1 UY26038A UY26038A UY26038A1 UY 26038 A1 UY26038 A1 UY 26038A1 UY 26038 A UY26038 A UY 26038A UY 26038 A UY26038 A UY 26038A UY 26038 A1 UY26038 A1 UY 26038A1
Authority
UY
Uruguay
Prior art keywords
substituted
group
raf
members
aryl
Prior art date
Application number
UY26038A
Other languages
English (en)
Inventor
Bernd Riedl
Jhacques Dumas
Uday Khire
Tomothy B Lowinger
William J Scott
Roger A Smith
Jill E Wood
Mary-Katherine Monahan
Reina Natero
Joel Renick
Robert E Sibley
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of UY26038A1 publication Critical patent/UY26038A1/es
Priority to UY0001032230A priority Critical patent/UY32230A/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Compuestos que son inhibidores de la enzima raf-quinasa, que se describen en general como ureas arílicas, incluyendo análogos tanto arílicos como heteroarílicos, que inhiben el pasaje de la raf-quinasa. Así pues, el invento se refiere a compuestos, composiciones y métodos para el tratamiento del crecimiento de las células cancerosas trasmitido por la raf-quinasa cuando se administra un compuesto de fórmula (I): A-D-B o una sal farmacéutica aceptable del mismo, en donde: D es NH-C(O)-NH, A es una porción sustituida de hasta 40 átomos de carbono de la fórmula: L-(M-L1)q, donde L es una estructura cíclica de 5 o 6 miembro unida directamente a D, L1 comprende una parte cíclica sustituida con al menos 5 miembros, M es un grupo de puente que tiene al menos un átomo, q es un entero de 1 a 3, y cada estructura cíclica de L y L1 contiene 0 a 4 miembros del grupo que consta de nitrógeno, oxígeno y azufre; B es una porción arílica o heteroarílica sustituida o no, que puede ser hasta tricíclica, de hasta 30 átomos de carbono con al menos una estructura cíclica de 6 miembros unida directamente a D que contiene 0 a 4 miembros del grupo que consta de notrógeno, oxígeno y azufre, donde L1 es sustituida por al menos un sustituyente seleccionado dentro del grupo que consta de SO2Rx, C(O)Rx y C(NRy)Rz. Por ejemplo: N-(3-ter-butilfenil)-N'-(4-(3-(N-metilcarbamoil)fenoxi)fenilurea.
UY26038A 1999-02-25 2000-02-25 Difenilureas w-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa UY26038A1 (es)

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UY0001032230A UY32230A (es) 1999-02-25 2009-11-09 Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa

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US25726699A 1999-02-25 1999-02-25
US42522899A 1999-10-22 1999-10-22

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AU2002353147A1 (en) * 2001-12-13 2003-06-30 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
CA2824028A1 (en) * 2011-01-06 2012-07-12 Beta Pharma Canada Inc. Novel ureas for the treatment and prevention of cancer

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CH479557A (de) * 1961-09-11 1969-10-15 Wander Ag Dr A Verfahren zur Herstellung neuer mehrbasischer Verbindungen
CH575208A5 (es) 1973-07-30 1976-05-14 Ciba Geigy Ag
JPS57185219A (en) * 1981-05-12 1982-11-15 Chugai Pharmaceut Co Ltd Remedy for cancer
JPH0222650A (ja) * 1988-07-11 1990-01-25 Konica Corp ハロゲン化銀カラー写真感光材料
JPH0223337A (ja) * 1988-07-12 1990-01-25 Konica Corp 新規なカプラーを含有するハロゲン化銀写真感光材料
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FR2683818B1 (fr) 1991-11-14 1993-12-31 Adir Cie Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
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CZ59398A3 (cs) 1996-06-29 1998-07-15 Samjin Pharmaceutical Co., Ltd. Piperazinové deriváty a způsob jejich přípravy
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AU9802198A (en) * 1997-10-21 1999-05-10 Pharmacia & Upjohn Company Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors
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JP4403482B2 (ja) * 1997-12-22 2010-01-27 バイエル コーポレイション 置換複素環尿素合成のための中間体およびその製造方法
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ES2377847T3 (es) * 1999-01-13 2012-04-02 Bayer Healthcare Llc Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38

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UA73731C2 (en) 2005-09-15
CA2549558C (en) 2010-08-31
SI1140840T1 (sl) 2006-06-30
UY32230A (es) 2010-06-30
SI1690853T1 (sl) 2010-07-30
CA2549558A1 (en) 2000-07-20
EP1690853A1 (en) 2006-08-16
EP1690853B1 (en) 2010-03-10
DK1690853T3 (da) 2010-06-07

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