UY32230A - Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa - Google Patents

Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa

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Publication number
UY32230A
UY32230A UY0001032230A UY32230A UY32230A UY 32230 A UY32230 A UY 32230A UY 0001032230 A UY0001032230 A UY 0001032230A UY 32230 A UY32230 A UY 32230A UY 32230 A UY32230 A UY 32230A
Authority
UY
Uruguay
Prior art keywords
raf
difenilureas
carboxiarilics
quinasa
omega
Prior art date
Application number
UY0001032230A
Other languages
English (en)
Inventor
William J Scott
Roger A Smith
Dr Bernd Riedl
Khire Uday
Timothy B Lowinger
Wood Jill
Mary Katherine Monahan
Natero Reina
Renick Joel
Robert E Sibley
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Priority to UY0001032230A priority Critical patent/UY32230A/es
Publication of UY32230A publication Critical patent/UY32230A/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract

La presente invención divulga compuestos difenilureas w-carboxiarilicas sustituidas, composiciones farmacéuticas que las contienen y sus usos en la terapia de los procesos inhibidores de la ref-quinasa, tales como el tratamiento de tumores y/o del crecimiento de células cancerosas trasmitido por la raf-quinasa.
UY0001032230A 1999-02-25 2009-11-09 Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa UY32230A (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY0001032230A UY32230A (es) 1999-02-25 2009-11-09 Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25726699A 1999-02-25 1999-02-25
US42522899A 1999-10-22 1999-10-22
UY26038A UY26038A1 (es) 1999-02-25 2000-02-25 Difenilureas w-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa
UY0001032230A UY32230A (es) 1999-02-25 2009-11-09 Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa

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UY32230A true UY32230A (es) 2010-06-30

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UY26038A UY26038A1 (es) 1999-02-25 2000-02-25 Difenilureas w-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa
UY0001032230A UY32230A (es) 1999-02-25 2009-11-09 Difenilureas (omega)-carboxiarilicas sustituidas como inhibidoras de la raf-quinasa

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CA (1) CA2549558C (es)
DK (1) DK1690853T3 (es)
SI (2) SI1690853T1 (es)
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UY (2) UY26038A1 (es)

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EP1463505A2 (en) * 2001-12-13 2004-10-06 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
EP2661434A4 (en) * 2011-01-06 2014-07-09 Beta Pharma Canada Inc NEW URGES FOR THE TREATMENT AND PREVENTION OF CANCER

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CH520657A (de) * 1961-09-11 1972-03-31 Wander Ag Dr A Verfahren zur Herstellung mehrbasischer Verbindungen
CH575208A5 (es) 1973-07-30 1976-05-14 Ciba Geigy Ag
JPS57185219A (en) * 1981-05-12 1982-11-15 Chugai Pharmaceut Co Ltd Remedy for cancer
JPH0222650A (ja) * 1988-07-11 1990-01-25 Konica Corp ハロゲン化銀カラー写真感光材料
JPH0223337A (ja) * 1988-07-12 1990-01-25 Konica Corp 新規なカプラーを含有するハロゲン化銀写真感光材料
US4973675A (en) * 1989-04-13 1990-11-27 University Of Tennessee Research Center Hybrid nitrosoureidoanthracyclines having antitumor activity
FR2683818B1 (fr) 1991-11-14 1993-12-31 Adir Cie Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
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DE69622183D1 (de) * 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
DE69722360T2 (de) 1996-06-29 2003-11-27 Samjin Pharm, Co. Piperazin-derivate und verfahren zu ihrer herstellung
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EP1616865A1 (en) * 1997-12-22 2006-01-18 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
WO1999032110A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS
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CA2359244C (en) * 1999-01-13 2013-10-08 Bayer Corporation .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors

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UA73731C2 (en) 2005-09-15
CA2549558C (en) 2010-08-31
SI1140840T1 (sl) 2006-06-30
UY26038A1 (es) 2000-09-29
CA2549558A1 (en) 2000-07-20
SI1690853T1 (sl) 2010-07-30
DK1690853T3 (da) 2010-06-07
EP1690853B1 (en) 2010-03-10
EP1690853A1 (en) 2006-08-16

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