AR012730A1 - Compuestos derivados de aminocicloalquilpirrolidina sustituida cis-sustituidos, droga, agente antimicrobiano y compuesto intermediario - Google Patents
Compuestos derivados de aminocicloalquilpirrolidina sustituida cis-sustituidos, droga, agente antimicrobiano y compuesto intermediarioInfo
- Publication number
- AR012730A1 AR012730A1 ARP980102355A ARP980102355A AR012730A1 AR 012730 A1 AR012730 A1 AR 012730A1 AR P980102355 A ARP980102355 A AR P980102355A AR P980102355 A ARP980102355 A AR P980102355A AR 012730 A1 AR012730 A1 AR 012730A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- carbon atoms
- substituted
- alkyl group
- drug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compuestos derivados de aminocicloalquilpirrolidina sustituida cis-sustituidos de formula (I) donde R1 representa un átomo de hidrogeno o ungrupo alquilo que tiene 1 a 6 átomos de carbono; R2 representa un átomo de hidrogeno o un grupo alquilo que tiene 1 a 6 átomos de carbono, siempre que elgrupo alquilo pueda tener uno o más sustituyentes seleccionados del grupo formado por un grupo hidroxilo, un átomo de halogeno y un grupo alcoxilo quetiene hasta 6 átomos de carbono;R3 y R5 representan cada uno lun átomo de hidrogeno; R4 representa un grupo hidroxilo, un átomo de halogeno, un grupocarbamoilo, un grupo alquilo que tiene entre 1 a 6 átomos de carbono, un grupo alcoxilo que tiene 1 a 6 átomos de carbono o ungrupo alquiltio que tiene 1 a 6átomos de carbon, siempre que el grupo alquilo pueda tener uno o más sustituyentes seleccionados del grupo formado por un grupo hidroxilo, un átomode halogeno y un grupo alcoxilo que tiene 1 a 6 átomos de carbono; y R4 y el sustituyente en el anillo pirrolidina de la formula (II) están ubicados en laconfiguracion cis: R6 y R7 representan cada uno independientemente un átomo de hidrogeno o un grupo alquilo que tiene entre 1 y 6 átomos de carbono; N esunentero entre 1 y 3 ; y Q representa una estructura parcial representada por la formula (III). Los derivados de aminocicloalquilpirrolidina se usan comoprincipio activo en una droga y como agente antimicrobiano. También se incluye un intermediario en la preparacion de los derivados deaminocicloalquilpirrolidina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13141397 | 1997-05-21 | ||
| JP14064397 | 1997-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012730A1 true AR012730A1 (es) | 2000-11-08 |
Family
ID=26466258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102355A AR012730A1 (es) | 1997-05-21 | 1998-05-21 | Compuestos derivados de aminocicloalquilpirrolidina sustituida cis-sustituidos, droga, agente antimicrobiano y compuesto intermediario |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20020077345A1 (es) |
| EP (1) | EP1020459B1 (es) |
| KR (1) | KR20010012740A (es) |
| CN (1) | CN1263527A (es) |
| AR (1) | AR012730A1 (es) |
| AT (1) | ATE292632T1 (es) |
| AU (1) | AU7449398A (es) |
| BR (1) | BR9810235A (es) |
| CA (1) | CA2289605A1 (es) |
| DE (1) | DE69829682T2 (es) |
| ID (1) | ID24434A (es) |
| IL (1) | IL132982A0 (es) |
| NO (1) | NO995653L (es) |
| WO (1) | WO1998052939A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9812644B1 (pt) | 1997-09-15 | 2010-07-13 | quinolonas antimicrobianas, composição farmacêutica e uso das mesmas. | |
| EP1161956A4 (en) | 1999-03-17 | 2005-03-16 | Daiichi Seiyaku Co | DRUG COMPOSITIONS |
| WO2002030893A1 (fr) * | 2000-10-12 | 2002-04-18 | Daiichi Pharmaceutical Co., Ltd. | Procedes permettant de produire un compose pour la production de composes antibacteriens et produit intermediaire utilise |
| CN1269817C (zh) | 2000-11-20 | 2006-08-16 | 第一制药株式会社 | 脱卤代化合物 |
| WO2002048143A2 (en) | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Antimicrobial 2-pyridones, their compositions and uses |
| BR0116217A (pt) | 2000-12-14 | 2003-12-30 | Procter & Gamble | Quinolonas antimicrobianas, composição farmacêutica, bem como aplicação farmacêutica das referidas quinolonas |
| WO2005030752A1 (ja) * | 2003-09-29 | 2005-04-07 | Daiichi Pharmaceutical Co., Ltd. | ８−シアノキノロンカルボン酸誘導体 |
| ATE507219T1 (de) | 2006-03-28 | 2011-05-15 | Warner Chilcott Co Llc | Malatsalze und polymorphe von (3s,5s)-7-ä3-amino- 5-methyl-piperidinylü-1-cyclopropyl-1,4-dihydro 8-methoxy-4-oxo-3-chinolincarbonsäure |
| EP1999125A2 (en) | 2006-03-28 | 2008-12-10 | The Procter and Gamble Company | A coupling process for preparing quinolone intermediates |
| US11529130B2 (en) | 2017-01-25 | 2022-12-20 | J.D. Franco & Co., Llc | Blood vessel access and closure devices and related methods of use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79189A (en) * | 1985-06-26 | 1990-07-12 | Daiichi Seiyaku Co | Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them |
| JPH0674261B2 (ja) * | 1988-06-21 | 1994-09-21 | 塩野義製薬株式会社 | キノロンカルボン酸誘導体 |
| US5580872A (en) * | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| US5726182A (en) * | 1990-05-02 | 1998-03-10 | Abbott Laboratories | Quinolizinone type compounds |
| US5157128A (en) * | 1990-11-30 | 1992-10-20 | Warner-Lambert Company | Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates |
| BR9407806A (pt) * | 1993-10-14 | 1997-08-19 | Abbott Lab | Composto processo de tratamento de uma infecção bacteriana em um paciente humano ou veterinário e intermediário sintético |
| JP3745433B2 (ja) * | 1995-02-02 | 2006-02-15 | 第一製薬株式会社 | 複素環式化合物 |
| DK0911328T3 (da) * | 1995-11-22 | 2006-06-06 | Daiichi Seiyaku Co | Substituerede aminocycloalkylpyrrolidinderivater |
-
1998
- 1998-05-20 BR BR9810235-4A patent/BR9810235A/pt not_active IP Right Cessation
- 1998-05-20 AU AU74493/98A patent/AU7449398A/en not_active Abandoned
- 1998-05-20 KR KR1019997010701A patent/KR20010012740A/ko not_active Application Discontinuation
- 1998-05-20 IL IL13298298A patent/IL132982A0/xx unknown
- 1998-05-20 EP EP98921738A patent/EP1020459B1/en not_active Expired - Lifetime
- 1998-05-20 CA CA002289605A patent/CA2289605A1/en not_active Abandoned
- 1998-05-20 CN CN98807148A patent/CN1263527A/zh active Pending
- 1998-05-20 ID IDW991418A patent/ID24434A/id unknown
- 1998-05-20 AT AT98921738T patent/ATE292632T1/de not_active IP Right Cessation
- 1998-05-20 WO PCT/JP1998/002219 patent/WO1998052939A1/ja not_active Application Discontinuation
- 1998-05-20 DE DE69829682T patent/DE69829682T2/de not_active Expired - Fee Related
- 1998-05-21 AR ARP980102355A patent/AR012730A1/es unknown
-
1999
- 1999-11-18 NO NO995653A patent/NO995653L/no unknown
-
2001
- 2001-11-02 US US09/985,256 patent/US20020077345A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR9810235A (pt) | 2001-09-18 |
| ATE292632T1 (de) | 2005-04-15 |
| DE69829682D1 (de) | 2005-05-12 |
| US20020077345A1 (en) | 2002-06-20 |
| EP1020459A4 (en) | 2001-03-07 |
| CN1263527A (zh) | 2000-08-16 |
| ID24434A (id) | 2000-07-20 |
| EP1020459B1 (en) | 2005-04-06 |
| CA2289605A1 (en) | 1998-11-26 |
| NO995653D0 (no) | 1999-11-18 |
| AU7449398A (en) | 1998-12-11 |
| WO1998052939A1 (fr) | 1998-11-26 |
| DE69829682T2 (de) | 2006-03-09 |
| EP1020459A1 (en) | 2000-07-19 |
| KR20010012740A (ko) | 2001-02-26 |
| IL132982A0 (en) | 2001-03-19 |
| NO995653L (no) | 2000-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |