UY25877A1 - Antígenos estreptococo - Google Patents
Antígenos estreptococoInfo
- Publication number
- UY25877A1 UY25877A1 UY25877A UY25877A UY25877A1 UY 25877 A1 UY25877 A1 UY 25877A1 UY 25877 A UY25877 A UY 25877A UY 25877 A UY25877 A UY 25877A UY 25877 A1 UY25877 A1 UY 25877A1
- Authority
- UY
- Uruguay
- Prior art keywords
- polypeptide
- streptococcal
- infection
- proteins
- useful
- Prior art date
Links
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010061372 Streptococcal infection Diseases 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 208000031729 Bacteremia Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000009906 Meningitis Diseases 0.000 abstract 1
- 206010033078 Otitis media Diseases 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Proteínas de estreptococos y polinucleótidos que las codifican; donde dicha proteínas son antigénicas y por lo tanto son componentes de vacunas útiles para la profilaxis o terapia de la infección de estreptococos en mamíferos. Se incluye un método para producir un polipéptido que comprende cultivar una célula huésped transfectada con un vector que comprende un polipéptido donde el ADN está unido en forma operativa a la región de control de expresión, bajo la condiciones adecuadas para la expresión de dicho polipéptido; como también se incluyen métodos recombinantes para producir los antígenos proteicos así como ensayos de diagnostico para detectar infección bacteriana por estreptococos. Una composición de vacuna que comprende un polipéptido según lo descrito y un vehículo, diluyente o adyuvante farmacéuticamente aceptable es útil para el tratamiento terapéutico o profiláctico de la meningitis, otitis media y bacteriemia o infección de neumonía.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11380098P | 1998-12-23 | 1998-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25877A1 true UY25877A1 (es) | 2000-08-21 |
Family
ID=22351610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25877A UY25877A1 (es) | 1998-12-23 | 1999-12-23 | Antígenos estreptococo |
Country Status (30)
Country | Link |
---|---|
EP (2) | EP1141306B1 (es) |
JP (2) | JP4761623B2 (es) |
KR (4) | KR101078919B1 (es) |
CN (3) | CN1191362C (es) |
AP (1) | AP2001002199A0 (es) |
AR (1) | AR029322A1 (es) |
AT (1) | ATE394489T1 (es) |
AU (1) | AU1764900A (es) |
BR (1) | BR9916477A (es) |
CA (1) | CA2356836C (es) |
CL (1) | CL2009002037A1 (es) |
CY (3) | CY1108223T1 (es) |
CZ (2) | CZ302790B6 (es) |
DE (1) | DE69938670D1 (es) |
DK (3) | DK2261358T3 (es) |
EA (1) | EA007409B1 (es) |
ES (3) | ES2400280T3 (es) |
HK (1) | HK1118575A1 (es) |
HU (1) | HU229664B1 (es) |
IL (3) | IL143905A0 (es) |
MX (1) | MXPA01006427A (es) |
NO (1) | NO330800B1 (es) |
NZ (1) | NZ512574A (es) |
OA (1) | OA11736A (es) |
PL (3) | PL206576B1 (es) |
PT (3) | PT1141306E (es) |
TR (2) | TR200102497T2 (es) |
UY (1) | UY25877A1 (es) |
WO (1) | WO2000039299A2 (es) |
ZA (1) | ZA200105114B (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1757697A3 (en) | 1998-02-20 | 2007-05-30 | ID Biomedical Corporation | Group B streptococcus antigens |
US20030134407A1 (en) | 1998-07-27 | 2003-07-17 | Le Page Richard William Falla | Nucleic acids and proteins from Streptococcus pneumoniae |
EP1801218A3 (en) * | 1998-07-27 | 2007-10-10 | Sanofi Pasteur Limited | Nucleic acids and proteins from streptococcus pneumoniae |
JP4689044B2 (ja) | 1998-12-21 | 2011-05-25 | メディミューン,インコーポレーテッド | ワクチン用の肺炎連鎖球菌タンパク質と免疫原断片 |
ES2400280T3 (es) * | 1998-12-23 | 2013-04-08 | Id Biomedical Corporation Of Quebec | Antígenos de estreptococos |
US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
ES2316450T3 (es) | 2000-06-12 | 2009-04-16 | University Of Saskatchewan | Proteina gapc quimerica de streptococcus y su uso en vacunacion y diagnostico. |
US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
US7074415B2 (en) | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
EP2281891A3 (en) | 2000-06-20 | 2011-08-17 | ID Biomedical Corporation | Streptococcus antigens |
WO2002079475A2 (en) * | 2001-03-30 | 2002-10-10 | Shire Biochem Inc. | Streptococcus pyogenes antigens and corresponding dna fragments |
CA2453062C (en) | 2001-07-06 | 2013-04-02 | Shire Biochem Inc. | Group b streptococcus bvh-a5 antigens and corresponding dna fragments |
GB0130228D0 (en) * | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
US7262024B2 (en) | 2001-12-20 | 2007-08-28 | Id Biomedical Corporation | Streptococcus antigens |
WO2004078907A2 (en) * | 2003-03-04 | 2004-09-16 | Intercell Ag | Streptococcus pyogenes antigens |
EP2333114A1 (en) * | 2003-04-15 | 2011-06-15 | Intercell AG | S. pneumoniae antigens |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
US20090010959A1 (en) | 2005-12-22 | 2009-01-08 | Ralph Leon Biemans | Pneumococcal Polysaccharide Conjugate Vaccine |
BRPI0813307C1 (pt) | 2007-06-26 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, e, processo para fabricar a vacina |
AU2008280799B2 (en) * | 2007-07-23 | 2013-07-11 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
AU2009237647A1 (en) | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
US20100092526A1 (en) | 2008-09-26 | 2010-04-15 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
BRPI1014494A2 (pt) | 2009-04-30 | 2016-08-02 | Coley Pharm Group Inc | vacina pneumocócica e usos da mesma |
US8668911B2 (en) | 2009-05-14 | 2014-03-11 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
NZ620441A (en) | 2009-09-03 | 2015-08-28 | Pfizer Vaccines Llc | Pcsk9 vaccine |
GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
US9944680B2 (en) | 2010-12-03 | 2018-04-17 | Sandfi Pasteur Limited | Composition for immunization against Streptococcus pneumoniae |
WO2012100234A1 (en) | 2011-01-20 | 2012-07-26 | Genocea Biosciences, Inc. | Vaccines and compositions against streptococcus pneumoniae |
WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
JP2014515035A (ja) | 2011-05-17 | 2014-06-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ストレプトコッカス・ニューモニエに対するワクチン |
SG11201403877PA (en) * | 2012-01-05 | 2014-09-26 | Deutsches Krebsforsch | Means and methods for treating or diagnosing idh1 r132h mutant-positive cancers |
EP2931743A4 (en) * | 2012-12-14 | 2016-08-03 | Sanofi Pasteur Ltd | METHOD FOR ASSESSING IMMUNOGENICITY |
PL3096783T3 (pl) | 2014-01-21 | 2021-12-13 | Pfizer Inc. | Polisacharydy otoczkowe streptococcus pneumoniae i ich koniugaty |
SG11201604728XA (en) | 2014-01-21 | 2016-08-30 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
KR102049825B1 (ko) | 2014-01-21 | 2019-12-03 | 화이자 인코포레이티드 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 및 그의 접합체 |
WO2015121783A1 (en) | 2014-02-14 | 2015-08-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
MX2017009308A (es) | 2015-01-15 | 2017-11-08 | Pfizer | Composiciones inmunogenicas para usar en vacunas neumococicas. |
PE20180657A1 (es) | 2015-07-21 | 2018-04-17 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados, kits que las comprenden y sus usos |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
WO2017085586A1 (en) | 2015-11-20 | 2017-05-26 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
HRP20220573T1 (hr) | 2017-01-20 | 2022-06-10 | Pfizer Inc. | Imunogeni pripravci, namijenjeni upotrebi u pneumokoknim cjepivima |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
US20220016229A1 (en) | 2018-12-12 | 2022-01-20 | Pfizer Inc. | Immunogenic Multiple Hetero-Antigen Polysaccharide-Protein Conjugates and uses thereof |
JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
JP2022542316A (ja) | 2019-07-31 | 2022-09-30 | サノフィ パスツール インコーポレイテッド | 多価肺炎球菌多糖体-タンパク質コンジュゲート組成物およびその使用方法 |
CN114667343A (zh) | 2019-11-01 | 2022-06-24 | 辉瑞大药厂 | 大肠杆菌组合物及其方法 |
CN115362177A (zh) | 2020-02-21 | 2022-11-18 | 辉瑞公司 | 糖类的纯化 |
CA3173729A1 (en) | 2020-02-23 | 2021-08-26 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
WO2022084852A1 (en) | 2020-10-22 | 2022-04-28 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
CA3199610A1 (en) | 2020-10-27 | 2022-05-05 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
CA3200602A1 (en) | 2020-11-04 | 2022-05-12 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
US20220202923A1 (en) | 2020-12-23 | 2022-06-30 | Pfizer Inc. | E. coli fimh mutants and uses thereof |
WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
EP4333879A1 (en) | 2021-05-03 | 2024-03-13 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
AU2022281543A1 (en) | 2021-05-28 | 2023-11-23 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
CA3221075A1 (en) | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
EP0656014B1 (en) * | 1993-03-19 | 2003-05-14 | LINDAHL, Gunnar | Protein rib, a cell surface protein that confers immunity to many strains of the group b streptococcus; process for purification of the protein, reagent kit and pharmaceutical composition |
EP0832238A1 (en) * | 1995-06-07 | 1998-04-01 | Biochem Vaccines Inc. | Streptococcal heat shock proteins members of the hsp70 family |
US5928895A (en) * | 1996-09-24 | 1999-07-27 | Smithkline Beecham Corporation | IgA Fc binding protein |
US5882896A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
WO1998018930A2 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae antigens and vaccines |
CA2305016A1 (en) * | 1997-09-24 | 1999-04-01 | Regents Of The University Of Minnesota | Human complement c3-degrading proteinase from streptococcus pneumoniae |
WO1999053940A1 (en) * | 1998-04-23 | 1999-10-28 | Uab Research Foundation | PNEUMOCOCCAL SURFACE PROTEIN C(PspC), EPITOPIC REGIONS AND STRAIN SELECTION THEREOF, AND USES THEREFOR |
WO2000006737A2 (en) * | 1998-07-27 | 2000-02-10 | Microbial Technics Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
CN1318103A (zh) * | 1998-07-27 | 2001-10-17 | 微生物技术有限公司 | 肺炎链球菌的核酸和蛋白质 |
EP1115875A1 (en) * | 1998-09-24 | 2001-07-18 | Regents Of The University Of Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
JP4689044B2 (ja) * | 1998-12-21 | 2011-05-25 | メディミューン,インコーポレーテッド | ワクチン用の肺炎連鎖球菌タンパク質と免疫原断片 |
ES2400280T3 (es) * | 1998-12-23 | 2013-04-08 | Id Biomedical Corporation Of Quebec | Antígenos de estreptococos |
-
1999
- 1999-12-20 ES ES08155317T patent/ES2400280T3/es not_active Expired - Lifetime
- 1999-12-20 MX MXPA01006427A patent/MXPA01006427A/es not_active IP Right Cessation
- 1999-12-20 WO PCT/CA1999/001218 patent/WO2000039299A2/en active Application Filing
- 1999-12-20 CZ CZ20100674A patent/CZ302790B6/cs not_active IP Right Cessation
- 1999-12-20 AU AU17649/00A patent/AU1764900A/en not_active Abandoned
- 1999-12-20 DE DE69938670T patent/DE69938670D1/de not_active Expired - Lifetime
- 1999-12-20 AP APAP/P/2001/002199A patent/AP2001002199A0/en unknown
- 1999-12-20 DK DK10180372.4T patent/DK2261358T3/da active
- 1999-12-20 ES ES99960748T patent/ES2306528T3/es not_active Expired - Lifetime
- 1999-12-20 DK DK08155317.4T patent/DK1950302T3/da active
- 1999-12-20 PL PL349777A patent/PL206576B1/pl unknown
- 1999-12-20 CA CA2356836A patent/CA2356836C/en not_active Expired - Fee Related
- 1999-12-20 PT PT99960748T patent/PT1141306E/pt unknown
- 1999-12-20 KR KR1020107009285A patent/KR101078919B1/ko not_active IP Right Cessation
- 1999-12-20 KR KR1020087008264A patent/KR101170203B1/ko not_active IP Right Cessation
- 1999-12-20 TR TR2001/02497T patent/TR200102497T2/xx unknown
- 1999-12-20 PL PL382438A patent/PL204073B1/pl not_active IP Right Cessation
- 1999-12-20 ES ES10180372.4T patent/ES2480417T3/es not_active Expired - Lifetime
- 1999-12-20 CN CNB998149047A patent/CN1191362C/zh not_active Expired - Fee Related
- 1999-12-20 CN CNA2007101481600A patent/CN101134775A/zh active Pending
- 1999-12-20 BR BR9916477-9A patent/BR9916477A/pt active Search and Examination
- 1999-12-20 PT PT81553174T patent/PT1950302E/pt unknown
- 1999-12-20 KR KR1020017007963A patent/KR100802198B1/ko not_active IP Right Cessation
- 1999-12-20 EP EP99960748A patent/EP1141306B1/en not_active Expired - Lifetime
- 1999-12-20 CZ CZ20012161A patent/CZ303675B6/cs not_active IP Right Cessation
- 1999-12-20 TR TR2002/00633T patent/TR200200633T2/xx unknown
- 1999-12-20 HU HU0104774A patent/HU229664B1/hu not_active IP Right Cessation
- 1999-12-20 DK DK99960748T patent/DK1141306T3/da active
- 1999-12-20 PT PT101803724T patent/PT2261358E/pt unknown
- 1999-12-20 CN CNB2005100037492A patent/CN100398653C/zh not_active Expired - Fee Related
- 1999-12-20 KR KR1020067025282A patent/KR100891398B1/ko not_active IP Right Cessation
- 1999-12-20 OA OA1200100165A patent/OA11736A/en unknown
- 1999-12-20 NZ NZ512574A patent/NZ512574A/xx not_active IP Right Cessation
- 1999-12-20 EP EP10180372.4A patent/EP2261358B1/en not_active Expired - Lifetime
- 1999-12-20 AT AT99960748T patent/ATE394489T1/de active
- 1999-12-20 JP JP2000591190A patent/JP4761623B2/ja not_active Expired - Fee Related
- 1999-12-20 PL PL382437A patent/PL205041B1/pl unknown
- 1999-12-20 EA EA200100565A patent/EA007409B1/ru not_active IP Right Cessation
- 1999-12-20 IL IL14390599A patent/IL143905A0/xx unknown
- 1999-12-23 UY UY25877A patent/UY25877A1/es unknown
- 1999-12-23 AR ARP990106746A patent/AR029322A1/es not_active Application Discontinuation
-
2001
- 2001-06-19 NO NO20013045A patent/NO330800B1/no not_active IP Right Cessation
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2008
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2009
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2010
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2012
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2014
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