USRE46276E1 - Triazolo(4,5-D)pyrimidine compounds - Google Patents

Triazolo(4,5-D)pyrimidine compounds Download PDF

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Publication number
USRE46276E1
USRE46276E1 US14/976,977 US199914976977A USRE46276E US RE46276 E1 USRE46276 E1 US RE46276E1 US 199914976977 A US199914976977 A US 199914976977A US RE46276 E USRE46276 E US RE46276E
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US
United States
Prior art keywords
triazolo
pyrimidin
amino
cyclopropyl
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US14/976,977
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English (en)
Inventor
David Hardem
Anthony Ingall
Brian Springthorpe
Paul Willis
Simon Guile
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AstraZeneca UK Ltd
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AstraZeneca UK Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26663448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=USRE46276(E1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9804211A external-priority patent/SE9804211D0/xx
Priority claimed from SE9901271A external-priority patent/SE9901271D0/xx
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Priority to US14/976,977 priority Critical patent/USRE46276E1/en
Application granted granted Critical
Publication of USRE46276E1 publication Critical patent/USRE46276E1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
US14/976,977 1998-12-04 1999-12-02 Triazolo(4,5-D)pyrimidine compounds Active 2024-10-30 USRE46276E1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/976,977 USRE46276E1 (en) 1998-12-04 1999-12-02 Triazolo(4,5-D)pyrimidine compounds

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
SE9804211 1998-12-04
SE9804211A SE9804211D0 (sv) 1998-12-04 1998-12-04 Novel compounds
SE9901271A SE9901271D0 (sv) 1999-04-09 1999-04-09 Novel compounds
SE9901271 1999-04-09
US50819599A 1999-12-02 1999-12-02
PCT/SE1999/002256 WO2000034283A1 (en) 1998-12-04 1999-12-02 Novel triazolo(4,5-d)pyrimidine compounds
US14/976,977 USRE46276E1 (en) 1998-12-04 1999-12-02 Triazolo(4,5-D)pyrimidine compounds

Publications (1)

Publication Number Publication Date
USRE46276E1 true USRE46276E1 (en) 2017-01-17

Family

ID=26663448

Family Applications (12)

Application Number Title Priority Date Filing Date
US09/508,195 Ceased US6525060B1 (en) 1998-12-04 1999-12-02 Triazolo(4,5-d)pyrimidine compounds
US14/976,977 Active 2024-10-30 USRE46276E1 (en) 1998-12-04 1999-12-02 Triazolo(4,5-D)pyrimidine compounds
US10/323,655 Expired - Lifetime US6974868B2 (en) 1998-12-04 2002-12-20 Compounds
US11/230,493 Expired - Lifetime US7250419B2 (en) 1998-12-04 2005-09-21 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US11/711,838 Abandoned US20070265282A1 (en) 1998-12-04 2007-02-28 Novel compounds
US12/149,771 Abandoned US20080214812A1 (en) 1998-12-04 2008-05-08 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US12/591,395 Abandoned US20100069408A1 (en) 1998-12-04 2009-11-18 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US13/137,125 Abandoned US20120165348A1 (en) 1998-12-04 2011-07-21 Novel compounds
US13/423,848 Abandoned US20130072503A1 (en) 1998-12-04 2012-03-19 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US13/665,241 Abandoned US20130109702A1 (en) 1998-12-04 2012-10-31 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US14/068,942 Abandoned US20140296258A1 (en) 1998-12-04 2013-10-31 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibiton
US14/310,315 Abandoned US20150152111A1 (en) 1998-12-04 2014-06-20 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US09/508,195 Ceased US6525060B1 (en) 1998-12-04 1999-12-02 Triazolo(4,5-d)pyrimidine compounds

Family Applications After (10)

Application Number Title Priority Date Filing Date
US10/323,655 Expired - Lifetime US6974868B2 (en) 1998-12-04 2002-12-20 Compounds
US11/230,493 Expired - Lifetime US7250419B2 (en) 1998-12-04 2005-09-21 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US11/711,838 Abandoned US20070265282A1 (en) 1998-12-04 2007-02-28 Novel compounds
US12/149,771 Abandoned US20080214812A1 (en) 1998-12-04 2008-05-08 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US12/591,395 Abandoned US20100069408A1 (en) 1998-12-04 2009-11-18 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US13/137,125 Abandoned US20120165348A1 (en) 1998-12-04 2011-07-21 Novel compounds
US13/423,848 Abandoned US20130072503A1 (en) 1998-12-04 2012-03-19 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US13/665,241 Abandoned US20130109702A1 (en) 1998-12-04 2012-10-31 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
US14/068,942 Abandoned US20140296258A1 (en) 1998-12-04 2013-10-31 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibiton
US14/310,315 Abandoned US20150152111A1 (en) 1998-12-04 2014-06-20 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition

Country Status (36)

Country Link
US (12) US6525060B1 (ja)
EP (5) EP1386921B1 (ja)
JP (4) JP4202607B2 (ja)
KR (4) KR100822602B1 (ja)
CN (1) CN1128801C (ja)
AR (3) AR023920A1 (ja)
AT (3) ATE261970T1 (ja)
AU (1) AU766618B2 (ja)
BR (1) BRPI9915883B8 (ja)
CA (1) CA2351709C (ja)
CY (3) CY1110501T1 (ja)
CZ (3) CZ295234B6 (ja)
DE (4) DE69940171D1 (ja)
DK (3) DK1386921T3 (ja)
EG (1) EG24814A (ja)
ES (3) ES2318081T3 (ja)
FR (1) FR11C0016I2 (ja)
HK (3) HK1039933B (ja)
HU (2) HU228589B1 (ja)
ID (1) ID29927A (ja)
IL (6) IL143232A0 (ja)
LT (1) LTC1135391I2 (ja)
LU (1) LU91819I2 (ja)
MY (1) MY121867A (ja)
NO (2) NO319806B1 (ja)
NZ (1) NZ511778A (ja)
PL (1) PL201283B1 (ja)
PT (2) PT1386921E (ja)
RU (3) RU2317990C2 (ja)
SA (1) SA99200848B1 (ja)
SI (3) SI1386921T1 (ja)
SK (1) SK286007B6 (ja)
TR (1) TR200101567T2 (ja)
TW (1) TWI229674B (ja)
WO (1) WO2000034283A1 (ja)
ZA (1) ZA200104094B (ja)

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