US8933047B2 - Poly(acrylate) polymers for in vivo nucleic acid delivery - Google Patents

Poly(acrylate) polymers for in vivo nucleic acid delivery Download PDF

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Publication number
US8933047B2
US8933047B2 US13/592,403 US201213592403A US8933047B2 US 8933047 B2 US8933047 B2 US 8933047B2 US 201213592403 A US201213592403 A US 201213592403A US 8933047 B2 US8933047 B2 US 8933047B2
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US
United States
Prior art keywords
acrylate
polymer
poly
random copolymer
polynucleotide
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Active, expires
Application number
US13/592,403
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English (en)
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US20130317079A1 (en
Inventor
Darren H. Wakefield
David B. Rozema
Nicholas Rossi
Lauren Almeida
Anthony L. Perillo-Nicholas
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Arrowhead Madison Inc
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Arrowhead Madison Inc
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Publication date
Priority to US13/592,403 priority Critical patent/US8933047B2/en
Priority to CA2842041A priority patent/CA2842041A1/fr
Application filed by Arrowhead Madison Inc filed Critical Arrowhead Madison Inc
Priority to KR1020147004853A priority patent/KR20150001710A/ko
Priority to BR112014004528A priority patent/BR112014004528A2/pt
Priority to AU2012377385A priority patent/AU2012377385A1/en
Priority to MX2014001965A priority patent/MX2014001965A/es
Priority to CN201280041457.6A priority patent/CN103764153A/zh
Priority to PCT/US2012/051973 priority patent/WO2013158141A1/fr
Priority to JP2015506951A priority patent/JP2015515530A/ja
Assigned to Arrowhead Madison Inc. reassignment Arrowhead Madison Inc. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ALMEIDA, Lauren, ROZEMA, DAVID B, WAKEFIELD, DARREN H, PERILLO-NICHOLAS, ANTHONY L, ROSSI, Nicholas
Publication of US20130317079A1 publication Critical patent/US20130317079A1/en
Priority to IL231147A priority patent/IL231147A0/en
Priority to US14/552,664 priority patent/US9452221B2/en
Application granted granted Critical
Publication of US8933047B2 publication Critical patent/US8933047B2/en
Priority to US15/284,564 priority patent/US10286539B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23D—PLANING; SLOTTING; SHEARING; BROACHING; SAWING; FILING; SCRAPING; LIKE OPERATIONS FOR WORKING METAL BY REMOVING MATERIAL, NOT OTHERWISE PROVIDED FOR
    • B23D45/00—Sawing machines or sawing devices with circular saw blades or with friction saw discs
    • B23D45/16—Hand-held sawing devices with circular saw blades
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23Q—DETAILS, COMPONENTS, OR ACCESSORIES FOR MACHINE TOOLS, e.g. ARRANGEMENTS FOR COPYING OR CONTROLLING; MACHINE TOOLS IN GENERAL CHARACTERISED BY THE CONSTRUCTION OF PARTICULAR DETAILS OR COMPONENTS; COMBINATIONS OR ASSOCIATIONS OF METAL-WORKING MACHINES, NOT DIRECTED TO A PARTICULAR RESULT
    • B23Q13/00—Equipment for use with tools or cutters when not in operation, e.g. protectors for storage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
    • B25F—COMBINATION OR MULTI-PURPOSE TOOLS NOT OTHERWISE PROVIDED FOR; DETAILS OR COMPONENTS OF PORTABLE POWER-DRIVEN TOOLS NOT PARTICULARLY RELATED TO THE OPERATIONS PERFORMED AND NOT OTHERWISE PROVIDED FOR
    • B25F5/00—Details or components of portable power-driven tools not particularly related to the operations performed and not otherwise provided for
    • B25F5/02—Construction of casings, bodies or handles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B27—WORKING OR PRESERVING WOOD OR SIMILAR MATERIAL; NAILING OR STAPLING MACHINES IN GENERAL
    • B27B—SAWS FOR WOOD OR SIMILAR MATERIAL; COMPONENTS OR ACCESSORIES THEREFOR
    • B27B5/00—Sawing machines working with circular or cylindrical saw blades; Components or equipment therefor
    • B27B5/29—Details; Component parts; Accessories
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B27—WORKING OR PRESERVING WOOD OR SIMILAR MATERIAL; NAILING OR STAPLING MACHINES IN GENERAL
    • B27B—SAWS FOR WOOD OR SIMILAR MATERIAL; COMPONENTS OR ACCESSORIES THEREFOR
    • B27B9/00—Portable power-driven circular saws for manual operation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C08F220/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
US13/592,403 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery Active 2033-02-07 US8933047B2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
PCT/US2012/051973 WO2013158141A1 (fr) 2012-04-18 2012-08-23 Polymères de poly(acrylate) pour une administration d'acide nucléique in vivo
KR1020147004853A KR20150001710A (ko) 2012-04-18 2012-08-23 Ｉｎ Ｖｉｖｏ 핵산 전달용 폴리(아크릴레이트) 고분자
BR112014004528A BR112014004528A2 (pt) 2012-04-18 2012-08-23 polímeros de poli(acrilato) para entrega de ácido nucleico in vivo
AU2012377385A AU2012377385A1 (en) 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery
MX2014001965A MX2014001965A (es) 2012-04-18 2012-08-23 Polimeros de poli(acrilato) para suministro de acido nucleico in vivo.
CA2842041A CA2842041A1 (fr) 2012-04-18 2012-08-23 Polymeres de poly(acrylate) pour une administration d'acide nucleique in vivo
US13/592,403 US8933047B2 (en) 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery
JP2015506951A JP2015515530A (ja) 2012-04-18 2012-08-23 インビボ核酸送達のためのポリ（アクリラート）ポリマー
CN201280041457.6A CN103764153A (zh) 2012-04-18 2012-08-23 用于体内核酸递送的聚(丙烯酸酯)聚合物
IL231147A IL231147A0 (en) 2012-04-18 2014-02-25 Polymers from poly(acrylate) for the transfer of nucleic acid to a living body
US14/552,664 US9452221B2 (en) 2012-04-18 2014-11-25 Poly(acrylate) polymers for in vivo nucleic acid delivery
US15/284,564 US10286539B2 (en) 2012-04-18 2016-10-04 Dual axis hook assembly for a power tool

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261625955P 2012-04-18 2012-04-18
US13/592,403 US8933047B2 (en) 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/552,664 Continuation US9452221B2 (en) 2012-04-18 2014-11-25 Poly(acrylate) polymers for in vivo nucleic acid delivery

Publications (2)

Publication Number Publication Date
US20130317079A1 US20130317079A1 (en) 2013-11-28
US8933047B2 true US8933047B2 (en) 2015-01-13

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
US13/592,403 Active 2033-02-07 US8933047B2 (en) 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery
US14/552,664 Active US9452221B2 (en) 2012-04-18 2014-11-25 Poly(acrylate) polymers for in vivo nucleic acid delivery
US15/284,564 Active 2034-10-12 US10286539B2 (en) 2012-04-18 2016-10-04 Dual axis hook assembly for a power tool

Family Applications After (2)

Application Number Title Priority Date Filing Date
US14/552,664 Active US9452221B2 (en) 2012-04-18 2014-11-25 Poly(acrylate) polymers for in vivo nucleic acid delivery
US15/284,564 Active 2034-10-12 US10286539B2 (en) 2012-04-18 2016-10-04 Dual axis hook assembly for a power tool

Country Status (10)

Country Link
US (3) US8933047B2 (fr)
JP (1) JP2015515530A (fr)
KR (1) KR20150001710A (fr)
CN (1) CN103764153A (fr)
AU (1) AU2012377385A1 (fr)
BR (1) BR112014004528A2 (fr)
CA (1) CA2842041A1 (fr)
IL (1) IL231147A0 (fr)
MX (1) MX2014001965A (fr)
WO (1) WO2013158141A1 (fr)

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US20170021490A1 (en) 2017-01-26
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