US20180049686A1 - Biological Fluid Separation Device and Biological Fluid Separation and Testing System - Google Patents
Biological Fluid Separation Device and Biological Fluid Separation and Testing System Download PDFInfo
- Publication number
- US20180049686A1 US20180049686A1 US15/803,001 US201715803001A US2018049686A1 US 20180049686 A1 US20180049686 A1 US 20180049686A1 US 201715803001 A US201715803001 A US 201715803001A US 2018049686 A1 US2018049686 A1 US 2018049686A1
- Authority
- US
- United States
- Prior art keywords
- blood
- biological fluid
- fluid separation
- collection chamber
- separation cartridge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150213—Venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150221—Valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150267—Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150305—Packages specially adapted for piercing devices or blood sampling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150442—Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150748—Having means for aiding positioning of the piercing device at a location where the body is to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150763—Details with identification means
- A61B5/150778—Details with identification means having complementary physical shapes for indexing or registration purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15142—Devices intended for single use, i.e. disposable
- A61B5/15144—Devices intended for single use, i.e. disposable comprising driving means, e.g. a spring, for retracting the piercing unit into the housing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
- A61B5/15188—Constructional features of reusable driving devices
- A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
- A61B5/15198—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing purely manually retracted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/08—Rotary bowls
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150435—Specific design of proximal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
- G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Definitions
- the present disclosure relates generally to devices, assemblies, and systems adapted for use with vascular access devices. More particularly, the present disclosure relates to devices, assemblies, and systems adapted for collecting biological samples for use in point-of-care testing.
- Blood sampling is a common health care procedure involving the withdrawal of at least a drop of blood from a patient.
- Blood samples are commonly taken from hospitalized, homecare, and emergency room patients either by finger stick, heel stick, or venipuncture. Blood samples may also be taken from patients by venous or arterial lines. Once collected, blood samples may be analyzed to obtain medically useful information including chemical composition, hematology, or coagulation, for example.
- Blood tests determine the physiological and biochemical states of the patient, such as disease, mineral content, drug effectiveness, and organ function. Blood tests may be performed in a clinical laboratory or at the point-of-care near the patient.
- One example of point-of-care blood testing is the routine testing of a patient's blood glucose levels which involves the extraction of blood via a finger stick and the mechanical collection of blood into a diagnostic cartridge. Thereafter, the diagnostic cartridge analyzes the blood sample and provides the clinician a reading of the patient's blood glucose level.
- Other devices are available which analyze blood gas electrolyte levels, lithium levels, and ionized calcium levels. Some other point-of-care devices identify markers for acute coronary syndrome (ACS) and deep vein thrombosis/pulmonary embolism (DVT/PE).
- ACS acute coronary syndrome
- DVD/PE deep vein thrombosis/pulmonary embolism
- Blood samples are frequently drawn using hypodermic needles or vacuum tubes attached to a proximal end of a needle or a catheter assembly.
- clinicians collect blood from a catheter assembly using a needle and syringe that is inserted into the catheter to withdraw blood from a patient through the inserted catheter.
- needles and vacuum tubes as intermediate devices from which the collected blood sample is typically withdrawn prior to testing.
- Point-of-care testing devices allow for a blood sample to be tested without needing to send the blood sample to a lab for analysis. Thus, it is desirable to create a device that provides an easy, safe, reproducible, and accurate process with a point-of-care testing system.
- the present disclosure provides a biological fluid separation device, such as a blood separation device, that is adapted to receive a multi-component blood sample, for example, having a cellular portion and a plasma portion. After collecting the blood sample, the blood separation device is able to separate the plasma portion from the cellular portion. After separation, the blood separation device is able to transfer the plasma portion of the blood sample to a point-of-care testing device.
- the blood separation device of the present disclosure also provides a closed separation system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer, which could be an anticoagulant, or a substance designed to preserve a specific element within the blood such as, for example, RNA, protein analyte, or other element.
- the blood separation device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the blood separation device to the blood testing device.
- the blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.
- the blood separation device and the biological fluid separation and testing system of the present disclosure are that it is a closed system which reduces blood sample exposure, it provides passive and fast mixing of the blood sample with a sample stabilizer, it facilitates separation of the blood sample without transferring the blood sample to a separate device, and it is capable of transferring pure plasma to a point-of-care testing device.
- the blood separation device of the present disclosure enables integrated blood collection and plasma creation in a closed system without centrifugation. The clinician may collect and separate the blood sample and then immediately transfer the plasma portion to the point-of-care testing device without further manipulation. This enables collection and transfer of plasma to the point-of-care testing device without exposure to blood.
- the blood separation device of the present disclosure minimizes process time by processing the blood within the blood separation device and without external machinery. Further, for tests which only require small amounts of blood, it eliminates the waste associated with blood collection and plasma separation with an evacuated tube.
- a biological fluid separation cartridge such as a blood separation cartridge, includes a housing having an inlet port and a flow channel defined within the housing in fluid communication with the inlet port, a first collection chamber defined within the housing in fluid communication with the flow channel and including a first outlet port, and a second collection chamber defined within the housing in fluid communication with the flow channel and including a second outlet port.
- the second collection chamber is isolated from the first collection chamber, and the second outlet port is spaced apart from the first outlet port.
- the flow channel has a spiral shape. At least a portion of the flow channel may include a sample stabilizer.
- the cartridge may include an inlet channel in fluid communication with the inlet port and the flow channel, with the inlet channel including a sample stabilizer.
- the biological fluid separation cartridge may be adapted to receive a multi-component blood sample.
- the multi-component blood sample may include a cellular portion and a plasma portion.
- the cartridge may include a flow channel having a separation element adapted to separate the cellular portion and the plasma portion of the multi-component blood sample.
- the separation element may include a plurality of posts.
- the inlet port may be adapted to receive the multi-component blood sample via connection to a blood collection device.
- the first collection chamber may be adapted to receive at least a portion of the plasma portion therein, and the second collection chamber may be adapted to receive at least a portion of the cellular portion.
- the cellular portion is prevented from entering the first collection chamber.
- the first outlet port may be adapted for connection to a point-of-care testing device for closed transfer of a portion of the plasma portion from the first collection chamber to the point-of-care testing device.
- a portion of the blood separation cartridge is adapted for connection with a drive device. When the drive device is connected to the blood separation cartridge, the drive device causes flow of the plasma portion from the first collection chamber to the point-of-care testing device.
- a biological fluid separation device is adapted to receive a multi-component blood sample.
- the blood separation device includes a separation cartridge having an inlet port and a flow channel defined within the cartridge in fluid communication with the inlet port.
- the flow channel contains a separation element adapted to separate the multi-component blood sample into at least a first component and a second component.
- a first collection chamber defined within the cartridge in fluid communication with the flow channel includes a first outlet port, and a second collection chamber defined within the cartridge in fluid communication with the flow channel includes a second outlet port, with the second collection chamber isolated from the first collection chamber.
- the first component is a cellular portion of the multi-component blood sample and the second component is a plasma portion of the multi-component blood sample.
- the separation element may include a plurality of posts.
- the flow channel has a spiral shape.
- the inlet channel may be provided in fluid communication with the inlet port and the flow channel, with the inlet channel including a sample stabilizer.
- the second component is a plasma portion of the multi-component blood sample.
- the first collection chamber is adapted to receive at least a portion of the second component therein and the second collection chamber is adapted to receive at least a portion of the first component.
- the first component may be a cellular portion of the multi-component blood sample and the second component may be a plasma portion of the multi-component blood sample. In certain embodiments, the cellular portion is prevented from entering the first collection chamber.
- at least a portion of the flow channel includes a sample stabilizer.
- the second component may be a plasma portion of the multi-component blood sample.
- the inlet port is adapted to receive the multi-component blood sample via connection to a blood collection device.
- the first outlet port may be adapted for connection to a point-of-care testing device for closed transfer of a portion of the second component of the multi-component blood sample from the first collection chamber to the point-of-care testing device.
- a portion of the blood separation device may be adapted for connection with a drive device. When the drive device is connected to the blood separation device, the drive device causes flow of the second component of the multi-component blood sample from the first collection chamber to the point-of-care testing device.
- a biological fluid separation and testing system such as a blood separation and testing system, for a multi-component blood sample
- the blood separation cartridge includes a housing having an inlet port and a flow channel defined within the housing in fluid communication with the inlet port.
- the cartridge further includes a first collection chamber defined within the housing in fluid communication with the flow channel and including a first outlet port, and a second collection chamber defined within the housing in fluid communication with the flow channel and including a second outlet port.
- the second collection chamber is isolated from the first collection chamber, and the second outlet port is spaced apart from the first outlet port.
- the system further includes a blood testing device having a receiving port adapted to receive the first outlet port of the blood separation cartridge for closed transfer of a portion of a component of the multi-component blood sample from the first collection chamber to the blood testing device.
- the multi-component blood sample includes a first cellular portion component and a second plasma portion component.
- a portion of the blood separation cartridge may be adapted for connection with a drive device. When the drive device is connected to the blood separation cartridge, the drive device causes flow of the plasma portion from the first collection chamber to the blood testing device.
- the blood testing device may include a point-of-care testing device.
- FIG. 1 is a perspective view of a biological fluid separation device in accordance with an embodiment of the present invention.
- FIG. 2 is a top view of a biological fluid separation device in accordance with an embodiment of the present invention.
- FIG. 3 is a perspective view of a biological fluid separation device in accordance with an embodiment of the present invention, with a first biological fluid collection device.
- FIG. 4 is a perspective view of a biological fluid separation device in accordance with an embodiment of the present invention, with a second biological fluid collection device.
- FIG. 5 is a cross-sectional, top view of a biological fluid separation cartridge in accordance with an embodiment of the present invention.
- FIG. 6 is a detailed, fragmentary view of a portion of FIG. 5 .
- FIG. 7 is a perspective view of a biological fluid separation device and a point-of-care testing device in accordance with an embodiment of the present invention.
- FIG. 8 is a cross-sectional view of a septum of a biological fluid separation device in accordance with an embodiment of the present invention, with the septum in a closed position.
- FIG. 9 is a cross-sectional view of a septum of a biological fluid separation device in accordance with an embodiment of the present invention, with the septum in an open position.
- FIG. 10 is a side elevation view of a biological fluid separation device in accordance with an embodiment of the present invention.
- FIG. 11 is a side elevation view of a biological fluid separation device in accordance with an embodiment of the present invention, with a first component being removed from a second component.
- Point-of-care testing devices include test strips, glass slides, diagnostic cartridges, or other testing devices for testing and analysis.
- Test strips, glass slides, and diagnostic cartridges are point-of-care testing devices that receive a blood sample and test that blood for one or more physiological and biochemical states.
- Testing cartridges such as the i-STAT® cartridges may be used to test for a variety of conditions including the presence of chemicals and electrolytes, hematology, blood gas concentrations, coagulation, or cardiac markers. The results of tests using such cartridges are quickly provided to the clinician.
- a system of the present disclosure enhances the reliability of the point-of-care testing device by: 1) incorporating a more closed type of sampling and transfer system; 2) minimizing open exposure of the sample; 3) improving sample quality; 4) improving the overall ease of use; and 5) separating the sample at the point of collection.
- FIGS. 1-11 illustrate an exemplary embodiment of the present disclosure.
- a biological fluid separation device such as a blood separation device 10
- a biological fluid separation device 10 of the present disclosure is adapted to receive a blood sample 12 having a cellular portion 14 and a plasma portion 16 .
- the blood separation device 10 is able to separate the plasma portion 16 from the cellular portion 14 .
- the blood separation device 10 is able to transfer the plasma portion 16 of the blood sample 12 to a point-of-care testing device.
- the blood separation device 10 of the present disclosure also provides a closed separation system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer.
- FIG. 7 illustrates an exemplary embodiment of the present disclosure.
- a biological fluid separation and testing system such as a blood separation and testing system 20 of the present disclosure, includes a blood separation device 10 and a blood testing device or point-of-care testing device 22 engageable with the blood separation device 10 for closed transfer of a portion of the plasma portion 16 ( FIG. 6 ) from the blood separation device 10 to the blood testing device 22 .
- the blood testing device 22 is adapted to receive the plasma portion 16 to analyze the blood sample and obtain test results.
- the blood separation device and the blood separation and testing system of the present disclosure are a closed system which reduces blood sample exposure, it provides passive and fast mixing of the blood sample with a sample stabilizer, it facilitates separation of the blood sample without transferring the blood sample to a separate device, and it is capable of transferring pure plasma to a point-of-care testing device.
- the blood separation device of the present disclosure enables integrated blood collection and plasma creation in a closed system without centrifugation. The clinician may collect and separate the blood sample and then immediately transfer the plasma portion to the point-of-care testing device without further manipulation. This enables collection and transfer of plasma to the point-of-care testing device without exposure to blood.
- the blood separation device of the present disclosure minimizes process time by processing the blood within the blood separation device and without external machinery. Further, for tests which only require small amounts of blood, it eliminates the waste associated with blood collection and plasma separation with an evacuated tube.
- a blood separation device 10 includes a first component or biological fluid separation cartridge, such as a blood separation cartridge 11 and a second component or drive device 13 that is removably connected to the blood separation cartridge 11 .
- the blood separation cartridge 11 is adapted to receive a blood sample 12 having a cellular portion 14 and a plasma portion 16 .
- a blood separation cartridge 11 is a disposable component and connects with a reusable drive device 13 that is in the shape of a standard pipette which drives the flow of blood through the blood separation cartridge 11 and drives the flow of plasma into a point-of-care testing device 22 .
- the blood separation cartridge 11 generally includes a housing 30 , an inlet port 32 , a flow channel 34 having an inlet channel 36 and an exit channel 38 , a first collection chamber 40 defined within the housing 30 and in fluid communication with the flow channel 34 and including a first outlet port 42 , a second collection chamber 44 defined within the housing 30 and in fluid communication with the flow channel 34 and including a second outlet port 46 , and a valve or septum 86 disposed at the first outlet port 42 .
- the second collection chamber 44 is isolated from the first collection chamber 40 and the second outlet port 46 is spaced apart from the first outlet port 42 .
- the flow channel 34 includes a separation element 50 that is adapted to separate the cellular portion 14 and the plasma portion 16 of the blood sample 12 .
- the separation element 50 includes a plurality of posts 52 .
- the inlet channel 36 is in fluid communication with the inlet port 32 .
- the blood separation cartridge 11 is connectable with the drive device 13 to allow vacuum or pressure to drive flow of a blood sample within the blood separation cartridge 11 .
- the connection between the blood separation cartridge 11 and the drive device 13 does not allow blood contact with the drive device 13 .
- the use of materials that only let air to pass, or one way valves, ensures that blood does not come in contact with the drive device 13 .
- the flow channel 34 has a spiral shape for inertial separation of blood cells, e.g., a cellular portion 14 , from a plasma portion 16 as shown in FIG. 6 .
- the flow channel 34 includes a plurality of posts 52 arranged to enhance plasma separation by filtering and directing the cellular portion 14 to the outside of the flow channel 34 , which is the same direction the inertial forces drive the cellular portion 14 .
- the posts 52 can be of any suitable shape, such as rounded, and may have a generally circular cross-section. In another configuration, the posts 52 may have any polygon shape, such as a polygon cross-sectional shape.
- the flow channel 34 splits into a first collection chamber 40 for collecting the plasma portion 16 and a second collection chamber 44 for collecting the cellular portion 14 .
- the first collection chamber 40 and the second collection chamber 44 includes no posts 52 to take advantage of laminar flow properties in a microfluidic channel. In one embodiment, to increase throughput, multiple spirals can be fabricated that operate in parallel to generate sufficient plasma volume for a downstream application.
- the first collection chamber 40 includes the first outlet port 42 which interfaces with a point-of-care testing device 22 or storage vessel as discussed in more detail below.
- the second outlet port 46 provides an outlet for the cellular portion 14 of the blood sample 12 .
- the junction point 48 contains a mechanism for substantially preventing the cellular portion 14 from entering the first collection chamber 40 .
- the junction point 48 may contain a filter or one-way valve or other mechanism.
- the flow channel 34 is adapted to contain a sample stabilizer to provide passive and fast mixing of a blood sample with the sample stabilizer.
- the sample stabilizer can be an anticoagulant, or a substance designed to preserve a specific element within the blood such as, for example, RNA, protein analyte, or other element.
- the sample stabilizer is provided in other areas of the housing 30 of the blood separation cartridge 11 such as the inlet channel 36 . In this manner, as a blood sample 12 flows through the inlet port 32 and into the flow channel 34 , the blood separation device 10 provides passive and fast mixing of the blood sample 12 with the sample stabilizer.
- the drive device 13 may comprise an electronic durable component that is in the shape of a standard pipette which drives the flow of blood through the blood separation cartridge 11 and drives the flow of plasma into a point-of-care testing device 22 .
- the drive device 13 drives flow by vacuum or pressure and can actuate any required valves on the blood separation cartridge 11 .
- the drive device 13 can be battery operated or plugged into a wall outlet in some embodiments or, like some automated pipettes, use induction or plug-in charging with an internal rechargeable battery.
- the drive device 13 may include an actuation member 60 and flow in or out is controlled by pressing the actuation member 60 on the top of the drive device 13 in a similar location to a plunger on a standard laboratory pipette.
- the actuation member 60 or buttons may be located in a trigger position on the handle similar to automated serological pipettes.
- the blood separation cartridge 11 and the drive device 13 are removably connectable theretogether such that significant relative movement between the blood separation cartridge 11 and the drive device 13 is prevented.
- the blood separation cartridge 11 and the drive device 13 are removably connectable theretogether via engagement of a first securement portion 47 of the blood separation cartridge 11 with a second securement portion 62 of the drive device 13 .
- similar connection mechanisms may be used.
- a snap fit engagement mechanism or a friction fit engagement mechanism may be used.
- the inlet port 32 of the blood separation cartridge 11 is adapted to be connected to a blood collection set or blood collection device 100 to allow for the collection of a blood sample 12 into the blood separation device 10 .
- the inlet port 32 may be sized and adapted for engagement with a separate device, such as a needle assembly or IV connection assembly and, therefore, may include a mechanism for such engagement as is conventionally known.
- the inlet port 32 may include a luer lock or luer tip for engagement with an optional separate luer mating component of such a separate device for attachment therewith.
- a separate device such as a needle assembly or IV connection assembly
- the inlet port 32 may include a luer lock or luer tip for engagement with an optional separate luer mating component of such a separate device for attachment therewith.
- the blood collection set 100 may include a luer component 102 for engagement with the inlet port 32 of the blood separation device 10 .
- the inlet port 32 is connectable to the blood collection set 100 for the collection of a blood sample into the blood separation device 10 .
- a mechanism for locking engagement between the inlet port 32 and the blood collection set 100 may also be provided.
- Such luer connections and luer locking mechanisms are well known in the art.
- the blood collection set 100 may include a needle assembly, an IV connection assembly, a PICC line, an arterial indwelling line, or similar blood collection means.
- the inlet port 32 may also include a resealable septum that is transitionable between a closed position and an open position. With the septum in an open position, a blood sample 12 may flow through the inlet port 32 to the flow channel 34 via the inlet channel 36 .
- the blood separation cartridge 11 also may include a valve or septum 86 ( FIGS. 8 and 9 ) at the first outlet port 42 .
- the first outlet port 42 is adapted for connection to a point-of-care testing device 22 for closed transfer of a portion of the plasma portion 16 from the blood separation device 10 to the point-of-care testing device 22 via the first outlet port 42 as described in more detail below.
- the valve or septum 86 at the first outlet port 42 is transitionable between a closed position and an open position. With the valve or septum 86 in an open position ( FIG. 9 ), the plasma portion 16 of the blood sample 12 may flow through the first outlet port 42 to a blood testing device or a point-of-care testing device 22 ( FIG. 7 ).
- a blood testing device or point-of-care testing device 22 includes a receiving port 24 adapted to receive the first outlet port 42 of the blood separation device 10 .
- the blood testing device 22 is adapted to receive the first outlet port 42 of the blood separation device 10 for closed transfer of a portion of the plasma portion 16 ( FIG. 6 ) from the blood separation device 10 to the blood testing device 22 .
- the blood testing device 22 is adapted to receive the plasma portion 16 to analyze the blood sample and obtain test results.
- the first outlet port 42 of the blood separation device 10 may include a valve or septum 86 that is transitionable between a closed position and an open position. With the valve or septum 86 in an open position ( FIG. 9 ), the plasma portion 16 of the blood sample 12 may flow through the first outlet port 42 to a blood testing device or a point-of-care testing device 22 ( FIG. 7 ).
- the valve 86 may generally include a transfer channel 90 , a bellows or deformable wall member 92 , and a septum or barrier 94 having a first barrier wall 96 and a second barrier wall 98 .
- the valve 86 is in a closed position to prevent the plasma portion 16 of the blood sample 12 from flowing through the first outlet port 42 . In this manner, the plasma portion 16 is sealed within the blood separation device 10 .
- the valve 86 is in an open position so that the plasma portion 16 of the blood sample 12 may flow through the first outlet port 42 to a blood testing device or a point-of-care testing device 22 ( FIG. 7 ).
- the first outlet port 42 of the blood separation device 10 is then positioned over the receiving port 24 of the point-of-care testing device 22 .
- Pushing down in the direction of arrow B compresses the deformable wall member 92 and opens up the first barrier wall 96 and the second barrier wall 98 of the septum 94 as shown in FIG. 9 .
- the valve 86 With the valve 86 in the open position, the plasma portion 16 of the blood sample 12 is allowed to flow through the first outlet port 42 and the receiving port 24 to the point-of-care testing device 22 in a closed manner, reducing exposure to the clinician and the patient.
- the valve 86 of the blood separation device 10 only opens when the first outlet port 42 is pressed upon the receiving port 24 of the point-of-care testing device 22 . This releases the isolated plasma portion 16 directly into the receiving port 24 of the point-of-care testing device 22 , thus mitigating unnecessary exposure to the patient's blood.
- the drive device 13 is connectable with any number of blood separation cartridges 11 .
- a blood separation cartridge 11 is a replaceable single use component.
- the blood separation cartridge 11 can be removed from the drive device 13 , as shown in FIG. 11 , and the blood separation cartridge 11 can be disposed of into a biological hazard container.
- a new and clean blood separation cartridge 11 can be selected and used with the drive device 13 .
- One advantage of the blood separation system of the present disclosure is that a plurality of blood separation cartridges 11 can be used with the drive device 13 .
- the drive device 13 can be repeatedly used.
- the inlet port 32 of the blood separation device 10 is adapted to be connected to a blood collection set 100 to allow for the collection of a blood sample 12 into the blood separation device 10 as discussed above.
- the actuation member 60 of the drive device 13 is activated, e.g., a power switch is pushed down, to draw the blood sample into the flow channel 34 of the blood separation cartridge 11 .
- the blood sample 12 slowly fills the blood separation device 10 , it is collected and stabilized over a layer of sample stabilizer.
- the blood sample 12 may then flow through the flow channel 34 for inertial separation of the cellular portion 14 from the plasma portion 16 .
- the series of posts 52 are arranged to enhance plasma separation by filtering and directing the cellular portion 14 to the outside of the flow channel 34 , which is the same direction that the inertial forces drive the cellular portion 14 .
- the flow channel 34 splits into a first collection chamber 40 for collecting the plasma portion 16 and a second collection chamber 44 for collecting the cellular portion 14 .
- the first collection chamber 40 and the second collection chamber 44 include no posts 52 to take advantage of laminar flow properties in a microfluidic channel. In one embodiment, to increase throughput, multiple spirals can be fabricated that operate in parallel to generate sufficient plasma volume for a downstream application.
- the first collection chamber 40 includes the first outlet port 42 which interfaces with a point-of-care testing device 22 or storage vessel.
- the blood separation device 10 may be engaged with a blood testing device 22 .
- the first outlet port 42 is placed over the receiving port 24 of the point-of-care testing device 22 as shown in FIG. 7 .
- the actuation member 60 of the drive device 13 may be activated or depressed to advance the plasma portion 16 and to transfer the collected plasma portion 16 to the point-of-care testing device 22 .
- the blood testing device 22 is adapted to receive the first outlet port 42 of the blood separation device 10 for closed transfer of a portion of the plasma portion 16 from the blood separation device 10 to the blood testing device 22 .
- the blood testing device 22 is adapted to receive the plasma portion 16 to analyze the blood sample and obtain test results.
- the blood separation cartridge 11 can be removed from the drive device 13 , as shown in FIG. 11 , and the blood separation cartridge 11 can be disposed of into a biological hazard container.
- the blood separation system of the present disclosure relies on inertial forces and a gentler filtration to generate plasma.
- the filtration posts are made of the same material as the device so analyte bias and passivation is the same for the posts as the parent device.
- the blood separation device and the blood separation and testing system of the present disclosure is a closed system which reduces blood sample exposure, it provides passive and fast mixing of the blood sample with a sample stabilizer, it facilitates separation of the blood sample without transferring the blood sample to a separate device, and it is capable of transferring pure plasma to the point-of-care testing device 22 .
- the blood separation device of the present disclosure enables integrated blood collection and plasma creation in a closed system without centrifugation. The clinician may collect and separate the blood sample and then immediately transfer the plasma portion to the point-of-care testing device 22 without further manipulation. This enables collection and transfer of plasma to the point-of-care testing device 22 without exposure to blood.
- the blood separation device of the present disclosure minimizes process time by processing the blood within the blood separation device and without external machinery. Further, for tests which only require small amounts of blood, it eliminates the waste associated with blood collection and plasma separation with an evacuated tube.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Anesthesiology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- External Artificial Organs (AREA)
- Centrifugal Separators (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/803,001 US20180049686A1 (en) | 2013-04-15 | 2017-11-03 | Biological Fluid Separation Device and Biological Fluid Separation and Testing System |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361811918P | 2013-04-15 | 2013-04-15 | |
US14/251,699 US9833182B2 (en) | 2013-04-15 | 2014-04-14 | Biological fluid separation device and biological fluid separation and testing system |
US15/803,001 US20180049686A1 (en) | 2013-04-15 | 2017-11-03 | Biological Fluid Separation Device and Biological Fluid Separation and Testing System |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/251,699 Continuation US9833182B2 (en) | 2013-04-15 | 2014-04-14 | Biological fluid separation device and biological fluid separation and testing system |
Publications (1)
Publication Number | Publication Date |
---|---|
US20180049686A1 true US20180049686A1 (en) | 2018-02-22 |
Family
ID=58804713
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/803,001 Abandoned US20180049686A1 (en) | 2013-04-15 | 2017-11-03 | Biological Fluid Separation Device and Biological Fluid Separation and Testing System |
US16/015,381 Active 2035-03-01 US10827965B2 (en) | 2013-04-15 | 2018-06-22 | Biological fluid collection device and biological fluid separation and testing system |
US16/165,157 Abandoned US20190046096A1 (en) | 2013-04-15 | 2018-10-19 | Biological Fluid Collection Device and Biological Fluid Separation and Testing System |
US16/280,449 Active 2035-05-21 US11291393B2 (en) | 2013-04-15 | 2019-02-20 | Medical device for collection of a biological sample |
US16/425,015 Active US10791975B2 (en) | 2013-04-15 | 2019-05-29 | Biological fluid transfer device and biological fluid sampling system |
US17/007,875 Active 2034-08-09 US11974846B2 (en) | 2013-04-15 | 2020-08-31 | Biological fluid transfer device and biological fluid sampling system |
US17/153,696 Active 2036-10-03 US12082931B2 (en) | 2013-04-15 | 2021-01-20 | Blood sampling transfer device |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/015,381 Active 2035-03-01 US10827965B2 (en) | 2013-04-15 | 2018-06-22 | Biological fluid collection device and biological fluid separation and testing system |
US16/165,157 Abandoned US20190046096A1 (en) | 2013-04-15 | 2018-10-19 | Biological Fluid Collection Device and Biological Fluid Separation and Testing System |
US16/280,449 Active 2035-05-21 US11291393B2 (en) | 2013-04-15 | 2019-02-20 | Medical device for collection of a biological sample |
US16/425,015 Active US10791975B2 (en) | 2013-04-15 | 2019-05-29 | Biological fluid transfer device and biological fluid sampling system |
US17/007,875 Active 2034-08-09 US11974846B2 (en) | 2013-04-15 | 2020-08-31 | Biological fluid transfer device and biological fluid sampling system |
US17/153,696 Active 2036-10-03 US12082931B2 (en) | 2013-04-15 | 2021-01-20 | Blood sampling transfer device |
Country Status (4)
Country | Link |
---|---|
US (7) | US20180049686A1 (fr) |
JP (7) | JP6431555B2 (fr) |
CA (2) | CA3005826C (fr) |
ES (3) | ES2832756T3 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019236822A1 (fr) * | 2018-06-07 | 2019-12-12 | Becton, Dickinson And Company | Dispositif de séparation de fluide biologique |
US11231409B2 (en) * | 2018-10-02 | 2022-01-25 | Instrumentation Laboratory Company | Disposable hemolysis sensor |
US11959907B2 (en) | 2015-01-12 | 2024-04-16 | Instrumentation Laboratory Company | Spatial separation of particles in a particle containing solution for biomedical sensing and detection |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5829608B2 (ja) | 2009-07-29 | 2015-12-09 | アイシーユー・メディカル・インコーポレーテッド | 流体移行デバイスおよびその使用方法 |
KR102481494B1 (ko) | 2011-12-22 | 2022-12-26 | 아이씨유 메디칼 인코퍼레이티드 | 의료용 유체 전달 시스템, 유체 전달 방법, 전자 의료용 유체 전달 시스템, 및 전자 의료용 유체 전달 시스템 이용 방법 |
CA2931195C (fr) | 2013-11-25 | 2019-09-24 | Icu Medical, Inc. | Procedes et systeme pour remplir des sacs pour perfusion intraveineuse d'un fluide therapeutique |
JP6710758B2 (ja) | 2015-12-04 | 2020-06-17 | アイシーユー・メディカル・インコーポレーテッド | 医療用流体を移送するための電子式医療用流体移送装置 |
USD851745S1 (en) | 2016-07-19 | 2019-06-18 | Icu Medical, Inc. | Medical fluid transfer system |
EP3487468A4 (fr) | 2016-07-25 | 2020-03-25 | ICU Medical, Inc. | Systèmes, procédés et composants pour piéger des bulles d'air dans des modules et des systèmes de transfert de fluide médical. |
EP3600514B1 (fr) | 2017-03-21 | 2022-06-08 | Velano Vascular, Inc. | Systèmes et procédés de commande de la taille d'un dispositif de cathéter |
RU2021138683A (ru) | 2017-03-21 | 2022-02-24 | Велано Васкулар, Инк. | Устройства и способы для перемещения текучей среды через установленный периферический внутривенный катетер |
BR112020000204A2 (pt) * | 2017-07-06 | 2020-07-07 | Becton, Dickinson And Company | dispositivo de coleta de fluido biológico |
BR112020007278B1 (pt) * | 2017-10-31 | 2023-03-21 | Halliburton Energy Services, Inc | Método para estimar um ângulo de lama e sistema para determinar um limite de formação |
US11193862B2 (en) * | 2018-02-26 | 2021-12-07 | Becton, Dickinson And Company | Biological fluid collection device and collection module |
CN112119295B (zh) | 2018-07-24 | 2024-08-09 | 报知希株式会社 | 火灾探测装置 |
US11604204B2 (en) | 2019-06-03 | 2023-03-14 | University Of Washington | Self-contained systems and methods for controlled dispensing of hazardous fluid |
AU2020333843A1 (en) | 2019-08-20 | 2022-03-31 | Velano Vascular, Inc. | Fluid transfer devices with extended length catheters and methods of using the same |
US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
US20210330228A1 (en) * | 2020-04-22 | 2021-10-28 | Cercacor Laboratories, Inc. | Self-contained minimal action invasive blood constituent system |
MX2023001835A (es) * | 2020-08-14 | 2023-03-13 | Becton Dickinson Co | Dispositivo de extraccion de sangre y sistemas y metodos relacionados. |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
US11877848B2 (en) * | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12048543B2 (en) * | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
US11510602B1 (en) * | 2021-11-08 | 2022-11-29 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12053284B2 (en) * | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
WO2024167806A1 (fr) * | 2023-02-07 | 2024-08-15 | Qurasense, Inc. | Système de collecte de tampon menstruel |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5657963A (en) * | 1993-06-16 | 1997-08-19 | United States Surgical Corporation | Seal assembly for accommodating introduction of surgical instruments |
US20130086980A1 (en) * | 2010-04-20 | 2013-04-11 | Eltek S.P.A. | Microfluidic devices and/or equipment for microfluidic devices |
Family Cites Families (186)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3159159A (en) | 1960-06-01 | 1964-12-01 | Milton J Cohen | Fluid withdrawal device and container |
US3322114A (en) | 1964-07-01 | 1967-05-30 | Hynson Westcott & Dunning Inc | Apparatus for securing a sample of blood plasma for testing |
US3640388A (en) | 1970-08-20 | 1972-02-08 | Damon Corp | Dialyzing liquid-collecting container |
US3848579A (en) | 1973-02-23 | 1974-11-19 | Real A Villa | Automatic elasto-valvular hypodermic sampling needle |
JPS5538489Y2 (fr) | 1975-06-19 | 1980-09-09 | ||
JPS5323170A (en) | 1977-03-25 | 1978-03-03 | Hitachi Ltd | Hollow cathode tube for atomic adsorption method |
US4134512A (en) | 1977-06-08 | 1979-01-16 | Becton, Dickinson And Company | One-way evacuated tube stopper |
US4146172A (en) | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
JPS6136249Y2 (fr) * | 1980-02-18 | 1986-10-21 | ||
US4436098A (en) * | 1981-03-16 | 1984-03-13 | Becton Dickinson Company | Needle assembly with vein entry indicator |
US4511349A (en) | 1982-07-06 | 1985-04-16 | Beckman Instruments, Inc. | Ultracentrifuge tube with multiple chambers |
JPS59168843A (ja) * | 1983-03-14 | 1984-09-22 | ジエルマン サイエンシスインコ−ポレ−テツド | 血漿試料を採取する方法とそのためのフィルタ |
JPS6113937A (ja) * | 1984-06-28 | 1986-01-22 | ミツチエル ピー ドムブロウスキ | 胎児の血液サンプリング器具 |
US4627445A (en) | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
US4818842A (en) | 1986-08-22 | 1989-04-04 | Walty Robert J | Diesel fuel heater |
US4999304A (en) | 1987-12-28 | 1991-03-12 | Miles Inc. | Dynamic braking centrifuge |
US4842591A (en) | 1988-01-21 | 1989-06-27 | Luther Ronald B | Connector with one-way septum valve, and assembly |
JPH0275332A (ja) * | 1988-09-09 | 1990-03-15 | Nissho Corp | 液体分離方法 |
US5046509A (en) | 1988-12-30 | 1991-09-10 | Spacelabs, Inc. | Device for the conditioning, handling and measurement of blood |
US5160702A (en) * | 1989-01-17 | 1992-11-03 | Molecular Devices Corporation | Analyzer with improved rotor structure |
JPH0778025B2 (ja) | 1990-03-20 | 1995-08-23 | 日本赤十字社 | 免疫グロブリンgの製造方法 |
US5055203A (en) * | 1990-05-22 | 1991-10-08 | Eastman Kodak Company | Blood collection device with reduced serum dispensing volume and integral needle |
DE69130986T2 (de) | 1990-06-04 | 1999-09-30 | Abaxis, Inc. | Rotoren für die Analytik und Verfahren zur Analyse biologischer Fluide |
US5242606A (en) | 1990-06-04 | 1993-09-07 | Abaxis, Incorporated | Sample metering port for analytical rotor having overflow chamber |
JP3130547B2 (ja) | 1991-02-28 | 2001-01-31 | テルモ株式会社 | 血液バッグ |
US5163442A (en) | 1991-07-30 | 1992-11-17 | Harry Ono | Finger tip blood collector |
US5231993A (en) | 1991-11-20 | 1993-08-03 | Habley Medical Technology Corporation | Blood sampler and component tester with guide member |
JPH05188053A (ja) * | 1992-01-10 | 1993-07-27 | Sanwa Kagaku Kenkyusho Co Ltd | 血液から血清又は血漿成分を分離する器具 |
US5304348A (en) | 1992-02-11 | 1994-04-19 | Abaxis, Inc. | Reagent container for analytical rotor |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
EP0725593B1 (fr) | 1993-10-28 | 2004-04-07 | I-Stat Corporation | Procede de prelevement et d'introduction d'un echantillon de fluide |
US5578459A (en) * | 1993-11-24 | 1996-11-26 | Abbott Laboratories | Method and apparatus for collecting a cell sample from a liquid specimen |
JP3393920B2 (ja) * | 1993-12-09 | 2003-04-07 | 富士写真フイルム株式会社 | 微量定容採血点着用具 |
US5422018A (en) | 1994-01-31 | 1995-06-06 | Applied Imaging | Centrifuge tube and adaptor |
CA2192196C (fr) | 1994-06-06 | 2004-11-23 | Anne R. Kopf-Sill | Siphons modifies garantissant une precision de dosage ameliore |
US5733446A (en) | 1994-12-02 | 1998-03-31 | Bristol-Myers Squibb Company | Centrifuge with annular filter |
US5636640A (en) | 1995-02-06 | 1997-06-10 | Volunteers For Medical Engineering | Liquid sampling and test apparatus |
US6074183A (en) | 1995-02-09 | 2000-06-13 | First Medical, Inc. | Peristaltic system and method for plasma separation and blood dispensation |
US5690618A (en) | 1995-02-22 | 1997-11-25 | Mark Timothy Smith | Electronic syringe |
US5839715A (en) | 1995-05-16 | 1998-11-24 | Alaris Medical Systems, Inc. | Medical adapter having needleless valve and sharpened cannula |
CA2178523C (fr) | 1995-06-09 | 2001-08-28 | Tomohiro Kitagawa | Procede, dispositif et filtre pour la separation de plasma |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
JPH09196911A (ja) | 1996-01-19 | 1997-07-31 | Fuji Photo Film Co Ltd | 血液濾過ユニット |
US6063039A (en) | 1996-12-06 | 2000-05-16 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US6071249A (en) | 1996-12-06 | 2000-06-06 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US5879624A (en) | 1997-01-15 | 1999-03-09 | Boehringer Laboratories, Inc. | Method and apparatus for collecting and processing blood |
NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
US6506167B1 (en) | 1997-12-24 | 2003-01-14 | I-Design Co., Ltd. | Blood-collecting tubes |
WO1999056630A1 (fr) | 1998-05-01 | 1999-11-11 | Aalto Scientific, Ltd. | Systeme integre de collecte et d'analyse de liquide organique comportant un element de transfert d'echantillon |
JP2000074908A (ja) * | 1998-09-02 | 2000-03-14 | Fuji Photo Film Co Ltd | 血液濾過器 |
US6948843B2 (en) | 1998-10-28 | 2005-09-27 | Covaris, Inc. | Method and apparatus for acoustically controlling liquid solutions in microfluidic devices |
US6264619B1 (en) | 1999-09-01 | 2001-07-24 | Becton, Dickinson And Company | Kit for drawing a blood sample |
US6319719B1 (en) | 1999-10-28 | 2001-11-20 | Roche Diagnostics Corporation | Capillary hematocrit separation structure and method |
EP1106065A3 (fr) | 1999-11-26 | 2004-03-03 | CellContol Biomedical Laboratories GmbH | Procédé et récipient pour conserver et expédier du tissu, du fluide, ou de la matière cellulaire vivante |
PL191428B1 (pl) | 2000-04-06 | 2006-05-31 | Htl Strefa Sp Z Oo | Zespół regulacji głębokości nakłucia w przyrządzie do nakłuwania |
JP2001299730A (ja) * | 2000-04-21 | 2001-10-30 | Fuji Photo Film Co Ltd | 血漿採取具 |
US20060263888A1 (en) * | 2000-06-02 | 2006-11-23 | Honeywell International Inc. | Differential white blood count on a disposable card |
US6537242B1 (en) | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
JP2004522500A (ja) | 2001-01-22 | 2004-07-29 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 毛管作用を有するランセット装置 |
US6869405B2 (en) | 2001-03-30 | 2005-03-22 | Becton, Dickinson And Company | Blunt cannula and filter assembly and method of use with point-of-care testing cartridge |
US7001344B2 (en) | 2001-06-12 | 2006-02-21 | Pelikan Technologies, Inc. | Blood sampling device with diaphragm actuated lancet |
US20030013205A1 (en) | 2001-07-06 | 2003-01-16 | Franz Konrad | Separating device |
US20040116830A1 (en) * | 2001-08-24 | 2004-06-17 | Trudeau William M | Blood testing deivce |
JP2003107080A (ja) * | 2001-09-30 | 2003-04-09 | Jun Kikuchi | 血液分析装置ならびに血液分析方法 |
ATE479490T1 (de) | 2001-10-11 | 2010-09-15 | Aviva Biosciences Corp | Verfahren zum trennen von seltenen zellen von fluidproben |
US7166443B2 (en) | 2001-10-11 | 2007-01-23 | Aviva Biosciences Corporation | Methods, compositions, and automated systems for separating rare cells from fluid samples |
DE10208575C1 (de) | 2002-02-21 | 2003-08-14 | Hartmann Paul Ag | Blutanalysegerät zur Bestimmung eines Analyten |
EP1477804A4 (fr) | 2002-02-27 | 2016-12-28 | Pfaff Medical Gmbh | Instrument de separation de plasma ou de serum, procede de collecte de plasma ou de serum, procede de separation de plasma ou de serum, support d'essai et fibre de verre |
US20050026301A1 (en) * | 2002-03-25 | 2005-02-03 | Henry Petithory | Method and apparatus for controlling fluid movement in a microfluidic system |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US6982038B2 (en) | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
JP4032954B2 (ja) | 2002-07-05 | 2008-01-16 | ソニー株式会社 | 冷却装置、電子機器装置、音響装置及び冷却装置の製造方法 |
WO2004018021A2 (fr) | 2002-08-23 | 2004-03-04 | Gambro, Inc. | Methodes et dispositifs de separation de constituants sanguins |
JP2004109099A (ja) * | 2002-09-16 | 2004-04-08 | Jun Kikuchi | 血液分析方法、血液分析装置および血液分析装置の製造方法 |
US7014625B2 (en) | 2002-10-07 | 2006-03-21 | Novo Nordick A/S | Needle insertion device |
JP2004150891A (ja) | 2002-10-29 | 2004-05-27 | Starlite Co Ltd | 化学マイクロデバイス |
WO2004046716A1 (fr) | 2002-11-19 | 2004-06-03 | Sekisui Chemical Co., Ltd. | Membrane de separation de plasma ou serum et appareil filtre comprenant la membrane de separation de plasma ou serum |
US20040143226A1 (en) | 2003-01-16 | 2004-07-22 | Becton, Dickinson And Company | Blood collection set with venting mechanism |
US7374949B2 (en) | 2003-05-29 | 2008-05-20 | Bayer Healthcare Llc | Diagnostic test strip for collecting and detecting an analyte in a fluid sample |
US7160025B2 (en) * | 2003-06-11 | 2007-01-09 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
US20070160503A1 (en) | 2003-06-13 | 2007-07-12 | Palaniappan Sethu | Microfluidic systems for size based removal of red blood cells and platelets from blood |
EP1522260A1 (fr) | 2003-06-27 | 2005-04-13 | Ehrfeld Mikrotechnik AG | Dispositif de prélèvement de sang et détetermination quantitative simultanée d'analytes dans le sang |
US7488297B2 (en) * | 2003-07-30 | 2009-02-10 | Patrice Flaherty | Blood collecting devices |
WO2005018710A2 (fr) | 2003-08-20 | 2005-03-03 | Facet Technologies, Llc | Dispositif d'echantillonnage sanguin |
US7476326B2 (en) | 2003-09-26 | 2009-01-13 | Ahn Chong H | On-chip sample preparation for whole blood analysis |
US7332096B2 (en) | 2003-12-19 | 2008-02-19 | Fenwal, Inc. | Blood filter assembly having multiple filtration regions |
WO2005066627A1 (fr) | 2003-12-24 | 2005-07-21 | Becton, Dickinson And Company | Tube pour plasma a la demande |
WO2005070292A1 (fr) | 2004-01-23 | 2005-08-04 | Medigard Limited | Ameliorations apportees a un dispositif de prelevement sanguin |
US8282608B2 (en) * | 2004-01-29 | 2012-10-09 | Becton, Dickinson And Company | Self priming intravenous delivery system |
US7588724B2 (en) * | 2004-03-05 | 2009-09-15 | Bayer Healthcare Llc | Mechanical device for mixing a fluid sample with a treatment solution |
US7763209B2 (en) | 2004-03-11 | 2010-07-27 | Handylab, Inc. | Sample preparation device and method |
JP2005270729A (ja) | 2004-03-23 | 2005-10-06 | Nippon Sheet Glass Co Ltd | マイクロ化学システム用チップホルダ |
JP2005287955A (ja) | 2004-04-02 | 2005-10-20 | Sekisui Chem Co Ltd | 真空採血管用栓体及び真空採血管 |
US20050273019A1 (en) | 2004-06-02 | 2005-12-08 | Becton, Dickinson And Company | Blood collection set with venting mechanism |
US7378259B2 (en) | 2004-07-15 | 2008-05-27 | Applera Corporation | Fluid processing device |
DE102004037270B4 (de) | 2004-07-31 | 2008-01-31 | Roche Diagnostics Gmbh | Blutentnahmesystem zur Entnahme von Blut für Diagnosezwecke |
US7758815B2 (en) | 2004-08-03 | 2010-07-20 | Hartselle R Lawrence | Specimen collection, storage, transportation and assaying device |
JP2004361419A (ja) | 2004-08-26 | 2004-12-24 | Fuji Photo Film Co Ltd | 血液濾過ユニット |
JP2006068384A (ja) | 2004-09-03 | 2006-03-16 | Advance Co Ltd | 体液移送具及び体液移送具を用いた体液検査システム |
WO2006047831A1 (fr) | 2004-11-03 | 2006-05-11 | Agen Biomedical Limited | Dispositif et procede de detection |
JP4455306B2 (ja) | 2004-12-13 | 2010-04-21 | キヤノン株式会社 | 生化学処理方法 |
US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
JP4645211B2 (ja) | 2005-02-07 | 2011-03-09 | パナソニック株式会社 | Hdl−コレステロール分析用ディスク、及びhdl−コレステロール分析用装置 |
JP4411605B2 (ja) | 2005-02-14 | 2010-02-10 | 横河電機株式会社 | マイクロ流路デバイス |
JP2006288680A (ja) * | 2005-04-11 | 2006-10-26 | Enomoto Co Ltd | 採血キット |
US20060228258A1 (en) | 2005-04-12 | 2006-10-12 | Chromedx Inc. | Blood collection and measurement apparatus |
US8206650B2 (en) | 2005-04-12 | 2012-06-26 | Chromedx Inc. | Joint-diagnostic spectroscopic and biosensor meter |
US7473216B2 (en) | 2005-04-21 | 2009-01-06 | Fresenius Hemocare Deutschland Gmbh | Apparatus for separation of a fluid with a separation channel having a mixer component |
US8211036B2 (en) | 2005-05-27 | 2012-07-03 | Stat Medical Devices, Inc. | Disposable lancet device cap with integral lancet and/or test strip and testing device utilizing the cap |
US20070031283A1 (en) | 2005-06-23 | 2007-02-08 | Davis Charles Q | Assay cartridges and methods for point of care instruments |
EP1901847B1 (fr) * | 2005-07-01 | 2015-04-08 | Honeywell International Inc. | Analyseur hématologique microfluidique |
JP2007050100A (ja) | 2005-08-18 | 2007-03-01 | Rohm Co Ltd | 被検体採取チップ |
WO2007050528A1 (fr) | 2005-10-25 | 2007-05-03 | Bayer Healthcare Llc | Dispositif d’incision a usage unique |
WO2008002462A2 (fr) | 2006-06-23 | 2008-01-03 | Micronics, Inc. | Procédés et dispositifs destinés à des dosages immunologiques microfluidiques pratiqués au point de service |
US8630016B2 (en) * | 2006-02-08 | 2014-01-14 | Becton, Dickinson And Company | Label processor and method relating thereto |
JP2007249306A (ja) | 2006-03-13 | 2007-09-27 | Fuzzy Logic Systems | 情報配信システム、情報配信方法及びプログラム |
JP4702182B2 (ja) * | 2006-05-25 | 2011-06-15 | パナソニック株式会社 | 光学分析用デバイス及び光学分析装置 |
EP1916524A1 (fr) | 2006-09-27 | 2008-04-30 | Roche Diagnostics GmbH | Elément d'essai rotatif |
US8377040B2 (en) * | 2006-11-06 | 2013-02-19 | Becton, Dickinson And Company | Extravascular system venting |
KR100843339B1 (ko) | 2006-12-07 | 2008-07-03 | 한국전자통신연구원 | 혈액 중의 혈장 분리를 위하여 마이크로채널을 이용한혈장분리기 및 이에 의한 혈장분리방법 |
DE102007003755A1 (de) | 2007-01-19 | 2008-07-31 | Tesa Ag | Bahnförmiges Material mit einer Beschichtung, die ein dauerhaftes schnelles Spreiten beziehungsweise einen dauerhaften sehr schnellen Transport von Flüssigkeiten ermöglicht |
US8888713B2 (en) | 2007-03-07 | 2014-11-18 | Becton, Dickinson And Company | Safety blood collection assembly with indicator |
US7858037B2 (en) | 2007-03-30 | 2010-12-28 | Instrumentation Laboratory Company | Adaptor for sample vial |
EP1982644B1 (fr) | 2007-04-21 | 2016-03-09 | Roche Diagnostics GmbH | Système analytique pour détecter une analyte dans un liquide du corps et perforation jetable intégrée et élément d'analyse |
US20080302932A1 (en) * | 2007-06-08 | 2008-12-11 | Smiths Medical Asd, Inc. | Mounting Clip for Fluid Reservoir |
JP2008302077A (ja) | 2007-06-08 | 2008-12-18 | Sekisui Chem Co Ltd | 真空検体採取容器 |
CN101332320A (zh) | 2007-06-27 | 2008-12-31 | 上海达华医疗器械有限公司 | 一次性使用离心式血浆分离器 |
JP5433139B2 (ja) | 2007-06-29 | 2014-03-05 | 株式会社東芝 | マイクロ化学分析装置、その測定方法、及びマイクロカセット |
KR101009447B1 (ko) | 2007-11-12 | 2011-01-19 | 바디텍메드 주식회사 | 체액 샘플링, 전처리 및 투입장치 및 방법 |
KR100912530B1 (ko) * | 2007-11-13 | 2009-08-18 | 한국전자통신연구원 | 일회용 다층형 혈장 분리 필터 소자 |
US20110097814A1 (en) * | 2007-11-20 | 2011-04-28 | Bommarito G Marco | Detection devices and methods |
EP2062643B1 (fr) | 2007-11-24 | 2012-01-18 | Roche Diagnostics GmbH | Système d'analyse et procédé d'analyse d'un échantillon de liquide corporel sur un analyte contenu dans celui-ci |
US9968931B2 (en) | 2007-12-12 | 2018-05-15 | Nan Zhang | Rapid and efficient filtering whole blood in capillary flow device |
JP5354947B2 (ja) | 2008-04-24 | 2013-11-27 | パナソニック株式会社 | 生体分析用デバイスおよびそれを用いた試料定量攪拌方法 |
JP5348707B2 (ja) * | 2008-02-27 | 2013-11-20 | モン4ディー リミテッド | モジュールの検体モニタのための装置、システム及び方法 |
US7854893B2 (en) * | 2008-03-28 | 2010-12-21 | Panasonic Corporation | Analysis device and an analysis apparatus using the analysis device |
FR2929135A1 (fr) | 2008-03-31 | 2009-10-02 | Commissariat Energie Atomique | Dispositif d'aliquotage et de dispense d'un liquide |
WO2009123592A1 (fr) | 2008-04-03 | 2009-10-08 | Zyomyx, Inc. | Dispositif et procédé d'analyse d'échantillons avec déplétion du contenu en analytes |
US9101748B2 (en) | 2008-05-08 | 2015-08-11 | Becton, Dickinson And Company | Push-button blood control |
JP5229665B2 (ja) * | 2008-05-13 | 2013-07-03 | 学校法人立命館 | 血漿又は血清分離方法、及び血漿又は血清分離装置 |
DE102008023545A1 (de) | 2008-05-14 | 2009-11-19 | Roderfeld Und Bora Gmbh & Co.Kg | Vorrichtung zur Herstellung einer biologisch aktiven Substanz |
WO2010005000A1 (fr) * | 2008-07-10 | 2010-01-14 | 三光純薬株式会社 | Disque pour examen médical, paquet de disques et dispositif d'examen clinique |
US8491840B2 (en) | 2008-07-14 | 2013-07-23 | Samsung Electronics Co., Ltd. | Microfluidic device, sample analyzing method using the same, and dilution ratio measuring method |
JP5795255B2 (ja) * | 2008-07-18 | 2015-10-14 | キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. | 微小流体dna試料調製のための方法およびシステム |
DE202008010918U1 (de) | 2008-08-15 | 2008-12-24 | Dienst, Michael | Einweg-Spritzensystem auf Blister-Basis zur Entnahme einer Körperblutprobe |
US20100093551A1 (en) | 2008-10-09 | 2010-04-15 | Decision Biomarkers, Inc. | Liquid Transfer and Filter System |
US20100241031A1 (en) | 2009-03-20 | 2010-09-23 | Venture Corporation Limited | Analyte Test Device Integral With Lancet Firing Mechanism |
JP2010146123A (ja) | 2008-12-16 | 2010-07-01 | Murata Machinery Ltd | 文書処理装置、文書処理方法、及びプログラム |
JP5508709B2 (ja) | 2008-12-22 | 2014-06-04 | 株式会社Sokudo | 塗布処理装置および基板処理装置 |
US9119578B2 (en) * | 2011-04-29 | 2015-09-01 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
US20110172508A1 (en) * | 2010-01-13 | 2011-07-14 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
JP5608943B2 (ja) * | 2009-03-31 | 2014-10-22 | マイクロ化学技研株式会社 | 血漿分離装置及び方法 |
EP2264453B1 (fr) * | 2009-06-17 | 2013-04-03 | Leukocare Ag | Procédé de filtrage de sang |
US8383044B2 (en) | 2009-07-09 | 2013-02-26 | Becton, Dickinson And Company | Blood sampling device |
EP2456355B1 (fr) | 2009-07-20 | 2016-09-14 | Optiscan Biomedical Corporation | Connecteur réglable à espace mort réduit |
JP2011055916A (ja) | 2009-09-07 | 2011-03-24 | Terumo Corp | 検査用血液容器および採血器具 |
SE534542C2 (sv) | 2009-09-30 | 2011-09-27 | Calmark Sweden Ab | Testsystem för bestämning av hypoxiutlöst cellskada |
CN101695446B (zh) | 2009-10-30 | 2011-01-12 | 天津市百利康泰生物技术有限公司 | 一次性软接带收集容器及放血口的抗凝真空采血针 |
EP2493536B1 (fr) * | 2009-10-30 | 2017-09-20 | Seventh Sense Biosystems, Inc. | Dispositifs relativement petits appliqués sur la peau, systèmes modulaires, et procédés d'utilisation de ceux-ci |
DE102009052671B4 (de) * | 2009-11-12 | 2015-07-30 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur Behandlung eines Filtrationsmediums |
CN102762990B (zh) | 2009-12-04 | 2014-10-29 | 生命技术公司 | 用于声学流式细胞计量术的装置、系统、方法和计算机可读介质 |
KR101722548B1 (ko) | 2010-01-29 | 2017-04-03 | 삼성전자주식회사 | 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법 |
LT3622883T (lt) | 2010-03-24 | 2021-08-25 | Abbott Diabetes Care, Inc. | Medicinos prietaiso įvedikliai ir medicinos prietaisų įvedimo ir naudojimo būdai |
US8846333B2 (en) | 2010-06-10 | 2014-09-30 | Hemcheck Sweden Ab | Method and device for visual detection of hemolysis |
US9028425B2 (en) * | 2010-07-15 | 2015-05-12 | Becton, Dickinson And Company | Vented blood sampling device |
US8747333B2 (en) * | 2010-07-15 | 2014-06-10 | Becton, Dickinson And Company | Blood test strip and an intravenous catheter system |
US9549701B2 (en) * | 2010-07-19 | 2017-01-24 | Becton, Dickinson And Company | Device and method for collecting a blood sample |
EP2413138B1 (fr) | 2010-07-27 | 2020-04-29 | BOEHRINGER INGELHEIM microParts GmbH | Dispositif et procédé de séparation de composants d'un liquide d'échantillon |
US8808202B2 (en) * | 2010-11-09 | 2014-08-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
US20120134974A1 (en) | 2010-11-30 | 2012-05-31 | Biovec Transfusion, Llc | Methods for removing plasma |
US8980106B2 (en) | 2010-12-15 | 2015-03-17 | Abbott Laboratories | Apparatus and method for separation of whole blood into plasma or serum and cells |
WO2012121686A1 (fr) | 2011-03-09 | 2012-09-13 | Becton, Dickinson And Company | Manchon pour lancette amovible d'autopiqueur |
EP3106092A3 (fr) | 2011-04-29 | 2017-03-08 | Seventh Sense Biosystems, Inc. | Systèmes et procédés pour recueillir un fluide provenant d'un sujet |
KR102237667B1 (ko) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
DE102011078961B4 (de) | 2011-07-11 | 2021-02-18 | Robert Bosch Gmbh | System zum Separieren von Körperflüssigkeitsbestandteilen und Verfahren zum Herstellen eines derartigen Systems |
US9162186B2 (en) | 2011-07-22 | 2015-10-20 | Chromedx Corp. | Sample filtration assembly |
CN102429665B (zh) | 2011-08-08 | 2014-06-25 | 上海科华检验医学产品有限公司 | 一种可直接分离血浆的血液采集组件 |
US8852446B2 (en) | 2011-10-03 | 2014-10-07 | Palo Alto Research Center Incorporated | Platelet extraction from blood |
US9358364B2 (en) | 2011-10-06 | 2016-06-07 | Becton, Dickinson And Company | Activator attachment for blood control catheters |
CN102764133A (zh) | 2012-08-10 | 2012-11-07 | 上海科华检验医学产品有限公司 | 一种可直接分离血浆的真空采血管及其方法 |
CN202714857U (zh) | 2012-08-23 | 2013-02-06 | 王丽青 | 一种血液采集器 |
WO2014172247A1 (fr) * | 2013-04-15 | 2014-10-23 | Becton, Dickinson And Company | Dispositif de transfert d'échantillon de sang |
US9517026B2 (en) * | 2013-04-15 | 2016-12-13 | Becton, Dickinson And Company | Biological fluid collection device and biological fluid separation and testing system |
BR112015026262B1 (pt) | 2013-04-15 | 2022-10-18 | Becton, Dickinson And Company | Dispositivo de transferência de amostragem de fluido biológico e sistema de separação e de teste de fluido biológico |
MX347465B (es) * | 2013-04-15 | 2017-04-26 | Becton Dickinson Co | Dispositivo de muestreo de fluidos biológicos. |
-
2014
- 2014-04-14 ES ES19153076T patent/ES2832756T3/es active Active
- 2014-04-14 ES ES16171029.8T patent/ES2686359T3/es active Active
- 2014-04-14 ES ES17193109T patent/ES2755490T3/es active Active
- 2014-04-14 CA CA3005826A patent/CA3005826C/fr active Active
- 2014-04-14 CA CA3026548A patent/CA3026548C/fr active Active
-
2017
- 2017-01-13 JP JP2017004215A patent/JP6431555B2/ja active Active
- 2017-02-24 JP JP2017033367A patent/JP6426777B2/ja active Active
- 2017-11-03 US US15/803,001 patent/US20180049686A1/en not_active Abandoned
- 2017-11-09 JP JP2017216704A patent/JP6550439B2/ja active Active
-
2018
- 2018-05-10 JP JP2018091574A patent/JP6737835B2/ja active Active
- 2018-06-22 US US16/015,381 patent/US10827965B2/en active Active
- 2018-08-02 JP JP2018146177A patent/JP6685349B2/ja active Active
- 2018-10-19 US US16/165,157 patent/US20190046096A1/en not_active Abandoned
- 2018-11-02 JP JP2018207401A patent/JP6723320B2/ja active Active
- 2018-11-02 JP JP2018207400A patent/JP6791931B2/ja active Active
-
2019
- 2019-02-20 US US16/280,449 patent/US11291393B2/en active Active
- 2019-05-29 US US16/425,015 patent/US10791975B2/en active Active
-
2020
- 2020-08-31 US US17/007,875 patent/US11974846B2/en active Active
-
2021
- 2021-01-20 US US17/153,696 patent/US12082931B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5657963A (en) * | 1993-06-16 | 1997-08-19 | United States Surgical Corporation | Seal assembly for accommodating introduction of surgical instruments |
US20130086980A1 (en) * | 2010-04-20 | 2013-04-11 | Eltek S.P.A. | Microfluidic devices and/or equipment for microfluidic devices |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11959907B2 (en) | 2015-01-12 | 2024-04-16 | Instrumentation Laboratory Company | Spatial separation of particles in a particle containing solution for biomedical sensing and detection |
US12072329B2 (en) | 2015-01-12 | 2024-08-27 | Instrumentation Laboratory Company | Spatial separation of particles in a particle containing solution for biomedical sensing and detection |
US12092630B2 (en) | 2015-01-12 | 2024-09-17 | Instrumentation Laboratory Company | Spatial separation of particles in a particle containing solution for biomedical sensing and detection |
WO2019236822A1 (fr) * | 2018-06-07 | 2019-12-12 | Becton, Dickinson And Company | Dispositif de séparation de fluide biologique |
KR20210018917A (ko) * | 2018-06-07 | 2021-02-18 | 벡톤 디킨슨 앤드 컴퍼니 | 생물학적 유체 분리 장치 |
CN112400111A (zh) * | 2018-06-07 | 2021-02-23 | 贝克顿·迪金森公司 | 生物流体分离装置 |
EP4001916A1 (fr) * | 2018-06-07 | 2022-05-25 | Becton, Dickinson and Company | Dispositif de séparation de fluide biologique |
AU2019282329B2 (en) * | 2018-06-07 | 2022-06-30 | Becton, Dickinson And Company | Biological fluid separation device |
KR102512973B1 (ko) | 2018-06-07 | 2023-03-22 | 벡톤 디킨슨 앤드 컴퍼니 | 생물학적 유체 분리 장치 |
US12076146B2 (en) | 2018-06-07 | 2024-09-03 | Becton, Dickinson And Company | Biological fluid separation device |
US11231409B2 (en) * | 2018-10-02 | 2022-01-25 | Instrumentation Laboratory Company | Disposable hemolysis sensor |
Also Published As
Publication number | Publication date |
---|---|
JP2018196751A (ja) | 2018-12-13 |
JP2018138210A (ja) | 2018-09-06 |
US20210137434A1 (en) | 2021-05-13 |
JP6431555B2 (ja) | 2018-11-28 |
US20200397359A1 (en) | 2020-12-24 |
ES2755490T3 (es) | 2020-04-22 |
JP2019034198A (ja) | 2019-03-07 |
JP6737835B2 (ja) | 2020-08-12 |
JP6723320B2 (ja) | 2020-07-15 |
US10791975B2 (en) | 2020-10-06 |
US20190274609A1 (en) | 2019-09-12 |
ES2686359T3 (es) | 2018-10-17 |
US10827965B2 (en) | 2020-11-10 |
US11974846B2 (en) | 2024-05-07 |
JP6426777B2 (ja) | 2018-11-21 |
ES2832756T3 (es) | 2021-06-11 |
JP6791931B2 (ja) | 2020-11-25 |
CA3005826C (fr) | 2021-11-23 |
US12082931B2 (en) | 2024-09-10 |
JP2018020243A (ja) | 2018-02-08 |
US11291393B2 (en) | 2022-04-05 |
US20180296148A1 (en) | 2018-10-18 |
JP2019015747A (ja) | 2019-01-31 |
US20190175088A1 (en) | 2019-06-13 |
JP2017099947A (ja) | 2017-06-08 |
JP6550439B2 (ja) | 2019-07-24 |
JP2017096972A (ja) | 2017-06-01 |
US20190046096A1 (en) | 2019-02-14 |
JP6685349B2 (ja) | 2020-04-22 |
CA3026548C (fr) | 2022-01-04 |
CA3026548A1 (fr) | 2014-10-23 |
CA3005826A1 (fr) | 2014-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20180049686A1 (en) | Biological Fluid Separation Device and Biological Fluid Separation and Testing System | |
US20180049685A1 (en) | Biological Fluid Separation Device and Biological Fluid Separation and Testing System | |
US10080516B2 (en) | Biological fluid collection device and biological fluid separation and testing system | |
US9597028B2 (en) | Biological fluid collection device and biological fluid separation and testing system | |
EP3085307B1 (fr) | Dispositif de collecte de fluides biologiques | |
EP2986220B1 (fr) | Dispositif de collecte de fluide biologique et système de collecte et d'analyse de fluide biologique | |
CA2909176C (fr) | Dispositif de transfert d'echantillon sanguin et systeme de separation et d'analyse sanguine | |
EP2986383B1 (fr) | Dispositif de séparation de fluide biologique et séparation de fluide biologique et système de test |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BECTON, DICKINSON AND COMPANY, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MARCHIARULLO, DANIEL J.;WILKINSON, BRADLEY M.;SIGNING DATES FROM 20140507 TO 20140513;REEL/FRAME:044031/0001 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: FINAL REJECTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: FINAL REJECTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: ADVISORY ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |