US20140271660A1 - Monoclonal antibodies against antithrombin beta - Google Patents

Monoclonal antibodies against antithrombin beta Download PDF

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Publication number
US20140271660A1
US20140271660A1 US14/214,267 US201414214267A US2014271660A1 US 20140271660 A1 US20140271660 A1 US 20140271660A1 US 201414214267 A US201414214267 A US 201414214267A US 2014271660 A1 US2014271660 A1 US 2014271660A1
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US
United States
Prior art keywords
seq
antibody
atβh
amino acid
amino acids
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Abandoned
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US14/214,267
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English (en)
Inventor
Ye Jin
John E. Murphy
Terry Hermiston
Timothy Myles
Frank Dittmer
Michael Strerath
Uwe Gritzan
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Bayer Healthcare LLC
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Bayer Healthcare LLC
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50680168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20140271660(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Priority to US14/214,267 priority Critical patent/US20140271660A1/en
Publication of US20140271660A1 publication Critical patent/US20140271660A1/en
Assigned to BAYER HEALTHCARE LLC reassignment BAYER HEALTHCARE LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MURPHY, JOHN E., DITTMER, FRANK, GRITZAN, UWE, STRERATH, MICHAEL, JIN, YE, HERMISTON, TERRY, MYLES, Timothy
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Definitions

  • AT ⁇ is proposed to play a major and potent role in inhibition of FXa and thrombin at the vascular injury sites (Carlson and Atencio 1982; McCoy A J, Pei X Y. et al. 2003; Turk B, Brieditis I. et al. 1997; Witmer M R, Hatton M W. 1991; Frebelius S, et al. 1996).
  • McCoy A J Pei X Y. et al. 2003
  • Turk B Brieditis I. et al. 1997
  • Witmer M R Hatton M W. 1991
  • Frebelius S, et al. 1996 The importance and stronger potency of AT ⁇ relative to that of AT ⁇ is also reported in clinical studies.
  • FIGS. 10A and 10B show an experimental protocol for a tail vein transection (TVT) model in HemA and the efficacy of antibody TPP-2009 in the TVT model in HemA mice.
  • FIG. 10B shows the antibody TPP-2009 has potent efficacy in the Tail Vein Transection (TVT) model of HemA mice.
  • TVT Tail Vein Transection
  • AT ⁇ refers to any variant, isoform, and/or species homolog of AT in its form that is naturally expressed by cells and present in plasma and is distinct from AT ⁇ . Further, the term “AT ⁇ ” or “AT ⁇ H” as used herein can also refer to an activated form of AT ⁇ complexed with heparin or a heparin-like structure.
  • antibodies that can compete with any of the antibodies described herein for binding to human AT ⁇ H.
  • a competing antibody can bind to one or more epitopes described above.
  • a 1:2 serial dilution of AT ⁇ H antibody was made in HemA human plasma starting from 1 uM of final concentration to 0.015 uM. Heparin was added in each antibody solution at a final concentration of 50 nM. An 80 ul of the antibody-heparin-plasma mixture was then added to each well containing 20 ul of reconstitute PPP reagent or calibrator in a 96 well TGA plate. The plate was placed in the TGA instrument and the machine automatically dispensed 20 ul of FluCa (Fluo substrate+CaCl2) into each well. The reaction was allowed to run 60 min. Plasma alone was used as the negative control.
  • FluCa FluCa

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US14/214,267 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta Abandoned US20140271660A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/214,267 US20140271660A1 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784590P 2013-03-14 2013-03-14
US14/214,267 US20140271660A1 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta

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US20140271660A1 true US20140271660A1 (en) 2014-09-18

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US14/214,267 Abandoned US20140271660A1 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta
US14/214,382 Expired - Fee Related US9593166B2 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin β
US14/770,222 Expired - Fee Related US9908942B2 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin β
US15/908,705 Expired - Fee Related US10144784B2 (en) 2013-03-14 2018-02-28 Monoclonal antibodies against antithrombin beta

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US14/214,382 Expired - Fee Related US9593166B2 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin β
US14/770,222 Expired - Fee Related US9908942B2 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin β
US15/908,705 Expired - Fee Related US10144784B2 (en) 2013-03-14 2018-02-28 Monoclonal antibodies against antithrombin beta

Country Status (18)

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US (4) US20140271660A1 (es)
EP (1) EP2970500A1 (es)
JP (1) JP2016519081A (es)
KR (1) KR20150127202A (es)
CN (1) CN105229033B (es)
AR (1) AR095499A1 (es)
AU (1) AU2014236198A1 (es)
BR (1) BR112015021399A2 (es)
CA (1) CA2916421A1 (es)
HK (1) HK1215261A1 (es)
MX (1) MX2015012441A (es)
PE (1) PE20160533A1 (es)
RU (1) RU2015143696A (es)
SG (1) SG11201506886TA (es)
TW (1) TW201529602A (es)
UY (1) UY35457A (es)
WO (1) WO2014153195A1 (es)
ZA (1) ZA201507628B (es)

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PE20181004A1 (es) 2015-10-02 2018-06-26 Hoffmann La Roche Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
WO2017158176A1 (en) * 2016-03-18 2017-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-antithrombin single-domain antibodies and polypeptides comprising thereof

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BR112015021399A2 (pt) 2017-07-18
CN105229033A (zh) 2016-01-06
AU2014236198A1 (en) 2015-10-15
KR20150127202A (ko) 2015-11-16
EP2970500A1 (en) 2016-01-20
ZA201507628B (en) 2017-11-29
CA2916421A1 (en) 2014-09-25
US20160024222A1 (en) 2016-01-28
UY35457A (es) 2014-10-31
US9908942B2 (en) 2018-03-06
HK1215261A1 (zh) 2016-08-19
CN105229033B (zh) 2019-04-23
US9593166B2 (en) 2017-03-14
RU2015143696A (ru) 2017-04-19
PE20160533A1 (es) 2016-06-09
TW201529602A (zh) 2015-08-01
MX2015012441A (es) 2016-08-08
JP2016519081A (ja) 2016-06-30
AR095499A1 (es) 2015-10-21
US10144784B2 (en) 2018-12-04
US20140271661A1 (en) 2014-09-18
WO2014153195A1 (en) 2014-09-25
US20180244799A1 (en) 2018-08-30
SG11201506886TA (en) 2015-09-29

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