US20130209528A1 - Use of exosomes to promote or enhance hair growth - Google Patents

Use of exosomes to promote or enhance hair growth Download PDF

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Publication number
US20130209528A1
US20130209528A1 US13/879,905 US201113879905A US2013209528A1 US 20130209528 A1 US20130209528 A1 US 20130209528A1 US 201113879905 A US201113879905 A US 201113879905A US 2013209528 A1 US2013209528 A1 US 2013209528A1
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Prior art keywords
exosome
wound
alopecia
cells
kda
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Abandoned
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US13/879,905
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English (en)
Inventor
Sai Kiang Levi
Matthew Sze Wei Yeo
Tian Sheng Chen
Ruenn Chai Lai
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Agency for Science Technology and Research Singapore
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Agency for Science Technology and Research Singapore
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Publication of US20130209528A1 publication Critical patent/US20130209528A1/en
Assigned to AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH reassignment AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CHEN, TIAN SHENG, YEO, MATHEW SZE WEI, LAI, RUENN CHAI, LIM, SAI KIANG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
US13/879,905 2010-10-18 2011-10-17 Use of exosomes to promote or enhance hair growth Abandoned US20130209528A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG2010076602 2010-10-18
SG201007660-2 2010-10-18
PCT/SG2011/000362 WO2012053976A1 (fr) 2010-10-18 2011-10-17 Utilisation d'exosomes pour activer ou amplifier la croissance des cheveux

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2011/000362 A-371-Of-International WO2012053976A1 (fr) 2010-10-18 2011-10-17 Utilisation d'exosomes pour activer ou amplifier la croissance des cheveux

Related Child Applications (1)

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US14/444,113 Continuation US20150024011A1 (en) 2010-10-18 2014-07-28 Use of exosomes to promote or enhance hair growth

Publications (1)

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US20130209528A1 true US20130209528A1 (en) 2013-08-15

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Family Applications (3)

Application Number Title Priority Date Filing Date
US13/879,905 Abandoned US20130209528A1 (en) 2010-10-18 2011-10-17 Use of exosomes to promote or enhance hair growth
US14/444,113 Abandoned US20150024011A1 (en) 2010-10-18 2014-07-28 Use of exosomes to promote or enhance hair growth
US15/224,844 Active 2031-11-23 US11185481B2 (en) 2010-10-18 2016-08-01 Use of exosomes to promote or enhance hair growth

Family Applications After (2)

Application Number Title Priority Date Filing Date
US14/444,113 Abandoned US20150024011A1 (en) 2010-10-18 2014-07-28 Use of exosomes to promote or enhance hair growth
US15/224,844 Active 2031-11-23 US11185481B2 (en) 2010-10-18 2016-08-01 Use of exosomes to promote or enhance hair growth

Country Status (5)

Country Link
US (3) US20130209528A1 (fr)
EP (2) EP3563858A1 (fr)
JP (1) JP5911874B2 (fr)
SG (2) SG2014010706A (fr)
WO (1) WO2012053976A1 (fr)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140093545A1 (en) * 2012-09-28 2014-04-03 Orthogen Ag Antibacterial pharmaceutical preparation
US20150023908A1 (en) * 2011-03-04 2015-01-22 Ahmed H. Al-Qahtani Skin cream
US20150190429A1 (en) * 2012-07-18 2015-07-09 Universitaet Duisburg-Essen Use of Preparations Comprising Exosomes Derived From Mesenchymal Stem Cells (MSCs) in the Prevention and Therapy of Inflammatory Conditions
CN106511385A (zh) * 2016-12-09 2017-03-22 济南万泉生物技术有限公司 一种治疗化疗脱发的药物
WO2017078641A1 (fr) 2015-11-02 2017-05-11 Yeditepe Universitesi Produit de prévention de la perte des cheveux
US20170173076A1 (en) * 2013-12-20 2017-06-22 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
WO2017123022A1 (fr) * 2016-01-12 2017-07-20 주식회사 강스템바이오텍 Exosome dérivé de cellules souches contenant une quantité importante de facteurs de croissance
US20170216195A1 (en) * 2015-09-29 2017-08-03 Anicell Biotech, Llc Methods and articles of manufacture for cosmetic results
CN107106613A (zh) * 2014-11-07 2017-08-29 胞外体干细胞株式会社 用于成脂分化诱导、脂肪组织再生、皮肤美白或改善皱纹的包含干细胞来源外泌体的组合物
KR20180005546A (ko) * 2016-07-06 2018-01-16 인천대학교 산학협력단 약물이 탑재된 엑소좀 또는 나노베지클을 이용한 약학적 조성물
US20190015452A1 (en) * 2015-08-03 2019-01-17 Osaka University Mesenchymal stem cell-derived exosome
CN109432127A (zh) * 2018-11-21 2019-03-08 海门生原干细胞科技有限公司 间充质干细胞外泌体在制备促毛发再生的药物制剂中的应用
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
CN111544577A (zh) * 2020-05-27 2020-08-18 和携科技有限公司 一种女性生殖护理制剂以及制备方法
CN112153957A (zh) * 2018-04-13 2020-12-29 北卡罗来纳州立大学 微针贴剂促进毛发生长的用途
CN112618572A (zh) * 2020-10-16 2021-04-09 中科细胞科技(广州)有限公司 一种治疗秃发的组合物
US20210169928A1 (en) * 2019-07-22 2021-06-10 Erivan Bio, Llc Topical Exosome Compositions and Associated Methods
KR102292608B1 (ko) * 2020-03-09 2021-08-23 주식회사 바이오솔루션 기능이 강화된 세포외 소포를 고농도로 함유하고 있는 조건화 배양액의 탈모 완화 및 방지 용도
US11203754B2 (en) 2016-04-29 2021-12-21 Advanced ReGen Medical Technologies, LLC Microrna compositions and methods of making and using same
US11219643B2 (en) 2013-12-20 2022-01-11 Advanced ReGen Medical Technologies, LLC Compositions for cellular restoration and methods of making and using same
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
US20220323492A1 (en) * 2021-04-09 2022-10-13 Kyungpook National University Industry-Academic Cooperation Foundation Composition for hair regeneration comprising macrophage-derived extracellular vesicle mimetics
WO2023027859A1 (fr) * 2021-08-26 2023-03-02 Abbott Laboratories Méthodes et compositions permettant d'améliorer la cicatrisation de plaies
CN115997760A (zh) * 2023-03-24 2023-04-25 北京汉氏联合生物技术股份有限公司 一种外泌体凝胶及其制备方法
US20230172838A1 (en) * 2021-10-17 2023-06-08 ELEVAI Labs, Inc. Method of Treating Hair Loss and Formulation for Treatment
WO2023123215A1 (fr) * 2021-12-30 2023-07-06 医微细胞生物技术(广州)有限公司 Utilisations de vésicules extracellulaires
US11753682B2 (en) 2016-03-07 2023-09-12 Father Flanagan's Boys'Home Noninvasive molecular controls

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20110403A1 (it) * 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
WO2014078420A1 (fr) * 2012-11-13 2014-05-22 Allan Wu Procédés et systèmes de traitement d'exosomes
US10500231B2 (en) 2013-03-13 2019-12-10 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
JP2014172899A (ja) * 2013-03-13 2014-09-22 Nobuhiko Miwa バイオ活性化剤およびその組成並びに製法
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
US20160220613A1 (en) * 2013-09-16 2016-08-04 Agency For Science, Technology And Research Method
EP3052616A4 (fr) * 2013-10-02 2017-03-29 Paradigm Biopharmaceuticals Limited Procédé de production d'exosomes
GB201317889D0 (en) * 2013-10-09 2013-11-20 Reneuron Ltd Product and use
KR20160145778A (ko) * 2014-07-07 2016-12-20 메디포스트(주) 작은 크기 줄기세포의 발모 촉진능 및 이의 용도
KR101673059B1 (ko) * 2014-11-26 2016-11-07 가톨릭관동대학교산학협력단 중간엽줄기세포 유래 미세소포체를 포함하는 발모촉진 또는 창상 치료용 약제학적 조성물
KR101766373B1 (ko) 2015-01-05 2017-08-09 권영아 루테리온을 이용한 암세포의 텔로머라아제 억제방법
EP3267965A4 (fr) * 2015-03-11 2018-11-14 Atta Behfar Technologie d'administration d'exosomes
US11077147B2 (en) * 2015-07-20 2021-08-03 Vivex Biologics Group, Inc. Acellular biologic composition and method of manufacture
JP6980955B2 (ja) * 2015-07-31 2021-12-15 ゼン−バイオ インコーポレイテッドZen−Bio, Inc. エキソソーム組成物ならびに調製方法ならびに皮膚および毛髪の調節および調整のためのその使用
KR102475127B1 (ko) * 2015-09-30 2022-12-07 (주)아모레퍼시픽 인삼 유래의 엑소좀 유사 베지클을 포함하는 탈모 방지 또는 육모 촉진용 조성물
KR102311832B1 (ko) * 2015-10-16 2021-10-13 (주)프로스테믹스 줄기세포 유래 엑소좀을 포함하는 상처 치료, 피부 개선 및 탈모 방지 또는 치료용 조성물 및 그 제조방법
JP7120628B2 (ja) * 2016-03-22 2022-08-17 カプリコール，インコーポレイテッド 細胞外小胞による放射線誘発性皮膚炎を予防するまたは治療する方法
EP3254684B1 (fr) 2016-06-08 2019-10-23 Lysatpharma GmbH Lysat de plaquettes humaines ou fraction enrichie de vésicules extracellulaires dérivées de lysat de plaquettes humaines pour utilisation medicale
JP6152205B1 (ja) * 2016-08-09 2017-06-21 仁幸 小林 化粧品、医薬用組成物、およびそれらの製造方法
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WO2018155979A1 (fr) * 2017-02-24 2018-08-30 (주)인핸스드바이오 Nanovésicule dérivée de cellules souches, et composition favorisant et restaurant la pousse des cheveux la contenant
CN106913583A (zh) * 2017-04-20 2017-07-04 深圳市赛欧细胞生物科技有限公司 人间充质干细胞源外泌体生物活性制剂的制备方法及应用
CN107217034A (zh) * 2017-04-20 2017-09-29 深圳市赛欧细胞生物科技有限公司 一种人脐带间充质干细胞源外泌体及其获取方法和应用
US20220088274A1 (en) * 2017-05-18 2022-03-24 The Board Of Trustees Of The Leland Stanford Junior University Targeted in Situ Therapeutic Delivery of Secreted Factors from Stem Cells for Treatment of Damaged Tissue
AU2018386209A1 (en) * 2017-12-14 2020-07-30 Mayo Foundation For Medical Education And Research Purified exosome products, method of making, and methods of using
KR102095628B1 (ko) * 2018-01-05 2020-04-01 재단법인 아산사회복지재단 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물
WO2019146612A1 (fr) * 2018-01-23 2019-08-01 ノバセラ株式会社 Composition pour une utilisation dans le traitement de maladies cutanées
WO2019168184A1 (fr) * 2018-03-02 2019-09-06 公益財団法人川崎市産業振興財団 Population de vésicules extracellulaires et sa méthode de fabrication
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SG11202111548SA (en) * 2019-04-18 2021-11-29 Agency Science Tech & Res Composition
CN110184235B (zh) * 2019-05-21 2021-03-02 葛楠 一种adsc外泌体及其制备方法与应用
CN110538197A (zh) * 2019-09-27 2019-12-06 北京臻惠康生物科技有限公司 一种外泌体在治疗脱发的药物中的应用
WO2021107706A1 (fr) * 2019-11-28 2021-06-03 한국과학기술연구원 Nouvelle utilisation d'exosomes du lait
CN113197918A (zh) * 2021-05-08 2021-08-03 奥镁(上海)医药科技有限公司 一种基于干细胞的毛发再生技术的方法及应用
CN113662966B (zh) * 2021-07-09 2023-01-24 广东医科大学 一种促进毛发再生的含激活囊泡水凝胶及其药物用途
US11878038B2 (en) * 2021-10-17 2024-01-23 ELEVAI Labs, Inc. Exosome-based skincare product
WO2023164241A1 (fr) * 2022-02-28 2023-08-31 Jlm Exograde, Llc Procédé d'enrichissement de cellules muse et d'obtention d'exosomes, de microvésicules ou du sécrétome à partir de celles-ci
WO2024015123A1 (fr) * 2022-07-14 2024-01-18 Elevai, Inc. Procédé de traitement de la chute des cheveux et formulation pour le traitement

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165667A1 (en) * 2004-12-03 2006-07-27 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2109362T3 (es) 1991-06-21 1998-01-16 Univ Cincinnati Unas proteinas administrables oralmente y metodo para hacerlas.
US5661034A (en) 1991-07-18 1997-08-26 Fuji Yakuhin Kogyo Kabushiki Kaisha Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium
US5482710A (en) 1993-07-30 1996-01-09 Chesebrough-Pond'usa Co., Division Of Conopco, Inc. Cosmetic composition for treatment of pimples and redness
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US5538945A (en) 1994-06-17 1996-07-23 Procyte Corporation Stimulation of hair growth by peptide copper complexes
FR2791684B1 (fr) 1999-03-30 2001-05-11 Sederma Sa Composition cosmetiques ou dermopharmaceutiques contenant le tripeptide n-n-biotinyl-gly-his-lys pour prevenir, reduire ou supprimer la chute des cheveux ainsi que pour favoriser leur repousse
US6376557B1 (en) 2000-03-16 2002-04-23 Chanda Bhuwalka Zaveri Methods for treating alopecia
US6861077B1 (en) 2000-03-17 2005-03-01 L'oreal S.A. Use of plant extracts in a cosmetic composition to protect keratinous fibers
DE10224982A1 (de) * 2002-06-05 2003-12-24 Rolf Hoffmann Mesenchymale Stammzellen des Haarfollikels und deren Verwendung
JP2008505104A (ja) * 2004-07-01 2008-02-21 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 免疫抑制性エキソソーム
US20070292401A1 (en) * 2006-06-20 2007-12-20 Harmon Alexander M Soft tissue repair and regeneration using stem cell products
US20120269774A1 (en) * 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
CA2678493A1 (fr) * 2007-02-23 2008-08-28 The Trustees Of Columbia University In The City Of New York Methodes d'activation ou de blocage de la voie de regulation des lymphocytes t cd8+ restreints par hla-e/qa-1 pour le traitement d'une maladie immunologique
KR101640381B1 (ko) * 2008-02-22 2016-07-18 에이전시 포 사이언스, 테크놀로지 앤드 리서치 중간엽 줄기세포 입자
WO2010038232A1 (fr) * 2008-10-05 2010-04-08 Hymie Friedlander Soin pour la peau et les cheveux utilisant un extrait provenant d’un milieu conditionné cultivé par des cellules souches mésenchymateuses et d’autres cellules régénératrices
SG10201403202XA (en) * 2009-07-23 2014-08-28 Agency Science Tech & Res Pre-natal mesenchymal stem cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165667A1 (en) * 2004-12-03 2006-07-27 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bruno et al. "Mesenchymal stem cell-derived microvesicles protect against acute tubular injury", Journal of the American Society of Nephrology 20(5): 1053-67, 2009 *
Nishio et al. "Neutrophil depletion delays wound repair in aged mice", Age 30: 11-19, 2008 *
Raposo et al. "Exracellular vesicles: exosomes, microvesicles, and friends", Journal of Cell Biology 200(4): 373-83, 2013 *

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* Cited by examiner, † Cited by third party
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US9119974B2 (en) * 2011-03-04 2015-09-01 Ahmed H. Al-Qahtani Skin cream
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
US9877989B2 (en) * 2012-07-18 2018-01-30 Universitaet Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
US20150190429A1 (en) * 2012-07-18 2015-07-09 Universitaet Duisburg-Essen Use of Preparations Comprising Exosomes Derived From Mesenchymal Stem Cells (MSCs) in the Prevention and Therapy of Inflammatory Conditions
US20140093545A1 (en) * 2012-09-28 2014-04-03 Orthogen Ag Antibacterial pharmaceutical preparation
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US11219643B2 (en) 2013-12-20 2022-01-11 Advanced ReGen Medical Technologies, LLC Compositions for cellular restoration and methods of making and using same
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US10071050B2 (en) * 2014-11-07 2018-09-11 Exostemtech Co., Ltd. Cosmetic composition containing exosomes extracted from stem cell for skin whitening, antiwrinkle or regeneration
CN107106613A (zh) * 2014-11-07 2017-08-29 胞外体干细胞株式会社 用于成脂分化诱导、脂肪组织再生、皮肤美白或改善皱纹的包含干细胞来源外泌体的组合物
AU2015343845B2 (en) * 2014-11-07 2018-11-08 Exostemtech Co., Ltd. Composition for differentiation induction of adipocyte containing stem cell-derived exosome, regeneration of adipose tissue, and skin whitening or wrinkle improvement
AU2017202287B2 (en) * 2014-11-07 2018-11-08 Exostemtech Co., Ltd. Composition for differentiation induction of adipocyte containing stem cell-derived exosome, regeneration of adipose tissue, and skin whitening or wrinkle improvement
US11357798B2 (en) 2015-08-03 2022-06-14 Osaka University Mesenchymal stem cell-derived exosome
US20190015452A1 (en) * 2015-08-03 2019-01-17 Osaka University Mesenchymal stem cell-derived exosome
US20170216195A1 (en) * 2015-09-29 2017-08-03 Anicell Biotech, Llc Methods and articles of manufacture for cosmetic results
US20180318206A1 (en) * 2015-11-02 2018-11-08 Yeditepe Universitesi A product preventing hair loss
WO2017078641A1 (fr) 2015-11-02 2017-05-11 Yeditepe Universitesi Produit de prévention de la perte des cheveux
WO2017123022A1 (fr) * 2016-01-12 2017-07-20 주식회사 강스템바이오텍 Exosome dérivé de cellules souches contenant une quantité importante de facteurs de croissance
US11753682B2 (en) 2016-03-07 2023-09-12 Father Flanagan's Boys'Home Noninvasive molecular controls
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KR102065819B1 (ko) * 2016-07-06 2020-01-13 인천대학교 산학협력단 약물이 탑재된 엑소좀 또는 나노베지클을 이용한 약학적 조성물
KR20180005546A (ko) * 2016-07-06 2018-01-16 인천대학교 산학협력단 약물이 탑재된 엑소좀 또는 나노베지클을 이용한 약학적 조성물
CN106511385A (zh) * 2016-12-09 2017-03-22 济南万泉生物技术有限公司 一种治疗化疗脱发的药物
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
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US20210161968A1 (en) * 2018-04-13 2021-06-03 North Carolina State University Use of microneedle patch to promote hair growth
CN109432127A (zh) * 2018-11-21 2019-03-08 海门生原干细胞科技有限公司 间充质干细胞外泌体在制备促毛发再生的药物制剂中的应用
US20210169928A1 (en) * 2019-07-22 2021-06-10 Erivan Bio, Llc Topical Exosome Compositions and Associated Methods
WO2021182725A1 (fr) * 2020-03-09 2021-09-16 주식회사 바이오솔루션 Utilisation de milieu conditionné pour soulager et prévenir la perte de cheveux contenant une concentration élevée de vésicules extracellulaires ayant une fonction améliorée
KR102292608B1 (ko) * 2020-03-09 2021-08-23 주식회사 바이오솔루션 기능이 강화된 세포외 소포를 고농도로 함유하고 있는 조건화 배양액의 탈모 완화 및 방지 용도
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US20220323492A1 (en) * 2021-04-09 2022-10-13 Kyungpook National University Industry-Academic Cooperation Foundation Composition for hair regeneration comprising macrophage-derived extracellular vesicle mimetics
WO2023027859A1 (fr) * 2021-08-26 2023-03-02 Abbott Laboratories Méthodes et compositions permettant d'améliorer la cicatrisation de plaies
US20230172838A1 (en) * 2021-10-17 2023-06-08 ELEVAI Labs, Inc. Method of Treating Hair Loss and Formulation for Treatment
WO2023123215A1 (fr) * 2021-12-30 2023-07-06 医微细胞生物技术(广州)有限公司 Utilisations de vésicules extracellulaires
CN115997760A (zh) * 2023-03-24 2023-04-25 北京汉氏联合生物技术股份有限公司 一种外泌体凝胶及其制备方法

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US20150024011A1 (en) 2015-01-22
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JP2013540150A (ja) 2013-10-31
EP2629782A1 (fr) 2013-08-28
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US11185481B2 (en) 2021-11-30
WO2012053976A1 (fr) 2012-04-26

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