WO2024015123A1 - Procédé de traitement de la chute des cheveux et formulation pour le traitement - Google Patents
Procédé de traitement de la chute des cheveux et formulation pour le traitement Download PDFInfo
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- WO2024015123A1 WO2024015123A1 PCT/US2023/011750 US2023011750W WO2024015123A1 WO 2024015123 A1 WO2024015123 A1 WO 2024015123A1 US 2023011750 W US2023011750 W US 2023011750W WO 2024015123 A1 WO2024015123 A1 WO 2024015123A1
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- sodium
- exosome
- skincare product
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- 238000000034 method Methods 0.000 title claims abstract description 36
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- 230000003676 hair loss Effects 0.000 title claims abstract description 23
- 238000011282 treatment Methods 0.000 title abstract description 9
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 14
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- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- DSLZVSRJTYRBFB-DUHBMQHGSA-N galactaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O DSLZVSRJTYRBFB-DUHBMQHGSA-N 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000003803 hair density Effects 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019795 sodium metasilicate Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 230000037359 steroid metabolism Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
Definitions
- the present invention relates generally to treatments for hair loss along with products used to treat hair loss. More specifically, the present invention relates to exosome-based methods and products for treating hair loss.
- a method for treating hair loss, along with formulations for use comprises applying an exosome-based skincare product to skin where hair loss has occurred.
- the exosome-based skincare product contains exosomes produced by and excreted from human umbilical mesenchymal stem cells cultured in vitro under specific conditions and then contained within a solvent. Note that the exosome-based skincare product does not contain live human umbilical mesenchymal stem cells.
- Optional ingredients such as skin-conditioning agents, antioxidants, surfactants, buffering agents, viscosity decreasing agents, viscosity increasing agents, peptides, binders, and/or humectants may be included.
- media is used to mean any substrate which can contain an exosome-based product and is not to be read as the plural form of “medium”.
- Appropriate substrates for skincare are well known within the industry and as such are not discussed in detail herein.
- human umbilical mesenchymal stem cells is used to mean any preparation of human umbilical mesenchymal stem cells, including human umbilical mesenchymal stem cells contained within human umbilical stem cell conditioned media.
- human umbilical mesenchymal stem cells are known by a number of different names, including but not limited to human Wharton’s Jelly derived mesenchymal stem cells, human Wharton’s Jelly derived mesenchymal stromal cells, human umbilical derived mesenchymal stromal cells, hUMSCs, hWJMSCs, Wharton's Jelly derived multipotent progenitor cells, and umbilical derived multipotent progenitor cells. Additionally, these stem cells can be identified by cell surface markers, such as CD90+, CD105+, CD73+, and CD45-.
- exosomes discussed are much smaller than a typical mesenchymal stem cell, about 1/100th the size of a cell, and have a diameter of approximately 30- 150 nanometers (nm).
- Exosomes are roughly spherical and made up of a lipid bilayer produced by the cell they originated from. This lipid bilayer forms a protective ‘shell’ or outer casing, and within the ‘shell’ or outer casing is the exosome pay load which contains molecules deposited there by the cell that generated the exosome. While exosomes are generated using some of the origin cell’s own cellular material, the exosomes do not contain cells, nor are they explicitly cellular material.
- the method comprises the step of applying an exosome-based skincare product to skin where hair loss has occurred.
- the exosome- based skincare product contains exosomes in or derived from a media conditioned by human umbilical mesenchymal stem cells within a solvent.
- skin-conditioning agents, antioxidants, surfactants, buffering agents, viscosity decreasing agents, viscosity increasing agents, peptides, binders, and/or humectants may be included.
- Other optional ingredients are contemplated and described herein. Frequently, all of these optional ingredients are included with the human umbilical mesenchymal stem cell derived exosomes, or media, and solvent. Additional optional ingredients beyond those explicitly described herein are contemplated.
- the solvent is water.
- oil-based solvents are contemplated.
- Skin-conditioning agents within the skincare industry are vast and well documented. Any of the well-known skin-conditioning agents work well with the invention and is contemplated. Specifically, glycerin, sodium hyaluronate, niacinamide, panthenol, Caesalpinia spinosa gum, ceramide NP, ceramide AP, ceramide EOP, yeast extract, Citrullus ianatus fruit extract, Pyrus malus fruit extract, Lens esculenta fruit extract, sodium PCA, caprylyl glycol, ethylhexylglycerin, hydrolyzed sodium hyaluronate, and phytosphingosine are frequently used with the invention.
- antioxidants are well known and well documented. With the invention, the antioxidants most frequently used are ascorbic acid, magnesium ascorbyl phosphate, ascorbyl glucoside, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, glutathione, and Camellia sinensis leaf extract. Any other well-known antioxidants in the skincare industry can be and is contemplated.
- Surfactants frequently used with the invention include polysorbate 20, polysorbate 60, and sodium lauroyl lactylate. Any other well-known surfactant in the skincare industry can be used and is contemplated. While not a surfactant itself, cholesterol is commonly used to stabilize the emulsions that are achieved with surfactants. Some embodiments of the exosome-based skincare product include cholesterol.
- Buffering agents such as sodium lactate, disodium phosphate, and sodium phosphate most frequently used with the invention, are common in the skincare industry. As many skincare products have harsh pH, both acidic and basic, buffers are frequently used to ensure that the final product is of a neutral pH for the skin. Other well-known buffering agents in the skincare industry are acceptable and are contemplated.
- Viscosity increasing and decreasing agents are frequently used in the skincare industry. Those most frequently used with the invention are hydroxyethylcellulose, Caesalpinia spinosa gum, dextran, carbomer, hexylene glycol, and butylene glycol. Any other well-known viscosity increasing or decreasing agent in the skincare industry can be used and is contemplated.
- Peptides are commonly added to skincare products. Peptides such as bis(tripeptide-l) copper acetate, acetyl octapeptide-3, palmitoyl tripeptide-37, palmitoyl pripeptide-1, palmitoyl tetrapeptide-7, acetyl hexapeptide- 8, and trifluoroacetyl tripeptide-2 are most frequently used with the invention. Other peptides well-known in the skincare industry can be used and are contemplated.
- Binders and bulking agents are frequently used in the skincare industry to improve the usability of a product for the consumer. Binders such as hydroxyethylcellulose, dextran, pullulan, and xanthan gum are the binders and bulking agents most frequently used. However, other binders and bulking agents are contemplated, especially those well-known within the skincare industry.
- Aloe barbadensis leaf juice for the skin are well studied, well known, and well documented. Some embodiments include Aloe barbadensis leaf juice for its skincare related properties.
- Humectants are frequently used in the skincare industry to prevent the loss of moisture from the skin. Glycerin, sodium hyaluronate, arginine in all of its forms, Nannochloropsis oculate extract, sodium PCA, and hydrolyzed sodium hyaluronate are the most common humectants used. Other humectants well-known within the skincare industry are contemplated.
- Antimicrobials such as Leuconostoc root ferment filtrate most commonly used, are vitally important to the skincare industry. Other antimicrobials are contemplated, especially those well-known in the skincare industry.
- Chelating agents are commonly used within the skincare industry to stabilize the metal ions found in many skincare products.
- sodium phytate is the most frequently used chelating agent.
- Other chelating agents such as ethylenediaminetetraacetic acid, etidronic acid, galactaric acid, sodium metasilicate, and phosphate derivatives, as well as derivatives of each of the previously listed acids, are also used in some embodiments.
- Other chelating agents known within the skincare industry are contemplated.
- Preservatives such as phenoxyethanol, sodium benzoate, and potassium sorbate, are key to preserving the life of skincare products. Other preservatives, especially those known in the skincare industry, are contemplated.
- the exosome-based skincare product contains human umbilical mesenchymal stem cell conditioned media between 25.0 and 50.0 percent by mass, water between 0.1 and 60.0 percent by mass, glycerin between 3.0 and 10.0 percent by mass, Aloe barbadensis leaf juice between 1.0 and 5.0 percent by mass, sodium hyaluronate between 1.0 and 5.0 percent by mass, niacinamide between 1.0 and 5.0 percent by mass, panthenol between 1.0 and 5.0 percent by mass, magnesium ascorbyl phosphate between 1.0 and 5.0 percent by mass, ascorbyl glucoside between 0.5 and 3.0 percent by mass, sodium ascorbyl phosphate between 0.1 and 3.0 percent by mass, hydroxyethylcellulose between 0.1 and 5.0 percent by mass, Caesalpinia spinosa gum between 0.1 and 3.0 percent by mass, bis(tripeptide-l) copper acetate between 0.1 and 5.0 percent by mass,
- the exosome-based skincare product contains human umbilical mesenchymal stem cell conditioned media between 10.0 and 55.0 percent by mass, water between 1.0 and 30.0 percent by mass, glycerin between 0.1 and 5.0 percent by mass, Aloe barbadensis leaf juice between 0.1 and 5.0 percent by mass, hydroxyethylcellulose between 0.1 and 5.0 percent by mass, hydrolyzed sodium hyaluronate between 0.1 and 5.0 percent by mass, sodium hyaluronate between 1.0 and 5.0 percent by mass, bis(tripeptide-l) copper acetate between 0.1 and 5.0 percent by mass, polysorbate 20 between 0.1 and 3.0 percent by mass, polysorbate 60 between 0.1 and 3.0 percent by mass, ceramide NP between 0.1 and 5.0 percent by mass, ceramide AP between 0.1 and 5.0 percent by mass, ceramide EOP between 0.1 and 5.0 percent by mass, acetyl octa
- the most frequent embodiment of the invention will be to treat hair loss on the scalp. Treating hair loss on the face, such as eye lashes, eyebrows, beard, or mustache, is also possible using this invention.
- the hair loss may be as a result of androgenic alopecia, alopecia areta, or telogen effulvium.
- the hair loss may be in male or female patients, as the treatment works on with both sexes.
Abstract
L'invention concerne un procédé et des formulations pour le procédé, pour le traitement de la chute des cheveux. Généralement, le procédé consiste à appliquer un produit de soin de la peau à base d'exosomes sur la peau affectée par la chute des cheveux, telle que la peau du cuir chevelu. Le produit de soin de la peau à base d'exosomes contient des exosomes produits par et excrétés à partir de cellules souches mésenchymateuses ombilicales humaines cultivées in vitro dans des conditions spécifiques, puis contenues dans un solvant. La perte des cheveux peut être provoquée par l'alopécie androgénique, l'alopécie areta ou l'effulvium télogène.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17/865,229 US11878038B2 (en) | 2021-10-17 | 2022-07-14 | Exosome-based skincare product |
| US17/865,229 | 2022-07-14 | ||
| US18/101,974 | 2023-01-26 | ||
| US18/101,974 US20230172838A1 (en) | 2021-10-17 | 2023-01-26 | Method of Treating Hair Loss and Formulation for Treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2024015123A1 true WO2024015123A1 (fr) | 2024-01-18 |
Family
ID=89537195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2023/011750 WO2024015123A1 (fr) | 2022-07-14 | 2023-01-27 | Procédé de traitement de la chute des cheveux et formulation pour le traitement |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2024015123A1 (fr) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170135915A1 (en) * | 2010-10-18 | 2017-05-18 | Agency For Science, Technology And Research (A*Star) | Use of exosomes to promote or enhance hair growth |
| US20190133922A1 (en) * | 2016-01-12 | 2019-05-09 | Kangstem Biotech Co., Ltd. | Stem Cell-Derived Exosomes Containing a High Amount of Growth Factors |
| US20190330594A1 (en) * | 2017-01-11 | 2019-10-31 | Stemlab Inc. | Method for preparing composition, included within exosome obtained from nanog-introduced, fetus-derived mesenchymal stem cell in amniotic fluid, for hair growth |
| WO2020018926A1 (fr) * | 2018-07-19 | 2020-01-23 | Intrexon Corporation | Administration d'exosomes de peptides de soin cutané |
| US20220016183A1 (en) * | 2018-11-22 | 2022-01-20 | Prostemics Co., Ltd. | Exosome and various uses thereof |
-
2023
- 2023-01-27 WO PCT/US2023/011750 patent/WO2024015123A1/fr unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170135915A1 (en) * | 2010-10-18 | 2017-05-18 | Agency For Science, Technology And Research (A*Star) | Use of exosomes to promote or enhance hair growth |
| US20190133922A1 (en) * | 2016-01-12 | 2019-05-09 | Kangstem Biotech Co., Ltd. | Stem Cell-Derived Exosomes Containing a High Amount of Growth Factors |
| US20190330594A1 (en) * | 2017-01-11 | 2019-10-31 | Stemlab Inc. | Method for preparing composition, included within exosome obtained from nanog-introduced, fetus-derived mesenchymal stem cell in amniotic fluid, for hair growth |
| WO2020018926A1 (fr) * | 2018-07-19 | 2020-01-23 | Intrexon Corporation | Administration d'exosomes de peptides de soin cutané |
| US20220016183A1 (en) * | 2018-11-22 | 2022-01-20 | Prostemics Co., Ltd. | Exosome and various uses thereof |
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