US20090130227A1 - External preparation for skin - Google Patents

External preparation for skin Download PDF

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US20090130227A1
US20090130227A1 US11/912,433 US91243305A US2009130227A1 US 20090130227 A1 US20090130227 A1 US 20090130227A1 US 91243305 A US91243305 A US 91243305A US 2009130227 A1 US2009130227 A1 US 2009130227A1
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iron
skin
sodium
group
citrate
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Yoshiyasu Ito
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SBI ALApromo Co Ltd
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SBI ALApromo Co Ltd
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Assigned to COSMO OIL CO., LTD. reassignment COSMO OIL CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ITO, YOSHIYASU
Publication of US20090130227A1 publication Critical patent/US20090130227A1/en
Assigned to SBI ALAPROMO CO., LTD. reassignment SBI ALAPROMO CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: COSMO OIL CO., LTD.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Definitions

  • the present invention relates to an external preparation for skin which is excellent in skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum, and an external preparation for skin which is excellent in an ameliorating effect on skin diseases such as atopic dermatitis, more particularly, to an external preparation for skin wherein 5-aminolevulinic acids and an iron compound are used in combination.
  • external preparations for skin have been developed, which focused on prevention and amelioration of skin roughness.
  • external preparations for skin include: skin external preparations for ameliorating skin roughness which contains alum, calcium salt and magnesium salt (see Japanese Laid-open Patent Application No. 2004-284962), and an agent for preventing/ameliorating skin roughness which consists of N- ⁇ -benzoyl-L-arginine, N- ⁇ -benzoyl-L-arginine ethyl ester or salt of N- ⁇ -benzoyl-L-arginine ethyl ester (see Japanese Laid-open Patent Application No. 2000-281556).
  • 5-aminolevulinic acids are used as herbicides (for example, see Japanese Laid-open Patent Application No. 08-081322), plant growth regulators (for example, see Japanese Laid-open Patent Application No. 07-53487), external preparations for head (for example, see Japanese Laid-open Patent Application No. 11-116446), etc.
  • the object of the present invention is to provide an external preparation for skin which contains 5-aminolevulinicacids as active components and having excellent skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum; and an ameliorating effect on skin diseases such as atopic dermatitis.
  • the present inventor has conducted a keen study and found out that a mixture of 5-aminolevulinic acids and iron compounds have: skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum; and an ameliorating effect on skin diseases such as atopic dermatitis.
  • skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum
  • an ameliorating effect on skin diseases such as atopic dermatitis.
  • the present invention has been thus completed.
  • the present invention relates to: (“1”) an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; (“2”) the external preparation for skin according to (“1”) mentioned above, which further contains urea as an active component; and the (“3”) the external preparation for skin according to (“1”) or (“2”) mentioned above, wherein the iron compound is one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepent
  • the present invention also relates to: (“4”) a preventive/ameliorating drug for skin roughness which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; and (“5”) the preventive/ameliorating drug for skin roughness according to (“4”) mentioned above, wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethyl
  • the present invention further relates to: (“6”) a preventive/ameliorating drug for dry skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; and (“7”) the preventive/ameliorating drug for dry skin according to (“6”) mentioned above, wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylgluta
  • the present invention also relates to: (“8”) a preventive/ameliorating drug for wrinkles/flecks which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; and (“9”) the preventive/ameliorating drug for wrinkles/flecks according to (“8”) mentioned above, wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium di
  • the present invention further relates to: (“10”) a method for preventing/ameliorating skin roughness comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components.
  • the present invention also relates to: (“11”) a method for preventing/ameliorating dry skin comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components.
  • the present invention further relates to: (“12”) a method for preventing/ameliorating wrinkles/flecks comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components.
  • the present invention also relates to: (“13”) an ameliorating drug for atopic dermatitis which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; and (“14”) the ameliorating drug for atopic dermatitis according to (“13”) mentioned above, wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and
  • the present invention further relates to: (“15”) a method for ameliorating atopic dermatitis comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components.
  • the present invention also relates to: (“16”) a set of external preparations for skin consisting of a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound; (“17”) the set of external preparations for skin according to (“16”) mentioned above, wherein the first agent and/or the second agent further contain urea; and (“18”) the set of external preparations for skin according to (“16”) or (“17”) mentioned above, wherein the iron compound is one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium
  • the present invention further relates to: (“19”) a method for preventing/ameliorating skin roughness comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound; (“20”) a method for preventing/ameliorating dry skin comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound; (“21”) a method for preventing/ameliorating wrinkles/flecks comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound; and (“22”) a method for ameliorating atopic dermatitis comprising administering transdermally a first agent which
  • FIG. 1 is a photograph showing an example of clinical testing of an external preparation for skin of the present invention.
  • the photograph was taken 5 days after the start of the treatment with the formulation example 1.
  • the treated cheek the cheek on the left side of FIG. 1
  • the skin became resilient and dry skin was ameliorated in comparison to the cheek without treatment (the cheek on the right side of FIG. 1 ).
  • the treated cheek the cheek on the left side of FIG. 1
  • FIG. 2 is a set of photographs showing an example of clinical testing of an external preparation for skin of the present invention.
  • the left photograph is a photograph of the face before the start of the treatment with the formulation example 1
  • the right photograph is a photograph of the face 14 days after the start of the treatment with the formulation example 1. After the treatment, the redness and the pigmentation of the affected area are ameliorated in comparison to those before the treatment.
  • FIG. 3 is a set of photographs showing an example of clinical testing of an external preparation for skin of the present invention.
  • the left photograph is a photograph of the inside of the elbow before the start of the treatment with the formulation example 1
  • the right photograph is a photograph of the inside of the elbow 7 days after the start of the treatment with the formulation example 1. After the treatment, the redness and pigmentation of the affected area are ameliorated in comparison to those before the treatment, and the appearance of the skin is nearly normal.
  • FIG. 4 is a set of photographs showing an example of clinical testing of an external preparation for skin of the present invention.
  • the left photograph is a photograph of the underarm before the start of the treatment with the formulation example 1
  • the right photograph is a photograph of the underarm 7 days after the start of the treatment with the formulation example 1.
  • the redness and the pigmentation of the affected area are ameliorated in comparison to those before the treatment, and the appearance of the skin is nearly normal.
  • no scratches are observed in the photograph after the treatment because the itching subsided.
  • the external preparation for skin of the present invention is not particularly limited as long as it contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and an iron compound, as active components.
  • the above-mentioned 5-aminolevulinic acid is also referred to as ⁇ -aminolevulinic acid, and is one of the amino acids shown by the formula HOOC—(CH 2 ) 2 —(CO)—CH 2 —NH 2 (hereinafter, also referred to as 5-ALA).
  • This 5-aminolevulinic acid is widely distributed in various organisms, and is generally biosynthesized by 5-aminolevulinic acid synthetase from succinyl CoA and glycine. This 5-aminolevulinic acid is also known as an intermediate of porphyrin biosynthesis.
  • salts of 5-aminolevulinic acid of the present invention include acid addition salts such as hydrochloride, phosphate, nitrate, sulfate, acetate, propionate, butylate, valerate, citrate, fumarate, maleate, andmalate; and metal salts such as sodium salt, potassium salt, and calcium salt. It is preferred that these salts are used as aqueous solutions, suspensions, or powders at the point of use, and have a same effect as that of 5-aminolevulinic acid.
  • 5-aminolevulinic acid ester and N-acyl-5-aminolevulinic acid are exemplified.
  • 5-aminolevulinic acid ester the followings are exemplified: optionally substituted linear, branched or cyclic alkyl ester having 1 to 24 carbon atoms, preferably, for example, an 5-aminolevulinic acid ester whose ester residue is a methyl group, an ethyl group, an isopropyl group, an n-hexyl group, a cyclohexyl group, an n-heptyl group, an n-octyl group, an n-nonyl group, an n-dodecyl group, an n-hexadecyl group, a benzyl group, a phenethyl group, a 3-phenylpropyl group, a hydroxyethyl group, or an ethoxyethyl group.
  • an 5-aminolevulinic acid ester whose ester residue is a methyl group, an ethyl
  • N-acyl-5-aminolevulinic acid a compound wherein an amino group of 5-aminolevulinic acid is acylated with, for example, an alkanoyl group, an aromatic acyl group, a benzyloxycarbonyl group or the like, each having 1 to 24 carbon atoms is exemplified.
  • an N-acyl group the followings are specifically exemplified: an acetyl group, an n-pentanoyl group, an n-hexanoyl group, an n-nonanoyl group, a benzoyl group, and a benzyloxycarbonyl group.
  • the ester of 5-aminolevulinic acid and N-acyl-5-aminolevulinic acid can be produced by publicly known chemical synthesis methods such as methods described in Japanese Laid-open Patent Application No. 4-9360, for example. In addition to chemical synthesis, they can be produced by production methods either by microorganisms or by enzymes. Further, a roughly-purified product containing an object obtained in the process of the production can also be used without separation and purification as long as the roughly-purified product does not contain a toxic substance. Each of 5-aminolevulinic acid, its salt, and their derivatives may be used alone, or by mixing two or more of them.
  • the total amount of 5-aminolevulinic acid, its salt, or a derivative of them contained in the external preparation for skin of the present invention is usually 0.01 to 40 wt %, preferably 0.1 to 10 wt % based on the whole of the external preparation for skin.
  • the iron compound in the present invention is not particularly limited as long as it is a compound having iron in its molecule.
  • the iron compound include ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammomium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminetetraacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, ammonium dicarboxymethylglutamate, iron choline citrate, ferrous formate, ferric formate, ferric ammonium potassium oxalate, ferrous sulfate, ferric sulfate, iron ammonium sulfate, ferr
  • iron sodium diethylenetriaminepentaacetate and iron ammomium diethylenetriaminepentaacetate are preferred.
  • Each of these iron compounds may be used alone, or by mixing two or more of them.
  • the total amount of the iron compound contained in the external preparation for skin of the present invention is usually 0.01 to 80 wt %, preferably 0.5 to 50 wt % based on the whole of the external preparation for skin.
  • the external preparation for skin of the present invention acts on sebaceous glands of the skin, and promote the secretion of sebum. Further, the external preparation for skin of the present invention acts on epidermal cells and corneocytes, and activate these cells. It is considered that, as a result of that, it exerts skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum. Therefore, the external preparation for skin of the present invention can be used as a preventive/ameliorating drug for skin roughness, a preventive/ameliorating drug for dry skin, and a preventive/ameliorating drug for wrinkles/flecks.
  • preventive/ameliorating drug in the preventive/ameliorating drug for skin roughness, the preventive/ameliorating drug for dry skin, and the preventive/ameliorating drug for wrinkles/flecks of the present invention means “preventive and/or ameliorating drug”.
  • wrinkles/flecks of the present invention means “wrinkles and/or flecks”.
  • the external preparation for skin of the present invention has an ameliorating effect on skin diseases such as atopic dermatitis, eczema and dyskeratosis, as well. More specifically, it has an ameliorating effect on dryness of the skin, pigmentation of the skin, itching of the skin, etc., caused by skin diseases such as atopic dermatitis, eczema and dyskeratosis. Therefore, the external preparation for skin of the present invention can be used as an ameliorating drug for the skin diseases such as atopic dermatitis, eczema and dyskeratosis.
  • urea is contained therein, however, those further containing urea as an active component are preferred.
  • Urea is a colorless to white crystal or crystalline powder, and is freely soluble in water, soluble in ethanol, and can be formed into many kinds of dosage forms such as lotions and creams, as external preparations.
  • urea has a high affinity for the skin, and therefore, it has a suitable property as a component of external preparations for skin. Though it depends on the base material and other components used in combination, it is possible to blend urea into the external preparation for skin of the present invention at a ratio of 0.01 to 40 (W/W %; weight ratio), preferably 0.1 to 10%. Commercially available urea can be used directly in applications.
  • the set of external preparations for skin of the present invention consists of a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound.
  • a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them
  • a second agent which contains an iron compound.
  • the set of external preparations for skin of the present invention can be used as a set of preventive/ameliorating drugs for skin roughness, a set of preventive/ameliorating drugs for dry skin, a set of preventive/ameliorating drugs for wrinkles/flecks, and a set of ameliorating drugs for skin diseases such as atopic dermatitis, eczema and dyskeratosis.
  • first agent and/or the second agent of a set of external preparations for skin of the present invention it is not essential that urea is further contained therein, however, it is preferred that urea is further contained therein.
  • the amount of urea contained in the first agent and the second agent is not particularly limited, and it is possible to blend urea at a ratio of 0.01 to 40 (W/W %; weight ratio), preferably 0.1 to 10%.
  • aqueous components oily components, powdery components, chemical agents such as surface active agents, moisturizing agents, thickeners, colorants, fragrances, pH adjusters, antioxidants, antiseptics, or UV protectants, and anti-inflammatory agents can be blended into the external preparation for skin of the present invention, and the first agent and the second agent of the set of external preparations for skin of the present invention, to the extent that they do not damage the effect of the present invention.
  • aqueous components for example, water, lower alcohol (methanol, ethanol, denatured ethanol, propanol, isopropyl alcohol), etc., are exemplified.
  • oily components for example, higher fatty acids (stearic acid, palmitic acid, myristic acid, lauric acid and esters thereof, etc.), higher alcohols (cetanol, lanolin alcohol, stearyl alcohol, cetostearyl alcohol, etc.) and waxes (hard paraffin, microcrystalline wax, ceresin wax, polyethylene wax, beeswax, Japan wax, carnauba wax, candelilla wax, etc.), natural or synthetic oily substances (squalane, liquid paraffin, lanolin or derivatives thereof, olive oil, camellia oil, cottonseed oil, oleyl alcohol, castor oil, Vaseline, diethoxyethyl adipate ester, silicon oil, fluorine oil, etc.) are exemplified.
  • higher fatty acids stearic acid, palmitic acid, myristic acid, lauric acid and esters thereof, etc.
  • higher alcohols cetanol, lanolin alcohol, stearyl alcohol, cetoste
  • powdery components for example, aluminum powders, titanium oxide powders, zinc oxide powders, iron oxide powders, acrylic powders, silica beads, talc, sericite, etc., are exemplified.
  • sorbitan fatty acid ester for example, sorbitan fatty acid ester, glycerine fatty acid ester, polyglycerine fatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerine fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene beeswax derivatives, polyoxyethylene lanolin derivatives, polyoxyethylene alkylamide, polyoxyethylene alkylamine, lecithin derivatives, polymeric emulsifiers, etc., are exemplified.
  • moisturizing agents for example, polyhydric alcohols such as glycerine, propylene glycol, 1,3-butylene glycol, dipropylene glycol, ethylene glycol, 1,4-butylene glycol, diglycerine, triglycerine, sorbit or derivatives thereof, polyethylene glycol, etc.; and glucose, maltose, maltitol, sucrose, fructose, threitol, erythritol, sorbit, starch-degraded sugar, hyaluronic acid, chondroitin sulfate, hydrolyzed collagen, hydrolyzed elastin, carboxymethyl chitin, casein soda, muchin, glycosphingolipid, etc., are exemplified.
  • polyhydric alcohols such as glycerine, propylene glycol, 1,3-butylene glycol, dipropylene glycol, ethylene glycol, 1,4-butylene glycol, diglycerine,
  • thickeners for example, carboxyvinyl polymer, CP jelly, carboxymethyl cellulose, carageenan, sodium alginate, bentonite, veegum, synthetic hectorite, etc., are exemplified.
  • antioxidants for example, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), sodium pyrosulfite, sodium bisulfate, tocopherol, sodium edetate, ascorbic acid, isopropyl gallate, etc.
  • BHT butylated hydroxytoluene
  • BHA butylated hydroxyanisole
  • sodium pyrosulfite sodium bisulfate
  • tocopherol sodium edetate
  • ascorbic acid sodium edetate
  • isopropyl gallate etc.
  • pH adjusters for example, citric acid, lactic acid, tartaric acid, phosphoric acid, etc., are exemplified.
  • antihistamines for example, diphenhydramine hydrochloride, isothipendyl hydrochloride, etc., are exemplified.
  • antiseptics for example, methyl, ethyl, propyl, and butyl esters of p-hydroxybenzoic acid, phenoxyethanol, o-phenylphenol, dehydroacetic acid or salts thereof, p-cresol, m-cresol, o-chlor-m-xylenol, etc., are exemplified.
  • UV protectants for example, ascorbic acid or derivatives thereof, isoferulic acid or salts thereof, oxybenzone or derivatives thereof, p-aminobenzoic acid or derivatives thereof, urocanic acid or derivatives thereof, kojic acid, dibenzoyl methane or derivatives thereof, p-methoxycinnamic acid or derivatives thereof, particulate titanium oxide, particulate zinc oxide, particulate iron oxide, etc., are exemplified.
  • anti-inflammatory agents for example, glycyrrhetinic acid or derivatives thereof, glycyrrhizinic acid or derivatives thereof, guaiazulene or derivatives thereof, bisabolol, geraniin, horse chestnut extracts, aloe extracts, etc., are exemplified.
  • any form of powders, liquids and ointments can be employed.
  • Dosage forms such as lotions, emulsions, creams (ointments), gels, and aerosols can be prepared, according to methods usually used (for example, methods prescribed in The Japanese Pharmacopoeia 12 th Edition).
  • the external preparation for skin of the present invention may be liposomally encapsulated. Methods for liposomal encapsulation are not particularly limited, and are described, for example, in Japanese Laid-open Patent Application No. 11-199488, etc.
  • 5-aminolevulinic acid or its salt or a derivative of them When prepared as aqueous solutions such as lotions, or creams (ointments), in order to prevent degradation of 5-aminolevulinic acid or its salt or a derivative of them, it is preferred to prepare the external preparation for skin while paying attention not to cause alkalinization. In case of alkalinization, degradation can be prevented by removing oxygen. Paying attention to this, 5-aminolevulinic acid or its salt or a derivative of them can be used in combination with components of liquids or ointments usually used.
  • the external preparation for skin of the present invention is transdermally administered to the skin by methods such as spraying, application, or a poultice.
  • transdermal administration using a drug delivery system such as iontophoresis is preferred because it promotes the speed of drug absorption into skin tissues and increases the ratio of drug absorption, as well.
  • the method for using a set of external preparations for skin of the present invention there is no particular limitation to the method for using a set of external preparations for skin of the present invention, and the following methods can be adapted: a method comprising mixing the first agent and the second agent together, and applying the mixture to the skin; a method comprising applying the first agent and the second agent to the skin at the same time; a method comprising applying the first agent to the skin and then applying the second agent to the same part; and a method comprising the second agent to the skin and then applying the first agent to the same part.
  • the method comprising administering the first agent and the second agent is not particularly limited, methods such as spraying, application, or a poultice to the skin, or methods using a drug delivery system such as iontophoresis are preferred.
  • the dosage of the external preparation for skin of the present invention and the first agent and the second agent of the set of external preparations for skin of the present invention, there is no particular limitation as long as it is a level exerting an effect on skin roughness etc.
  • it is preferred to administer the external preparation for skin such that 5-aminolevulinic acid or its salt and a derivative of them is administered in an amount of 10 ⁇ g to 10 mg, desirably 100 ⁇ g to 5 mg, more desirably 1 mg to 5 mg per 10 cm 2 of skin, in 5-aminolevulinic acid hydrochloride equivalent.
  • the dosage of iron compounds to be combined with 5-aminolevulinic acid, etc. is 50 ⁇ g to 50 mg, desirably 500 ⁇ g to 25 mg, more desirably 5 mg to 25 mg, in iron equivalent under the same conditions.
  • the following method is preferably exemplified but not limited thereto: a method comprising administering transdermally the external preparation for skin of the present invention, or the first agent and the second agent of the set of external preparations for skin of the present invention from the twilight to the night by methods such as application, and rinsing off in the same night.
  • the external preparation for skin and the set of external preparations for skin of the present invention resides in the point that there is no need for a strict light shielding treatment, which is necessary when 5-aminolevulinic acid is administered (application, etc.) alone. However, it is preferred to avoid being exposed to strong light, for example, being in a scorching sun.
  • skin-beautifying effects such as amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum, and an ameliorating effect on skin diseases such as atopic dermatitis are seen from day 3. In case the effects reach a plateau, the effects can be expected again by stopping the administration once and resuming the administration 3 months later, though the external preparation for skin and the set of external preparations for skin of the present invention can be used continuously.
  • the methods of the present invention are: a method for preventing/ameliorating skin roughness comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; a method for preventing/ameliorating dry skin comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; a method for preventing/ameliorating wrinkles/flecks comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components; a method for ameliorating atopic dermatitis comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-amin
  • the method for transdermally administering the first agent and the second agent mentioned above there is no particular limitation to the method for transdermally administering the first agent and the second agent mentioned above, and the following methods can be adapted: a method comprising mixing the first agent and the second agent together, and applying the mixture to the skin; a method comprising applying the first agent and the second agent to the skin at the same time; a method comprising applying the first agent to the skin and applying the second agent to the same part; and a method comprising applying the second agent to the skin and then applying the first agent to the same part.
  • the formulation example 1 was evaluated 5 days after the start of the application by each of 8 subjects. The results are shown below.
  • Subject 1 only the right half of the face was treated with the formulation example 1, and the skin at the treated part became resilient and the dryness was ameliorated. In addition, the treated cheek (the cheek on the left side of FIG. 1 ) was lifted up in comparison to the cheek without treatment.
  • Subject 2 the skin became resilient. The nasolabial folds that run from the nose to the both sides of the mouth became less prominent. When the formulation example 1 was being applied longer, the secretion of sebum increased, and dry skin was ameliorated. Makeup was put on in a better state.
  • Subject 3 the skin became resilient. The nasolabial folds became less prominent. Crow's feet disappeared. Makeup was put on in a better state.
  • Subject 4 the skin became resilient. The complexion became fairer.
  • Subject 5 the skin became resilient. Dry skin was ameliorated. Makeup was put on in a better state.
  • Subject 6 the skin became resilient. The skin became moisturized. Subject 7: there was no special change. Subject 8: there was no special change.
  • the external preparation for skin of the present invention has an effect on promoting the secretion of sebum, and it is considered that, as a result of that, it exerts effects on improving skin resilience, ameliorating dry skin, and making nasolabial folds less prominent, etc.
  • subject 1 who is a patient of atopic dermatitis, the skin became resilient and the dryness was ameliorated. Consequently, it is suggested that the external preparation for skin of the present invention is also effective for prevention/amelioration of skin roughness, dry skin, wrinkles, and sagging of skin resulted from atopic dermatitis.
  • an effect on making complexion fairer, as in the case of subject 4 was observed as well.
  • the formulation example 1 in Example 1 was applied once every night to affected areas of 6 patients of atopic dermatitis (subjects 9 to 13; and subject 1 in Example 1), and 2 patients of chronic eczema (subjects 14 to 15) in an amount of about 1 ml per 100 cm 2 of skin. After application, the affected areas were left for 30 minutes to 1 hour, and then the areas to which the formulation example 1 was applied were washed in the same night to rinse off the formulation example. The affected areas, 1, 2 weeks after the start of the administration of the formulation example 1, were compared with the affected areas before the administration, and the judgment and the evaluation of “markedly ameliorated” “ameliorated” “no change” and “worsened” were conducted by the inventor, who is a doctor.
  • Subject 1 has been suffering from atopic dermatitis. Only the right half of the face was treated with the formulation example 1, and the skin at the treated part became resilient and the dryness was ameliorated. In addition, the skin at the treated part became soft and the treated cheek was lifted up in comparison to the cheek without treatment.
  • Subject 9 has been suffering from atopic dermatitis since elementary school, and has been using external preparations of steroid intermittently for several decades.
  • Major affected areas are the face and neck.
  • the skin was hard and exhibited redness and pigmentation (see FIG. 2 , the left photograph of the face), and was accompanied by itching, and a typical atopy-like appearance was observed.
  • Subject 9 was instructed to use the formulation example 1 together with an external preparation of steroid, and 3 days later, the external preparation of steroid was discontinued because the itching disappeared. After that, only the formulation example 1 was used, and the redness and pigmentation in the affected areas were ameliorated, and the skin became soft (see FIG. 2 , the right photograph of the face). Further, the conditions of wrinkles and flecks of the skin were also ameliorated.
  • Subject 10 has been suffering from atopic dermatitis since elementary school, and has been using external preparations of steroid intermittently for several decades.
  • Major affected areas are the underarm and inside of the elbow. In the affected areas, there was itching, and the skin was hard and exhibited redness, pigmentation and scratches [see the left photographs of FIG. 3 (the inside of the elbow) and FIG. 4 (the underarm)], and a typical atopy-like appearance was observed.
  • Subject 10 was instructed to use the formulation example 1 together with an external preparation of steroid, and 3 days later, the external preparation of steroid was discontinued because the itching disappeared.
  • the external preparation for skin of the present invention which contains 5-aminolevulinic acids has skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum; and an ameliorating effect on dermatitis such as atopic dermatitis.
  • 5-aminolevulinic acids and an iron compound are used in combination in the external preparation for skin of the present invention, light shielding at the point of use is not an absolute requirement for the external preparation for skin of the present invention and its usage is simple.
  • the external preparation for skin of the present invention exhibits a remarkable effect equal to or stronger than the effect observed when 5-aminolevulinic acids are used alone.

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100120916A1 (en) * 2007-04-05 2010-05-13 Sbi Alapromo Co., Ltd. Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases
US20110041652A1 (en) * 2008-05-30 2011-02-24 Jfe Steel Corporation Method for producing pig iron
US20110196033A1 (en) * 2008-10-27 2011-08-11 Sbi Alapromo Co., Ltd. Prophylactic/ameliorating agent for adult diseases comprising 5-aminolevulinic acid, derivative of 5-aminolevulinic acid, or salt of 5-aminolevulinic acid or the derivative or 5-aminolevulinic acid as active ingredient
US8999296B2 (en) 2008-04-22 2015-04-07 Kochi University Method of detecting bladder cancer
US20150174090A1 (en) * 2012-07-13 2015-06-25 Sbi Pharmaceuticals Co., Ltd. Immune tolerance inducer
US9089530B2 (en) 2010-05-19 2015-07-28 Sbi Pharmaceuticals Co., Ltd. Antimalarial drug which contains 5-aminolevulinic acid or derivative thereof as active ingredient
CN114081851A (zh) * 2021-11-01 2022-02-25 苏州纳美特生物科技有限公司 保湿喷雾
US20220313580A1 (en) * 2017-02-06 2022-10-06 3Skin As Sunscreen Composition

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1912795B1 (fr) 2005-08-12 2012-02-22 TCMS Transparent Beauty LLC Systeme et procede d'application d'un agent modifiant la reflectance pour ameliorer l'attrait visuel de la peau humaine
US8184901B2 (en) * 2007-02-12 2012-05-22 Tcms Transparent Beauty Llc System and method for applying a reflectance modifying agent to change a person's appearance based on a digital image
EP1938801A1 (fr) * 2006-12-22 2008-07-02 Biofrontera Bioscience GmbH Nanoémulsion
CN101641161B (zh) 2007-02-12 2012-04-18 Tcms剔透美丽有限责任公司 用于向人类皮肤静电施与试剂的系统和方法
US10092082B2 (en) 2007-05-29 2018-10-09 Tcms Transparent Beauty Llc Apparatus and method for the precision application of cosmetics
JP5496881B2 (ja) * 2008-05-14 2014-05-21 Ｓｂｉファーマ株式会社 男性不妊治療剤
JP5295652B2 (ja) * 2008-06-16 2013-09-18 Ｓｂｉファーマ株式会社 光障害の軽減剤
JP5081121B2 (ja) * 2008-10-17 2012-11-21 株式会社ミルボン 育毛剤組成物
CN103054736B (zh) * 2013-01-05 2015-07-15 陕西佰美基因股份有限公司 一种含有血红素的抗衰老化妆品
RU2538084C1 (ru) * 2013-07-25 2015-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГБОУ ВПО УГМА Минздрава России) Средство для лечения и профилактики атопического дерматита
KR101654028B1 (ko) * 2015-02-17 2016-09-05 제너럴바이오(주) 피부 도포용 화장료 조성물 및 이의 제조방법
US10933010B2 (en) 2015-05-11 2021-03-02 Hayashibara Co., Ltd. External dermal agent
US11622963B2 (en) * 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition
BR102019005545A2 (pt) * 2019-03-21 2020-10-06 Natbio Ltda Me Formulações cosméticas constituídas por uma mistura nutritiva proveniente de um processo fermentativo
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372234B1 (en) * 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6911194B2 (en) * 2000-05-10 2005-06-28 Photocure Asa Skin preparation

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259318A (en) * 1978-03-02 1981-03-31 University Of Houston, Central Campus Poison ivy relief composition
JPS58152805A (ja) * 1982-03-06 1983-09-10 Masayuki Shirai 温泉水含有皮膚化粧料
JP2694756B2 (ja) 1988-08-19 1997-12-24 有限会社アイ・ビー・イー 二価三価鉄塩配合化粧品
JPH02108612A (ja) * 1988-10-19 1990-04-20 Shizen:Kk 二価三価複合鉄塩配合化粧品
JP2767318B2 (ja) 1990-04-11 1998-06-18 株式会社コスモ総合研究所 ５―アミノレブリン酸アルキルエステル又はその塩及びその製造方法並びにこれを有効成分とする除草剤
DE4320871C2 (de) 1993-06-24 1995-05-04 Beiersdorf Ag Kosmetische und dermatologische Zubereitungen mit einem Gehalt an delta-Aminolävulinsäure
JP2747644B2 (ja) 1993-08-19 1998-05-06 株式会社コスモ総合研究所 植物成長調節剤
EP0734371B1 (fr) * 1993-12-15 2000-04-05 Avon Products, Inc. Nouveaux composes conjugues de retinoides et procedes de traitement du vieillissement de la peau
JPH0881322A (ja) 1994-09-16 1996-03-26 Mitsui Toatsu Chem Inc 微生物雑草防除組成物
GB9510162D0 (en) * 1995-05-19 1995-07-12 Bouras Elias Compositions for the treatment of skin conditions
JP3644809B2 (ja) 1997-10-15 2005-05-11 コスモ石油株式会社 頭部用外用剤
JP3948588B2 (ja) 1998-03-05 2007-07-25 株式会社資生堂 皮膚バリアー機能回復促進剤
JP2000281556A (ja) 1999-03-29 2000-10-10 Shiseido Co Ltd 皮膚外用剤
JP3970492B2 (ja) * 1999-12-14 2007-09-05 コスモ石油株式会社 ピーリング用組成物
JP2002020294A (ja) 2000-06-30 2002-01-23 Lion Corp 皮膚外用剤
FR2811563B1 (fr) * 2000-07-13 2003-06-20 Oreal Composition, notamment cosmetique, comprenant la dhea et/ou un precurseur ou derive, et au moins un compose augmentant la synthese des glycosaminoglycanes
JP2002179518A (ja) * 2000-12-14 2002-06-26 Kyowa Hakko Kogyo Co Ltd 化粧料
US6565864B2 (en) * 2000-12-28 2003-05-20 Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. Skin care product containing retinoids and phytoestrogens in a dual compartment package
ITMI20010685A1 (it) * 2001-03-30 2002-09-30 Biochimici Psn S P A Acido delta-amminolevulinico per uso medico e cosmetico
JP4754731B2 (ja) 2001-07-31 2011-08-24 コスモ石油株式会社 豚成育促進剤及び豚成育促進方法
EP1312353A1 (fr) * 2001-11-16 2003-05-21 Ecole Polytechnique Federale De Lausanne (Epfl) Méthode d'épilation
AT410633B (de) 2002-04-25 2003-06-25 Oekopharm Forschungs Und Entwi Verwendung eines auf einer biologisch inerten, hochdispersen matrix getrockneten stutenmilchkonzentrats
US20030212127A1 (en) * 2002-05-09 2003-11-13 Bradley Pharmaceuticals, Inc. Method of treating actinic keratosis
DE20213787U1 (de) * 2002-09-04 2002-12-19 Warner Lambert Co Hautpflegemittel
US20040048842A1 (en) * 2002-09-10 2004-03-11 Mcmillan Kathleen Method of treating skin disorders
US7820145B2 (en) * 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
JP4425554B2 (ja) 2003-03-19 2010-03-03 日本メナード化粧品株式会社 皮膚外用剤
US7258875B2 (en) * 2003-12-04 2007-08-21 Chiou Consulting, Inc. Compositions and methods for topical treatment of skin infection
EP1743621B1 (fr) * 2004-04-28 2014-03-05 Cosmo Oil Co., Ltd. Fortifiant pour cheveux

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372234B1 (en) * 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6911194B2 (en) * 2000-05-10 2005-06-28 Photocure Asa Skin preparation

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927532B2 (en) 2007-04-05 2015-01-06 Sbi Pharmaceuticals Co., Ltd. Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases
US20100120916A1 (en) * 2007-04-05 2010-05-13 Sbi Alapromo Co., Ltd. Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases
US8999296B2 (en) 2008-04-22 2015-04-07 Kochi University Method of detecting bladder cancer
US20110041652A1 (en) * 2008-05-30 2011-02-24 Jfe Steel Corporation Method for producing pig iron
US9095165B2 (en) 2008-10-27 2015-08-04 Sbi Pharmaceuticals Co., Ltd. Prophylactic/ameliorating agent for adult diseases comprising 5-aminolevulinic acid, derivative of 5-aminolevulinic acid, or salt of 5-aminolevulinic acid or the derivative of 5-aminolevulinic acid as active ingredient
US20110196033A1 (en) * 2008-10-27 2011-08-11 Sbi Alapromo Co., Ltd. Prophylactic/ameliorating agent for adult diseases comprising 5-aminolevulinic acid, derivative of 5-aminolevulinic acid, or salt of 5-aminolevulinic acid or the derivative or 5-aminolevulinic acid as active ingredient
US9730904B2 (en) 2008-10-27 2017-08-15 Sbi Pharmaceuticals Co., Ltd. Prophylactic/ameliorating agent for adult diseases comprising 5-aminolevulinic acid, derivative of 5-aminolevulinic acid, or salt of 5-aminolevulinic acid or the derivative of 5-aminolevulinic acid as active ingredient
US9089530B2 (en) 2010-05-19 2015-07-28 Sbi Pharmaceuticals Co., Ltd. Antimalarial drug which contains 5-aminolevulinic acid or derivative thereof as active ingredient
US9463175B2 (en) 2010-05-19 2016-10-11 Sbi Pharmaceuticals Co., Ltd. Antimalarial drug which contains 5-aminolevulinic acid or derivative thereof as active ingredient
EP2873417A4 (fr) * 2012-07-13 2016-03-09 Sbi Pharmaceuticals Co Ltd Inducteur de tolérance immunitaire
US9399029B2 (en) * 2012-07-13 2016-07-26 Sbi Pharmaceuticals Co., Ltd. Immune tolerance inducer
US20150174090A1 (en) * 2012-07-13 2015-06-25 Sbi Pharmaceuticals Co., Ltd. Immune tolerance inducer
US20220313580A1 (en) * 2017-02-06 2022-10-06 3Skin As Sunscreen Composition
CN114081851A (zh) * 2021-11-01 2022-02-25 苏州纳美特生物科技有限公司 保湿喷雾

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AU2005331416B2 (en) 2009-10-01
RU2007143517A (ru) 2009-06-10
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BRPI0520076A2 (pt) 2009-08-18
CN101166510B (zh) 2012-03-07
IL186871A (en) 2015-08-31
IL186871A0 (en) 2008-06-05
KR20080003916A (ko) 2008-01-08
EP1878421B1 (fr) 2019-04-03
WO2006117885A8 (fr) 2006-12-21
US20110060042A1 (en) 2011-03-10
NZ587597A (en) 2011-11-25
RU2381022C2 (ru) 2010-02-10
AU2005331416A1 (en) 2006-11-09
NO341897B1 (no) 2018-02-12
CA2606140A1 (fr) 2006-11-09
KR100929264B1 (ko) 2009-12-01
CA2606140C (fr) 2011-07-19
NO20076019L (no) 2008-01-28
JPWO2006117885A1 (ja) 2008-12-18
CN101166510A (zh) 2008-04-23
WO2006117885A1 (fr) 2006-11-09
US9333156B2 (en) 2016-05-10
EP1878421A4 (fr) 2015-11-18
MX2007013623A (es) 2008-02-12
ZA200708438B (en) 2008-09-25
EP1878421A1 (fr) 2008-01-16
PL1878421T3 (pl) 2019-09-30
JP3991063B2 (ja) 2007-10-17

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