US20020076470A1 - Composition and method - Google Patents

Composition and method Download PDF

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Publication number
US20020076470A1
US20020076470A1 US09/922,660 US92266001A US2002076470A1 US 20020076470 A1 US20020076470 A1 US 20020076470A1 US 92266001 A US92266001 A US 92266001A US 2002076470 A1 US2002076470 A1 US 2002076470A1
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US
United States
Prior art keywords
diet
pet
ppm
accordance
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US09/922,660
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English (en)
Inventor
Steven Zicker
Karen Wedekind
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hills Pet Nutrition Inc
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27399769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20020076470(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Priority to US09/922,660 priority Critical patent/US20020076470A1/en
Assigned to COLGATE-PALMOLIVE COMPANY reassignment COLGATE-PALMOLIVE COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEDEKIND, KAREN J., ZICKER, STEVEN CURTIS
Priority to US09/978,132 priority patent/US6914071B2/en
Priority to EP01991459.7A priority patent/EP1339292B2/en
Priority to DK01991459.7T priority patent/DK1339292T3/da
Priority to CNB018209491A priority patent/CN1303896C/zh
Priority to ES01991459T priority patent/ES2336305T3/es
Priority to DE60140895T priority patent/DE60140895D1/de
Priority to JP2002538766A priority patent/JP2004512053A/ja
Priority to AT01991459T priority patent/ATE452540T1/de
Priority to CA2427692A priority patent/CA2427692C/en
Priority to PCT/US2001/049654 priority patent/WO2002035943A2/en
Priority to AU2002231183A priority patent/AU2002231183A1/en
Priority to ARP010105078A priority patent/AR031283A1/es
Publication of US20020076470A1 publication Critical patent/US20020076470A1/en
Priority to US11/154,210 priority patent/US8592478B2/en
Priority to JP2007062332A priority patent/JP2007190029A/ja
Priority to US12/336,060 priority patent/US20090156658A1/en
Priority to US12/336,024 priority patent/US8592479B2/en
Priority to US12/319,287 priority patent/US8669282B2/en
Priority to JP2010137171A priority patent/JP2010279357A/ja
Assigned to HILL'S PET NUTRITION, INC. reassignment HILL'S PET NUTRITION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: COLGATE-PALMOLIVE COMPANY
Priority to JP2014130312A priority patent/JP2014195468A/ja
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Definitions

  • a companion pet diet meeting ordinary nutritional requirements of an adult pet and further comprising a sufficient amount of an antioxidant or mixture thereof to inhibit the onset of deterioration of the mental capacity of said companion pet in its aged years.
  • a further aspect of the invention is a method for inhibiting the deterioration of the mental capacity of an aged companion pet, which comprises feeding said pet in his adult years an antioxidant or mixture thereof at sufficient levels to accomplish this inhibition.
  • a companion adult pet diet meeting ordinary nutritional requirements of an adult companion pet and further comprising an antioxidant selected from the group consisting of Vitamin E, vitamin C, alpha-lipoic acid, 1-carnitine and any mixtures thereof in quantities sufficient to inhibit the deterioration of the mental capacity of said pet in its aged years.
  • an antioxidant selected from the group consisting of Vitamin E, vitamin C, alpha-lipoic acid, 1-carnitine and any mixtures thereof in quantities sufficient to inhibit the deterioration of the mental capacity of said pet in its aged years.
  • a still further aspect of the invention is a method for increasing the mental capacity of an aged companion pet, which comprises feeding the pet in its adult years an amount of an antioxidant or mixture thereof sufficient to increase the mental capacity.
  • Another aspect of the invention is a method for increasing the mental capacity of an adult companion pet which comprises feeding the pet an amount of an antioxidant or mixture thereof sufficient to increase the mental capacity of said pet.
  • the diet fed to the adult companion pet for example canine and feline is the standard normal diet fed to an animal of that age.
  • a typical diet for a canine of 1 to 6 years of age is the standard normal diet fed to an animal of that age.
  • TABLE 1 Component Target Protein (% of dry matter) 23 Fat (% of dry matter) 15 Phosphorous (% of dry matter) 0.6 Sodium (% of dry matter) 0.3
  • Adding significant quantities of an antioxidant or mixture thereof to the companion adult pet diet can bring about delay of the onset of demonstrative changes in the behavior, particularly the deterioration of mental capacity, as specifically shown by problem-solving capacity, in an aged pet.
  • the term, adult is intended to mean, in general, a canine of at least 1 to 6 years and a feline of at least 1 to 6 years.
  • An aged dog or cat is 7 years and above.
  • the loss of mental capacity for canines and felines has been observed for a number of years. This loss of mental capacity is manifested in numerous ways. For a canine, for example, it can be manifested as disorientation, house soiling, altered sleep-wake patterns, decreased or altered interaction with humans and other pets, and inability to learn and concentrate. These conditions can be manifested in felines as well. Alzheimer's, as exhibited in man, is not found in canines and felines.
  • the inventors have succeeded in accomplishing delaying the onset of this deterioration.
  • aged pets mental capacity can be maintained for a longer period of time.
  • the deterioration of mental capacity can be stopped or delayed.
  • Memory and learning ability can be improved.
  • Overall mental alertness can be enhanced.
  • Age related cognitive decline could be slowed.
  • Cognitive Dysfunction Syndrome its progress can be slowed in aged dogs and clinical signs associated with this Syndrome can be controlled. Prophylaxis where appropriate and pets in need of these components are the target group.
  • the component in the diet which accomplishes this is an antioxidant or mixture thereof.
  • An antioxidant is a material that quenches a free radical. Examples of such materials include foods such as Ginkgo Biloba, citrus pulp, grape pomace, tomato pomace, carrot and spinach, all preferably dried as well as various other materials such as beta-carotene, selenium, coenzyme Q10 (ubiquinone), lutein, tocotrienols, soy isoflavones, S-adenosylmethionine, glutathione, taurine, N-acetylcysteine, Vitamin E, Vitamin C, alpha-lipoic acid, 1-carnitine and the like.
  • Vitamin E can be administered as a tocopherol or a mixture of tocopherols and various derivatives thereof such as esters like vitamin E acetate, succinate, palmitate, and the like.
  • the alpha form is preferable but beta, gamma and delta forms can be included.
  • the d form is preferable but racemic mixtures are acceptable.
  • the forms and derivatives will function in a Vitamin E like activity after ingestion by the pet.
  • Vitamin C can be administered in this diet as ascorbic acid and its various derivatives thereof such as calcium phosphate salts, cholesteryl salt, 2-monophosphate, and the like which will function in a vitamin C like activity after ingesting by the pet. They can be in any form such as liquid, semisolid, solid and heat stable form.
  • Alpha-lipoic acid can be administered into the diet as alpha lipoic acid or as a lipoate derivative as in U.S. Pat. No. 5,621,117, racemic mixtures, salts, esters or amides thereof.
  • L-carnitine can be administered in the diet and various derivatives of carnitine such as the salts such as the hydrochloride, fumarate and succinates, as well as acetylated carnitine, and the like can be used.
  • the quantities administered in the diet, all as wt % (dry matter basis) of the diet, are calculated as the active material, per se, that is measured as free material.
  • the maximum amounts employed should not bring about toxicity.
  • At least about 100 ppm or at least about 150 ppm of Vitamin E can be used.
  • a preferred range of about 500 to about 1,000 ppm can be employed.
  • a maximum of about 2000 ppm or about 1500 ppm is generally not exceeded.
  • Vitamin C at least about 50 ppm is used, desirably at least about 75 ppm and more desirably at least about 100 ppm.
  • a nontoxic maximum can be employed.
  • the quantity of alpha-lipoic acid can vary from at least about 25, desirably at least about 50 ppm, more desirably about 100 ppm. Maximum quantities can vary from about 100 ppm to 600 ppm or to an amount which remains non toxic to the pet. A preferred range is from about 100 ppm to about 200 ppm.
  • For felines slightly higher minimums of 1-carnitine can be employed such as about 100 ppm, 200 ppm, and 500 ppm.
  • a nontoxic maximum quantity can be employed, for example, less than about 5,000 ppm.
  • For canines lower quantities can be employed, for example, less than about 5,000 ppm.
  • For canines a preferred range is about 200 ppm to about 400 ppm.
  • For felines a preferred range is about 400 ppm to about 600 ppm.
  • Beta-carotene at about 1- 15 ppm can be employed.
  • Lutein at least about 5 ppm can be employed.
  • Tocotrienols at least about 25 ppm can be employed.
  • Coenzyme Q10 at least about 25 ppm can be employed.
  • S-adenosylmethionine at least about 50 ppm can be employed.
  • Taurine at least about 1000 ppm can be employed.
  • Soy isoflavones at least about 25 ppm can be used.
  • N-acetylcysteine at least about 50 ppm can be used.
  • Glutathione at least about 50 ppm can be used.
  • Gingko Biloba at least 50 ppm of extract can be used.
  • ORAC Oxygen radical absorbing capacity
  • any ingredient with an ORAC content >25 umole of Trolox equivalents per gram of dry matter could be used if added at 1% combination with four other 1% ingredients for a total of 5% addition to the diet.
  • Landmark discrimination learning requires subjects to select a particular object based on proximity to an object.
  • the initial learning is based on the dogs' ability to learn an object discrimination task. We have previously found that the effects of age on discrimination learning depends on task difficulty.
  • the adult dogs proceeded on to landmark 1 and 2 testing, where the landmark is moved further away from the positive well.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US09/922,660 2000-10-31 2001-08-06 Composition and method Abandoned US20020076470A1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
US09/922,660 US20020076470A1 (en) 2000-10-31 2001-08-06 Composition and method
US09/978,132 US6914071B2 (en) 2000-10-31 2001-10-16 Antioxidant containing composition and method
PCT/US2001/049654 WO2002035943A2 (en) 2000-10-31 2001-10-25 Pet food composition and method
AU2002231183A AU2002231183A1 (en) 2000-10-31 2001-10-25 Pet food composition and method
CA2427692A CA2427692C (en) 2000-10-31 2001-10-25 Pet food composition and method
DK01991459.7T DK1339292T3 (da) 2000-10-31 2001-10-25 Sammensætning og fremgangsmåde
CNB018209491A CN1303896C (zh) 2000-10-31 2001-10-25 组合物和方法
ES01991459T ES2336305T3 (es) 2000-10-31 2001-10-25 Composicion y metodo.
DE60140895T DE60140895D1 (de) 2000-10-31 2001-10-25 Zusammensetzung und verfahren
JP2002538766A JP2004512053A (ja) 2000-10-31 2001-10-25 ペットフード組成物および方法
AT01991459T ATE452540T1 (de) 2000-10-31 2001-10-25 Zusammensetzung und verfahren
EP01991459.7A EP1339292B2 (en) 2000-10-31 2001-10-25 Companion pet diet
ARP010105078A AR031283A1 (es) 2000-10-31 2001-10-30 Composicion y metodo de dieta para animales
US11/154,210 US8592478B2 (en) 2000-10-31 2005-06-16 Antioxidant-containing food composition
JP2007062332A JP2007190029A (ja) 2000-10-31 2007-03-12 ペットフード組成物および方法
US12/336,024 US8592479B2 (en) 2000-10-31 2008-12-16 Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals
US12/336,060 US20090156658A1 (en) 2000-10-31 2008-12-16 Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals
US12/319,287 US8669282B2 (en) 2000-10-31 2008-12-30 Companion animal compositions including lipoic acid and methods of use thereof
JP2010137171A JP2010279357A (ja) 2000-10-31 2010-06-16 ペットフード組成物および方法
JP2014130312A JP2014195468A (ja) 2000-10-31 2014-06-25 ペットフード組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24450400P 2000-10-31 2000-10-31
US25344800P 2000-11-28 2000-11-28
US09/922,660 US20020076470A1 (en) 2000-10-31 2001-08-06 Composition and method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/978,132 Continuation-In-Part US6914071B2 (en) 2000-10-31 2001-10-16 Antioxidant containing composition and method

Publications (1)

Publication Number Publication Date
US20020076470A1 true US20020076470A1 (en) 2002-06-20

Family

ID=27399769

Family Applications (3)

Application Number Title Priority Date Filing Date
US09/922,660 Abandoned US20020076470A1 (en) 2000-10-31 2001-08-06 Composition and method
US09/978,132 Expired - Lifetime US6914071B2 (en) 2000-10-31 2001-10-16 Antioxidant containing composition and method
US11/154,210 Expired - Fee Related US8592478B2 (en) 2000-10-31 2005-06-16 Antioxidant-containing food composition

Family Applications After (2)

Application Number Title Priority Date Filing Date
US09/978,132 Expired - Lifetime US6914071B2 (en) 2000-10-31 2001-10-16 Antioxidant containing composition and method
US11/154,210 Expired - Fee Related US8592478B2 (en) 2000-10-31 2005-06-16 Antioxidant-containing food composition

Country Status (12)

Country Link
US (3) US20020076470A1 (https=)
EP (1) EP1339292B2 (https=)
JP (4) JP2004512053A (https=)
CN (1) CN1303896C (https=)
AR (1) AR031283A1 (https=)
AT (1) ATE452540T1 (https=)
AU (1) AU2002231183A1 (https=)
CA (1) CA2427692C (https=)
DE (1) DE60140895D1 (https=)
DK (1) DK1339292T3 (https=)
ES (1) ES2336305T3 (https=)
WO (1) WO2002035943A2 (https=)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058248A2 (en) 2004-11-24 2006-06-01 Hill's Pet Nutrition, Inc. Methods for increasing the immune response in an animal
US20080038323A1 (en) * 2004-11-24 2008-02-14 Zicker Steven C Methods for Improving Liver Clearance of Xenobiotic Substances in an Animal
US20080206398A1 (en) * 2004-12-30 2008-08-28 Ryan Yamka Methods for Enhancing the Quality of Life of a Senior Animal
US20090004299A1 (en) * 2004-12-29 2009-01-01 Karen Joy Wedekind Methods for Inhibiting a Decline in Learning and/or Memory in Animals
US20090111877A1 (en) * 2004-12-30 2009-04-30 Hill's Pet Nutrition, Inc. Methods for Enhancing the Quality of Life of a Senior Animal
US20090155393A1 (en) * 2005-07-14 2009-06-18 Steven Curtis Zicker Method for prolonging the life of animals
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
US20090182032A1 (en) * 2000-10-31 2009-07-16 Hill's Pet Nutrition, Inc. Companion animal compositions including lipoic acid and methods of use thereof
US20110274808A1 (en) * 2008-12-30 2011-11-10 Hill's Pet Nutrition, Inc. Methods for increasing the palatability of companion animal food compositions
US8592478B2 (en) 2000-10-31 2013-11-26 Hill's Pet Nutrition, Inc. Antioxidant-containing food composition
US8952052B2 (en) 2008-12-30 2015-02-10 Hill's Pet Nutrition, Inc. Use of lipoic acid for treating or preventing degenerative joint conditions, osteoarthritis, cartilage damage, and related disorders in companion animals
CN119279072A (zh) * 2024-10-30 2025-01-10 深圳市红瑞生物科技有限公司 一种中老年宠物营养支持的组合物及其制备方法

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US8642581B1 (en) * 2000-02-11 2014-02-04 Brian D. Halevie-Goldman Compositions and methods for the production of S-adenosylmethionine within the body
US8592479B2 (en) * 2000-10-31 2013-11-26 Hill's Pet Nutrition, Inc. Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals
US7547450B2 (en) * 2002-10-24 2009-06-16 Nestec Ltd. Senior feline food
JP2007525201A (ja) * 2003-07-07 2007-09-06 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド コンパニオンアニマルにおいて改良された酸化的状態を得るための組成物
RU2433819C2 (ru) * 2004-11-09 2011-11-20 Хилл'С Пет Ньютришн, Инк. Применение антиоксидантов для модуляции генов
FR2884421B1 (fr) * 2005-04-15 2007-08-10 Virbac Sa Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie
CN101287460B (zh) 2005-08-17 2012-04-25 希尔氏宠物营养品公司 预防和治疗肾病的组合物
US20080226696A1 (en) * 2007-03-15 2008-09-18 Ben Treadwell Methods of improving learning abilities of aged companion animals
US20080317884A1 (en) * 2007-06-22 2008-12-25 Jewell Dennis E Enhancing Disease Resistance In An Animal
BRPI0923454A2 (pt) * 2008-12-16 2015-07-28 Hills Pet Nutrition Inc "métodos para intensificar uma capacidade de um animal de estimação resistir ou combater uma infecção viral e para tratar uma infecção viral em um animal de estimação.
EP2365759B1 (en) * 2008-12-16 2018-03-07 Hill's Pet Nutrition, Inc. Antioxidant-containing food composition for use in inhibiting histamine pathways in companion animals
JP2012513764A (ja) * 2008-12-30 2012-06-21 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド コンパニオンアニマルにおいて体重に関連する障害を処置および予防するための組成物および方法
WO2011084886A1 (en) * 2010-01-06 2011-07-14 Nestec S. A. Dietary regimens useful for mimicking caloric restriction
JP2013532128A (ja) * 2010-05-12 2013-08-15 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法
AU2011345226B2 (en) * 2010-12-23 2014-11-13 Hill's Pet Nutrition, Inc. Pet food compositions and methods for treating arthritis and inflammation associated with arthritis
ES2589180T3 (es) 2010-12-23 2016-11-10 Hill's Pet Nutrition, Inc. Composiciones de alimento para mascotas y métodos para la pérdida y el mantenimiento de peso
KR20140019827A (ko) * 2011-04-05 2014-02-17 론자 아게 (론자 엘티디.) 피로를 감소 또는 예방하고 인지 기능을 개선시키기 위한 l-카르니틴, 그의 염 및 유도체의 용도
FR2982460B1 (fr) * 2011-11-14 2016-08-05 Virbac Sa Produits pour administration orale comprenant des extraits de grenade punica granatum, destines a un animal de compagnie, et ses applications
CN106138037A (zh) * 2016-08-24 2016-11-23 江苏农林职业技术学院 一种抗生物细胞氧化损伤的组合物及其应用
CN110537630A (zh) * 2019-09-09 2019-12-06 天津农学院 1，2二硫戊环-3-戊酸的应用、幼犬鲜粮和延长幼犬鲜粮贮藏期的方法
CA3164484A1 (en) * 2019-12-19 2021-06-24 Hill's Pet Nutrition, Inc. Compositions and methods of treating and reducing risk of conditions associated with elevated 4-ethylphenyl sulfate in canines using tomato pomace and methods of identifying canines at risk of such conditions
US20220079188A1 (en) * 2020-09-05 2022-03-17 High Plains Nutrition, Llc Methods of safely determining and delivering amounts of cannabinoids in animals
CU24748B1 (es) 2022-11-04 2025-04-04 Centro Nac De Biopreparados Nutracéutico para la prevención y tratamiento del deterioro cognitivo

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