US11717192B2 - Physiological signal monitoring device and sensor holder thereof - Google Patents

Physiological signal monitoring device and sensor holder thereof Download PDF

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Publication number
US11717192B2
US11717192B2 US16/945,634 US202016945634A US11717192B2 US 11717192 B2 US11717192 B2 US 11717192B2 US 202016945634 A US202016945634 A US 202016945634A US 11717192 B2 US11717192 B2 US 11717192B2
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holder
sensor
implantation hole
physiological signal
monitoring device
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US20210030320A1 (en
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Chun-Mu Huang
Chieh-Hsing Chen
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Bionime Corp
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Bionime Corp
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    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
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Definitions

  • the present invention is related to a physiological signal monitoring device.
  • the present invention is related to a thin physiological signal monitoring device.
  • Patients with chronic conditions need to routinely monitor changes in the data of certain physiological parameters (such as concentrations of blood glucose, blood lipid and cholesterol, or other parameters) so as to control the condition effectively and avoid deterioration of their condition and get timely treatment.
  • physiological parameters such as concentrations of blood glucose, blood lipid and cholesterol, or other parameters
  • a lot of physiological data has to be obtained via invasive methods.
  • a traditional blood glucose measurement is usually performed by using a test strip and a glucose meter, and the level of the blood glucose is obtained by measuring the magnitude of current generated by the reaction between the glucose in the blood and glucose oxidase in the test strip.
  • This measuring method requires patients to collect blood from their fingertips every day and drip blood onto the test strip to obtain a single blood glucose data.
  • patients need to obtain multiple measurements, they must experience the discomfort of repeated blood collections.
  • the present invention provides a physiological signal monitoring device suitable for implantation under the skin for a long time, which can monitor the patient's physiological data in real time.
  • the present invention discloses a physiological signal monitoring device for implantation under a skin of a living body to measure a physiological signal of an analyte in a biological fluid from the living body
  • the physiological signal monitoring device includes: a sensor having a signal detection end and a signal output end, a transmitter having a port connected to the signal output end and receiving the physiological signal, and a holder carrying thereon the sensor, wherein the signal detection end is to be implanted under the skin to detect the physiological signal, and the signal output end is to output the physiological signal.
  • the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a waterproof seal disposed above the implantation hole and abutting against the transmitter to form therebetween a waterproof sealing structure, and an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole.
  • the present invention further discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a waterproof seal disposed above the implantation hole, and an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole.
  • the present invention further discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole, a waterproof seal disposed above the implantation hole, and a blocking element disposed in the implantation hole to hold the sensor in the holder.
  • the physiological signal monitoring device of the present invention achieves the purpose of thinness and detachability by the complementary structural design between the transmitter and the holder, prevents external liquid from flowing into the device and prevents blood from leaking through the implantation site by the waterproof sealing effect of elastic body.
  • the physiological signal monitoring device of the present invention enables the sensor to be more stably carried on the holder through the limiting and fixing means of the filler, the limiter and the blocking element.
  • FIG. 1 is a perspective view of the physiological signal monitoring device in the present invention.
  • FIG. 2 A is an exploded perspective view of the physiological signal monitoring device in the present invention.
  • FIG. 2 B is another exploded perspective view of the physiological signal monitoring device in the present invention.
  • FIG. 3 is a cross-sectional view of FIG. 1 along Line I.
  • FIG. 4 is a cross-sectional view of FIG. 1 along Line II.
  • FIG. 5 A is a perspective view of the holder of the physiological signal monitoring device in the present invention.
  • FIG. 5 B is an exploded perspective view of FIG. 5 A .
  • FIG. 6 is a cross-sectional view of FIG. 5 A .
  • FIG. 7 A is another perspective view of the holder of the physiological signal monitoring device in the present invention.
  • FIG. 7 B is an exploded perspective view of FIG. 7 A .
  • FIG. 8 is a bottom view of the holder of the physiological signal monitoring device in the present invention.
  • FIG. 9 is a cross-sectional view of another physiological signal monitoring device in the present invention.
  • FIG. 10 is an assembly view of the holder and the jig according to a first embodiment.
  • FIGS. 11 A and 11 B are a perspective view and a cross-sectional view of the holder according to the second embodiment, respectively.
  • FIGS. 12 A and 12 B are a perspective view and a cross-sectional view of the holder according to the third embodiment, respectively.
  • the physiological signal monitoring device of the present invention is used to measure the physiological signals of an analyte in a biological fluid.
  • biological fluid refers the biological fluid such as blood, interstitial fluid, cerebrospinal fluid, lymphatic fluid, etc.
  • analyte refers to substances from the above biological fluid that can reflect the physiological state of a living body, including but not limited to sugar, protein, lipid, cholesterol, vitamins and cytokines, or other substances present in the biological fluid.
  • biological signal refers to the amount or concentration of the analyte above.
  • the physiological signal is the glucose concentration in the human body, preferably the glucose concentration in the interstitial fluid.
  • the physiological signals may be also constituted by content or concentration of metabolites, antigens, antibodies, etc. that naturally occur in the body fluids or are endogenous.
  • the physiological signal may also be the content or concentration of the substance introduced into the body or the exogenous substance, for example, the concentration of the chemical agent, drug, pharmaceutical composition, or metabolite of the pharmaceutical composition.
  • the exogenous substance may be insulin or glucagon.
  • FIG. 1 is a perspective view of the physiological signal monitoring device 1 in the present invention.
  • the physiological signal monitoring device 1 of the present invention includes a base 10 , a holder 20 (not shown), a transmitter 30 and a sensor 40 (not shown).
  • the base 10 can be fixed on the skin surface of a living body (such as a human body), the sensor 40 is fixed in the holder 20 , the holder 20 can be combined with the base 10 , and the transmitter 30 is detachably disposed on the holder 20 .
  • FIG. 2 A is an exploded perspective view of the physiological signal monitoring device 1 in the present invention.
  • the corresponding positions among the base 10 , the holder 20 carrying a sensor 40 and the transmitter 30 can be seen from the Figure.
  • the base 10 is first fixed on the skin surface, and the holder 20 is engaged with the base 10 by an additional implanting device (not shown) to implant the sensor 40 under the skin.
  • the holder 20 is combined with the base 10 fixed to the skin surface of the user.
  • the transmitter 30 is covered on the base 10 and electrically connected to the sensor 40 , to receive the physiological signal from the sensor 40 and transmit it to an external device.
  • an upper surface 30 A of the transmitter 30 is shown in FIG. 2 A .
  • FIG. 2 B is another exploded perspective view of the physiological signal monitoring device 1 in the present invention.
  • a lower surface 30 B of the transmitter 30 is shown in FIG. 2 B .
  • the lower surface 30 B of the transmitter 30 is provided with a first open portion 34 and a pair of second open portions 36 , wherein the first open portion 34 is used to accommodate the holder 20 and the accommodating portion 14 of the base 10 , and the second open portions 36 are used to contain a pair of first engaging members 16 of the base 10 .
  • a second engaging member 38 is provided inside each second open portion 36 to correspond to the first engaging members 16 .
  • the second engaging member 38 of each second open portion 36 is engaged with its corresponding first engaging member 16 .
  • the base 10 includes a patch 11 , a through-hole 12 , a base body 13 , the accommodating portion 14 , a first fool-proof portion 15 , a pair of first engaging members 16 , two positioning pillars 17 and a first elastic body 18 .
  • the patch 11 is disposed on the bottom surface of the base 10 and is used to adhere to the skin surface of the living body.
  • a waterproof material is included in the patch 11 to prevent unclean liquid from penetrating through the patch 11 and contacting the wound, thereby the risk of wound infection is avoided.
  • the through-hole 12 is provided with the accommodating portion 14 therethrough for implanting the signal detection end 44 of the sensor 40 under the skin of living body.
  • the accommodating portion 14 is used to accommodate the holder 20 .
  • the base body 13 has a peripheral portion corresponding to the shape of the edge of the transmitter 30 .
  • the first fool-proof portion 15 is disposed on the peripheral portion of the base body 13 to correspond to a second fool-proof portion 32 on the transmitter 30 when the transmitter 30 is placed on the base 10 . With the aid of the first fool-proof portion 15 and the second fool-proof portion 32 , the user can easily identify the installation orientation of the transmitter 30 and that of the base 10 when he or she attaches the latter transmitter 30 onto the former base 10 .
  • the pair of first engaging members 16 are protrudingly provided on the top surface of the base body 13 , and each first engaging member 16 corresponds to the second open portion 36 on the transmitter 30 for engaging with the bottom of the transmitter 30 .
  • the two positioning pillars 17 are accommodated in the positioning holes 26 at the bottom of the holder 20 (as shown in FIGS. 7 A and 7 B ), and the first elastic body 18 is disposed on the edge of the accommodating portion 14 to forms an interference fit with the holder 20 , thereby limiting and fixing the holder 20 to the base 10 .
  • each first engaging member 16 includes an engaging portion 16 A.
  • Each engaging portion 16 A corresponds to the second engaging member 38 in the second open portion 36 of the transmitter 30 .
  • each engaging portions 16 A rotates away from the respective second engaging member 38 , so as to separate the first engaging members 16 from the second engaging members 38 .
  • the first elastic body 18 is disposed on the accommodating portion 14 on the top surface of the base 10 , and is made of an elastic material and formed with the base body 13 by double injection molding so as to form an interference fit with the holder 20 made by a harder material.
  • the first elastic body 18 is circularly disposed on the accommodating portion 14 to form a concave slot for containing the holder 20 .
  • the first elastic body 18 is formed on the inner surface, the outer surface, and the top surface of the peripheral wall of the accommodating portion 14 .
  • the first elastic body 18 is dispersedly disposed on the accommodating portion 14 to define a fixation area for containing the holder 20 in this fixation area.
  • the first elastic body 18 is dispersedly arranged on the inner surface, the outer surface and the top surface of the peripheral wall of the accommodating portion 14 .
  • the port 342 further includes a printed circuit board 33 located in the transmitter 30 and having a recess 332 for containing the top of the sensor 40 , so as to reduce the thickness along the assembly direction of the transmitter 30 and the holder 20 .
  • FIGS. 5 A, 5 B and 6 are a perspective view, an exploded perspective view and a cross-sectional view of the holder 20 of the physiological signal monitoring device 1 in the present invention, respectively.
  • the holder 20 has a containing indentation 22 for containing a sensor 40 therein.
  • the sensor 40 is a strip sensor, which has a signal output end 42 , a signal detection end 44 and a connecting section 46 connecting the signal output end 42 and the signal detection end 44 .
  • the signal output end 42 is disposed on the containing indentation 22 and partially protrudes beyond the containing indentation 22 for electrically connecting to the port 342 of the transmitter 30 and outputting the physiological signal to the transmitter 30 .
  • the signal detection end 44 is implanted under the skin of the living body to detect the physiological signal. There are spaces S 1 and S 2 between the surrounding wall of the containing indentation 22 and the sensor 40 to accommodate the corresponding structure of the transmitter 30 . As shown in FIG. 2 B and FIG. 4 , the lower surface 30 B of the transmitter 30 has a first open portion 34 , and a port 342 having a connecting slot 344 is provided in the first open portion 34 . The port 342 protrudes into the containing indentation 22 of the holder 20 and be contained in the containing indentation 22 , so that the sensor 40 is inserted into the connecting slot 344 in the port 342 for electrical connection between the signal output end 42 and the port 342 .
  • the port 342 is complementarily accommodated in the space S 1 and S 2 of the containing indentation 22 .
  • the holder 20 can be adapted to a thin design.
  • the holder 20 also has a implantation hole 24 , wherein the implantation hole 24 corresponds to the through-hole 12 on the base 10 to form an implanting channel.
  • the implanting channel is adapted for the inserting tool (not shown) to extend therethrough, so as to insert the signal detection end 44 under the skin of the living body.
  • the implantation hole 24 penetrates the upper and lower surfaces of the holder 20 and communicates with the containing indentation 22 , to contain a part of the sensor 40 .
  • the holder 20 has a fixing indentation 27 for fixing the sensor 40 , wherein the fixing indentation 27 communicates with the containing indentation 22 , and the implantation hole 24 communicates with the containing indentation 22 through the fixing indentation 27 .
  • the sensor 40 has turning angles, the signal output end 42 is contained in the containing indentation 22 , and the signal detection end 44 extends downward along the axial direction of the implantation hole 24 , and thus the sensor 40 penetrates the holder 20 .
  • the implantation hole 24 and the containing indentation 22 are respectively configurated on two different longitudinal axes (as shown by dashed axial lines in FIG. 6 ), so that the signal detection end 44 and the signal output end 42 of the sensor 40 are configurated on the longitudinal axes of the implantation hole 24 and the containing indentation 22 , respectively.
  • the holder 20 further has a second elastic body 25 for sealing the implantation hole 24 and fixing the sensor 40 .
  • the second elastic body 25 includes a waterproof seal 25 A, an elastic divider 25 B and a blocking element 25 C.
  • the waterproof seal 25 A is disposed above the implantation hole 24 , preferably at the outer edge of the implantation hole 24 , to abut against the transmitter 30 and form therebetween a waterproof sealing structure.
  • the waterproof seal 25 A corresponds to a fitting portion 346 of the port 342 of the transmitter 30 (as shown in FIG. 2 B ), and the fitting portion 346 and the waterproof seal 25 A form an interference fit in a complementary manner (as shown in FIG. 3 ).
  • the elastic divider 25 B is disposed in the implantation hole 24 and corresponds to the space above the implanting channel defined by the implantation hole 24 and the through-hole 12 , to separate the implantation hole 24 and covers all over the cross-sectional area of the implantation hole 24 .
  • a sealing member 12 A disposed on the through-hole 12 of the base 10 and the elastic divider 25 B disposed in the implantation hole 24 of the holder 20 are provided in the present invention, to seal the through-hole 12 and the implantation hole 24 , respectively.
  • the sealing member 12 A and the elastic divider 25 B are arranged so that blood effusing from the implantation site of the skin surface of the living body cannot penetrate into the transmitter 30 through the implanting channel above, so as to avoid the electronic components inside the transmitter 30 from being damaged.
  • the material of the sealing member 12 A and the elastic divider 25 B can be an elastic body (such as rubber), so that it can enclose after the implantation needle is withdrawn and be densely pressed against the signal detection end 44 of the sensor 40 to maintain the seal performance inside the device. Furthermore, the sealing member 12 A can also be omitted if the bottom of the holder 20 is sealed by gluing or any form of sealing. In other embodiment, one of the sealing member 12 A and the elastic divider 25 B can be selected to prevent the blood effusing.
  • the blocking element 25 C is disposed between the implantation hole 24 and the fixing indentation 27 for holding the connecting section 46 of the sensor 40 so as to fix the sensor 40 .
  • the material of both of the waterproof seal 25 A and the elastic divider 25 B is rubber but not limited thereto, it may also be other elastic materials that prevent liquid leakage.
  • the blocking element 25 C may be an elastic element or a non-elastic element.
  • the waterproof seal 25 A, the elastic divider 25 B and the blocking element 25 C are integrally formed and embedded in the implantation hole 24 .
  • the waterproof seal 25 A, the elastic divider 25 B and the blocking element 25 C may be separate elements.
  • the bottom of the holder 20 is provided with a plurality of limiters 29 , which are arranged between the containing indentation 22 and the fixing indentation 27 to restrict the sensor 40 .
  • the plurality of limiters 29 may include at least one hook portion 29 A and a pressing portion 29 B.
  • the hook portion 29 A of the limiters 29 is used to limit the connecting portion 46
  • the pressing portion 29 B of the limiters 29 is used to hold the connecting portion 46 .
  • the plurality of limiters 29 of the present invention may be configured alternately or symmetrically without affecting the functions of the hook portion 29 A and the pressing portion 29 B.
  • FIG. 9 is a cross-sectional view of another physiological signal monitoring device 1 of the present invention, which only shows the outer contour of the physiological signal monitoring device 1 of the present invention and the structures of the sensor 40 and the second elastic body 25 .
  • the holder 20 and the transmitter 30 are molded integrally, and the holder 20 and the transmitter 30 directly cover the sensor 40 during insert molding, so as to encapsulate the sensor 40 in the physiological signal monitoring device 1 .
  • the implantation hole 24 is provided in the integrally formed holder 20 and the transmitter 30 for being a channel for implanting the sensor 40 and containing a part of the sensor 40 , the opening at one end of the implantation hole 24 is located below the holder 20 , and the opening at the other end is located above the transmitter 30 .
  • the waterproof seal 25 A is disposed above the implantation hole 24
  • the elastic divider 25 B is disposed in the implantation hole 24 to separate the implantation hole 24 and cover all over the cross-sectional area of the implantation hole 24 .
  • the blocking element 25 C can be disposed in the implantation hole 24 to hold the sensor 40 .
  • the second elastic body 25 can be made of an elastic material and formed with the physiological signal monitoring device 1 by double injection molding. With the arrangement of the waterproof seal 25 A and the elastic divider 25 B in the implantation hole 24 , this physiological signal monitoring device 1 of the present invention can achieve the waterproof sealing effect and the function of fixing the sensor 40 .
  • the bottom of the holder 20 is further sealed.
  • the purposes of waterproofing and fixing the sensor 40 is achieved in the present invention by configuring a filler (i.e. the dotted area as shown in FIGS. 7 A, 7 B, 8 and 9 ) in the fixing indentation 27 of the holder 20 .
  • the bottom of the holder 20 is filled with glue 28 .
  • a jig 50 with a shape matching the containing indentation 22 is inserted into the containing indentation 22 from the top surface of the holder 20 and clamps the signal output end 42 of the sensor 40 , to ensure that the glue 28 does not overflow.
  • the glue 28 is filled into the fixing indentation 27 from the bottom surface of the holder 20 .
  • the glue 28 can be filled into the whole fixing indentation 27 and blocked by the blocking element 25 C without overflowing into the implantation hole 24 .
  • the degree of sealing can be altered according to the required seal performance and configurations of other components, and the present invention is not limited to the embodiments as described.
  • the holder 20 is made as one-piece by an insert molding.
  • the holder 20 directly covers the sensor 40 during the insert molding, so as to partially encapsulate the sensor 40 in the holder 20 .
  • FIG. 10 B shows a cross-sectional view along the dashed line in FIG. 10 A .
  • the limiter 29 and the blocking element 25 C can be omitted.
  • FIG. 11 A is a perspective view of the holder according to a third embodiment
  • FIG. 11 B shows a cross-sectional view along the dashed line in FIG. 11 A
  • the bottom of the holder 20 is sealed by filling an inserter 20 A rather than glue in the fixing indentation 27 to achieve the effects of sealing the bottom of the holder 20 and holding the sensor 40 .
  • the inserter 20 A is a bottom cap.
  • the physiological signal monitoring device 1 of the present invention has the following advantages over the prior art:
  • the implantation hole 24 and the containing indentation 22 of the holder 20 are respectively positioned along two different longitudinal axes and communicate with each other, so that the sensor 40 can be held within the holder 20 .
  • the holder 20 provided in the present invention can be adapted to a thin design.
  • the port 342 of the transmitter 30 is accommodated in the space S 1 of the containing indentation 22 of the holder 20 .
  • the top of the holder 20 is lower than the top of the signal output end 42 , thereby the signal output end 42 partially protrudes beyond the holder 20 and is contained in the connecting slot 344 of the port 342 and the recess 332 of the printed circuit board 33 (as shown in FIGS. 3 and 4 ).
  • the purpose of thinness and detachability is achieved by the above-mentioned complementary structural design.
  • the second elastic body 25 disposed in the implantation hole 24 of the holder 20 includes the waterproof seal 25 A and the elastic divider 25 B.
  • the waterproof seal 25 A abuts against the transmitter 30 to form therebetween a waterproof sealing structure, to prevent external liquid from flowing into the space between the transmitter 30 and the base 10 and affecting the electrical properties of the transmitter 30 and the detection sensitivity of the sensor 40 .
  • the elastic divider 25 B is disposed in the implantation hole 24 and corresponds to the space above the implanting channel defined by the implantation hole 24 and the through-hole 12 , to prevent blood refluxing through the implanting channel from leaking toward the transmitter 30 .
  • the holder 20 of the present invention is used to carry the sensor 40 through the filler filling the fixing indentation 27 and the limiters 29 arranged between the containing indentation 22 and the fixing indentation 27 .
  • the blocking element 25 C of the second elastic body 25 holds the connecting section 46 of the sensor 40 so as to fix the sensor 40 . Therefore, the present invention enables the sensor 40 to be more stably carried on the holder 20 through the limiting and fixing means of the filler, the limiter 29 and the blocking element 25 C.

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US16/944,693 Pending US20210030969A1 (en) 2019-08-02 2020-07-31 Insertion module and insertion device having the same
US16/945,305 Active 2041-05-24 US11737686B2 (en) 2019-08-02 2020-07-31 Physiological signal monitoring device and sensor holder thereof
US16/945,555 Active US11504032B2 (en) 2019-08-02 2020-07-31 Physiological signal monitoring device and sensor holder thereof
US16/983,198 Pending US20210030332A1 (en) 2019-08-02 2020-08-03 Physiological signal monitoring device and assembling method of a transmitter thereof
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US16/945,305 Active 2041-05-24 US11737686B2 (en) 2019-08-02 2020-07-31 Physiological signal monitoring device and sensor holder thereof
US16/945,555 Active US11504032B2 (en) 2019-08-02 2020-07-31 Physiological signal monitoring device and sensor holder thereof
US16/983,198 Pending US20210030332A1 (en) 2019-08-02 2020-08-03 Physiological signal monitoring device and assembling method of a transmitter thereof
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