UA94568C2 - Способ получения промежуточных соединений, которые применяют для синтеза аналогов витамина d - Google Patents

Способ получения промежуточных соединений, которые применяют для синтеза аналогов витамина d

Info

Publication number
UA94568C2
UA94568C2 UAA200611527A UAA200611527A UA94568C2 UA 94568 C2 UA94568 C2 UA 94568C2 UA A200611527 A UAA200611527 A UA A200611527A UA A200611527 A UAA200611527 A UA A200611527A UA 94568 C2 UA94568 C2 UA 94568C2
Authority
UA
Ukraine
Prior art keywords
synthesis
preparation
analogues
vitamin
intermediates useful
Prior art date
Application number
UAA200611527A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Эрик Торнгард Хансен
Томас Петер Сабро
Мартин Джон Келверли
Хенрик Педерсен
Хайнц-Йозеф Вильгельм Дюссен
Original Assignee
Лео Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of UA94568C2 publication Critical patent/UA94568C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
UAA200611527A 2004-04-02 2005-03-23 Способ получения промежуточных соединений, которые применяют для синтеза аналогов витамина d UA94568C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55854604P 2004-04-02 2004-04-02

Publications (1)

Publication Number Publication Date
UA94568C2 true UA94568C2 (ru) 2011-05-25

Family

ID=34961754

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200611527A UA94568C2 (ru) 2004-04-02 2005-03-23 Способ получения промежуточных соединений, которые применяют для синтеза аналогов витамина d

Country Status (18)

Country Link
US (1) US20070135395A1 (enExample)
EP (1) EP1735276B1 (enExample)
JP (1) JP4744507B2 (enExample)
KR (1) KR20070056001A (enExample)
CN (1) CN1938268B (enExample)
AR (1) AR048462A1 (enExample)
AT (1) ATE498609T1 (enExample)
BR (1) BRPI0508704A (enExample)
CA (1) CA2561590C (enExample)
DE (2) DE602005026378D1 (enExample)
ES (1) ES2361389T3 (enExample)
IL (1) IL177357A (enExample)
MX (1) MXPA06010824A (enExample)
MY (1) MY146099A (enExample)
RU (1) RU2378252C2 (enExample)
TW (1) TWI322800B (enExample)
UA (1) UA94568C2 (enExample)
WO (1) WO2005095336A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1948283B (zh) * 2005-10-14 2010-12-29 台耀化学股份有限公司 维生素d衍生物的制备方法
EP1844010B1 (en) 2006-03-17 2013-02-13 Leo Pharma A/S Isomerisation of pharmaceutical intermediates
WO2009057136A2 (en) * 2007-08-03 2009-05-07 Glenmark Generics Limited Epimerization by stereoselective synthesis of vitamin d analogues
EP2299809B1 (en) * 2008-06-17 2018-10-17 Ben Gurion University Of The Negev R&D Authority Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
US20120184514A1 (en) * 2009-07-01 2012-07-19 Vitamin Derivatives Inc. Vitamin d compounds and methods for preparing same
CN101607932B (zh) * 2009-07-23 2012-05-09 青岛正大海尔制药有限公司 一种光化学反应制备骨化三醇的方法及其装置
CN103980172A (zh) * 2014-04-26 2014-08-13 湖南华腾制药有限公司 一种1α,25-二羟基维生素D2的制备方法
CN103980173A (zh) * 2014-04-26 2014-08-13 湖南华腾制药有限公司 一种帕立骨化醇中间体的制备方法
CN105624215B (zh) * 2014-10-27 2020-10-27 天津金耀集团有限公司 一种卡泊三醇合成新方法
CN104447211A (zh) * 2014-12-12 2015-03-25 重庆华邦制药有限公司 维生素d类药物的中间体化合物及制备方法
CN105777665B (zh) * 2014-12-17 2018-11-06 上虞京新药业有限公司 卡泊三醇的中间体化合物及其制备方法
ES2575744B1 (es) * 2014-12-30 2017-02-09 Laboratorios Viñas S.A. Procedimiento para proteger derivados de vitamina D con SO2 y uso correspondiente
CN106905358B (zh) * 2015-12-23 2020-12-01 重庆华邦胜凯制药有限公司 一种制备维生素d3类似物中间体的方法
CN105717206B (zh) * 2016-01-27 2018-02-06 重庆华邦制药有限公司 分离测定卡泊三醇中间体f及其杂质的方法
CN107643354B (zh) * 2016-07-22 2022-02-01 重庆华邦胜凯制药有限公司 卡泊三醇起始原料a及相关杂质的分离与测定方法
ES2674336B1 (es) * 2016-12-28 2019-04-11 Laboratorios Vinas S A Procedimiento para reducir derivados carbonilicos de vitamina d y uso correspondiente
CN113845541B (zh) * 2021-10-19 2023-11-07 重庆华邦胜凯制药有限公司 一种制备维生素d3类似物的方法
CN116396268A (zh) * 2021-12-27 2023-07-07 上海信谊万象药业股份有限公司 一种阿法骨化醇中间体合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866048A (en) * 1985-08-02 1989-09-12 Leo Pharmaceutical Products Ltd. Novel vitamin D analogues
US5244104A (en) * 1992-01-02 1993-09-14 Sias Equipment Company Drying rack and spacer
US5247104A (en) * 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
JPH08325226A (ja) * 1995-05-30 1996-12-10 Teijin Ltd ビタミンｄ３ 誘導体の製造法
WO2004037781A1 (en) * 2002-10-23 2004-05-06 Leo Pharma A/S Vitamin d analogues, compositions comprising said analogues and their use
ES2233209B1 (es) * 2003-11-28 2006-04-01 Laboratorios Viñas S.A. Compuestos monohalogenovinilderivados de vitamina d.
JP4667450B2 (ja) * 2004-03-18 2011-04-13 レオ ファーマ アクティーゼルスカブ ビタミンｄ類似体の立体選択的合成

Also Published As

Publication number Publication date
MY146099A (en) 2012-06-29
MXPA06010824A (es) 2007-01-17
WO2005095336A2 (en) 2005-10-13
IL177357A (en) 2008-04-13
WO2005095336A3 (en) 2005-11-10
CN1938268B (zh) 2010-06-02
ES2361389T3 (es) 2011-06-16
KR20070056001A (ko) 2007-05-31
RU2378252C2 (ru) 2010-01-10
TW200613257A (en) 2006-05-01
CA2561590C (en) 2008-11-18
JP2007530602A (ja) 2007-11-01
JP4744507B2 (ja) 2011-08-10
US20070135395A1 (en) 2007-06-14
CA2561590A1 (en) 2005-10-13
ATE498609T1 (de) 2011-03-15
BRPI0508704A (pt) 2007-08-07
EP1735276B1 (en) 2011-02-16
AR048462A1 (es) 2006-04-26
TWI322800B (en) 2010-04-01
DE05715124T1 (de) 2008-02-21
RU2006138613A (ru) 2008-05-10
EP1735276A2 (en) 2006-12-27
HK1098124A1 (en) 2007-07-13
CN1938268A (zh) 2007-03-28
DE602005026378D1 (de) 2011-03-31

Similar Documents

Publication Publication Date Title
MY146099A (en) Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
MY145604A (en) Process for the preparation of chiral 8-(3-aminopiperidine-1-yl)-xanthines
MX2010003599A (es) Intermediarios y metodos para la sintesis de analogos de halicondrina b.
IL187586A0 (en) Method for producing dihydroquinazolines
PT1928882E (pt) (s)-n-metilnaltrexona, processo para a sua síntese e sua utilização farmacêutica
MY151036A (en) Synthesis of (r)-n-methylnaltrexone
TW200603798A (en) Disalt inhibitors of il-12 production
MX2010005530A (es) Activadores de receptor de vitamina d nuevos y metodos de elaboracion de los mismos.
IL195341A0 (en) Methods and materials for making simvastatin and related compounds
CY1108156T1 (el) Στερεοεκλεκτικη συνθεση αναλογων βιταμινης d
MX2012005968A (es) 7- [3,5 - dihidroxi - 2 - (3 - hidroxi - 5 - fenil - 1 - enil) - ciclopentil] - n - etil - hept - 5 - enamida (bmato prost) en la forma cristalina ii, metodos de preparacion y metodos para uso del mismo.
WO2005118564A3 (en) Methods for the synthesis of milnacipran and congeners thereof
TW200728310A (en) Process for the preparation of ferri-succinylcasein
TW200738713A (en) Diazepinoquinolines, synthesis thereof, and intermediates thereto
TW200800986A (en) Tetrahydroquinolines, synthesis thereof, and intermediates thereto
MX2007002833A (es) Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorios.
MY139521A (en) Stereoselective synthesis of vitamin d analogues
TW200635905A (en) Processes for producing 4-aminoquinazolines
TW200740729A (en) Methods for preparing glutamic acid derivatives
SG158860A1 (en) Processes for the preparation of aminoethoxybenzyl alcohols
TW200728267A (en) Processes and intermediates for the preparation of prostaglandins
UA87832C2 (ru) Стереоселективный синтез аналогов витамина д
SG155231A1 (en) Process for synthesis of dialkoxyorganoboranes
MY159745A (en) Method of preparing deoxyribofuranose compounds
WO2006062901A3 (en) Silacycle compounds and methods of use thereof