UA88648C2 - Inhibitors of c-fms kinase - Google Patents

Inhibitors of c-fms kinase

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Publication number
UA88648C2
UA88648C2 UAA200704498A UAA200704498A UA88648C2 UA 88648 C2 UA88648 C2 UA 88648C2 UA A200704498 A UAA200704498 A UA A200704498A UA A200704498 A UAA200704498 A UA A200704498A UA 88648 C2 UA88648 C2 UA 88648C2
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UA
Ukraine
Prior art keywords
cancer
diseases
treating
compounds
formula
Prior art date
Application number
UAA200704498A
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English (en)
Ukrainian (uk)
Inventor
Карл Иллиг
Шелли К. Баллентайн
Джиншенг Чен
Санат Меегалла
М. Рудольф
Марк УОЛЛ
Кен Уилсон
Рене Десжарле
Кристофер Моллой
Карл Менти
Кристофер Флорес
Original Assignee
Янссэн Фармацэвтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Янссэн Фармацэвтика Н.В. filed Critical Янссэн Фармацэвтика Н.В.
Publication of UA88648C2 publication Critical patent/UA88648C2/ru

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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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Abstract

Изобретение относится к соединениям Формулы (І), где А, X, Rи W определены в описании, а также к их сольватам, гидратам, таутомерам и фармацевтически приемлемых солей, которые ингибируют протеинтирозинкиназы, особенно c-fms киназу.Также описаны способы лечения аутоиммунных болезней и болезней с воспалительным компонентом; лечение метастаза, который является результатом рака яичников, рака маточных труб, рака молочной железы, рака толстой кишки, рака желудка, лейкоза ворсистых клеток и немелкоклеточной карциномы легкого; и лечения боли, включая скелетную боль, вызванную метастазом опухолей или остеоартритом, или висцеральной, воспалительной и нейрогенной болью; а также остеопороза, болезни Пагета и других болезней, в которых ресорбция кости обуславливает забол�
UAA200704498A 2004-10-22 2005-10-20 Inhibitors of c-fms kinase UA88648C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62121104P 2004-10-22 2004-10-22

Publications (1)

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UA88648C2 true UA88648C2 (en) 2009-11-10

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Country Status (18)

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EP (1) EP1807077B1 (ru)
JP (1) JP5046950B2 (ru)
KR (1) KR101273434B1 (ru)
CN (1) CN101437514B (ru)
AU (1) AU2005299837A1 (ru)
BR (1) BRPI0516947A (ru)
CA (1) CA2585053C (ru)
DK (1) DK1807077T3 (ru)
EA (1) EA013250B1 (ru)
ES (1) ES2611604T3 (ru)
HU (1) HUE033089T2 (ru)
MX (1) MX2007004784A (ru)
NO (1) NO339555B1 (ru)
PL (1) PL1807077T3 (ru)
PT (1) PT1807077T (ru)
UA (1) UA88648C2 (ru)
WO (1) WO2006047277A2 (ru)
ZA (1) ZA200704106B (ru)

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JP5046950B2 (ja) 2012-10-10
MX2007004784A (es) 2007-09-11
CA2585053A1 (en) 2006-05-04
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