EA200700918A1 - Ингибиторы c - fms киназы - Google Patents

Ингибиторы c - fms киназы

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Publication number
EA200700918A1
EA200700918A1 EA200700918A EA200700918A EA200700918A1 EA 200700918 A1 EA200700918 A1 EA 200700918A1 EA 200700918 A EA200700918 A EA 200700918A EA 200700918 A EA200700918 A EA 200700918A EA 200700918 A1 EA200700918 A1 EA 200700918A1
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EA
Eurasian Patent Office
Prior art keywords
pain
cancer
diseases
compounds
formula
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Application number
EA200700918A
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English (en)
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EA013250B1 (ru
Inventor
Карл Р. Иллиг
Шелли К. Баллентайн
Цзиньшэн Чэнь
Санатх Мигалла
М. Джонатан Рудольф
Марк Дж. Уолл
Кен Уилсон
Рене Дежарле
Кристофер Дж. Моллой
Карл Л. Менти
Кристофер Флорес
Original Assignee
Янссен Фармацевтика, Н. В.
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Application filed by Янссен Фармацевтика, Н. В. filed Critical Янссен Фармацевтика, Н. В.
Publication of EA200700918A1 publication Critical patent/EA200700918A1/ru
Publication of EA013250B1 publication Critical patent/EA013250B1/ru

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurology (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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Abstract

Настоящее изобретение относится к соединениям формулы (I)в которой значения А, X, Rи W определены в описании изобретения, а также к их сольватам, гидратам, таутомерам и фармацевтически приемлемым солям, которые ингибируют протеинтирозинкиназы, в особенности c-fms киназу. Также представлены способы лечения аутоиммунных заболеваний и заболеваний с воспалительной компонентой; лечения образования метастазов рака яичников, рака матки, рака молочной железы, рака толстой кишки, рака желудка, гистиоцитарного ретикулоэндотелиоза и немелкоклеточной карциномы легкого; и лечения боли, включая скелетную боль, вызванную метастазированием опухоли или остеоартритом, или висцеральную, воспалительную или нейрогенную боль; а также остеопороза, болезни Пэджета и других заболеваний, в которых болезненность опосредуется резорбцией кости, включая артрит, неудачное протезирование, остеолитическую саркому, миелому и метастазирование опухоли в кости, соединениями формулы (I).
EA200700918A 2004-10-22 2005-10-20 Ингибиторы c-fms киназы EA013250B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62121104P 2004-10-22 2004-10-22
PCT/US2005/037868 WO2006047277A2 (en) 2004-10-22 2005-10-20 Inhibitors of c-fms kinase

Publications (2)

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EA200700918A1 true EA200700918A1 (ru) 2008-06-30
EA013250B1 EA013250B1 (ru) 2010-04-30

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EP (1) EP1807077B1 (ru)
JP (1) JP5046950B2 (ru)
KR (1) KR101273434B1 (ru)
CN (1) CN101437514B (ru)
AU (1) AU2005299837A1 (ru)
BR (1) BRPI0516947A (ru)
CA (1) CA2585053C (ru)
DK (1) DK1807077T3 (ru)
EA (1) EA013250B1 (ru)
ES (1) ES2611604T3 (ru)
HU (1) HUE033089T2 (ru)
MX (1) MX2007004784A (ru)
NO (1) NO339555B1 (ru)
PL (1) PL1807077T3 (ru)
PT (1) PT1807077T (ru)
UA (1) UA88648C2 (ru)
WO (1) WO2006047277A2 (ru)
ZA (1) ZA200704106B (ru)

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