UA85373C2 - Слитый протеин регуляторных/аксессорных hіv протеинов - Google Patents

Слитый протеин регуляторных/аксессорных hіv протеинов

Info

Publication number
UA85373C2
UA85373C2 UA20041109408A UA20041109408A UA85373C2 UA 85373 C2 UA85373 C2 UA 85373C2 UA 20041109408 A UA20041109408 A UA 20041109408A UA 20041109408 A UA20041109408 A UA 20041109408A UA 85373 C2 UA85373 C2 UA 85373C2
Authority
UA
Ukraine
Prior art keywords
proteins
fusion protein
nucleic acids
hiv
accessory proteins
Prior art date
Application number
UA20041109408A
Other languages
English (en)
Ukrainian (uk)
Inventor
Пол Хаули
Сонья Лейрер
Ева Фелдер
Original Assignee
Бавариан Нордик А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бавариан Нордик А/С filed Critical Бавариан Нордик А/С
Publication of UA85373C2 publication Critical patent/UA85373C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Изобретение относится к слитому протеину, который содержит аминокислотную последовательность, по крайней мере, четырех HIV протеинов, выбранных из Vif, Vpr, Vpu, Vpx, Rev, Tat и Nef, или производной аминокислотной последовательности одного или более указанных протеинов, где слитый протеин не преобразуется до индивидуальных HIV протеинов, которые имеют естественные N и С концы. Кроме того, изобретение касается нуклеиновых кислот, которые кодируют указанный протеин, векторов, которые содержат указанные нуклеиновые кислоты, и способов получения указанных протеинов. Слитый протеин, нуклеиновые кислоты и векторы применяются как вакцины, по крайней мере, для профилактики HIV инфекций.
UA20041109408A 2002-05-16 2003-05-14 Слитый протеин регуляторных/аксессорных hіv протеинов UA85373C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200200754 2002-05-16

Publications (1)

Publication Number Publication Date
UA85373C2 true UA85373C2 (ru) 2009-01-26

Family

ID=29433046

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA200811374A UA92788C2 (ru) 2002-05-16 2003-05-14 Слитый протеин регуляторных/аксессорных hiv протеинов
UA20041109410A UA82998C2 (ru) 2002-05-16 2003-05-14 Экспрессия генов в модифицированном вирусе коровьей оспы ankara с использованием коровьего поксвирусного промотора аті
UA20041109408A UA85373C2 (ru) 2002-05-16 2003-05-14 Слитый протеин регуляторных/аксессорных hіv протеинов

Family Applications Before (2)

Application Number Title Priority Date Filing Date
UAA200811374A UA92788C2 (ru) 2002-05-16 2003-05-14 Слитый протеин регуляторных/аксессорных hiv протеинов
UA20041109410A UA82998C2 (ru) 2002-05-16 2003-05-14 Экспрессия генов в модифицированном вирусе коровьей оспы ankara с использованием коровьего поксвирусного промотора аті

Country Status (24)

Country Link
US (7) US20050222388A1 (ru)
EP (2) EP1506223B1 (ru)
JP (3) JP2006502704A (ru)
KR (4) KR101196178B1 (ru)
CN (3) CN1982332A (ru)
AT (2) ATE407143T1 (ru)
AU (2) AU2003240638B2 (ru)
BR (1) BR0309963A (ru)
CA (1) CA2483640A1 (ru)
CY (1) CY1108638T1 (ru)
DE (2) DE60323407D1 (ru)
DK (2) DK1506223T3 (ru)
EA (1) EA007154B1 (ru)
ES (2) ES2253675T3 (ru)
HK (1) HK1076822A1 (ru)
IL (3) IL164178A0 (ru)
MX (1) MXPA04010683A (ru)
NO (1) NO20045229L (ru)
NZ (2) NZ536499A (ru)
PL (2) PL397252A1 (ru)
PT (1) PT1652857E (ru)
SI (2) SI1506223T1 (ru)
UA (3) UA92788C2 (ru)
WO (1) WO2003097675A1 (ru)

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CN1982332A (zh) 2002-05-16 2007-06-20 巴法里安诺迪克有限公司 Hiv调节/辅助蛋白的融合蛋白
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EP1608675B1 (en) 2003-03-28 2011-08-17 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use
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JP2009544322A (ja) * 2006-07-27 2009-12-17 リゴサイト ファーマシューティカルズ インコーポレイテッド キメラウイルス様粒子
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EA021131B1 (ru) 2008-05-16 2015-04-30 Тэйга Байотекнолоджис, Инк. Антитела и способы их получения
WO2010011644A2 (en) 2008-07-21 2010-01-28 Taiga Biotechnologies, Inc. Differentiated anucleated cells and method for preparing the same
IL301475A (en) 2008-08-28 2023-05-01 Taiga Biotechnologies Inc Laboratory methods for increasing the vitality of the cells of the immune system
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CN102753582A (zh) 2009-11-03 2012-10-24 莱戈赛特医药股份有限公司 嵌合RSV-F多肽、和慢病毒或α-反转录病毒GAG基VLP
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US9789135B2 (en) 2012-07-20 2017-10-17 Taiga Biotechnologies, Inc. Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
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US10196426B1 (en) * 2014-06-18 2019-02-05 Sun Yat-Sen University Chimeric vector and preparation method and use thereof
CN104130331B (zh) * 2014-06-19 2017-06-06 中山大学 一种抗hiv‑1病毒药物及其制备和应用
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
CN105330729A (zh) * 2015-11-18 2016-02-17 南京医科大学 一种人类免疫缺陷病毒Vpr蛋白的制备方法
US10583156B2 (en) 2016-12-02 2020-03-10 Taiga Biotechnologies, Inc. Nanoparticle formulations
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
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Also Published As

Publication number Publication date
EP1506223A1 (en) 2005-02-16
EP1652857B9 (en) 2009-10-14
PL372092A1 (en) 2005-07-11
IL164178A0 (en) 2005-12-18
US20120142097A1 (en) 2012-06-07
IL197304A0 (en) 2011-07-31
US20060257974A1 (en) 2006-11-16
NZ556144A (en) 2008-04-30
WO2003097675A1 (en) 2003-11-27
US20050222388A1 (en) 2005-10-06
ES2253675T3 (es) 2006-06-01
AU2003240638A1 (en) 2003-12-02
NZ536499A (en) 2008-04-30
US8435535B2 (en) 2013-05-07
CN101108882A (zh) 2008-01-23
US8143054B2 (en) 2012-03-27
KR100996330B1 (ko) 2010-11-23
US20120142096A1 (en) 2012-06-07
EP1652857B1 (en) 2008-09-03
ATE407143T1 (de) 2008-09-15
US7569228B2 (en) 2009-08-04
KR20050010000A (ko) 2005-01-26
JP2009178165A (ja) 2009-08-13
ES2313166T3 (es) 2009-03-01
KR20120106894A (ko) 2012-09-26
PT1652857E (pt) 2008-12-12
EA007154B1 (ru) 2006-08-25
DE60302356D1 (de) 2005-12-22
EP1652857A3 (en) 2007-03-14
EP1506223B1 (en) 2005-11-16
JP2010099084A (ja) 2010-05-06
EP1652857A2 (en) 2006-05-03
DK1506223T3 (da) 2006-04-10
US20100047871A1 (en) 2010-02-25
BR0309963A (pt) 2005-02-22
UA82998C2 (ru) 2008-06-10
KR101196178B1 (ko) 2012-11-01
CN1325512C (zh) 2007-07-11
MXPA04010683A (es) 2005-02-17
UA92788C2 (ru) 2010-12-10
AU2008252074A1 (en) 2009-01-08
DK1652857T3 (da) 2009-01-05
SI1506223T1 (sl) 2006-04-30
NO20045229L (no) 2004-11-29
IL164178A (en) 2011-01-31
PL397252A1 (pl) 2012-04-10
DE60323407D1 (de) 2008-10-16
SI1652857T1 (sl) 2009-02-28
US8147839B2 (en) 2012-04-03
CN1982332A (zh) 2007-06-20
US20090280561A1 (en) 2009-11-12
KR20110099058A (ko) 2011-09-05
AU2008252074B2 (en) 2012-02-16
HK1076822A1 (en) 2006-01-27
US8389275B2 (en) 2013-03-05
US20100047268A1 (en) 2010-02-25
KR20100063126A (ko) 2010-06-10
ATE310016T1 (de) 2005-12-15
CA2483640A1 (en) 2003-11-27
US8137931B2 (en) 2012-03-20
AU2003240638B2 (en) 2008-05-15
DE60302356T2 (de) 2006-08-03
EA200401504A1 (ru) 2005-04-28
CN1653085A (zh) 2005-08-10
JP2006502704A (ja) 2006-01-26
CY1108638T1 (el) 2014-04-09

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