PL397252A1 - Białko fuzyjne białek regulatorowych i pomocniczych HIV, kwas nukleinowy kodujący to białko, zawierający je wektor, sposób jego wytwarzania, transfekowana komórka gospodarza, szczepionka i ich zastosowanie - Google Patents

Białko fuzyjne białek regulatorowych i pomocniczych HIV, kwas nukleinowy kodujący to białko, zawierający je wektor, sposób jego wytwarzania, transfekowana komórka gospodarza, szczepionka i ich zastosowanie

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Publication number
PL397252A1
PL397252A1 PL397252A PL39725203A PL397252A1 PL 397252 A1 PL397252 A1 PL 397252A1 PL 397252 A PL397252 A PL 397252A PL 39725203 A PL39725203 A PL 39725203A PL 397252 A1 PL397252 A1 PL 397252A1
Authority
PL
Poland
Prior art keywords
proteins
protein
fusion protein
vaccine
auxiliary
Prior art date
Application number
PL397252A
Other languages
English (en)
Inventor
Paul Howley
Sonja Leyrer
Eva Felder
Original Assignee
Bavarian Nordic A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bavarian Nordic A/S filed Critical Bavarian Nordic A/S
Publication of PL397252A1 publication Critical patent/PL397252A1/pl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16HIV-1 ; HIV-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL397252A 2002-05-16 2003-05-14 Białko fuzyjne białek regulatorowych i pomocniczych HIV, kwas nukleinowy kodujący to białko, zawierający je wektor, sposób jego wytwarzania, transfekowana komórka gospodarza, szczepionka i ich zastosowanie PL397252A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200200754 2002-05-16

Publications (1)

Publication Number Publication Date
PL397252A1 true PL397252A1 (pl) 2012-04-10

Family

ID=29433046

Family Applications (2)

Application Number Title Priority Date Filing Date
PL03372092A PL372092A1 (pl) 2002-05-16 2003-05-14 Białko fuzyjne białek regulatorowych i pomocniczych HIV
PL397252A PL397252A1 (pl) 2002-05-16 2003-05-14 Białko fuzyjne białek regulatorowych i pomocniczych HIV, kwas nukleinowy kodujący to białko, zawierający je wektor, sposób jego wytwarzania, transfekowana komórka gospodarza, szczepionka i ich zastosowanie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL03372092A PL372092A1 (pl) 2002-05-16 2003-05-14 Białko fuzyjne białek regulatorowych i pomocniczych HIV

Country Status (23)

Country Link
US (7) US20050222388A1 (pl)
EP (2) EP1506223B1 (pl)
JP (3) JP2006502704A (pl)
KR (4) KR100996330B1 (pl)
CN (3) CN1325512C (pl)
AT (2) ATE407143T1 (pl)
AU (2) AU2003240638B2 (pl)
BR (1) BR0309963A (pl)
CA (1) CA2483640A1 (pl)
CY (1) CY1108638T1 (pl)
DE (2) DE60302356T2 (pl)
DK (2) DK1652857T3 (pl)
EA (1) EA007154B1 (pl)
ES (2) ES2253675T3 (pl)
IL (3) IL164178A0 (pl)
MX (1) MXPA04010683A (pl)
NO (1) NO20045229L (pl)
NZ (2) NZ536499A (pl)
PL (2) PL372092A1 (pl)
PT (1) PT1652857E (pl)
SI (2) SI1506223T1 (pl)
UA (3) UA82998C2 (pl)
WO (1) WO2003097675A1 (pl)

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KR100996330B1 (ko) * 2002-05-16 2010-11-23 버베리안 노딕 에이/에스 Hiv 조절/부속 단백질의 융합 단백질
CA2519025A1 (en) 2003-03-28 2004-10-07 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services, Centers For Disea Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use
AU2006304392B2 (en) * 2005-10-18 2014-05-01 National Jewish Health Conditionally immortalized long-term stem cells and methods of making and using such cells
EP2044224A4 (en) * 2006-07-27 2011-04-13 Ligocyte Pharmaceuticals Inc CHIMERIC VIRUS TYPE PARTICLES
US9439959B2 (en) 2006-07-27 2016-09-13 Takeda Vaccines, Inc. Chimeric influenza virus-like particles
SG10201803982TA (en) 2008-05-16 2018-07-30 Taiga Biotechnologies Inc Antibodies and processes for preparing the same
AU2009274172B2 (en) 2008-07-21 2015-08-13 Htyr Acquisition Llc Differentiated anucleated cells and method for preparing the same
EP2966084B1 (en) 2008-08-28 2018-04-25 Taiga Biotechnologies, Inc. Modulators of myc, methods of using the same and methods of identifying agents that modulate myc
KR20120093941A (ko) * 2009-10-08 2012-08-23 버베리안 노딕 에이/에스 인간에서 hiv에 대한 광범위한 t-세포 반응의 생성
EP2485759A4 (en) * 2009-10-09 2013-07-24 Univ New York METHOD, AGENTS AND PEPTIDES FOR GENERATING A BORN IMMUNE RESPONSE IN HIV VACCINATION
CN102753582A (zh) 2009-11-03 2012-10-24 莱戈赛特医药股份有限公司 嵌合RSV-F多肽、和慢病毒或α-反转录病毒GAG基VLP
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
CN110643576A (zh) 2012-07-20 2020-01-03 泰加生物工艺学公司 造血区室的增强的重建和自动重建
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US10196426B1 (en) 2014-06-18 2019-02-05 Sun Yat-Sen University Chimeric vector and preparation method and use thereof
CN104130331B (zh) * 2014-06-19 2017-06-06 中山大学 一种抗hiv‑1病毒药物及其制备和应用
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
CN105330729A (zh) * 2015-11-18 2016-02-17 南京医科大学 一种人类免疫缺陷病毒Vpr蛋白的制备方法
US10583156B2 (en) 2016-12-02 2020-03-10 Taiga Biotechnologies, Inc. Nanoparticle formulations
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
CN113874033A (zh) 2019-04-08 2021-12-31 泰加生物工艺学公司 用于冷冻保存免疫细胞的组合物和方法
JP2022532608A (ja) 2019-05-14 2022-07-15 タイガ バイオテクノロジーズ,インク. T細胞疲弊を処置するための組成物および方法
CN116322757A (zh) 2019-11-14 2023-06-23 埃利克斯疗法公司 用于疫苗的剂量方案
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Also Published As

Publication number Publication date
EP1652857B9 (en) 2009-10-14
DK1506223T3 (da) 2006-04-10
DE60323407D1 (de) 2008-10-16
JP2009178165A (ja) 2009-08-13
US7569228B2 (en) 2009-08-04
US20120142097A1 (en) 2012-06-07
US20090280561A1 (en) 2009-11-12
KR100996330B1 (ko) 2010-11-23
US20100047268A1 (en) 2010-02-25
AU2008252074A1 (en) 2009-01-08
WO2003097675A1 (en) 2003-11-27
EA200401504A1 (ru) 2005-04-28
JP2006502704A (ja) 2006-01-26
US8389275B2 (en) 2013-03-05
ATE310016T1 (de) 2005-12-15
EP1506223A1 (en) 2005-02-16
US8435535B2 (en) 2013-05-07
ATE407143T1 (de) 2008-09-15
MXPA04010683A (es) 2005-02-17
CY1108638T1 (el) 2014-04-09
EA007154B1 (ru) 2006-08-25
NZ536499A (en) 2008-04-30
BR0309963A (pt) 2005-02-22
KR20100063126A (ko) 2010-06-10
CN101108882A (zh) 2008-01-23
KR101196178B1 (ko) 2012-11-01
US20120142096A1 (en) 2012-06-07
IL164178A0 (en) 2005-12-18
UA85373C2 (ru) 2009-01-26
UA92788C2 (ru) 2010-12-10
US20100047871A1 (en) 2010-02-25
NZ556144A (en) 2008-04-30
KR20120106894A (ko) 2012-09-26
PT1652857E (pt) 2008-12-12
CN1982332A (zh) 2007-06-20
SI1506223T1 (sl) 2006-04-30
DK1652857T3 (da) 2009-01-05
SI1652857T1 (sl) 2009-02-28
PL372092A1 (pl) 2005-07-11
US20050222388A1 (en) 2005-10-06
EP1652857A2 (en) 2006-05-03
JP2010099084A (ja) 2010-05-06
ES2313166T3 (es) 2009-03-01
US20060257974A1 (en) 2006-11-16
HK1076822A1 (en) 2006-01-27
US8137931B2 (en) 2012-03-20
CN1653085A (zh) 2005-08-10
AU2008252074B2 (en) 2012-02-16
US8143054B2 (en) 2012-03-27
US8147839B2 (en) 2012-04-03
DE60302356T2 (de) 2006-08-03
EP1652857B1 (en) 2008-09-03
IL164178A (en) 2011-01-31
AU2003240638A1 (en) 2003-12-02
DE60302356D1 (de) 2005-12-22
EP1652857A3 (en) 2007-03-14
NO20045229L (no) 2004-11-29
KR20110099058A (ko) 2011-09-05
KR20050010000A (ko) 2005-01-26
EP1506223B1 (en) 2005-11-16
UA82998C2 (ru) 2008-06-10
ES2253675T3 (es) 2006-06-01
IL197304A0 (en) 2011-07-31
CA2483640A1 (en) 2003-11-27
AU2003240638B2 (en) 2008-05-15
CN1325512C (zh) 2007-07-11

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