IL164178A0 - Fusion protein of hiv regulatory/accessory proteins - Google Patents

Fusion protein of hiv regulatory/accessory proteins

Info

Publication number
IL164178A0
IL164178A0 IL16417803A IL16417803A IL164178A0 IL 164178 A0 IL164178 A0 IL 164178A0 IL 16417803 A IL16417803 A IL 16417803A IL 16417803 A IL16417803 A IL 16417803A IL 164178 A0 IL164178 A0 IL 164178A0
Authority
IL
Israel
Prior art keywords
proteins
fusion protein
nucleic acids
hiv
accessory proteins
Prior art date
Application number
IL16417803A
Other languages
English (en)
Original Assignee
Bavarian Nordic As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bavarian Nordic As filed Critical Bavarian Nordic As
Publication of IL164178A0 publication Critical patent/IL164178A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL16417803A 2002-05-16 2003-05-14 Fusion protein of hiv regulatory/accessory proteins IL164178A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200754 2002-05-16
PCT/EP2003/005039 WO2003097675A1 (en) 2002-05-16 2003-05-14 Fusion protein of hiv regulatory/accessory proteins

Publications (1)

Publication Number Publication Date
IL164178A0 true IL164178A0 (en) 2005-12-18

Family

ID=29433046

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16417803A IL164178A0 (en) 2002-05-16 2003-05-14 Fusion protein of hiv regulatory/accessory proteins
IL164178A IL164178A (en) 2002-05-16 2004-09-21 Fusion protein comprising at least four hiv proteins and vaccine comprising said fusion protein
IL197304A IL197304A0 (en) 2002-05-16 2009-02-26 Fusion protein of hiv regulatory/accessory proteins

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL164178A IL164178A (en) 2002-05-16 2004-09-21 Fusion protein comprising at least four hiv proteins and vaccine comprising said fusion protein
IL197304A IL197304A0 (en) 2002-05-16 2009-02-26 Fusion protein of hiv regulatory/accessory proteins

Country Status (23)

Country Link
US (7) US20050222388A1 (pl)
EP (2) EP1506223B1 (pl)
JP (3) JP2006502704A (pl)
KR (4) KR100996330B1 (pl)
CN (3) CN1325512C (pl)
AT (2) ATE407143T1 (pl)
AU (2) AU2003240638B2 (pl)
BR (1) BR0309963A (pl)
CA (1) CA2483640A1 (pl)
CY (1) CY1108638T1 (pl)
DE (2) DE60302356T2 (pl)
DK (2) DK1652857T3 (pl)
EA (1) EA007154B1 (pl)
ES (2) ES2253675T3 (pl)
IL (3) IL164178A0 (pl)
MX (1) MXPA04010683A (pl)
NO (1) NO20045229L (pl)
NZ (2) NZ536499A (pl)
PL (2) PL372092A1 (pl)
PT (1) PT1652857E (pl)
SI (2) SI1506223T1 (pl)
UA (3) UA82998C2 (pl)
WO (1) WO2003097675A1 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501127B2 (en) 2002-05-16 2009-03-10 Bavarian Nordic A/S Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara
KR100996330B1 (ko) * 2002-05-16 2010-11-23 버베리안 노딕 에이/에스 Ｈｉｖ 조절/부속 단백질의 융합 단백질
CA2519025A1 (en) 2003-03-28 2004-10-07 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services, Centers For Disea Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use
AU2006304392B2 (en) * 2005-10-18 2014-05-01 National Jewish Health Conditionally immortalized long-term stem cells and methods of making and using such cells
EP2044224A4 (en) * 2006-07-27 2011-04-13 Ligocyte Pharmaceuticals Inc CHIMERIC VIRUS TYPE PARTICLES
US9439959B2 (en) 2006-07-27 2016-09-13 Takeda Vaccines, Inc. Chimeric influenza virus-like particles
SG10201803982TA (en) 2008-05-16 2018-07-30 Taiga Biotechnologies Inc Antibodies and processes for preparing the same
AU2009274172B2 (en) 2008-07-21 2015-08-13 Htyr Acquisition Llc Differentiated anucleated cells and method for preparing the same
EP2966084B1 (en) 2008-08-28 2018-04-25 Taiga Biotechnologies, Inc. Modulators of myc, methods of using the same and methods of identifying agents that modulate myc
KR20120093941A (ko) * 2009-10-08 2012-08-23 버베리안 노딕 에이/에스 인간에서 ｈｉｖ에 대한 광범위한 ｔ-세포 반응의 생성
EP2485759A4 (en) * 2009-10-09 2013-07-24 Univ New York METHOD, AGENTS AND PEPTIDES FOR GENERATING A BORN IMMUNE RESPONSE IN HIV VACCINATION
CN102753582A (zh) 2009-11-03 2012-10-24 莱戈赛特医药股份有限公司 嵌合RSV-F多肽、和慢病毒或α-反转录病毒GAG基VLP
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
CN110643576A (zh) 2012-07-20 2020-01-03 泰加生物工艺学公司 造血区室的增强的重建和自动重建
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US10196426B1 (en) 2014-06-18 2019-02-05 Sun Yat-Sen University Chimeric vector and preparation method and use thereof
CN104130331B (zh) * 2014-06-19 2017-06-06 中山大学 一种抗hiv‑1病毒药物及其制备和应用
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
CN105330729A (zh) * 2015-11-18 2016-02-17 南京医科大学 一种人类免疫缺陷病毒Vpr蛋白的制备方法
US10583156B2 (en) 2016-12-02 2020-03-10 Taiga Biotechnologies, Inc. Nanoparticle formulations
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
CN113874033A (zh) 2019-04-08 2021-12-31 泰加生物工艺学公司 用于冷冻保存免疫细胞的组合物和方法
JP2022532608A (ja) 2019-05-14 2022-07-15 タイガ バイオテクノロジーズ，インク． Ｔ細胞疲弊を処置するための組成物および方法
CN116322757A (zh) 2019-11-14 2023-06-23 埃利克斯疗法公司 用于疫苗的剂量方案
FR3160186A1 (fr) 2024-03-13 2025-09-19 Odimma Therapeutics Vecteur non-viral pour transcription augmentee

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Publication number Priority date Publication date Assignee Title
AU4088697A (en) * 1996-08-26 1998-03-19 Chiron Corporation Postinfection human immunodeficiency virus (hiv) vaccination therapy
GB9720585D0 (en) 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
IT1297090B1 (it) 1997-12-01 1999-08-03 Barbara Ensoli Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
FR2773156B1 (fr) * 1997-12-26 2000-03-31 Biovacs Inc Nouveaux immunogenes anti-retroviraux (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida
FI105105B (fi) 1998-02-27 2000-06-15 Finnish Immunotechnology Ltd O Itsereplikoiva DNA-vektori immunisoimiseksi HIV:ta vastaan
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
CA2398611A1 (en) 2000-01-31 2001-08-02 Smithkline Beecham Biologicals S.A. Vaccine for the prophylactic or therapeutic immunization against hiv
EP1418940A4 (en) * 2000-03-02 2006-09-20 Univ Emory DNA EXPRESSION VECTORS AND METHODS OF USE
US6544780B1 (en) * 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
JP2004525604A (ja) * 2000-07-14 2004-08-26 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア Ｈｉｖアクセサリータンパク質をコードするｄｎａワクチン
ES2386884T3 (es) * 2000-11-01 2012-09-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Vectores de expresión capaces de inducir respuesta inmunomejorada y métodos para usarlos
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
KR100996330B1 (ko) * 2002-05-16 2010-11-23 버베리안 노딕 에이/에스 Ｈｉｖ 조절/부속 단백질의 융합 단백질

Also Published As

Publication number Publication date
EP1652857B9 (en) 2009-10-14
DK1506223T3 (da) 2006-04-10
DE60323407D1 (de) 2008-10-16
JP2009178165A (ja) 2009-08-13
US7569228B2 (en) 2009-08-04
US20120142097A1 (en) 2012-06-07
US20090280561A1 (en) 2009-11-12
KR100996330B1 (ko) 2010-11-23
US20100047268A1 (en) 2010-02-25
AU2008252074A1 (en) 2009-01-08
WO2003097675A1 (en) 2003-11-27
EA200401504A1 (ru) 2005-04-28
JP2006502704A (ja) 2006-01-26
US8389275B2 (en) 2013-03-05
ATE310016T1 (de) 2005-12-15
EP1506223A1 (en) 2005-02-16
US8435535B2 (en) 2013-05-07
ATE407143T1 (de) 2008-09-15
MXPA04010683A (es) 2005-02-17
CY1108638T1 (el) 2014-04-09
EA007154B1 (ru) 2006-08-25
NZ536499A (en) 2008-04-30
BR0309963A (pt) 2005-02-22
KR20100063126A (ko) 2010-06-10
CN101108882A (zh) 2008-01-23
KR101196178B1 (ko) 2012-11-01
US20120142096A1 (en) 2012-06-07
UA85373C2 (ru) 2009-01-26
UA92788C2 (ru) 2010-12-10
US20100047871A1 (en) 2010-02-25
NZ556144A (en) 2008-04-30
KR20120106894A (ko) 2012-09-26
PT1652857E (pt) 2008-12-12
CN1982332A (zh) 2007-06-20
SI1506223T1 (sl) 2006-04-30
DK1652857T3 (da) 2009-01-05
SI1652857T1 (sl) 2009-02-28
PL372092A1 (pl) 2005-07-11
US20050222388A1 (en) 2005-10-06
EP1652857A2 (en) 2006-05-03
JP2010099084A (ja) 2010-05-06
ES2313166T3 (es) 2009-03-01
US20060257974A1 (en) 2006-11-16
HK1076822A1 (en) 2006-01-27
US8137931B2 (en) 2012-03-20
CN1653085A (zh) 2005-08-10
AU2008252074B2 (en) 2012-02-16
PL397252A1 (pl) 2012-04-10
US8143054B2 (en) 2012-03-27
US8147839B2 (en) 2012-04-03
DE60302356T2 (de) 2006-08-03
EP1652857B1 (en) 2008-09-03
IL164178A (en) 2011-01-31
AU2003240638A1 (en) 2003-12-02
DE60302356D1 (de) 2005-12-22
EP1652857A3 (en) 2007-03-14
NO20045229L (no) 2004-11-29
KR20110099058A (ko) 2011-09-05
KR20050010000A (ko) 2005-01-26
EP1506223B1 (en) 2005-11-16
UA82998C2 (ru) 2008-06-10
ES2253675T3 (es) 2006-06-01
IL197304A0 (en) 2011-07-31
CA2483640A1 (en) 2003-11-27
AU2003240638B2 (en) 2008-05-15
CN1325512C (zh) 2007-07-11

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