UA83881C2 - Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents - Google Patents
Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agentsInfo
- Publication number
- UA83881C2 UA83881C2 UAA200607007A UAA200607007A UA83881C2 UA 83881 C2 UA83881 C2 UA 83881C2 UA A200607007 A UAA200607007 A UA A200607007A UA A200607007 A UAA200607007 A UA A200607007A UA 83881 C2 UA83881 C2 UA 83881C2
- Authority
- UA
- Ukraine
- Prior art keywords
- сalkyl
- rrepresents
- morpholinyl
- hydrogen
- сalkyloxy
- Prior art date
Links
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- BWESROVQGZSBRX-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine Chemical compound C1=NC=NC2=CC=CN=C21 BWESROVQGZSBRX-UHFFFAOYSA-N 0.000 title 1
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000002757 morpholinyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0351062 | 2003-12-18 | ||
| EP0351058 | 2003-12-18 | ||
| PCT/EP2004/053501 WO2005058913A1 (en) | 2003-12-18 | 2004-12-15 | Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA83881C2 true UA83881C2 (en) | 2008-08-26 |
Family
ID=34702160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200607007A UA83881C2 (en) | 2003-12-18 | 2004-12-15 | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7799772B2 (enExample) |
| EP (1) | EP1697384B1 (enExample) |
| JP (1) | JP4936897B2 (enExample) |
| KR (1) | KR101174672B1 (enExample) |
| AR (1) | AR046957A1 (enExample) |
| AU (1) | AU2004298448B2 (enExample) |
| CA (1) | CA2549869C (enExample) |
| DE (1) | DE602004012891T2 (enExample) |
| EA (1) | EA013904B1 (enExample) |
| ES (1) | ES2305887T3 (enExample) |
| IL (1) | IL176357A (enExample) |
| MX (1) | MXPA06007017A (enExample) |
| MY (1) | MY146415A (enExample) |
| NO (1) | NO337701B1 (enExample) |
| NZ (1) | NZ547794A (enExample) |
| TW (1) | TWI347187B (enExample) |
| UA (1) | UA83881C2 (enExample) |
| WO (1) | WO2005058913A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799772B2 (en) | 2003-12-18 | 2010-09-21 | Janssen Pharmaceutica N.V. | Pyrido-and pyrimidopyrimidine derivatives as anti-profilerative agents |
| JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| MY169441A (en) | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| PH12012501003B1 (en) * | 2005-11-16 | 2018-04-06 | Cti Biopharma Corp | Oxygen linked pyrimidine derivatives |
| EA014779B1 (ru) | 2006-07-13 | 2011-02-28 | Янссен Фармацевтика Н.В. | Производные хиназолина в качестве mtki |
| KR20090089849A (ko) * | 2006-10-27 | 2009-08-24 | 얀센 파마슈티카 엔.브이. | Ｖｅｇｆｒ３ 저해제로서의 마크로사이클릭 퀴나졸린 유도체 |
| WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
| ES2435454T3 (es) * | 2007-06-21 | 2013-12-19 | Janssen Pharmaceutica, N.V. | Indolin-2-onas y aza-indolin-2-onas |
| EP2185562B1 (en) * | 2007-07-27 | 2015-12-02 | Janssen Pharmaceutica, N.V. | Pyrrolopyrimidines useful for the treatment of proliferative diseases |
| ES2464461T3 (es) | 2008-09-22 | 2014-06-02 | Array Biopharma, Inc. | Compuestos de imidazo[1,2B]piridazina sustituidos como inhibidores de la TRK cinasa |
| SG196855A1 (en) | 2008-10-22 | 2014-02-13 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| US8765727B2 (en) | 2009-01-23 | 2014-07-01 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| GB0921203D0 (en) | 2009-12-03 | 2010-01-20 | Al Lamee Kadem G | Drugs formulations for cardiovascular stents |
| AU2011256380C1 (en) | 2010-05-20 | 2016-09-08 | Array Biopharma Inc. | Macrocyclic compounds as Trk kinase inhibitors |
| WO2012125668A1 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| ES2583477T3 (es) * | 2011-09-30 | 2016-09-21 | Ipsen Pharma S.A.S. | Inhibidores macrocíclicos de cinasa de LRRK2 |
| CA2887203A1 (en) | 2012-10-05 | 2014-04-10 | Rigel Pharmaceuticals, Inc. | 2,3-(hetero)aryl substituted pyridinyl compounds and their use as gdf-8 inhibitors |
| US9861635B2 (en) * | 2013-05-06 | 2018-01-09 | Merck Patent Gmbh | Macrocycles as kinase inhibitors |
| ES2945905T3 (es) * | 2014-02-07 | 2023-07-10 | Exithera Pharmaceuticals Inc | Compuestos y composiciones terapéuticos |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| EP3699181B1 (en) | 2014-11-16 | 2023-03-01 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| JP6800158B2 (ja) | 2015-02-20 | 2020-12-16 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｇｄｆ−８阻害剤 |
| MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
| US10724102B2 (en) | 2015-10-26 | 2020-07-28 | Loxo Oncology, Inc. | Point mutations in TRK inhibitor-resistant cancer and methods relating to the same |
| SG11201808559PA (en) | 2016-04-04 | 2018-10-30 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| FI3800189T3 (fi) | 2016-05-18 | 2023-07-31 | Loxo Oncology Inc | (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin valmistaminen |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| CN110386945B (zh) * | 2018-04-18 | 2021-09-28 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种大环类激酶抑制剂 |
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| US7799772B2 (en) * | 2003-12-18 | 2010-09-21 | Janssen Pharmaceutica N.V. | Pyrido-and pyrimidopyrimidine derivatives as anti-profilerative agents |
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| MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| EA017545B1 (ru) | 2005-06-30 | 2013-01-30 | Янссен Фармацевтика Н.В. | Циклические анилино-пиридинотриазины в качестве ингибиторов gsk-3 |
| JP2007135441A (ja) | 2005-11-16 | 2007-06-07 | Kenichi Mikiya | 新規タンパク質及びそれをコードする遺伝子 |
| PH12012501003B1 (en) | 2005-11-16 | 2018-04-06 | Cti Biopharma Corp | Oxygen linked pyrimidine derivatives |
| EA014779B1 (ru) | 2006-07-13 | 2011-02-28 | Янссен Фармацевтика Н.В. | Производные хиназолина в качестве mtki |
| US20080219975A1 (en) * | 2006-10-27 | 2008-09-11 | Timothy Pietro Suren Perera | Vegfr3 inhibitors |
| KR20090089849A (ko) | 2006-10-27 | 2009-08-24 | 얀센 파마슈티카 엔.브이. | Ｖｅｇｆｒ３ 저해제로서의 마크로사이클릭 퀴나졸린 유도체 |
| ES2435454T3 (es) | 2007-06-21 | 2013-12-19 | Janssen Pharmaceutica, N.V. | Indolin-2-onas y aza-indolin-2-onas |
| EP2185562B1 (en) * | 2007-07-27 | 2015-12-02 | Janssen Pharmaceutica, N.V. | Pyrrolopyrimidines useful for the treatment of proliferative diseases |
| JP5480824B2 (ja) * | 2008-03-10 | 2014-04-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐｌｋキナーゼ阻害剤としての４−アリール−２−アニリノ−ピリミジン |
-
2004
- 2004-12-15 US US10/596,512 patent/US7799772B2/en active Active
- 2004-12-15 MX MXPA06007017A patent/MXPA06007017A/es active IP Right Grant
- 2004-12-15 DE DE602004012891T patent/DE602004012891T2/de not_active Expired - Lifetime
- 2004-12-15 AU AU2004298448A patent/AU2004298448B2/en not_active Expired
- 2004-12-15 UA UAA200607007A patent/UA83881C2/ru unknown
- 2004-12-15 ES ES04804852T patent/ES2305887T3/es not_active Expired - Lifetime
- 2004-12-15 JP JP2006544440A patent/JP4936897B2/ja not_active Expired - Lifetime
- 2004-12-15 CA CA2549869A patent/CA2549869C/en not_active Expired - Lifetime
- 2004-12-15 WO PCT/EP2004/053501 patent/WO2005058913A1/en not_active Ceased
- 2004-12-15 EP EP04804852A patent/EP1697384B1/en not_active Expired - Lifetime
- 2004-12-15 NZ NZ547794A patent/NZ547794A/en not_active IP Right Cessation
- 2004-12-15 EA EA200601177A patent/EA013904B1/ru not_active IP Right Cessation
- 2004-12-16 MY MYPI20045196A patent/MY146415A/en unknown
- 2004-12-17 AR ARP040104750A patent/AR046957A1/es unknown
- 2004-12-17 TW TW093139376A patent/TWI347187B/zh not_active IP Right Cessation
-
2006
- 2006-06-15 IL IL176357A patent/IL176357A/en active IP Right Grant
- 2006-07-14 KR KR1020067014283A patent/KR101174672B1/ko not_active Expired - Lifetime
- 2006-07-18 NO NO20063323A patent/NO337701B1/no unknown
-
2010
- 2010-03-15 US US12/724,203 patent/US8772272B2/en active Active
-
2013
- 2013-03-13 US US13/799,689 patent/US8933067B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004298448B2 (en) | 2010-09-09 |
| TWI347187B (en) | 2011-08-21 |
| DE602004012891D1 (de) | 2008-05-15 |
| KR101174672B1 (ko) | 2012-08-20 |
| US8933067B2 (en) | 2015-01-13 |
| TW200528111A (en) | 2005-09-01 |
| NO337701B1 (no) | 2016-06-06 |
| US8772272B2 (en) | 2014-07-08 |
| EP1697384B1 (en) | 2008-04-02 |
| WO2005058913A1 (en) | 2005-06-30 |
| AU2004298448A1 (en) | 2005-06-30 |
| JP4936897B2 (ja) | 2012-05-23 |
| EA013904B1 (ru) | 2010-08-30 |
| JP2007514712A (ja) | 2007-06-07 |
| KR20060126716A (ko) | 2006-12-08 |
| NO20063323L (no) | 2006-07-18 |
| CA2549869A1 (en) | 2005-06-30 |
| EA200601177A1 (ru) | 2006-10-27 |
| US7799772B2 (en) | 2010-09-21 |
| MY146415A (en) | 2012-08-15 |
| EP1697384A1 (en) | 2006-09-06 |
| CA2549869C (en) | 2015-05-05 |
| IL176357A (en) | 2011-08-31 |
| MXPA06007017A (es) | 2006-08-31 |
| US20130231353A1 (en) | 2013-09-05 |
| HK1099293A1 (zh) | 2007-08-10 |
| DE602004012891T2 (de) | 2009-04-09 |
| ES2305887T3 (es) | 2008-11-01 |
| US20070078132A1 (en) | 2007-04-05 |
| US20100173913A1 (en) | 2010-07-08 |
| IL176357A0 (en) | 2006-10-05 |
| NZ547794A (en) | 2009-11-27 |
| AR046957A1 (es) | 2006-01-04 |
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