UA82847C2 - Derivatives of dioxane-2-alkyl carbamates, method for the preparation thereof and application of same in therapeutics - Google Patents
Derivatives of dioxane-2-alkyl carbamates, method for the preparation thereof and application of same in therapeutics Download PDFInfo
- Publication number
- UA82847C2 UA82847C2 UAA200501766A UA2005001766A UA82847C2 UA 82847 C2 UA82847 C2 UA 82847C2 UA A200501766 A UAA200501766 A UA A200501766A UA 2005001766 A UA2005001766 A UA 2005001766A UA 82847 C2 UA82847 C2 UA 82847C2
- Authority
- UA
- Ukraine
- Prior art keywords
- dioxan
- alkyl
- trans
- general formula
- methoxynaphthalen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 20
- 239000003814 drug Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 76
- -1 trifluoromethoxy, benzyloxy Chemical group 0.000 claims abstract description 60
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 27
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 24
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 19
- 125000005843 halogen group Chemical group 0.000 claims abstract description 17
- 239000012453 solvate Substances 0.000 claims abstract description 17
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims abstract description 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 16
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract description 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 6
- 125000000217 alkyl group Chemical group 0.000 claims description 41
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
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- Virology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
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- Psychiatry (AREA)
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- Dermatology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0210707A FR2843964B1 (fr) | 2002-08-29 | 2002-08-29 | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
| PCT/FR2003/002590 WO2004020430A2 (fr) | 2002-08-29 | 2003-08-27 | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82847C2 true UA82847C2 (en) | 2008-05-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200501766A UA82847C2 (en) | 2002-08-29 | 2003-08-27 | Derivatives of dioxane-2-alkyl carbamates, method for the preparation thereof and application of same in therapeutics |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US7119116B2 (sr) |
| EP (2) | EP1537096B1 (sr) |
| JP (2) | JP4585854B2 (sr) |
| KR (2) | KR101051192B1 (sr) |
| CN (3) | CN101906071A (sr) |
| AR (1) | AR041053A1 (sr) |
| AT (2) | ATE434598T1 (sr) |
| AU (1) | AU2003274292B2 (sr) |
| BR (1) | BR0313846A (sr) |
| CA (2) | CA2700319C (sr) |
| CO (1) | CO5700820A2 (sr) |
| CY (2) | CY1108792T1 (sr) |
| DE (2) | DE60323754D1 (sr) |
| DK (2) | DK1840125T3 (sr) |
| EA (1) | EA008218B1 (sr) |
| ES (2) | ES2312808T3 (sr) |
| FR (1) | FR2843964B1 (sr) |
| HK (2) | HK1074445A1 (sr) |
| HR (2) | HRP20050190B1 (sr) |
| IL (1) | IL166882A (sr) |
| IS (1) | IS2733B (sr) |
| MA (1) | MA27390A1 (sr) |
| ME (2) | MEP24208A (sr) |
| MX (1) | MXPA05002319A (sr) |
| NO (2) | NO331165B1 (sr) |
| NZ (1) | NZ538404A (sr) |
| PL (1) | PL209339B1 (sr) |
| PT (2) | PT1840125E (sr) |
| RS (2) | RS51085B (sr) |
| SI (2) | SI1840125T1 (sr) |
| TN (1) | TNSN05057A1 (sr) |
| TW (2) | TWI337606B (sr) |
| UA (1) | UA82847C2 (sr) |
| WO (1) | WO2004020430A2 (sr) |
| ZA (1) | ZA200501537B (sr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843964B1 (fr) * | 2002-08-29 | 2004-10-01 | Sanofi Synthelabo | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
| US7176201B2 (en) * | 2002-10-07 | 2007-02-13 | The Regents Of The University Of California | Modulation of anxiety through blockade of anandamide hydrolysis |
| FR2854633B1 (fr) * | 2003-05-07 | 2005-06-24 | Sanofi Synthelabo | Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique |
| FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
| FR2866888B1 (fr) * | 2004-02-26 | 2006-05-05 | Sanofi Synthelabo | Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique |
| FR2866885B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique |
| FR2866884B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique |
| FR2866886B1 (fr) | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| US7269708B2 (en) * | 2004-04-20 | 2007-09-11 | Rambus Inc. | Memory controller for non-homogenous memory system |
| US20080103209A1 (en) * | 2004-04-23 | 2008-05-01 | The Regents Of The University Of California | Compounds And Methods For Treating Non-Inflammatory Pain Using Ppar Alpha Agonists |
| DE102004039326A1 (de) * | 2004-08-12 | 2006-02-16 | Abbott Gmbh & Co. Kg | Neue medizinische Verwendungen und Verfahren |
| CA2598294C (en) | 2005-02-17 | 2011-10-18 | Astellas Pharma Inc. | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative |
| FR2885364B1 (fr) * | 2005-05-03 | 2007-06-29 | Sanofi Aventis Sa | Derives d'alkyl-, alkenyl-et alkynylcarbamates, leur preparation et leur application en therapeutique |
| WO2008021625A2 (en) * | 2006-08-18 | 2008-02-21 | N.V. Organon | Combination faah inhibitor and analgesic, anti-inflammatory or anti-pyretic agent |
| WO2008030752A2 (en) * | 2006-09-07 | 2008-03-13 | N.V. Organon | Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo |
| WO2008042892A2 (en) * | 2006-10-02 | 2008-04-10 | N.V. Organon | Fatty acid amide hydrolase inhibitors for energy metabolism disorders |
| EP2096915A1 (en) * | 2006-11-20 | 2009-09-09 | N.V. Organon | Metabolically-stabilized inhibitors of fatty acid amide hydrolase |
| US8207226B1 (en) | 2008-06-03 | 2012-06-26 | Alcon Research, Ltd. | Use of FAAH antagonists for treating dry eye and ocular pain |
| FR2941696B1 (fr) * | 2009-02-05 | 2011-04-15 | Sanofi Aventis | Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
| TW201044234A (en) * | 2009-06-08 | 2010-12-16 | Chunghwa Picture Tubes Ltd | Method of scanning touch panel |
| CN102656172B (zh) | 2009-09-09 | 2016-03-23 | 大日本住友制药株式会社 | 8-氧代二氢嘌呤衍生物 |
| US8274566B2 (en) * | 2009-10-09 | 2012-09-25 | John Mezzalingua Associates, Inc. | Modulation analyzer and level measurement device |
| EP2545914A1 (en) | 2011-07-11 | 2013-01-16 | Sanofi | 2-amino-2-oxoethyl trans-3-[5-(6-methoxy-naphtalen-1-yl)-1,3-dioxan-2-yl]propyl-carbamate for use in the treatment of persistent cancer pain |
| EP2545915A1 (en) | 2011-07-11 | 2013-01-16 | Sanofi | 2-amino-2-oxoethyl trans-3-[5-(6-methoxy-naphtalen-1-yl)-1,3-dioxan-2-yl]propyl-carbamate for use in the treatment of persistent cancer pain |
| CN107982266B (zh) * | 2012-01-06 | 2021-07-30 | H.隆德贝克有限公司 | 氨基甲酸酯化合物及其制备和使用方法 |
| CN114835726B (zh) * | 2022-03-24 | 2024-01-26 | 上海诺精生物科技有限公司 | 一类抑制肿瘤细胞干性的化合物及用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0461958B1 (fr) * | 1990-06-15 | 1994-09-14 | Synthelabo | Dérivés de 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxanes, leur préparation et leur application en thérapeutique |
| US5173506A (en) * | 1990-08-16 | 1992-12-22 | Schering Corporation | N-(mercaptoalkyl)ureas and carbamates |
| FR2742152B1 (fr) * | 1995-12-06 | 1998-01-16 | Synthelabo | Derives de 5-naphtalen-1-yl-1,3-dioxanes, leur preparation et leur application en therapeutique |
| AT403579B (de) * | 1995-12-07 | 1998-03-25 | Agrolinz Melamin Gmbh | Verfahren zur herstellung von hochreinem melamin |
| AU8025198A (en) | 1997-06-05 | 1998-12-21 | Sanofi-Synthelabo | 5-naphthalen-1-yl-1,3-dioxane derivatives, preparation and therapeutic application |
| KR20010087125A (ko) * | 1998-04-16 | 2001-09-15 | 데이비드 비. 맥윌리암스 | 인테그린 수용체에 대한 인테그린의 결합을 억제하는 화합물 |
| FR2816938B1 (fr) | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
| FR2843964B1 (fr) * | 2002-08-29 | 2004-10-01 | Sanofi Synthelabo | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
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2002
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- 2003-08-27 NZ NZ538404A patent/NZ538404A/en not_active IP Right Cessation
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- 2003-08-27 EP EP07013954A patent/EP1840125B1/fr not_active Expired - Lifetime
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- 2003-08-27 WO PCT/FR2003/002590 patent/WO2004020430A2/fr active Application Filing
- 2003-08-27 PL PL375753A patent/PL209339B1/pl unknown
- 2003-08-27 CA CA2496040A patent/CA2496040C/en not_active Expired - Fee Related
- 2003-08-27 PT PT03758282T patent/PT1537096E/pt unknown
- 2003-08-27 DE DE60323754T patent/DE60323754D1/de not_active Expired - Lifetime
- 2003-08-27 RS YUP-2005/0182A patent/RS51085B/sr unknown
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- 2003-08-27 DE DE60328138T patent/DE60328138D1/de not_active Expired - Lifetime
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- 2003-08-27 KR KR1020107028059A patent/KR101139160B1/ko not_active IP Right Cessation
- 2003-08-27 ZA ZA200501537A patent/ZA200501537B/en unknown
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- 2005-02-17 IS IS7699A patent/IS2733B/is unknown
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- 2005-02-25 TN TNP2005000057A patent/TNSN05057A1/fr unknown
- 2005-02-28 MA MA28125A patent/MA27390A1/fr unknown
- 2005-02-28 HR HRP20050190AA patent/HRP20050190B1/hr not_active IP Right Cessation
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2006
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