UA80591C2 - C-6 modificated indazolilpyrrolotriazines, pharmaceutical composition upon their base and method of the treatment - Google Patents

Info

Publication number

UA80591C2

UA80591C2 UAA200506891A UA2005006891A UA80591C2 UA 80591 C2 UA80591 C2 UA 80591C2 UA A200506891 A UAA200506891 A UA A200506891A UA 2005006891 A UA2005006891 A UA 2005006891A UA 80591 C2 UA80591 C2 UA 80591C2

Authority

UA

Ukraine

Prior art keywords

ester

carbamic acid

indazol

ethyl

pyrrolo

Prior art date

2002-12-13

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 title claims description 44
• 239000008194 pharmaceutical composition Substances 0.000 title claims description 12
• 150000001875 compounds Chemical class 0.000 claims abstract description 111
• 150000003839 salts Chemical class 0.000 claims abstract description 18
• 201000010099 disease Diseases 0.000 claims abstract description 17
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
• 230000000694 effects Effects 0.000 claims abstract description 16
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• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims abstract description 9
• 230000019491 signal transduction Effects 0.000 claims abstract description 6
• -1 1-(2-thienylmethyl)-1H- indazol-5-ylamino Chemical group 0.000 claims description 194
• 150000002148 esters Chemical class 0.000 claims description 88
• 239000002253 acid Substances 0.000 claims description 45
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 43
• 125000000217 alkyl group Chemical group 0.000 claims description 28
• 125000003118 aryl group Chemical group 0.000 claims description 27
• 206010028980 Neoplasm Diseases 0.000 claims description 22
• 102000005962 receptors Human genes 0.000 claims description 21
• 108020003175 receptors Proteins 0.000 claims description 21
• 125000003107 substituted aryl group Chemical group 0.000 claims description 17
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 14
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• 239000001257 hydrogen Substances 0.000 claims description 11
• 229910052739 hydrogen Inorganic materials 0.000 claims description 11
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