UA80295C2 - Pyrazolopyridines and using the same - Google Patents
Pyrazolopyridines and using the same Download PDFInfo
- Publication number
- UA80295C2 UA80295C2 UAA200503095A UA2005003095A UA80295C2 UA 80295 C2 UA80295 C2 UA 80295C2 UA A200503095 A UAA200503095 A UA A200503095A UA 2005003095 A UA2005003095 A UA 2005003095A UA 80295 C2 UA80295 C2 UA 80295C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- heterocycloalkyl
- heteroaryl
- formula
- compound according
- Prior art date
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- 229910052759 nickel Inorganic materials 0.000 description 1
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- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000026341 positive regulation of angiogenesis Effects 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- NDRLPYIMWROJBG-UHFFFAOYSA-M pyridin-1-ium-1-amine;iodide Chemical compound [I-].N[N+]1=CC=CC=C1 NDRLPYIMWROJBG-UHFFFAOYSA-M 0.000 description 1
- MISVBCMQSJUHMH-UHFFFAOYSA-N pyrimidine-4,6-diamine Chemical group NC1=CC(N)=NC=N1 MISVBCMQSJUHMH-UHFFFAOYSA-N 0.000 description 1
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- 150000003384 small molecules Chemical class 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- SETMGIIITGNLAS-UHFFFAOYSA-N spizofurone Chemical compound O=C1C2=CC(C(=O)C)=CC=C2OC21CC2 SETMGIIITGNLAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
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- Dermatology (AREA)
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- Ophthalmology & Optometry (AREA)
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- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
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US40881102P | 2002-09-06 | 2002-09-06 | |
PCT/US2003/027722 WO2004022054A1 (en) | 2002-09-06 | 2003-09-05 | Pyrazolopyridines and methods of making and using the same |
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UAA200503095A UA80295C2 (en) | 2002-09-06 | 2003-05-09 | Pyrazolopyridines and using the same |
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US (1) | US7691865B2 (no) |
EP (1) | EP1551398A4 (no) |
JP (1) | JP2006502165A (no) |
KR (1) | KR20050057235A (no) |
CN (1) | CN1694698A (no) |
AR (1) | AR041207A1 (no) |
AU (1) | AU2003268447B2 (no) |
BR (1) | BR0314053A (no) |
CA (1) | CA2497970A1 (no) |
EA (1) | EA009441B1 (no) |
GE (1) | GEP20074125B (no) |
IS (2) | IS7725A (no) |
MX (1) | MXPA05002443A (no) |
NO (1) | NO20051503L (no) |
NZ (1) | NZ539069A (no) |
PL (1) | PL375699A1 (no) |
RS (1) | RS20050200A (no) |
UA (1) | UA80295C2 (no) |
WO (1) | WO2004022054A1 (no) |
ZA (1) | ZA200501856B (no) |
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WO2006004194A1 (ja) * | 2004-07-02 | 2006-01-12 | Nishimoto, Tomo | TGFβ2を標的としたアルツハイマー病治療薬のスクリーニング法 |
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EP1873157A1 (en) * | 2006-06-21 | 2008-01-02 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
US8642034B2 (en) | 2006-10-03 | 2014-02-04 | Genzyme Corporation | Use of TGF-β antagonists to treat infants at risk of developing bronchopulmonary dysplasia |
JP2010540451A (ja) * | 2007-09-20 | 2010-12-24 | ワイス・エルエルシー | ピラゾロ[5,1−c][1,2,4]トリアジン、その調製法および使用法 |
KR20100135255A (ko) * | 2008-03-14 | 2010-12-24 | 오츠카 세이야쿠 가부시키가이샤 | Mmp-2 및/또는 mmp-9 저해제 |
CN101544634B (zh) * | 2008-03-27 | 2011-08-10 | 天津药物研究院 | 2-苯基-3-取代吡唑并[1,5-a]吡啶类衍生物及其制备方法和用途 |
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EP2402344A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole fused bicyclic compounds |
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CN106132967B (zh) * | 2014-03-27 | 2019-05-28 | 詹森药业有限公司 | 作为ros1抑制剂的化合物 |
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JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
JP2023509760A (ja) | 2020-01-08 | 2023-03-09 | シンシス セラピューティクス,インコーポレイテッド | Alk5阻害剤複合体およびその使用 |
CN112707902B (zh) * | 2020-03-23 | 2022-04-15 | 杭州阿诺生物医药科技有限公司 | TGF-β受体抑制剂 |
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-
2003
- 2003-05-09 UA UAA200503095A patent/UA80295C2/uk unknown
- 2003-09-05 KR KR1020057003874A patent/KR20050057235A/ko not_active Application Discontinuation
- 2003-09-05 MX MXPA05002443A patent/MXPA05002443A/es active IP Right Grant
- 2003-09-05 RS YUP-2005/0200A patent/RS20050200A/sr unknown
- 2003-09-05 BR BR0314053-9A patent/BR0314053A/pt not_active IP Right Cessation
- 2003-09-05 WO PCT/US2003/027722 patent/WO2004022054A1/en active Application Filing
- 2003-09-05 NZ NZ539069A patent/NZ539069A/en unknown
- 2003-09-05 US US10/526,839 patent/US7691865B2/en not_active Expired - Fee Related
- 2003-09-05 EA EA200500450A patent/EA009441B1/ru not_active IP Right Cessation
- 2003-09-05 CA CA002497970A patent/CA2497970A1/en not_active Abandoned
- 2003-09-05 AU AU2003268447A patent/AU2003268447B2/en not_active Ceased
- 2003-09-05 JP JP2004534571A patent/JP2006502165A/ja active Pending
- 2003-09-05 GE GEAP20038727A patent/GEP20074125B/en unknown
- 2003-09-05 EP EP03749412A patent/EP1551398A4/en not_active Withdrawn
- 2003-09-05 CN CNA038248670A patent/CN1694698A/zh active Pending
- 2003-09-05 PL PL03375699A patent/PL375699A1/xx not_active Application Discontinuation
- 2003-09-08 AR ARP030103250A patent/AR041207A1/es unknown
-
2005
- 2005-03-03 ZA ZA200501856A patent/ZA200501856B/en unknown
- 2005-03-04 IS IS7725A patent/IS7725A/is unknown
- 2005-03-04 IS IS7726A patent/IS7726A/is unknown
- 2005-03-21 NO NO20051503A patent/NO20051503L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2004022054A1 (en) | 2004-03-18 |
BR0314053A (pt) | 2005-07-19 |
RS20050200A (en) | 2007-08-03 |
US7691865B2 (en) | 2010-04-06 |
IS7725A (is) | 2005-03-04 |
CA2497970A1 (en) | 2004-03-18 |
AU2003268447B2 (en) | 2008-07-24 |
KR20050057235A (ko) | 2005-06-16 |
AR041207A1 (es) | 2005-05-11 |
NZ539069A (en) | 2007-03-30 |
IS7726A (is) | 2005-03-04 |
EA200500450A1 (ru) | 2005-08-25 |
AU2003268447A1 (en) | 2004-03-29 |
EP1551398A4 (en) | 2006-06-07 |
PL375699A1 (en) | 2005-12-12 |
JP2006502165A (ja) | 2006-01-19 |
MXPA05002443A (es) | 2005-09-30 |
GEP20074125B (en) | 2007-06-11 |
NO20051503D0 (no) | 2005-03-21 |
EA009441B1 (ru) | 2007-12-28 |
US20060106033A1 (en) | 2006-05-18 |
EP1551398A1 (en) | 2005-07-13 |
CN1694698A (zh) | 2005-11-09 |
NO20051503L (no) | 2005-03-21 |
ZA200501856B (en) | 2006-04-26 |
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