UA79070C2 - Novel lhrh-antagonists, production and use thereof as medicament - Google Patents
Novel lhrh-antagonists, production and use thereof as medicament Download PDFInfo
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- UA79070C2 UA79070C2 UA2002108075A UA2002108075A UA79070C2 UA 79070 C2 UA79070 C2 UA 79070C2 UA 2002108075 A UA2002108075 A UA 2002108075A UA 2002108075 A UA2002108075 A UA 2002108075A UA 79070 C2 UA79070 C2 UA 79070C2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000007864 suspending Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/525,007 US6627609B1 (en) | 1999-03-17 | 2000-03-14 | LHRH antagonists having improved solubility properties |
| PCT/EP2001/002719 WO2001068676A2 (de) | 2000-03-14 | 2001-03-12 | Lh-rh-antagonisten, deren herstellung und verwendung als arzeimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA79070C2 true UA79070C2 (en) | 2007-05-25 |
Family
ID=24091545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002108075A UA79070C2 (en) | 2000-03-14 | 2001-12-03 | Novel lhrh-antagonists, production and use thereof as medicament |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1268522B1 (es) |
| JP (1) | JP3805679B2 (es) |
| KR (1) | KR100607396B1 (es) |
| CN (2) | CN1443195A (es) |
| AT (1) | ATE408619T1 (es) |
| AU (2) | AU6011001A (es) |
| BG (1) | BG107121A (es) |
| BR (1) | BR0109279A (es) |
| CA (1) | CA2402193C (es) |
| DE (1) | DE50114335D1 (es) |
| DK (1) | DK1268522T3 (es) |
| ES (1) | ES2312435T3 (es) |
| HR (1) | HRP20020810A2 (es) |
| HU (1) | HUP0300222A3 (es) |
| IL (1) | IL151647A0 (es) |
| MX (1) | MXPA02008870A (es) |
| NO (1) | NO20024363L (es) |
| NZ (1) | NZ521273A (es) |
| PL (1) | PL357999A1 (es) |
| PT (1) | PT1268522E (es) |
| RU (1) | RU2248982C9 (es) |
| SK (1) | SK14332002A3 (es) |
| UA (1) | UA79070C2 (es) |
| WO (1) | WO2001068676A2 (es) |
| ZA (1) | ZA200207248B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340572C (zh) * | 2004-12-01 | 2007-10-03 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的lhrh拮抗剂 |
| CN101037472B (zh) * | 2006-03-14 | 2013-03-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 具有低组胺释放作用的促黄体生成素释放激素拮抗剂 |
| DK2252627T3 (en) | 2008-01-24 | 2017-08-14 | Esperance Pharmaceuticals | MERGER CONSTRUCTION WITH LYTIC DOMAIN AND METHOD FOR PRODUCING AND USING SAME. |
| CN101597321B (zh) * | 2008-06-03 | 2013-04-24 | 中国人民解放军军事医学科学院毒物药物研究所 | 长效低组胺释放副作用的lhrh拮抗剂 |
| WO2010142060A1 (zh) * | 2009-06-11 | 2010-12-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 长效低组胺释放副作用的lhrh拮抗剂 |
| AU2013337926B2 (en) | 2012-10-30 | 2017-12-21 | Esperance Pharmaceuticals, Inc. | Antibody/drug conjugates and methods of use |
| CN104418936B (zh) * | 2013-08-20 | 2018-06-05 | 中国人民解放军军事医学科学院毒物药物研究所 | Lhrh拮抗剂衍生物及其药物用途 |
| FR3024612B1 (fr) * | 2014-08-04 | 2018-03-09 | Alstom Transp Tech | Module d'alimentation electrique d'un bloc moteur, systeme de traction et vehicule electrique associe |
| RU2585367C1 (ru) * | 2014-11-05 | 2016-05-27 | Наталья Владимировна Спиридонова | Способ лечения бесплодия у женщин с миомой матки |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300492A (en) | 1988-02-10 | 1994-04-05 | Tap Pharmaceuticals | LHRH analogs |
| US5140009A (en) | 1988-02-10 | 1992-08-18 | Tap Pharmaceuticals, Inc. | Octapeptide LHRH antagonists |
| US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| IL101074A (en) | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
| ATE144538T1 (de) | 1991-04-25 | 1996-11-15 | Romano Deghenghi | Lhrh-antagonisten |
| WO1994013313A1 (en) | 1992-12-04 | 1994-06-23 | Abbott Laboratories | 6-position modified decapeptide lhrh antagonists |
| JP3568952B2 (ja) | 1992-12-18 | 2004-09-22 | アボット・ラボラトリーズ | ５位及び６位に修飾アミノアシル残基を有するｌｈｒｈ拮抗薬 |
| IL108509A0 (en) | 1993-02-22 | 1994-05-30 | Salk Inst For Biological Studi | GnRH antagonist peptides |
| DE4320201A1 (de) * | 1993-06-18 | 1995-01-12 | Asta Medica Ag | Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation |
| DE19544212A1 (de) * | 1995-11-28 | 1997-06-05 | Asta Medica Ag | Neue LH-RH-Antagonisten mit verbesserter Wirkung |
| DE19911771B4 (de) | 1999-03-17 | 2006-03-30 | Zentaris Gmbh | LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung |
-
2001
- 2001-03-12 EP EP01933682A patent/EP1268522B1/de not_active Expired - Lifetime
- 2001-03-12 MX MXPA02008870A patent/MXPA02008870A/es active IP Right Grant
- 2001-03-12 CN CN01807543A patent/CN1443195A/zh active Pending
- 2001-03-12 SK SK1433-2002A patent/SK14332002A3/sk not_active Application Discontinuation
- 2001-03-12 HU HU0300222A patent/HUP0300222A3/hu unknown
- 2001-03-12 WO PCT/EP2001/002719 patent/WO2001068676A2/de active IP Right Grant
- 2001-03-12 BR BR0109279-0A patent/BR0109279A/pt not_active IP Right Cessation
- 2001-03-12 DK DK01933682T patent/DK1268522T3/da active
- 2001-03-12 NZ NZ521273A patent/NZ521273A/en unknown
- 2001-03-12 JP JP2001567766A patent/JP3805679B2/ja not_active Expired - Lifetime
- 2001-03-12 PT PT01933682T patent/PT1268522E/pt unknown
- 2001-03-12 PL PL01357999A patent/PL357999A1/xx unknown
- 2001-03-12 DE DE50114335T patent/DE50114335D1/de not_active Expired - Fee Related
- 2001-03-12 AU AU6011001A patent/AU6011001A/xx active Pending
- 2001-03-12 ES ES01933682T patent/ES2312435T3/es not_active Expired - Lifetime
- 2001-03-12 CA CA2402193A patent/CA2402193C/en not_active Expired - Lifetime
- 2001-03-12 AT AT01933682T patent/ATE408619T1/de not_active IP Right Cessation
- 2001-03-12 AU AU2001260110A patent/AU2001260110B2/en not_active Ceased
- 2001-03-12 IL IL15164701A patent/IL151647A0/xx unknown
- 2001-03-12 KR KR1020027012059A patent/KR100607396B1/ko active IP Right Grant
- 2001-03-12 CN CNB2006100817821A patent/CN100500692C/zh not_active Expired - Fee Related
- 2001-03-12 RU RU2002127786/04A patent/RU2248982C9/ru active
- 2001-12-03 UA UA2002108075A patent/UA79070C2/uk unknown
-
2002
- 2002-09-10 ZA ZA200207248A patent/ZA200207248B/en unknown
- 2002-09-12 NO NO20024363A patent/NO20024363L/no not_active Application Discontinuation
- 2002-09-18 BG BG107121A patent/BG107121A/bg unknown
- 2002-10-10 HR HRP20020810 patent/HRP20020810A2/hr not_active Application Discontinuation
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