UA77984C2 - Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants) - Google Patents
Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants) Download PDFInfo
- Publication number
- UA77984C2 UA77984C2 UA20040503612A UA20040503612A UA77984C2 UA 77984 C2 UA77984 C2 UA 77984C2 UA 20040503612 A UA20040503612 A UA 20040503612A UA 20040503612 A UA20040503612 A UA 20040503612A UA 77984 C2 UA77984 C2 UA 77984C2
- Authority
- UA
- Ukraine
- Prior art keywords
- general formula
- alkyl
- oxo
- dihydro
- carboxamide
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 17
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
- 239000000543 intermediate Substances 0.000 title abstract description 9
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- 238000003786 synthesis reaction Methods 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 101
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 37
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- -1 1-oxidopyndinyl Chemical group 0.000 claims abstract description 19
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- 125000002098 pyridazinyl group Chemical group 0.000 claims abstract description 10
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 10
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims abstract description 10
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- CQILOHWHIWNQOE-UHFFFAOYSA-N indole-1-carboxamide Chemical compound C1=CC=C2N(C(=O)N)C=CC2=C1 CQILOHWHIWNQOE-UHFFFAOYSA-N 0.000 claims description 32
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- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116701A FR2833953B1 (fr) | 2001-12-21 | 2001-12-21 | DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| PCT/FR2002/003979 WO2003055884A1 (fr) | 2001-12-21 | 2002-11-20 | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77984C2 true UA77984C2 (en) | 2007-02-15 |
Family
ID=8870861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040503612A UA77984C2 (en) | 2001-12-21 | 2002-11-20 | Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants) |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US7109194B2 (fr) |
| EP (1) | EP1458721B1 (fr) |
| JP (1) | JP5087204B2 (fr) |
| KR (1) | KR100936565B1 (fr) |
| CN (1) | CN100376579C (fr) |
| AR (1) | AR038024A1 (fr) |
| AT (1) | ATE346069T1 (fr) |
| AU (1) | AU2002361325B2 (fr) |
| BR (1) | BR0215174A (fr) |
| CA (1) | CA2465750C (fr) |
| CY (1) | CY1106029T1 (fr) |
| DE (1) | DE60216321T2 (fr) |
| DK (1) | DK1458721T3 (fr) |
| EA (1) | EA006251B1 (fr) |
| ES (1) | ES2276978T3 (fr) |
| FR (1) | FR2833953B1 (fr) |
| HK (1) | HK1065792A1 (fr) |
| HR (1) | HRP20040549B1 (fr) |
| HU (1) | HU229419B1 (fr) |
| IL (2) | IL161859A0 (fr) |
| IS (1) | IS2380B (fr) |
| ME (2) | ME00117B (fr) |
| MX (1) | MXPA04006144A (fr) |
| NO (1) | NO328587B1 (fr) |
| NZ (1) | NZ532996A (fr) |
| PL (1) | PL371201A1 (fr) |
| PT (1) | PT1458721E (fr) |
| RS (1) | RS51103B (fr) |
| SI (1) | SI1458721T1 (fr) |
| TW (1) | TWI275391B (fr) |
| UA (1) | UA77984C2 (fr) |
| WO (1) | WO2003055884A1 (fr) |
| ZA (1) | ZA200404245B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6278893B1 (en) | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| FR2838124B1 (fr) * | 2002-04-03 | 2004-05-28 | Sanofi Synthelabo | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique |
| US7732447B2 (en) * | 2006-06-22 | 2010-06-08 | Cephalon, Inc. | Fused [d]pyridazin-7-ones |
| CN1995041B (zh) * | 2006-12-18 | 2012-06-27 | 沈阳药科大学 | 哒嗪并吲哚类衍生物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
| FR2811990A1 (fr) * | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
2001
- 2001-12-21 FR FR0116701A patent/FR2833953B1/fr not_active Expired - Fee Related
-
2002
- 2002-11-20 EP EP02796852A patent/EP1458721B1/fr not_active Expired - Lifetime
- 2002-11-20 CA CA2465750A patent/CA2465750C/fr not_active Expired - Fee Related
- 2002-11-20 WO PCT/FR2002/003979 patent/WO2003055884A1/fr active IP Right Grant
- 2002-11-20 SI SI200230482T patent/SI1458721T1/sl unknown
- 2002-11-20 PL PL02371201A patent/PL371201A1/xx unknown
- 2002-11-20 ES ES02796852T patent/ES2276978T3/es not_active Expired - Lifetime
- 2002-11-20 AT AT02796852T patent/ATE346069T1/de active
- 2002-11-20 AU AU2002361325A patent/AU2002361325B2/en not_active Ceased
- 2002-11-20 MX MXPA04006144A patent/MXPA04006144A/es active IP Right Grant
- 2002-11-20 ME MEP-2008-224A patent/ME00117B/me unknown
- 2002-11-20 RS YUP-503/04A patent/RS51103B/sr unknown
- 2002-11-20 JP JP2003556414A patent/JP5087204B2/ja not_active Expired - Fee Related
- 2002-11-20 CN CNB028253353A patent/CN100376579C/zh not_active Expired - Fee Related
- 2002-11-20 DE DE60216321T patent/DE60216321T2/de not_active Expired - Lifetime
- 2002-11-20 PT PT02796852T patent/PT1458721E/pt unknown
- 2002-11-20 DK DK02796852T patent/DK1458721T3/da active
- 2002-11-20 BR BR0215174-0A patent/BR0215174A/pt not_active IP Right Cessation
- 2002-11-20 ME MEP-224/08A patent/MEP22408A/xx unknown
- 2002-11-20 KR KR1020047009601A patent/KR100936565B1/ko not_active IP Right Cessation
- 2002-11-20 US US10/499,725 patent/US7109194B2/en not_active Expired - Lifetime
- 2002-11-20 EA EA200400560A patent/EA006251B1/ru not_active IP Right Cessation
- 2002-11-20 IL IL16185902A patent/IL161859A0/xx unknown
- 2002-11-20 UA UA20040503612A patent/UA77984C2/uk unknown
- 2002-11-20 NZ NZ532996A patent/NZ532996A/en not_active IP Right Cessation
- 2002-11-20 HU HU0402578A patent/HU229419B1/hu not_active IP Right Cessation
- 2002-12-18 TW TW091136504A patent/TWI275391B/zh not_active IP Right Cessation
- 2002-12-18 AR ARP020104928A patent/AR038024A1/es active IP Right Grant
-
2004
- 2004-05-06 IL IL161859A patent/IL161859A/en not_active IP Right Cessation
- 2004-05-10 IS IS7259A patent/IS2380B/is unknown
- 2004-05-31 ZA ZA2004/04245A patent/ZA200404245B/en unknown
- 2004-06-16 HR HRP20040549AA patent/HRP20040549B1/hr not_active IP Right Cessation
- 2004-06-17 NO NO20042536A patent/NO328587B1/no not_active IP Right Cessation
- 2004-11-01 HK HK04108556A patent/HK1065792A1/xx not_active IP Right Cessation
-
2006
- 2006-06-29 US US11/427,508 patent/US7402682B2/en not_active Expired - Fee Related
-
2007
- 2007-02-20 CY CY20071100220T patent/CY1106029T1/el unknown
-
2008
- 2008-06-17 US US12/140,608 patent/US7569567B2/en not_active Expired - Fee Related
-
2009
- 2009-06-19 US US12/487,902 patent/US20090275576A1/en not_active Abandoned
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