EA200400560A1 - ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-КАРБОКСАМИДА, ИХ ПОЛУЧЕНИЕ И ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ - Google Patents

ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-КАРБОКСАМИДА, ИХ ПОЛУЧЕНИЕ И ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ

Info

Publication number
EA200400560A1
EA200400560A1 EA200400560A EA200400560A EA200400560A1 EA 200400560 A1 EA200400560 A1 EA 200400560A1 EA 200400560 A EA200400560 A EA 200400560A EA 200400560 A EA200400560 A EA 200400560A EA 200400560 A1 EA200400560 A1 EA 200400560A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
group
heteroaril
pyridazino
indol
Prior art date
Application number
EA200400560A
Other languages
English (en)
Other versions
EA006251B1 (ru
Inventor
Филипп Бурнье
Жак Фруассан
Бенуа Марабу
Франк Марге
Фредерик Пеш
Original Assignee
Санофи-Синтелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Синтелябо filed Critical Санофи-Синтелябо
Publication of EA200400560A1 publication Critical patent/EA200400560A1/ru
Publication of EA006251B1 publication Critical patent/EA006251B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к соединениям общей формулы (I), где X представляет собой атом водорода или галогена; Rпредставляет собой атом водорода или (C-C)алкильную группу; Rи R, каждый, независимо друг от друга, представляют собой атом водорода или (C-C)алкильную группу или же Rи Rобразуют с атомом, который их несет, пирролидинильную, пиперидинильную, морфолинильную или 4-алкилпиперазинильную группу; и Het представляет собой гетероароматическую группу пиридинильного, 1-оксидопиридинильного, хинолинильного, изохинолинильного, пиримидинильного, пиразинильного, пиридазинильного типа, причем гетероароматическая группа может нести один или более чем один атом галогена и/или одну или более чем одну (C-C)алкильную или (C-C)алкоксигруппу; в форме оснований, солей присоединения кислот, сольватов или гидратов. Данное изобретение также относится к фармацевтическим композициям, содержащим такие соединения, к способам получения таких соединений и к промежуточным соединениям их синтеза.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400560A 2001-12-21 2002-11-20 ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-КАРБОКСАМИДА, ИХ ПОЛУЧЕНИЕ И ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ EA006251B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116701A FR2833953B1 (fr) 2001-12-21 2001-12-21 DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR2002/003979 WO2003055884A1 (fr) 2001-12-21 2002-11-20 Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
EA200400560A1 true EA200400560A1 (ru) 2004-12-30
EA006251B1 EA006251B1 (ru) 2005-10-27

Family

ID=8870861

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400560A EA006251B1 (ru) 2001-12-21 2002-11-20 ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-КАРБОКСАМИДА, ИХ ПОЛУЧЕНИЕ И ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ

Country Status (33)

Country Link
US (4) US7109194B2 (ru)
EP (1) EP1458721B1 (ru)
JP (1) JP5087204B2 (ru)
KR (1) KR100936565B1 (ru)
CN (1) CN100376579C (ru)
AR (1) AR038024A1 (ru)
AT (1) ATE346069T1 (ru)
AU (1) AU2002361325B2 (ru)
BR (1) BR0215174A (ru)
CA (1) CA2465750C (ru)
CY (1) CY1106029T1 (ru)
DE (1) DE60216321T2 (ru)
DK (1) DK1458721T3 (ru)
EA (1) EA006251B1 (ru)
ES (1) ES2276978T3 (ru)
FR (1) FR2833953B1 (ru)
HK (1) HK1065792A1 (ru)
HR (1) HRP20040549B1 (ru)
HU (1) HU229419B1 (ru)
IL (2) IL161859A0 (ru)
IS (1) IS2380B (ru)
ME (2) ME00117B (ru)
MX (1) MXPA04006144A (ru)
NO (1) NO328587B1 (ru)
NZ (1) NZ532996A (ru)
PL (1) PL371201A1 (ru)
PT (1) PT1458721E (ru)
RS (1) RS51103B (ru)
SI (1) SI1458721T1 (ru)
TW (1) TWI275391B (ru)
UA (1) UA77984C2 (ru)
WO (1) WO2003055884A1 (ru)
ZA (1) ZA200404245B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
US7732447B2 (en) * 2006-06-22 2010-06-08 Cephalon, Inc. Fused [d]pyridazin-7-ones
CN1995041B (zh) * 2006-12-18 2012-06-27 沈阳药科大学 哒嗪并吲哚类衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
AU2002361325B2 (en) 2008-10-02
IL161859A (en) 2009-11-18
EP1458721B1 (fr) 2006-11-22
WO2003055884A1 (fr) 2003-07-10
NO20042536L (no) 2004-09-21
KR100936565B1 (ko) 2010-01-13
TW200301120A (en) 2003-07-01
EP1458721A1 (fr) 2004-09-22
FR2833953A1 (fr) 2003-06-27
RS51103B (sr) 2010-10-31
EA006251B1 (ru) 2005-10-27
ATE346069T1 (de) 2006-12-15
ES2276978T3 (es) 2007-07-01
US20050096321A1 (en) 2005-05-05
CN100376579C (zh) 2008-03-26
US20060241116A1 (en) 2006-10-26
IS7259A (is) 2004-05-10
HK1065792A1 (en) 2005-03-04
DE60216321T2 (de) 2007-06-21
US7402682B2 (en) 2008-07-22
PL371201A1 (en) 2005-06-13
US20080249098A1 (en) 2008-10-09
PT1458721E (pt) 2007-02-28
BR0215174A (pt) 2004-11-30
JP5087204B2 (ja) 2012-12-05
US7569567B2 (en) 2009-08-04
DK1458721T3 (da) 2007-03-26
HU229419B1 (en) 2013-12-30
KR20040068958A (ko) 2004-08-02
IL161859A0 (en) 2005-11-20
UA77984C2 (en) 2007-02-15
HRP20040549A2 (en) 2004-10-31
MXPA04006144A (es) 2004-11-01
CA2465750C (en) 2011-05-31
CA2465750A1 (en) 2003-07-10
IS2380B (is) 2008-07-15
DE60216321D1 (de) 2007-01-04
SI1458721T1 (sl) 2007-04-30
US7109194B2 (en) 2006-09-19
CY1106029T1 (el) 2011-04-06
TWI275391B (en) 2007-03-11
JP2005513158A (ja) 2005-05-12
MEP22408A (en) 2010-06-10
US20090275576A1 (en) 2009-11-05
AR038024A1 (es) 2004-12-22
ZA200404245B (en) 2005-08-31
AU2002361325A1 (en) 2003-07-15
HRP20040549B1 (hr) 2012-10-31
CN1604898A (zh) 2005-04-06
HUP0402578A3 (en) 2009-01-28
ME00117B (me) 2010-06-10
NZ532996A (en) 2006-11-30
FR2833953B1 (fr) 2004-12-03
RS50304A (en) 2006-12-15
HUP0402578A2 (hu) 2005-03-29
NO328587B1 (no) 2010-03-22

Similar Documents

Publication Publication Date Title
HRP20020712B1 (hr) Farmaceutske strukture koje sadrže derivate azetidina, novi derivati azetidina i njihovo pripremanje
WO2003080580A3 (en) Quinoline derivatives and their use as 5-ht6 ligands
CA2297326A1 (en) Heterocyclic compound and antitumor agent containing the same as active component
MY121778A (en) Benzosulfone derivatives
HUT40790A (en) Process for producing 2-/4-benzoyl-1-piperidinyl/-1-phenyl-alkanol derivatives and pharmaceutical compositions containing them
EA200100710A1 (ru) 4-(аминометил)пиперидинбензамиды для лечения желудочно-кишечных расстройств
EP0309422A3 (en) New amidino tricycle derivatives
TR200101711T2 (tr) Antihistaminik spiro bileşikler.
EA200400560A1 (ru) ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-КАРБОКСАМИДА, ИХ ПОЛУЧЕНИЕ И ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
BR0115480A (pt) Derivados de pirimidina
HK1102371A1 (en) Intermediate compound of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5- b]indole-1-acetamide derivatives
RS50921B (sr) Derivati 5-(piridin-3-il)-1-azabiciklo(3.2.1.)oktana, njihova priprema i terapeutska primena
AP1396A (en) 1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives.
EA200400470A1 (ru) Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции
UA72934C2 (ru) Translated By PlajФЕНИЛ- И ПИРИДИЛТЕТРАГИДРОПИРИДИНЫ, КОТОРЫЕ ИНГИБИРУЮТ ФАКТОР НЕКРОЗА ОПУХОЛЕЙ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
DE3470039D1 (en) 2-aminoethyl pyridine or pyrazine derivatives, their preparation and pharmaceutical compositions containing them
CO5631444A2 (es) Derivados 3-heteroaril-3,5-dihidro-4-oxo-4h-piridazino [4,5- b] indol-1-ecetamida
DK624086A (da) 6h-isoxazolo(3,4-d)pyrazolo(3,4-b)pyridiner eller farmaceutisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse som anxiolytika

Legal Events

Date Code Title Description
HC1A Change in name of an applicant in a eurasian application
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU