IL161859A0 - 3-Heteroaryl-3.5-dihydro-4-oxo-4H-pyridazinoÄ4.5-BÜindole-1-carboxamide derivatives, their preparation and therapeutic use - Google Patents

3-Heteroaryl-3.5-dihydro-4-oxo-4H-pyridazinoÄ4.5-BÜindole-1-carboxamide derivatives, their preparation and therapeutic use

Info

Publication number
IL161859A0
IL161859A0 IL16185902A IL16185902A IL161859A0 IL 161859 A0 IL161859 A0 IL 161859A0 IL 16185902 A IL16185902 A IL 16185902A IL 16185902 A IL16185902 A IL 16185902A IL 161859 A0 IL161859 A0 IL 161859A0
Authority
IL
Israel
Prior art keywords
büindole
dihydro
heteroaryl
oxo
preparation
Prior art date
Application number
IL16185902A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of IL161859A0 publication Critical patent/IL161859A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL16185902A 2001-12-21 2002-11-20 3-Heteroaryl-3.5-dihydro-4-oxo-4H-pyridazinoÄ4.5-BÜindole-1-carboxamide derivatives, their preparation and therapeutic use IL161859A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116701A FR2833953B1 (fr) 2001-12-21 2001-12-21 DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR2002/003979 WO2003055884A1 (fr) 2001-12-21 2002-11-20 Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
IL161859A0 true IL161859A0 (en) 2005-11-20

Family

ID=8870861

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16185902A IL161859A0 (en) 2001-12-21 2002-11-20 3-Heteroaryl-3.5-dihydro-4-oxo-4H-pyridazinoÄ4.5-BÜindole-1-carboxamide derivatives, their preparation and therapeutic use
IL161859A IL161859A (en) 2001-12-21 2004-05-06 Derivatives of 3 - Troaril - 3,5 - Dihydro - 4 - Oxy - H 4 - Pyridazine [B - 4.5] Indole - 1 - Carboxamide, their preparation and medical use

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL161859A IL161859A (en) 2001-12-21 2004-05-06 Derivatives of 3 - Troaril - 3,5 - Dihydro - 4 - Oxy - H 4 - Pyridazine [B - 4.5] Indole - 1 - Carboxamide, their preparation and medical use

Country Status (33)

Country Link
US (4) US7109194B2 (xx)
EP (1) EP1458721B1 (xx)
JP (1) JP5087204B2 (xx)
KR (1) KR100936565B1 (xx)
CN (1) CN100376579C (xx)
AR (1) AR038024A1 (xx)
AT (1) ATE346069T1 (xx)
AU (1) AU2002361325B2 (xx)
BR (1) BR0215174A (xx)
CA (1) CA2465750C (xx)
CY (1) CY1106029T1 (xx)
DE (1) DE60216321T2 (xx)
DK (1) DK1458721T3 (xx)
EA (1) EA006251B1 (xx)
ES (1) ES2276978T3 (xx)
FR (1) FR2833953B1 (xx)
HK (1) HK1065792A1 (xx)
HR (1) HRP20040549B1 (xx)
HU (1) HU229419B1 (xx)
IL (2) IL161859A0 (xx)
IS (1) IS2380B (xx)
ME (2) ME00117B (xx)
MX (1) MXPA04006144A (xx)
NO (1) NO328587B1 (xx)
NZ (1) NZ532996A (xx)
PL (1) PL371201A1 (xx)
PT (1) PT1458721E (xx)
RS (1) RS51103B (xx)
SI (1) SI1458721T1 (xx)
TW (1) TWI275391B (xx)
UA (1) UA77984C2 (xx)
WO (1) WO2003055884A1 (xx)
ZA (1) ZA200404245B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
US7732447B2 (en) * 2006-06-22 2010-06-08 Cephalon, Inc. Fused [d]pyridazin-7-ones
CN1995041B (zh) * 2006-12-18 2012-06-27 沈阳药科大学 哒嗪并吲哚类衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
AU2002361325B2 (en) 2008-10-02
IL161859A (en) 2009-11-18
EP1458721B1 (fr) 2006-11-22
WO2003055884A1 (fr) 2003-07-10
NO20042536L (no) 2004-09-21
KR100936565B1 (ko) 2010-01-13
TW200301120A (en) 2003-07-01
EP1458721A1 (fr) 2004-09-22
FR2833953A1 (fr) 2003-06-27
RS51103B (sr) 2010-10-31
EA006251B1 (ru) 2005-10-27
ATE346069T1 (de) 2006-12-15
ES2276978T3 (es) 2007-07-01
US20050096321A1 (en) 2005-05-05
CN100376579C (zh) 2008-03-26
US20060241116A1 (en) 2006-10-26
IS7259A (is) 2004-05-10
HK1065792A1 (en) 2005-03-04
DE60216321T2 (de) 2007-06-21
US7402682B2 (en) 2008-07-22
PL371201A1 (en) 2005-06-13
US20080249098A1 (en) 2008-10-09
PT1458721E (pt) 2007-02-28
BR0215174A (pt) 2004-11-30
JP5087204B2 (ja) 2012-12-05
US7569567B2 (en) 2009-08-04
DK1458721T3 (da) 2007-03-26
HU229419B1 (en) 2013-12-30
KR20040068958A (ko) 2004-08-02
UA77984C2 (en) 2007-02-15
HRP20040549A2 (en) 2004-10-31
MXPA04006144A (es) 2004-11-01
CA2465750C (en) 2011-05-31
CA2465750A1 (en) 2003-07-10
IS2380B (is) 2008-07-15
DE60216321D1 (de) 2007-01-04
SI1458721T1 (sl) 2007-04-30
US7109194B2 (en) 2006-09-19
CY1106029T1 (el) 2011-04-06
TWI275391B (en) 2007-03-11
JP2005513158A (ja) 2005-05-12
MEP22408A (en) 2010-06-10
US20090275576A1 (en) 2009-11-05
AR038024A1 (es) 2004-12-22
ZA200404245B (en) 2005-08-31
AU2002361325A1 (en) 2003-07-15
HRP20040549B1 (hr) 2012-10-31
CN1604898A (zh) 2005-04-06
HUP0402578A3 (en) 2009-01-28
ME00117B (me) 2010-06-10
NZ532996A (en) 2006-11-30
EA200400560A1 (ru) 2004-12-30
FR2833953B1 (fr) 2004-12-03
RS50304A (xx) 2006-12-15
HUP0402578A2 (hu) 2005-03-29
NO328587B1 (no) 2010-03-22

Similar Documents

Publication Publication Date Title
HK1061679A1 (en) Phenylsulfonyl-1,3-dihydro-2h-indole-2-ibe derivatives, their preparation and their therapeutic use.
AU2002340999A1 (en) Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
HK1053118A1 (en) Benzimidazole derivatives, preparation and therapeutic use thereof.
HUP0401335A3 (en) Herbicidal pyridylpropynyloxyphenyl derivatives, preparation and use thereof
HK1076110A1 (en) Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof
AU2002359126A8 (en) Benzodiazepine derivatives, preparation thereof and use thereof
TWI318974B (en) Acylaminothiazole derivatives, their preparation and their therapeutic use
AU2002359123A8 (en) Benzodiazepine derivatives, preparation thereof and use thereof
AU2001264042A1 (en) 1,4-diazabicyclo(3.2.2)nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof
ZA200003706B (en) Cyclobutene derivatives, their preparation and their therapeutic uses.
AU2001264044A1 (en) 1,4-diazabicyclo(3.2.2)nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof
PT1525193E (pt) Derivados do acilaminotiazole e sua utilização como inibidores de beta amilóide
ZA200001746B (en) 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use.
HK1074444A1 (en) Acyloxypyrrolidine derivatives, preparation and therapeutic use thereof
TWI320413B (en) 1,4-diazabicyclo [ 3.2.2 ] nonanecarboxamide derivatives, preparation thereof and therapeutic use thereof
MXPA03006249A (es) Derivados de 2-arilimino-2,3-dihidrotiazoles, sus procesos de preparacion y su uso terapeutico.
MXPA03006162A (es) Derivados de mikanolida, su preparacion y sus usos terapeuticos.
AU2002229870A1 (en) Mikanolide derivatives, their preparation and therapeutic uses
AU2001284084A1 (en) Polyfluoroalkyltriazole derivatives, preparation and therapeutic use thereof
IL161859A0 (en) 3-Heteroaryl-3.5-dihydro-4-oxo-4H-pyridazinoÄ4.5-BÜindole-1-carboxamide derivatives, their preparation and therapeutic use
MXPA03007634A (es) Derivados de imidazolidina, su preparacion, su uso y preparaciones farmaceuticas que los contienen.
ZA200001747B (en) 3-Amino-3-arylpropan-1-ol derivatives, their preparation and use.
HK1063793A1 (en) Mikanolide derivatives, their preparation and therapeutic uses
AU2002355351A1 (en) Acylaminothiazole derivatives, their preparation and therapeutic use
SI1513836T1 (sl) Derivati piperazinilacilpiperidina, njihova priprava in njihova terapevtska uporaba