UA77033C2 - Способ получения водорастворимых фосфонооксиметильных производных спирта и фенола - Google Patents
Способ получения водорастворимых фосфонооксиметильных производных спирта и фенола Download PDFInfo
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- UA77033C2 UA77033C2 UA20040604550A UA20040604550A UA77033C2 UA 77033 C2 UA77033 C2 UA 77033C2 UA 20040604550 A UA20040604550 A UA 20040604550A UA 20040604550 A UA20040604550 A UA 20040604550A UA 77033 C2 UA77033 C2 UA 77033C2
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- base
- reaction
- phosphoric acid
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Links
- 238000000034 method Methods 0.000 title claims abstract description 39
- 239000003814 drug Substances 0.000 title claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 16
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title claims abstract description 15
- VBKBIDUVUIYPEC-UHFFFAOYSA-N phosphonooxymethoxymethyl dihydrogen phosphate Chemical class OP(O)(=O)OCOCOP(O)(O)=O VBKBIDUVUIYPEC-UHFFFAOYSA-N 0.000 title abstract 2
- -1 phosphonooxymethyl Chemical class 0.000 claims abstract description 16
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims abstract description 14
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims abstract description 12
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940127093 camptothecin Drugs 0.000 claims abstract description 11
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
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Abstract
Способ получения водорастворимых фосфонооксиметильных производных спирта и фенола. Первый этап EMBED ISISServer (I). Второй этап EMBED ISISServer (II). Способ получения водорастворимых фосфонооксиметильных эфиров фармацевтических препаратов, которые содержат блокированный спирт или фенол, таких как камптотецин, пропофол, этопозид, витамин Е и циклоспорин А. В частности, способ получения водорастворимых фосфонооксиметильных производных включает этапы формулы (І) и формулы (ІІ); R-OH представляет собой лекарственное средство, содержащее спирт или фенол, n представляет собой целое число 1 или 2, R1 представляет собой водород, ион щелочного металла или фармацевтически приемлемый катион, и R2 представляет собой водород, ион щелочного металла или фармацевтически приемлемый катион.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34186701P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/040748 WO2003059255A2 (en) | 2001-12-21 | 2002-12-20 | Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77033C2 true UA77033C2 (ru) | 2006-10-16 |
Family
ID=23339347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040604550A UA77033C2 (ru) | 2001-12-21 | 2002-12-20 | Способ получения водорастворимых фосфонооксиметильных производных спирта и фенола |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7229978B2 (ru) |
| EP (2) | EP1471920B1 (ru) |
| JP (2) | JP4369237B2 (ru) |
| KR (3) | KR101016969B1 (ru) |
| CN (2) | CN101367834B (ru) |
| AT (1) | ATE423563T1 (ru) |
| AU (2) | AU2002360682B2 (ru) |
| CA (1) | CA2470423C (ru) |
| DE (1) | DE60231336D1 (ru) |
| ES (1) | ES2322245T3 (ru) |
| HU (1) | HU230216B1 (ru) |
| IL (1) | IL162550A (ru) |
| IN (1) | IN2012DN01975A (ru) |
| MX (1) | MXPA04005892A (ru) |
| NZ (1) | NZ533535A (ru) |
| PL (1) | PL205940B1 (ru) |
| RU (1) | RU2310659C2 (ru) |
| UA (1) | UA77033C2 (ru) |
| WO (1) | WO2003059255A2 (ru) |
| ZA (1) | ZA200404579B (ru) |
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|---|---|---|---|---|
| JP2005523922A (ja) | 2002-04-26 | 2005-08-11 | ギリアード サイエンシーズ， インコーポレイテッド | 非ヌクレオシド逆転写酵素阻害剤 |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| SG182849A1 (en) | 2003-04-25 | 2012-08-30 | Gilead Sciences Inc | Antiviral phosphonate analogs |
| US7300924B2 (en) | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| MXPA05011289A (es) * | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Compuestos de fosfato que tienen actividad inmunomoduladora. |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| AU2004233897A1 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US20040225022A1 (en) * | 2003-05-09 | 2004-11-11 | Desai Neil P. | Propofol formulation containing reduced oil and surfactants |
| JP2007508845A (ja) | 2003-10-24 | 2007-04-12 | ギリアード サイエンシーズ， インコーポレイテッド | 治療用化合物の同定のための方法および組成物 |
| WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| WO2005044308A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| NZ547907A (en) | 2003-12-22 | 2010-07-30 | Gilead Sciences Inc | 4'-Substituted carbovir-and abacavir-derivatives as well as related compounds with HIV and HCV antiviral activity |
| PL2258376T3 (pl) | 2004-07-27 | 2019-09-30 | Gilead Sciences, Inc. | Fosfonianowe analogi związków hamujących HIV |
| PL2307435T3 (pl) | 2008-07-08 | 2012-11-30 | Gilead Sciences Inc | Sole związków inhibitorów HIV |
| KR20100032803A (ko) * | 2008-09-18 | 2010-03-26 | 씨제이제일제당 (주) | 아데포비어디피복실의 개선된 제조방법 |
| CN101845057B (zh) * | 2009-03-27 | 2013-10-23 | 四川大学 | 取代苯酚的甲缩醛磷酸盐麻醉镇静药用化合物及制备方法 |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| CA2760953C (en) * | 2009-05-07 | 2017-05-30 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| JP2012140330A (ja) * | 2010-12-28 | 2012-07-26 | Tosoh Corp | 水溶性リン酸エステルの精製方法 |
| ITMI20110580A1 (it) * | 2011-04-08 | 2012-10-09 | Chemelectiva S R L | Iintermedi utili per la preparazione di fospropofol e processo per la loro preparazione |
| UY34072A (es) | 2011-05-17 | 2013-01-03 | Novartis Ag | Derivados sustituidos de indol |
| CN102351895A (zh) * | 2011-08-08 | 2012-02-15 | 陕西合成药业有限公司 | 甲磷丙泊酚二钠水合物及其制备方法和用途 |
| CN102382133B (zh) * | 2011-12-02 | 2016-03-23 | 陕西合成药业股份有限公司 | 一种磷丙泊酚钠的制备及纯化方法 |
| CN102516099B (zh) * | 2011-12-02 | 2013-07-17 | 成都苑东药业有限公司 | 一种水溶性三醇胺的衍生物 |
| CN102399236A (zh) * | 2011-12-27 | 2012-04-04 | 上海立科药物化学有限公司 | 磷丙泊酚钠的合成方法 |
| CN102603798A (zh) * | 2012-02-14 | 2012-07-25 | 陕西合成药业有限公司 | 一种唑系化合物水溶性前药的制备方法 |
| KR101871732B1 (ko) * | 2013-05-09 | 2018-06-27 | 스촨 하이스코 파마수티컬 씨오., 엘티디 | 페놀유도체, 이의 제조방법 및 의약에서의 이의 용도 |
| US11331271B2 (en) | 2016-05-27 | 2022-05-17 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
| EP3960740B1 (en) | 2017-08-01 | 2023-11-15 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections |
| CN109456360B (zh) * | 2018-12-17 | 2021-05-14 | 河南中医药大学 | 一种磷丙泊酚钠的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2833827A (en) * | 1955-01-17 | 1958-05-06 | Bayer Ag | Tri (3, 5-di lower alkyl-4-hydroxy phenyl)-sulfonium chlorides and method of preparing same |
| GB814278A (en) | 1956-11-13 | 1959-06-03 | Bataafsche Petroleum | Process for the preparation of 2.4.6 trialkylated phenols |
| JPS56131594A (en) * | 1980-03-17 | 1981-10-15 | Mitsui Toatsu Chem Inc | Preparation of alkyl phosphate |
| JPH04282337A (ja) * | 1991-03-08 | 1992-10-07 | Fuji Photo Film Co Ltd | ２−アリールオキシ−１−クロルプロパンの製造方法 |
| US6201257B1 (en) * | 1996-10-10 | 2001-03-13 | Advanced Scientific Concepts, Inc. | Semiconductor X-ray photocathodes devices |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
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2002
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- 2002-12-20 PL PL370489A patent/PL205940B1/pl unknown
- 2002-12-20 NZ NZ533535A patent/NZ533535A/en not_active IP Right Cessation
- 2002-12-20 UA UA20040604550A patent/UA77033C2/ru unknown
- 2002-12-20 WO PCT/US2002/040748 patent/WO2003059255A2/en active Application Filing
- 2002-12-20 HU HU0500139A patent/HU230216B1/hu not_active IP Right Cessation
- 2002-12-20 KR KR1020087007455A patent/KR100937162B1/ko not_active IP Right Cessation
- 2002-12-20 CN CN200810145160XA patent/CN101367834B/zh not_active Expired - Fee Related
- 2002-12-20 AT AT02795960T patent/ATE423563T1/de not_active IP Right Cessation
- 2002-12-20 JP JP2003559420A patent/JP4369237B2/ja not_active Expired - Fee Related
- 2002-12-20 IN IN1975DEN2012 patent/IN2012DN01975A/en unknown
- 2002-12-20 KR KR1020107017896A patent/KR20100101011A/ko not_active Application Discontinuation
- 2002-12-20 AU AU2002360682A patent/AU2002360682B2/en not_active Ceased
- 2002-12-20 EP EP02795960A patent/EP1471920B1/en not_active Expired - Lifetime
- 2002-12-20 EP EP09153421A patent/EP2058320B1/en not_active Expired - Lifetime
- 2002-12-20 US US10/498,013 patent/US7229978B2/en not_active Expired - Fee Related
- 2002-12-20 RU RU2004120071/04A patent/RU2310659C2/ru not_active IP Right Cessation
- 2002-12-20 DE DE60231336T patent/DE60231336D1/de not_active Expired - Lifetime
- 2002-12-20 CN CNB028258827A patent/CN100413508C/zh not_active Expired - Fee Related
- 2002-12-20 CA CA2470423A patent/CA2470423C/en not_active Expired - Fee Related
- 2002-12-20 ES ES02795960T patent/ES2322245T3/es not_active Expired - Lifetime
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2004
- 2004-06-09 ZA ZA200404579A patent/ZA200404579B/xx unknown
- 2004-06-16 MX MXPA04005892A patent/MXPA04005892A/es active IP Right Grant
- 2004-06-16 IL IL162550A patent/IL162550A/en not_active IP Right Cessation
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2006
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2008
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