UA76695C2 - Химера il6ril6 для лікування нейродегенеративних захворювань - Google Patents

Химера il6ril6 для лікування нейродегенеративних захворювань Download PDF

Info

Publication number
UA76695C2
UA76695C2 UA2002010458A UA2002010458A UA76695C2 UA 76695 C2 UA76695 C2 UA 76695C2 UA 2002010458 A UA2002010458 A UA 2002010458A UA 2002010458 A UA2002010458 A UA 2002010458A UA 76695 C2 UA76695 C2 UA 76695C2
Authority
UA
Ukraine
Prior art keywords
cells
chimera
apa
cultures
neurons
Prior art date
Application number
UA2002010458A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Мічел Ревел
Юдіт Чебат
Маріна Піцці
П'єрфранко Спано
Урсула Бошерт
Original Assignee
Yeda Res & Dev
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Applied Research Systems filed Critical Yeda Res & Dev
Publication of UA76695C2 publication Critical patent/UA76695C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/204IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA2002010458A 1999-06-21 2000-06-21 Химера il6ril6 для лікування нейродегенеративних захворювань UA76695C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13058699A IL130586A0 (en) 1999-06-21 1999-06-21 IL6RIL6 chimera for the treatment of demyelinating diseases
PCT/IL2000/000363 WO2000078331A2 (en) 1999-06-21 2000-06-21 Il6ril6 chimera for the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
UA76695C2 true UA76695C2 (uk) 2006-09-15

Family

ID=11072949

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002010458A UA76695C2 (uk) 1999-06-21 2000-06-21 Химера il6ril6 для лікування нейродегенеративних захворювань

Country Status (21)

Country Link
US (1) US7201896B1 (da)
EP (1) EP1185293B1 (da)
JP (1) JP4846148B2 (da)
KR (1) KR100678290B1 (da)
CN (1) CN1164328C (da)
AT (1) ATE306280T1 (da)
AU (1) AU778662B2 (da)
BR (1) BR0011363A (da)
CA (1) CA2374997C (da)
DE (1) DE60023139T2 (da)
DK (1) DK1185293T3 (da)
EA (1) EA004626B1 (da)
EE (1) EE05559B1 (da)
ES (1) ES2250140T3 (da)
HK (1) HK1047549A1 (da)
IL (2) IL130586A0 (da)
MX (1) MXPA02000116A (da)
NO (1) NO329028B1 (da)
UA (1) UA76695C2 (da)
WO (1) WO2000078331A2 (da)
ZA (1) ZA200109488B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1317273T3 (da) 2000-09-14 2006-09-04 Ares Trading Sa Anvendelse af IL-6R/IL-6-kimærer mod Huntingtons sygdom
DE10107737A1 (de) * 2001-02-16 2002-09-05 S Rose John Christian Albrecht Verwendung eines Konjugats aus IL-6 und einem IL-6 Rezeptor zur Tumortherapie
CN100405062C (zh) * 2001-04-10 2008-07-23 利兰·斯坦福青年大学托管委员会 抗体特异性分布的治疗和诊断使用
IL147412A0 (en) * 2001-12-31 2002-08-14 Yeda Res & Dev The use of il6r/il6 chimera in nerve cell regeneration
WO2004111210A1 (en) * 2003-06-12 2004-12-23 Yeda Research & Development Co.Ltd Enhancement of oligodendrocyte differentiation
US20070071727A1 (en) * 2003-11-14 2007-03-29 Olsson Mats J Melanocytes in therapy of neurodegenerative diseases
IL161672A0 (en) * 2004-04-29 2004-09-27 Yeda Res & Dev Compositions and methods for therapy of chemotherapy-induced neuropathy
IL163856A0 (en) * 2004-09-01 2005-12-18 Applied Research Systems Use of IL-6 in vascular complications
JP2019511261A (ja) * 2016-02-12 2019-04-25 エイエルエス・セラピー・デベロップメント・インスティテュートALS Therapy Development Institute 運動データに基づいたalsの進行の測定
WO2018056412A1 (ja) * 2016-09-23 2018-03-29 国立大学法人大阪大学 シュワン細胞分化促進剤及び末梢神経再生促進剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
JPH1148413A (ja) 1997-08-06 1999-02-23 Dainippon Printing Co Ltd ホルムアルデヒド捕捉壁紙およびその製造方法
JP4859153B2 (ja) * 1999-02-25 2012-01-25 東ソー株式会社 新規神経系細胞分化促進剤

Also Published As

Publication number Publication date
EA200200063A1 (ru) 2002-06-27
NO20015673D0 (no) 2001-11-20
ATE306280T1 (de) 2005-10-15
MXPA02000116A (es) 2003-07-21
EP1185293B1 (en) 2005-10-12
EE05559B1 (et) 2012-08-15
DE60023139D1 (de) 2006-02-23
DK1185293T3 (da) 2005-12-27
ZA200109488B (en) 2002-11-18
NO329028B1 (no) 2010-08-02
CA2374997C (en) 2010-04-13
HK1047549A1 (en) 2003-02-28
ES2250140T3 (es) 2006-04-16
NO20015673L (no) 2001-12-17
AU5423100A (en) 2001-01-09
KR100678290B1 (ko) 2007-02-05
IL130586A0 (en) 2000-06-01
CA2374997A1 (en) 2000-12-28
CN1164328C (zh) 2004-09-01
BR0011363A (pt) 2002-02-26
EA004626B1 (ru) 2004-06-24
WO2000078331A3 (en) 2001-07-05
JP2003502382A (ja) 2003-01-21
IL147188A (en) 2015-09-24
KR20020013901A (ko) 2002-02-21
US7201896B1 (en) 2007-04-10
JP4846148B2 (ja) 2011-12-28
DE60023139T2 (de) 2006-05-04
CN1364088A (zh) 2002-08-14
AU778662B2 (en) 2004-12-16
EP1185293A2 (en) 2002-03-13
EE200100689A (et) 2003-02-17
WO2000078331A2 (en) 2000-12-28

Similar Documents

Publication Publication Date Title
Morrissey et al. Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.
Deng et al. GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury
Kretz et al. Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation
Nesti et al. Human dental pulp stem cells protect mouse dopaminergic neurons against MPP+ or rotenone
Kadi et al. Differential effects of chemokines on oligodendrocyte precursor proliferation and myelin formation in vitro
JP2015529685A (ja) 筋萎縮性側索硬化症の処置のための組成物および方法
UA76695C2 (uk) Химера il6ril6 для лікування нейродегенеративних захворювань
Zhang et al. Long distance directional growth of dopaminergic axons along pathways of netrin-1 and GDNF
Cao et al. Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons
WO2019147036A1 (ko) 뇌유래-신경영양인자를 발현하는 중간엽줄기세포 및 이의 용도
DK2440225T3 (da) Hidtil ukendte anvendelser af hip/pap eller derivater deraf
Gao et al. Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20
AU2001259453B2 (en) Methods for stimulating nervous system regeneration and repair by regulating arginase 1 and polyamine synthesis
KR101544398B1 (ko) FoxA2 및 Nurr1 도입을 이용한 중뇌 도파민성 신경세포로의 분화방법
EP2630965A1 (en) A polypeptide for the protection from neurodegeneration in patients with amyotrophic lateral sclerosis (ALS)
Gu et al. Expression and regulation of versican in neural precursor cells and their lineages
Deng et al. GDNF reverses the inhibitory properties of reactive astrocytes allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury
Nakamoto et al. Tissues exhibiting inhibiory and repulsive activities during the initial stages of neurite outgrowth from the dorsal root ganglion in the chick embryo
US20090324612A1 (en) Modulating neuronal outgrowth via the major histocompatibility complex class i (mhc i) molecule
WO1996034619A1 (en) Methods of preventing neuron degeneration and promoting neuron regeneration
Wu et al. Transplantation of Neuregulin1-Overexpressing Bone Marrow Mesenchymal Cells Accelerates Motor Functional Recovery by Facilitating Neurite Outgrowth and Reducing Cell Apoptosis in Rat after Spinal Cord Injury
US20090291887A1 (en) Proteins of the SDF-1-Family for the Manufacturing of a Medicament
KR20100136633A (ko) 개의 베타-신경 성장 인자 및 이를 함유하는 개의 신경손상 관련 질환 치료용 수의학적 조성물
Hunt Molecular approaches to axonal regeneration
Doherty et al. Molecular specificity of ganglioside action on neurite regeneration in cell cultures of sensory neurons