CN1164328C - 治疗神经变性疾病的il6ril6嵌合物 - Google Patents
治疗神经变性疾病的il6ril6嵌合物 Download PDFInfo
- Publication number
- CN1164328C CN1164328C CNB008089108A CN00808910A CN1164328C CN 1164328 C CN1164328 C CN 1164328C CN B008089108 A CNB008089108 A CN B008089108A CN 00808910 A CN00808910 A CN 00808910A CN 1164328 C CN1164328 C CN 1164328C
- Authority
- CN
- China
- Prior art keywords
- cell
- block polymer
- myelin
- il6ril6
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (3)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL130586 | 1999-06-21 | ||
IL13058699A IL130586A0 (en) | 1999-06-21 | 1999-06-21 | IL6RIL6 chimera for the treatment of demyelinating diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1364088A CN1364088A (zh) | 2002-08-14 |
CN1164328C true CN1164328C (zh) | 2004-09-01 |
Family
ID=11072949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008089108A Expired - Fee Related CN1164328C (zh) | 1999-06-21 | 2000-06-21 | 治疗神经变性疾病的il6ril6嵌合物 |
Country Status (21)
Country | Link |
---|---|
US (1) | US7201896B1 (zh) |
EP (1) | EP1185293B1 (zh) |
JP (1) | JP4846148B2 (zh) |
KR (1) | KR100678290B1 (zh) |
CN (1) | CN1164328C (zh) |
AT (1) | ATE306280T1 (zh) |
AU (1) | AU778662B2 (zh) |
BR (1) | BR0011363A (zh) |
CA (1) | CA2374997C (zh) |
DE (1) | DE60023139T2 (zh) |
DK (1) | DK1185293T3 (zh) |
EA (1) | EA004626B1 (zh) |
EE (1) | EE05559B1 (zh) |
ES (1) | ES2250140T3 (zh) |
HK (1) | HK1047549A1 (zh) |
IL (2) | IL130586A0 (zh) |
MX (1) | MXPA02000116A (zh) |
NO (1) | NO329028B1 (zh) |
UA (1) | UA76695C2 (zh) |
WO (1) | WO2000078331A2 (zh) |
ZA (1) | ZA200109488B (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60119347T2 (de) * | 2000-09-14 | 2007-02-22 | Ares Trading S.A. | Verwendung von chimäres il6-il6r in huntingtonskrankheit |
DE10107737A1 (de) * | 2001-02-16 | 2002-09-05 | S Rose John Christian Albrecht | Verwendung eines Konjugats aus IL-6 und einem IL-6 Rezeptor zur Tumortherapie |
CN100405062C (zh) * | 2001-04-10 | 2008-07-23 | 利兰·斯坦福青年大学托管委员会 | 抗体特异性分布的治疗和诊断使用 |
IL147412A0 (en) * | 2001-12-31 | 2002-08-14 | Yeda Res & Dev | The use of il6r/il6 chimera in nerve cell regeneration |
WO2004111210A1 (en) * | 2003-06-12 | 2004-12-23 | Yeda Research & Development Co.Ltd | Enhancement of oligodendrocyte differentiation |
EP1692273A1 (en) * | 2003-11-14 | 2006-08-23 | Mats J. Olsson | Melanocytes in therapy of neurodegenerative diseases |
IL161672A0 (en) | 2004-04-29 | 2004-09-27 | Yeda Res & Dev | Compositions and methods for therapy of chemotherapy-induced neuropathy |
IL163856A0 (en) * | 2004-09-01 | 2005-12-18 | Applied Research Systems | Use of IL-6 in vascular complications |
AU2017218129A1 (en) * | 2016-02-12 | 2018-08-23 | Als Therapy Development Institute | Measurement of ALS progression based on kinetic data |
JP7064197B2 (ja) * | 2016-09-23 | 2022-05-10 | 国立大学法人大阪大学 | シュワン細胞分化促進剤及び末梢神経再生促進剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL122818A0 (en) | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
JPH1148413A (ja) | 1997-08-06 | 1999-02-23 | Dainippon Printing Co Ltd | ホルムアルデヒド捕捉壁紙およびその製造方法 |
JP4859153B2 (ja) * | 1999-02-25 | 2012-01-25 | 東ソー株式会社 | 新規神経系細胞分化促進剤 |
-
1999
- 1999-06-21 IL IL13058699A patent/IL130586A0/xx unknown
-
2000
- 2000-06-21 DK DK00939022T patent/DK1185293T3/da active
- 2000-06-21 EA EA200200063A patent/EA004626B1/ru not_active IP Right Cessation
- 2000-06-21 EE EEP200100689A patent/EE05559B1/xx not_active IP Right Cessation
- 2000-06-21 CN CNB008089108A patent/CN1164328C/zh not_active Expired - Fee Related
- 2000-06-21 ES ES00939022T patent/ES2250140T3/es not_active Expired - Lifetime
- 2000-06-21 WO PCT/IL2000/000363 patent/WO2000078331A2/en active IP Right Grant
- 2000-06-21 UA UA2002010458A patent/UA76695C2/uk unknown
- 2000-06-21 BR BR0011363-8A patent/BR0011363A/pt not_active Application Discontinuation
- 2000-06-21 CA CA2374997A patent/CA2374997C/en not_active Expired - Fee Related
- 2000-06-21 EP EP00939022A patent/EP1185293B1/en not_active Expired - Lifetime
- 2000-06-21 MX MXPA02000116A patent/MXPA02000116A/es active IP Right Grant
- 2000-06-21 US US09/980,823 patent/US7201896B1/en not_active Expired - Fee Related
- 2000-06-21 AT AT00939022T patent/ATE306280T1/de active
- 2000-06-21 DE DE60023139T patent/DE60023139T2/de not_active Expired - Lifetime
- 2000-06-21 KR KR1020017015303A patent/KR100678290B1/ko not_active IP Right Cessation
- 2000-06-21 AU AU54231/00A patent/AU778662B2/en not_active Ceased
- 2000-06-21 JP JP2001504394A patent/JP4846148B2/ja not_active Expired - Fee Related
-
2001
- 2001-11-16 ZA ZA200109488A patent/ZA200109488B/xx unknown
- 2001-11-20 NO NO20015673A patent/NO329028B1/no not_active IP Right Cessation
- 2001-12-19 IL IL147188A patent/IL147188A/en not_active IP Right Cessation
-
2002
- 2002-12-19 HK HK02109201A patent/HK1047549A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20015673L (no) | 2001-12-17 |
HK1047549A1 (en) | 2003-02-28 |
JP2003502382A (ja) | 2003-01-21 |
IL130586A0 (en) | 2000-06-01 |
EE05559B1 (et) | 2012-08-15 |
EA200200063A1 (ru) | 2002-06-27 |
NO329028B1 (no) | 2010-08-02 |
AU5423100A (en) | 2001-01-09 |
WO2000078331A3 (en) | 2001-07-05 |
AU778662B2 (en) | 2004-12-16 |
NO20015673D0 (no) | 2001-11-20 |
IL147188A (en) | 2015-09-24 |
EP1185293B1 (en) | 2005-10-12 |
BR0011363A (pt) | 2002-02-26 |
EA004626B1 (ru) | 2004-06-24 |
WO2000078331A2 (en) | 2000-12-28 |
KR100678290B1 (ko) | 2007-02-05 |
CA2374997C (en) | 2010-04-13 |
ATE306280T1 (de) | 2005-10-15 |
DE60023139T2 (de) | 2006-05-04 |
EP1185293A2 (en) | 2002-03-13 |
UA76695C2 (uk) | 2006-09-15 |
ZA200109488B (en) | 2002-11-18 |
JP4846148B2 (ja) | 2011-12-28 |
KR20020013901A (ko) | 2002-02-21 |
CA2374997A1 (en) | 2000-12-28 |
US7201896B1 (en) | 2007-04-10 |
MXPA02000116A (es) | 2003-07-21 |
DE60023139D1 (de) | 2006-02-23 |
ES2250140T3 (es) | 2006-04-16 |
DK1185293T3 (da) | 2005-12-27 |
EE200100689A (et) | 2003-02-17 |
CN1364088A (zh) | 2002-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11020456B2 (en) | Methods for modulating an inflammatory response | |
Kadi et al. | Differential effects of chemokines on oligodendrocyte precursor proliferation and myelin formation in vitro | |
Kang et al. | Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice | |
CN1164328C (zh) | 治疗神经变性疾病的il6ril6嵌合物 | |
CN1452492A (zh) | 神经保护肽 | |
CN101918556B (zh) | 可穿透细胞的nm23重组蛋白、编码其的多核苷酸以及包含其的抗转移组合物 | |
SK38998A3 (en) | Truncated glial cell line-derived neurotrophic factor | |
Takizawa et al. | Directly linked soluble IL-6 receptor–IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 | |
CN111989404A (zh) | 表达脑源性神经营养因子的间充质干细胞及其用途 | |
Haggiag et al. | Induction of myelin gene expression in Schwann cell cultures by an interleukin-6 receptor-interleukin-6 chimera | |
Gadient et al. | Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells | |
WO2023030489A1 (zh) | 经基因改造的少突胶质祖细胞在多发性硬化症中的应用 | |
IL292004A (en) | Composition for reprogramming cells into dendritic plasma cells or type I interferon-producing cells, methods and uses thereof | |
JP4783013B2 (ja) | 多能性神経幹細胞からの希突起神経膠細胞産生 | |
CA2519975C (en) | Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same | |
WO2004069177A2 (en) | Methods for modulating an inflammatory response | |
Jana et al. | Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis | |
JPWO2008093827A1 (ja) | 中枢神経障害治療剤及び中枢神経障害の治療方法 | |
Tregs Regulatory | Mahdieh Yousefi1, Abolghasem Nabipour, Mazdak Ganjalikhani Hakemi2, Mehnoosh Ashja‑Arvan2, Noushin Amirpour3 & Hossein Salehi3Ε | |
WO1996034619A1 (en) | Methods of preventing neuron degeneration and promoting neuron regeneration | |
Penna | UNDERSTANDING AND PROMOTING THE FUNCTIONAL INTEGRATION OF NEURAL TRANSPLANTS IN PARKINSON’S | |
Gonzalez | CXCL10 plays a critical role in secondary degeneration following spinal cord injury | |
Zullo | BATF transgenic mice: Investigating the role of AP-1 in the development and function of natural killer T lymphocytes | |
Lee | Cytokine network in the human central nervous system | |
Spooren | Regulation of IL-6 expression in astrocytes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1047549 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: SERONO LAB Free format text: FORMER OWNER: APPLIED RESEARCH SYSTEMS ARS HOLDING N. V. Owner name: MERCK SERONO S. A. Free format text: FORMER OWNER: SERONO LAB |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110201 Address after: Voight, Israel Co-patentee after: Merck Serono S.A. Patentee after: YEDA RESEARCH AND DEVELOPMENT CO.,LTD. Address before: Voight, Israel Co-patentee before: LABORATOIRES SERONO S.A. Patentee before: YEDA RESEARCH AND DEVELOPMENT CO.,LTD. Effective date of registration: 20110201 Address after: Voight, Israel Co-patentee after: LABORATOIRES SERONO S.A. Patentee after: YEDA RESEARCH AND DEVELOPMENT CO.,LTD. Address before: Voight, Israel Co-patentee before: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. Patentee before: YEDA RESEARCH AND DEVELOPMENT CO.,LTD. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040901 Termination date: 20160621 |
|
CF01 | Termination of patent right due to non-payment of annual fee |