UA73736C2 - Method for alleviating or preventing insomnia and inducing anesthesia - Google Patents
Method for alleviating or preventing insomnia and inducing anesthesia Download PDFInfo
- Publication number
- UA73736C2 UA73736C2 UA2001118125A UA2001118125A UA73736C2 UA 73736 C2 UA73736 C2 UA 73736C2 UA 2001118125 A UA2001118125 A UA 2001118125A UA 2001118125 A UA2001118125 A UA 2001118125A UA 73736 C2 UA73736 C2 UA 73736C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methoxymethyl
- hydroxy
- pregnan
- compound
- differs
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 22
- 206010002091 Anaesthesia Diseases 0.000 title claims description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims description 3
- 230000037005 anaesthesia Effects 0.000 title claims description 3
- 230000001939 inductive effect Effects 0.000 title claims description 3
- 206010022437 insomnia Diseases 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- 229940002612 prodrug Drugs 0.000 claims abstract description 4
- 239000000651 prodrug Substances 0.000 claims abstract description 4
- 239000012453 solvate Substances 0.000 claims abstract description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 14
- 241001465754 Metazoa Species 0.000 claims description 13
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 6
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 3
- 125000002619 bicyclic group Chemical group 0.000 claims description 3
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- 238000012876 topography Methods 0.000 claims 1
- -1 anthracyl Chemical group 0.000 description 35
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- 229940079593 drug Drugs 0.000 description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13157899P | 1999-04-29 | 1999-04-29 | |
| PCT/US2000/011680 WO2000066614A1 (en) | 1999-04-29 | 2000-04-28 | 3α-HYDROXY-3β METHOXYMETHYL-21-HETEROCYCLE SUBSTITUTED STEROIDS WITH ANESTHETIC ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73736C2 true UA73736C2 (en) | 2005-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001118125A UA73736C2 (en) | 1999-04-29 | 2000-04-28 | Method for alleviating or preventing insomnia and inducing anesthesia |
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| Country | Link |
|---|---|
| US (2) | US20040034002A1 (cs) |
| EP (1) | EP1177206A1 (cs) |
| JP (1) | JP2002543218A (cs) |
| KR (1) | KR20020013530A (cs) |
| CN (1) | CN1187367C (cs) |
| AU (1) | AU780989B2 (cs) |
| BR (1) | BR0010060A (cs) |
| CA (1) | CA2372342A1 (cs) |
| CZ (1) | CZ20013867A3 (cs) |
| HK (1) | HK1047594A1 (cs) |
| HU (1) | HUP0201818A3 (cs) |
| IL (1) | IL146230A0 (cs) |
| MX (1) | MXPA01010915A (cs) |
| NO (1) | NO321536B1 (cs) |
| NZ (1) | NZ515779A (cs) |
| PL (1) | PL351438A1 (cs) |
| RU (1) | RU2243232C2 (cs) |
| UA (1) | UA73736C2 (cs) |
| WO (1) | WO2000066614A1 (cs) |
| YU (1) | YU77701A (cs) |
| ZA (1) | ZA200109847B (cs) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105822A2 (en) * | 2004-04-23 | 2005-11-10 | Euro-Celtique S.A. | 3-alpha-hydroxy 21-n- heteroaryl-pregnane derivatives for modulation of brain excitability and a process for the production thereof |
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| US3953429A (en) * | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
| US3969345A (en) * | 1970-12-17 | 1976-07-13 | Glaxo Laboratories Limited | 20β,21-Epoxy-3α-hydroxy-5α-pregnanes and derivatives thereof |
| GB1377608A (en) * | 1970-12-17 | 1974-12-18 | Glaxo Lab Ltd | 3alpha-hydroxy or acyloxy pregnene-21-ethers |
| US3943124A (en) * | 1970-12-17 | 1976-03-09 | Gordon Hanley Phillipps | Chemical compounds |
| US3959260A (en) * | 1972-05-05 | 1976-05-25 | Glaxo Laboratories Limited | Anaesthetic steroids of the pregnane and 19-norpregnane series having a sulfur-containing group at the 21-position |
| GB1436324A (en) * | 1972-05-12 | 1976-05-19 | Glaxo Lab Ltd | Anaesthetic 3alpha-hydroxy pregnanes |
| US4192871A (en) * | 1976-01-06 | 1980-03-11 | Glaxo Laboratories Limited | Chemical compounds |
| US4197296A (en) * | 1977-03-23 | 1980-04-08 | Glaxo Group Limited | Androstanes |
| US4297350A (en) * | 1978-10-10 | 1981-10-27 | The Upjohn Company | Male contraceptive steroids and methods of use |
| US5319115A (en) * | 1987-08-25 | 1994-06-07 | Cocensys Inc. | Method for making 3α-hydroxy, 3β-substituted-pregnanes |
| US5208227A (en) * | 1987-08-25 | 1993-05-04 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| US4898694A (en) * | 1987-11-25 | 1990-02-06 | Schwartz Arthur G | 17-Hydroxy-steroids |
| ES2296594T3 (es) * | 1994-02-14 | 2008-05-01 | Euro-Celtique S.A. | Androstanos y pregnanos para la modulacion alosterica del receptor de gaba. |
| US5939545A (en) * | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
| DE69634039T2 (de) * | 1995-06-06 | 2005-12-08 | Euro-Celtique S.A. | Steroidderivate der Androstan- und der Pregnanreihe |
-
2000
- 2000-04-28 CA CA002372342A patent/CA2372342A1/en not_active Abandoned
- 2000-04-28 YU YU77701A patent/YU77701A/sh unknown
- 2000-04-28 AU AU48104/00A patent/AU780989B2/en not_active Ceased
- 2000-04-28 PL PL00351438A patent/PL351438A1/xx not_active Application Discontinuation
- 2000-04-28 WO PCT/US2000/011680 patent/WO2000066614A1/en not_active Application Discontinuation
- 2000-04-28 JP JP2000615643A patent/JP2002543218A/ja not_active Withdrawn
- 2000-04-28 HU HU0201818A patent/HUP0201818A3/hu unknown
- 2000-04-28 KR KR1020017013819A patent/KR20020013530A/ko not_active Application Discontinuation
- 2000-04-28 NZ NZ515779A patent/NZ515779A/en unknown
- 2000-04-28 IL IL14623000A patent/IL146230A0/xx unknown
- 2000-04-28 MX MXPA01010915A patent/MXPA01010915A/es unknown
- 2000-04-28 CN CNB008083606A patent/CN1187367C/zh not_active Expired - Fee Related
- 2000-04-28 CZ CZ20013867A patent/CZ20013867A3/cs unknown
- 2000-04-28 RU RU2001132583/04A patent/RU2243232C2/ru not_active IP Right Cessation
- 2000-04-28 BR BR0010060-9A patent/BR0010060A/pt not_active IP Right Cessation
- 2000-04-28 UA UA2001118125A patent/UA73736C2/uk unknown
- 2000-04-28 EP EP00930250A patent/EP1177206A1/en not_active Withdrawn
-
2001
- 2001-10-26 NO NO20015262A patent/NO321536B1/no unknown
- 2001-11-29 ZA ZA200109847A patent/ZA200109847B/xx unknown
-
2002
- 2002-11-29 HK HK02108656A patent/HK1047594A1/xx not_active IP Right Cessation
-
2003
- 2003-08-15 US US10/641,073 patent/US20040034002A1/en not_active Abandoned
-
2005
- 2005-01-03 US US11/027,682 patent/US20050171074A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO321536B1 (no) | 2006-05-22 |
| US20040034002A1 (en) | 2004-02-19 |
| CN1187367C (zh) | 2005-02-02 |
| NO20015262L (no) | 2001-12-19 |
| EP1177206A1 (en) | 2002-02-06 |
| MXPA01010915A (es) | 2002-11-07 |
| AU780989B2 (en) | 2005-04-28 |
| WO2000066614A1 (en) | 2000-11-09 |
| CN1360591A (zh) | 2002-07-24 |
| BR0010060A (pt) | 2002-01-15 |
| PL351438A1 (en) | 2003-04-22 |
| AU4810400A (en) | 2000-11-17 |
| HK1047594A1 (en) | 2003-02-28 |
| NO20015262D0 (no) | 2001-10-26 |
| JP2002543218A (ja) | 2002-12-17 |
| KR20020013530A (ko) | 2002-02-20 |
| YU77701A (sh) | 2005-07-19 |
| CA2372342A1 (en) | 2000-11-09 |
| IL146230A0 (en) | 2002-07-25 |
| HUP0201818A2 (en) | 2002-10-28 |
| ZA200109847B (en) | 2003-02-26 |
| WO2000066614A8 (en) | 2001-03-15 |
| US20050171074A1 (en) | 2005-08-04 |
| CZ20013867A3 (cs) | 2002-07-17 |
| HUP0201818A3 (en) | 2004-04-28 |
| NZ515779A (en) | 2003-11-28 |
| RU2243232C2 (ru) | 2004-12-27 |
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