UA73348C2 - Sodium-hydrogen exchanger inhibitor of the type 1 (nhe-1) - Google Patents
Sodium-hydrogen exchanger inhibitor of the type 1 (nhe-1) Download PDFInfo
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- UA73348C2 UA73348C2 UA2002108497A UA2002108497A UA73348C2 UA 73348 C2 UA73348 C2 UA 73348C2 UA 2002108497 A UA2002108497 A UA 2002108497A UA 2002108497 A UA2002108497 A UA 2002108497A UA 73348 C2 UA73348 C2 UA 73348C2
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- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 10
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- FNXKBSAUKFCXIK-UHFFFAOYSA-M sodium;hydrogen carbonate;8-hydroxy-7-iodoquinoline-5-sulfonic acid Chemical class [Na+].OC([O-])=O.C1=CN=C2C(O)=C(I)C=C(S(O)(=O)=O)C2=C1 FNXKBSAUKFCXIK-UHFFFAOYSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 235000008979 vitamin B4 Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treatment Of Water By Ion Exchange (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20043200P | 2000-04-28 | 2000-04-28 | |
| PCT/IB2001/000277 WO2001083470A1 (en) | 2000-04-28 | 2001-02-28 | Sodium-hydrogen exchanger type 1 inhibitor (nhe-1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73348C2 true UA73348C2 (en) | 2005-07-15 |
Family
ID=22741697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002108497A UA73348C2 (en) | 2000-04-28 | 2001-02-28 | Sodium-hydrogen exchanger inhibitor of the type 1 (nhe-1) |
Country Status (40)
| Country | Link |
|---|---|
| EP (1) | EP1276737A1 (xx) |
| JP (1) | JP2003531900A (xx) |
| KR (1) | KR20020093079A (xx) |
| CN (1) | CN1225466C (xx) |
| AP (1) | AP2002002651A0 (xx) |
| AR (1) | AR028375A1 (xx) |
| AU (1) | AU2001235896A1 (xx) |
| BG (1) | BG107139A (xx) |
| BR (1) | BR0110268A (xx) |
| CA (1) | CA2407535A1 (xx) |
| CO (1) | CO5221125A1 (xx) |
| CR (1) | CR6797A (xx) |
| CZ (1) | CZ20023408A3 (xx) |
| DZ (1) | DZ3310A1 (xx) |
| EA (1) | EA004882B1 (xx) |
| EE (1) | EE200200615A (xx) |
| GT (1) | GT200100064A (xx) |
| HN (1) | HN2001000042A (xx) |
| HR (1) | HRP20020851A2 (xx) |
| HU (1) | HUP0300651A2 (xx) |
| IL (1) | IL152075A0 (xx) |
| IS (2) | IS6567A (xx) |
| MA (1) | MA26897A1 (xx) |
| MX (1) | MXPA02010600A (xx) |
| MY (1) | MY133842A (xx) |
| NO (1) | NO20025132L (xx) |
| NZ (1) | NZ521348A (xx) |
| OA (1) | OA12256A (xx) |
| PA (1) | PA8513301A1 (xx) |
| PE (1) | PE20011270A1 (xx) |
| PL (1) | PL357765A1 (xx) |
| SK (1) | SK14872002A3 (xx) |
| SV (1) | SV2002000418A (xx) |
| TN (1) | TNSN01065A1 (xx) |
| TR (1) | TR200202439T2 (xx) |
| UA (1) | UA73348C2 (xx) |
| UY (1) | UY26680A1 (xx) |
| WO (1) | WO2001083470A1 (xx) |
| YU (1) | YU79602A (xx) |
| ZA (1) | ZA200208605B (xx) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004518686A (ja) * | 2001-01-31 | 2004-06-24 | ファイザー・プロダクツ・インク | ナトリウム−水素交換輸送体１型阻害剤のエタノラート |
| MXPA04004685A (es) * | 2001-12-19 | 2004-08-12 | Pfizer Prod Inc | Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogeno. |
| WO2003092694A1 (en) * | 2002-05-02 | 2003-11-13 | Pfizer Products Inc. | Treatment of diabetes and diabetic complications with nhe-1 inhibitors |
| FR2840302B1 (fr) * | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| ES2220185B1 (es) * | 2002-07-16 | 2006-04-01 | Consejo Sup. De Investig. Cientificas | Nuevo peptido inhibidor del intercambiador na+/h+ (pinhe), y sus aplicaciones. |
| AU2004212957A1 (en) * | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Novel compounds |
| RU2518741C1 (ru) * | 2013-03-22 | 2014-06-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ГАЛОГЕНИДЫ 1-ДИАЛКИЛАМИНОЭТИЛ-3-[ЗАМЕЩЕННЫЙ(ДИЗАМЕЩЕННЫЙ) ФЕНАЦИЛ]-2-АМИНОБЕНЗИМИДАЗОЛИЯ |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100449600B1 (ko) * | 1998-02-27 | 2004-09-21 | 화이자 프로덕츠 인크. | 허혈 치료용 ｎ-[(치환된 5원 디아자 이불포화 고리)카르보닐] 구아니딘 유도체 |
-
2001
- 2001-02-28 CA CA002407535A patent/CA2407535A1/en not_active Abandoned
- 2001-02-28 BR BR0110268-0A patent/BR0110268A/pt not_active IP Right Cessation
- 2001-02-28 DZ DZ013310A patent/DZ3310A1/fr active
- 2001-02-28 MX MXPA02010600A patent/MXPA02010600A/es active IP Right Grant
- 2001-02-28 CZ CZ20023408A patent/CZ20023408A3/cs unknown
- 2001-02-28 IL IL15207501A patent/IL152075A0/xx unknown
- 2001-02-28 HU HU0300651A patent/HUP0300651A2/hu unknown
- 2001-02-28 AP APAP/P/2002/002651A patent/AP2002002651A0/en unknown
- 2001-02-28 UA UA2002108497A patent/UA73348C2/uk unknown
- 2001-02-28 EE EEP200200615A patent/EE200200615A/xx unknown
- 2001-02-28 CN CNB018087256A patent/CN1225466C/zh not_active Expired - Fee Related
- 2001-02-28 EP EP01908037A patent/EP1276737A1/en not_active Withdrawn
- 2001-02-28 EA EA200201023A patent/EA004882B1/ru not_active IP Right Cessation
- 2001-02-28 WO PCT/IB2001/000277 patent/WO2001083470A1/en not_active Application Discontinuation
- 2001-02-28 YU YUP-796/02A patent/YU79602A/sh unknown
- 2001-02-28 PL PL01357765A patent/PL357765A1/xx not_active Application Discontinuation
- 2001-02-28 NZ NZ521348A patent/NZ521348A/en unknown
- 2001-02-28 KR KR1020027014355A patent/KR20020093079A/ko active IP Right Grant
- 2001-02-28 OA OA1200200331A patent/OA12256A/en unknown
- 2001-02-28 SK SK1487-2002A patent/SK14872002A3/sk unknown
- 2001-02-28 TR TR2002/02439T patent/TR200202439T2/xx unknown
- 2001-02-28 AU AU2001235896A patent/AU2001235896A1/en not_active Abandoned
- 2001-02-28 JP JP2001580898A patent/JP2003531900A/ja active Pending
- 2001-03-06 HN HN2001000042A patent/HN2001000042A/es unknown
- 2001-03-12 PA PA20018513301A patent/PA8513301A1/es unknown
- 2001-04-20 GT GT200100064A patent/GT200100064A/es unknown
- 2001-04-24 UY UY26680A patent/UY26680A1/es not_active Application Discontinuation
- 2001-04-26 MY MYPI20011977A patent/MY133842A/en unknown
- 2001-04-26 PE PE2001000376A patent/PE20011270A1/es not_active Application Discontinuation
- 2001-04-26 AR ARP010101970A patent/AR028375A1/es unknown
- 2001-04-27 SV SV2001000418A patent/SV2002000418A/es not_active Application Discontinuation
- 2001-04-27 CO CO01032977A patent/CO5221125A1/es not_active Application Discontinuation
- 2001-04-27 TN TNTNSN01065A patent/TNSN01065A1/fr unknown
-
2002
- 2002-09-23 BG BG107139A patent/BG107139A/bg unknown
- 2002-09-24 IS IS6567A patent/IS6567A/is unknown
- 2002-10-18 CR CR6797A patent/CR6797A/es not_active Application Discontinuation
- 2002-10-18 MA MA26875A patent/MA26897A1/fr unknown
- 2002-10-21 IS IS6588A patent/IS6588A/is unknown
- 2002-10-24 ZA ZA200208605A patent/ZA200208605B/en unknown
- 2002-10-25 NO NO20025132A patent/NO20025132L/no not_active Application Discontinuation
- 2002-10-25 HR HR20020851A patent/HRP20020851A2/hr not_active Application Discontinuation
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