UA72293C2 - Ep4 receptor selective agonists (variants) for treating conditions presenting with low bone mass and pharmaceutical composition - Google Patents
Ep4 receptor selective agonists (variants) for treating conditions presenting with low bone mass and pharmaceutical composition Download PDFInfo
- Publication number
- UA72293C2 UA72293C2 UA2002065186A UA2002065186A UA72293C2 UA 72293 C2 UA72293 C2 UA 72293C2 UA 2002065186 A UA2002065186 A UA 2002065186A UA 2002065186 A UA2002065186 A UA 2002065186A UA 72293 C2 UA72293 C2 UA 72293C2
- Authority
- UA
- Ukraine
- Prior art keywords
- butyl
- pyrrolidin
- hydroxy
- phenyl
- bone
- Prior art date
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- 229960000281 trometamol Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17135399P | 1999-12-22 | 1999-12-22 | |
| PCT/IB2000/001711 WO2001046140A1 (fr) | 1999-12-22 | 2000-11-20 | Agonistes selectifs au recepteur ep4 dans le traitement de l'osteoporose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72293C2 true UA72293C2 (en) | 2005-02-15 |
Family
ID=22623430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002065186A UA72293C2 (en) | 1999-12-22 | 2000-11-20 | Ep4 receptor selective agonists (variants) for treating conditions presenting with low bone mass and pharmaceutical composition |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6737437B2 (fr) |
| EP (1) | EP1110949B1 (fr) |
| JP (1) | JP2001181210A (fr) |
| KR (1) | KR100419681B1 (fr) |
| CN (1) | CN1413190A (fr) |
| AP (2) | AP2001002357A0 (fr) |
| AT (1) | ATE250575T1 (fr) |
| AU (2) | AU1293101A (fr) |
| BG (1) | BG106882A (fr) |
| BR (1) | BR0016560A (fr) |
| CA (1) | CA2329678A1 (fr) |
| CO (1) | CO5251453A1 (fr) |
| CR (1) | CR6678A (fr) |
| CZ (1) | CZ20022048A3 (fr) |
| DE (1) | DE60005471T2 (fr) |
| DK (1) | DK1110949T3 (fr) |
| EA (1) | EA005293B1 (fr) |
| EE (1) | EE200200355A (fr) |
| ES (1) | ES2204458T3 (fr) |
| GE (1) | GEP20043203B (fr) |
| HR (1) | HRP20020537A2 (fr) |
| HU (1) | HUP0005001A3 (fr) |
| IL (1) | IL140325A0 (fr) |
| IS (1) | IS6388A (fr) |
| MA (1) | MA26852A1 (fr) |
| MX (1) | MXPA02006322A (fr) |
| NO (1) | NO20022925L (fr) |
| OA (1) | OA12117A (fr) |
| PE (1) | PE20010953A1 (fr) |
| PL (1) | PL356662A1 (fr) |
| PT (1) | PT1110949E (fr) |
| SK (1) | SK8552002A3 (fr) |
| TR (2) | TR200201643T2 (fr) |
| UA (1) | UA72293C2 (fr) |
| WO (1) | WO2001046140A1 (fr) |
| ZA (1) | ZA200007694B (fr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010056060A1 (en) * | 2000-02-07 | 2001-12-27 | Cameron Kimberly O. | Treatment of osteoporsis with EP2/EP4 receptor selective agonists |
| SK5562003A3 (en) * | 2000-11-27 | 2004-08-03 | Pfizer Prod Inc | EP4 receptor selective agonists in the treatment of osteoporosis |
| DK1408961T3 (da) * | 2001-07-16 | 2007-11-05 | Hoffmann La Roche | 2 pyrrolidon-derivater som prostanoide agonister |
| KR20040015364A (ko) * | 2001-07-16 | 2004-02-18 | 에프. 호프만-라 로슈 아게 | Ｅｐ4 수용체 작용물질로서의 프로스타글란딘 유사체 |
| IL159996A0 (en) * | 2001-07-23 | 2004-06-20 | Ono Pharmaceutical Co | Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient |
| ES2360604T3 (es) * | 2001-07-23 | 2011-06-07 | Ono Pharmaceutical Co., Ltd. | Remedios para enfermedades con pérdida de masa osea que tienen como ingrediente activo agonistas de ep4. |
| KR20050012221A (ko) * | 2001-11-12 | 2005-01-31 | 오노 야꾸힝 고교 가부시키가이샤 | 프로스타글란딘 유도체를 유효성분으로 하는 국소 투여용지속성 필름형 제제 |
| CA2466751A1 (fr) * | 2001-12-03 | 2003-06-12 | Merck And Co., Inc. | Agoniste du recepteur ep4, compositions et procedes associes |
| US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
| ATE455758T1 (de) | 2001-12-20 | 2010-02-15 | Merck Serono Sa | Pyrrolidin-derivatie als prostaglandin- modulatoren |
| WO2003074483A1 (fr) | 2002-03-05 | 2003-09-12 | Ono Pharmaceutical Co., Ltd. | Composes derives de 8 azaprostaglandine et medicaments contenant ceux-ci comme principe actif |
| EP1490055A1 (fr) * | 2002-03-18 | 2004-12-29 | Pfizer Products Inc. | Utilisation d'agonistes du recepteur ep4 selectif pour le traitement de l'insuffisance hepatique, de la perte de la permeabilite du canal arteriel, du glaucome ou de l'hypertension oculaire |
| US6573294B1 (en) | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| AU2011202937B2 (en) * | 2002-05-14 | 2012-06-07 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
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| AU2003233729B2 (en) | 2002-06-06 | 2007-10-04 | Merck Frosst Canada Ltd | 1,5-distributed pyrrolid-2-one derivatives for use as EP4 receptor agonists in the treatment of eye diseases such as glaucoma |
| ES2584606T3 (es) | 2002-10-10 | 2016-09-28 | Ono Pharmaceutical Co., Ltd. | Microesferas que comprenden ONO-1301 |
| US7196082B2 (en) | 2002-11-08 | 2007-03-27 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
| JP2006510742A (ja) | 2002-11-08 | 2006-03-30 | メルク エンド カムパニー インコーポレーテッド | 高眼圧治療用眼科組成物 |
| US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
| CN1735597A (zh) | 2003-01-10 | 2006-02-15 | 霍夫曼-拉罗奇有限公司 | 作为前列腺素激动剂的2－哌啶酮衍生物 |
| WO2004065365A1 (fr) * | 2003-01-21 | 2004-08-05 | Ono Pharmaceutical Co., Ltd. | Derives de 8-azaprostalangine et utilisations de ces derives en tant que medicaments |
| CA2513652A1 (fr) | 2003-03-03 | 2004-09-16 | Applied Research Systems Ars Holding N.V. | Derives de la g-lactame utilises comme agonistes de la prostaglandine |
| US6734201B1 (en) | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents |
| US6734206B1 (en) | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| US7179820B2 (en) | 2003-06-06 | 2007-02-20 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| JP2006528154A (ja) | 2003-07-18 | 2006-12-14 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | プロスタグランジン受容体のモジュレータとしてのヒドラジド誘導体 |
| JP2007504228A (ja) | 2003-09-02 | 2007-03-01 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼組成物 |
| WO2005026128A1 (fr) | 2003-09-04 | 2005-03-24 | Merck & Co., Inc. | Compositions ophtalmiques traitant l'hypertension oculaire |
| EP1663221A4 (fr) | 2003-09-04 | 2009-04-22 | Merck & Co Inc | Compositions ophtalmiques pour traiter l'hypertension oculaire |
| WO2005027931A1 (fr) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Compositions pharmaceutiques et methodes de traitement consistant en des associations d'un derive de la 2-alkylidene-19-nor-vitamine d et d'un agoniste selectif de ep2 ou ep4 |
| WO2005080367A1 (fr) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Agonistes des recepteurs ep2 |
| JP2008507521A (ja) | 2004-07-20 | 2008-03-13 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼科用組成物 |
| US7696243B2 (en) | 2004-12-06 | 2010-04-13 | Merck Serono, S.A. | Pyrrolidin-2-one derivatives for use as DP1 receptor agonists |
| US7531533B2 (en) | 2005-01-27 | 2009-05-12 | Asahi Kasei Pharma Corporation | 6-Membered heterocyclic compound and use thereof |
| US20090074844A1 (en) | 2005-04-28 | 2009-03-19 | Ono Pharmaceutical Co., Ltd. | Trenadermal absorption preparation |
| KR100686186B1 (ko) * | 2005-06-13 | 2007-02-26 | 영진종합건설 주식회사 | 교량용 배수 구조물 |
| JP2009505973A (ja) | 2005-08-09 | 2009-02-12 | アステランド ユーケイ リミテッド | Ｅｐ２受容体アゴニスト |
| EP2085088A4 (fr) | 2006-10-26 | 2012-08-29 | Ono Pharmaceutical Co | Préparation adhésive |
| US9394520B2 (en) | 2006-12-08 | 2016-07-19 | University Of Rochester | Expansion of hematopoietic stem cells |
| US8063240B2 (en) | 2007-11-14 | 2011-11-22 | Cayman Chemical Company, Incorporated | Prostaglandin E1 and E2 analogs for the treatment of various medical conditions |
| CA2738045C (fr) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Composes conjugues, leurs procedes de fabrication et leurs utilisations |
| RU2627842C2 (ru) | 2011-08-02 | 2017-08-14 | Оно Фармасьютикал Ко., Лтд. | Средство для улучшения диастолической функции левого желудочка |
| WO2014015247A1 (fr) | 2012-07-19 | 2014-01-23 | Cayman Chemical Company, Inc. | Composés de difluorolactame comme agonistes sélectifs du récepteur ep4, destinés à être utilisés dans le traitement de maladies et d'affections médiées par ep4 |
| US20150272874A1 (en) | 2012-10-29 | 2015-10-01 | Cardio Incorporated | Pulmonary disease-specific therapeutic agent |
| EP3235817B1 (fr) * | 2013-03-15 | 2018-12-12 | Cayman Chemical Company, Incorporated | Composés de lactamine en tant qu'agonistes sélectifs du récepteur ep4 destinés à être utilisés dans le traitement des maladies et affections transmises par l'ep4 |
| US9676712B2 (en) | 2013-03-15 | 2017-06-13 | Cayman Chemical Company, Inc. | Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions |
| AU2014290512A1 (en) | 2013-07-19 | 2015-11-12 | Cayman Chemical Company, Inc. | Methods, systems, and compositions for promoting bone growth |
| JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
| WO2015056504A1 (fr) | 2013-10-15 | 2015-04-23 | 小野薬品工業株式会社 | Greffe d'endoprothèse à élution de médicament |
| CN107849072B (zh) | 2015-06-12 | 2020-12-15 | 西蒙弗雷泽大学 | 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途 |
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| JP2000507961A (ja) * | 1996-12-20 | 2000-06-27 | ファイザー・インク | Ｅｐ２受容体サブタイプ選択性のプロスタグランジンｅ２アゴニストによる骨格障害の予防と治療 |
| GB2330307A (en) * | 1998-02-07 | 1999-04-21 | Glaxo Group Ltd | EP4 Receptor antagonists as bone resorption inhibitors |
| EP1121133A1 (fr) * | 1998-10-15 | 2001-08-08 | Merck & Co., Inc. | Methodes de stimulation de la formation osseuse |
| AU1444200A (en) * | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for inhibiting bone resorption |
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2000
- 2000-11-20 WO PCT/IB2000/001711 patent/WO2001046140A1/fr active Application Filing
- 2000-11-20 AP APAP/P/2001/002357A patent/AP2001002357A0/en unknown
- 2000-11-20 MX MXPA02006322A patent/MXPA02006322A/es active IP Right Grant
- 2000-11-20 CZ CZ20022048A patent/CZ20022048A3/cs unknown
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- 2000-11-20 OA OA1200200177A patent/OA12117A/en unknown
- 2000-11-20 EA EA200200505A patent/EA005293B1/ru not_active IP Right Cessation
- 2000-11-20 AU AU12931/01A patent/AU1293101A/en not_active Abandoned
- 2000-11-20 BR BR0016560-3A patent/BR0016560A/pt not_active IP Right Cessation
- 2000-11-20 GE GEAP20006502A patent/GEP20043203B/en unknown
- 2000-11-20 CN CN00817566A patent/CN1413190A/zh active Pending
- 2000-11-20 UA UA2002065186A patent/UA72293C2/uk unknown
- 2000-11-20 PL PL00356662A patent/PL356662A1/xx not_active Application Discontinuation
- 2000-11-20 AP APAP/P/2002/002555A patent/AP2002002555A0/en unknown
- 2000-11-20 EE EEP200200355A patent/EE200200355A/xx unknown
- 2000-11-20 TR TR2002/01643T patent/TR200201643T2/xx unknown
- 2000-12-11 DE DE60005471T patent/DE60005471T2/de not_active Expired - Fee Related
- 2000-12-11 PT PT00311034T patent/PT1110949E/pt unknown
- 2000-12-11 EP EP00311034A patent/EP1110949B1/fr not_active Expired - Lifetime
- 2000-12-11 DK DK00311034T patent/DK1110949T3/da active
- 2000-12-11 TR TR2003/01841T patent/TR200301841T4/xx unknown
- 2000-12-11 ES ES00311034T patent/ES2204458T3/es not_active Expired - Lifetime
- 2000-12-11 AT AT00311034T patent/ATE250575T1/de not_active IP Right Cessation
- 2000-12-14 IL IL14032500A patent/IL140325A0/xx unknown
- 2000-12-15 US US09/738,670 patent/US6737437B2/en not_active Expired - Fee Related
- 2000-12-19 KR KR10-2000-0078214A patent/KR100419681B1/ko not_active IP Right Cessation
- 2000-12-19 PE PE2000001368A patent/PE20010953A1/es not_active Application Discontinuation
- 2000-12-20 CA CA002329678A patent/CA2329678A1/fr not_active Abandoned
- 2000-12-20 AU AU72393/00A patent/AU763983B2/en not_active Ceased
- 2000-12-20 ZA ZA200007694A patent/ZA200007694B/xx unknown
- 2000-12-21 HU HU0005001A patent/HUP0005001A3/hu unknown
- 2000-12-22 JP JP2000390594A patent/JP2001181210A/ja not_active Ceased
- 2000-12-22 CO CO00097391A patent/CO5251453A1/es not_active Application Discontinuation
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2001
- 2001-11-16 US US09/991,585 patent/US6642266B2/en not_active Expired - Fee Related
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2002
- 2002-05-17 IS IS6388A patent/IS6388A/is unknown
- 2002-06-12 CR CR6678A patent/CR6678A/es not_active Application Discontinuation
- 2002-06-13 MA MA26686A patent/MA26852A1/fr unknown
- 2002-06-18 NO NO20022925A patent/NO20022925L/no not_active Application Discontinuation
- 2002-06-20 HR HRP20020537 patent/HRP20020537A2/hr not_active Application Discontinuation
- 2002-06-28 BG BG106882A patent/BG106882A/xx unknown
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