UA63896C2 - Morphogenetic material for repairing cartilage and bone and method for treating - Google Patents

Morphogenetic material for repairing cartilage and bone and method for treating Download PDF

Info

Publication number
UA63896C2
UA63896C2 UA98063095A UA98063095A UA63896C2 UA 63896 C2 UA63896 C2 UA 63896C2 UA 98063095 A UA98063095 A UA 98063095A UA 98063095 A UA98063095 A UA 98063095A UA 63896 C2 UA63896 C2 UA 63896C2
Authority
UA
Ukraine
Prior art keywords
bone
cartilage
morphogenetic
polyoxyethylene
protein
Prior art date
Application number
UA98063095A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh
Publication of UA63896C2 publication Critical patent/UA63896C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2817Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30062(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
UA98063095A 1995-11-17 1996-11-14 Morphogenetic material for repairing cartilage and bone and method for treating UA63896C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7322402A JPH09143093A (ja) 1995-11-17 1995-11-17 軟骨・骨誘導性修復用材料
PCT/JP1996/003333 WO1997018829A1 (fr) 1995-11-17 1996-11-14 Materiaux inducteurs d'os/de cartilage en vue de leur reparation

Publications (1)

Publication Number Publication Date
UA63896C2 true UA63896C2 (en) 2004-02-16

Family

ID=18143268

Family Applications (1)

Application Number Title Priority Date Filing Date
UA98063095A UA63896C2 (en) 1995-11-17 1996-11-14 Morphogenetic material for repairing cartilage and bone and method for treating

Country Status (19)

Country Link
US (2) US6903071B2 (zh)
EP (1) EP0884052B1 (zh)
JP (1) JPH09143093A (zh)
KR (1) KR100458413B1 (zh)
CN (1) CN1165340C (zh)
AT (1) ATE254470T1 (zh)
AU (1) AU712445C (zh)
CA (1) CA2235400C (zh)
DE (1) DE69630811T2 (zh)
DK (1) DK0884052T3 (zh)
ES (1) ES2211993T3 (zh)
HK (1) HK1018205A1 (zh)
HU (1) HU226201B1 (zh)
NO (1) NO325119B1 (zh)
NZ (1) NZ322188A (zh)
PT (1) PT884052E (zh)
RU (1) RU2180234C2 (zh)
UA (1) UA63896C2 (zh)
WO (1) WO1997018829A1 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
WO1998034655A1 (en) * 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6309659B1 (en) 1997-09-02 2001-10-30 Gensci Orthobiologics, Inc. Reverse phase connective tissue repair composition
EP1231869B1 (en) * 1999-10-29 2005-09-21 Children's Hospital of Los Angeles Bone hemostasis method and materials
US9616150B2 (en) 1999-10-29 2017-04-11 Children's Hospital Los Angeles Bone hemostasis method and materials
WO2001036000A1 (en) 1999-11-15 2001-05-25 Bio Syntech Canada, Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US7747332B2 (en) * 2000-05-08 2010-06-29 International Rehabilitative Sciences, Inc. Electrical stimulation combined with a biologic to increase osteogenesis
JP5089006B2 (ja) * 2000-06-29 2012-12-05 ピラマル ヘルスケア (カナダ) リミテッド 軟骨および他の組織の修復および再生のための組成物および方法
JP2002306163A (ja) * 2001-04-11 2002-10-22 Chemo Sero Therapeut Res Inst 大腸菌を宿主とする遺伝子組換えヒトトロンビンの調製方法
CA2471403A1 (en) * 2001-12-21 2003-07-10 Gensci Orthobiologics, Inc. End-capped polyalkylene glycols and compositions containing such compounds
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
ES2633340T3 (es) * 2002-05-20 2017-09-20 Otsuka Pharmaceutical Co., Ltd. Composición para reducir la opacidad de la piel
AU2002337479A1 (en) * 2002-09-04 2004-03-29 Hadasit Medical Research Services & Development Ltd. Compositions comprising bone marrow cells, demineralized bone matrix and rtg polymers for use in the induction of bone and cartilage formation
AU2004211991B2 (en) 2003-02-12 2011-03-31 Syncera, Inc. Random and non-random alkylene oxide polymer alloy compositions
EP2001528A4 (en) * 2006-03-23 2012-04-04 Citagenix Inc REVERSE-PHASE OSSEOCONDUCTIVE COMPOSITION
DK2121142T3 (da) * 2007-01-25 2013-07-29 Bioph Biotech Entw Pharm Gmbh Anvendelse af GDF-5 til forbedring eller vedligeholdelse af hudens udseende
US8290780B2 (en) 2009-06-24 2012-10-16 International Business Machines Corporation Dynamically extending the speech prompts of a multimodal application
KR101405104B1 (ko) * 2011-12-26 2014-06-10 한남대학교 산학협력단 약물의 서방형 방출 특성을 가지는 골 시멘트
US10743996B2 (en) * 2017-03-24 2020-08-18 Robert L. Bundy Amnion putty for cartilage repair
CN109125791B (zh) * 2018-09-29 2019-08-30 广州贝奥吉因生物科技有限公司 一种具有促进骨修复功能的可吸收骨蜡及制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61277612A (ja) * 1985-05-31 1986-12-08 Kiyoshi Morikawa 接種用徐放性組成物
JPH0723322B2 (ja) * 1985-12-07 1995-03-15 克之 藤井 液状骨形成剤からなる注射液
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
US4863732A (en) * 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
JPH045227A (ja) * 1990-04-17 1992-01-09 Pharmetrix Corp 歯周疾患治療システム
CA2040460C (en) * 1990-05-01 1997-06-10 Tacey X. Viegas Drug delivery with thermoreversible gels
CA2102808A1 (en) * 1991-05-10 1992-11-11 Hanne Bentz Targeted delivery of bone growth factors
MX9203083A (es) * 1991-06-21 1994-08-31 Genetics Inst Formulaciones farmaceuticas de proteinas osteogenicas.
EP0551626A1 (en) * 1991-12-19 1993-07-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation
JPH08502082A (ja) * 1992-07-02 1996-03-05 コラーゲン コーポレイション 生体適合性ポリマー結合体
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
JP3696265B2 (ja) * 1994-02-04 2005-09-14 日本オルガノン株式会社 点鼻液剤
DE4423396C2 (de) 1994-07-04 2001-10-25 Fraunhofer Ges Forschung Verfahren zum Herstellen einer mikromechanischen Oberflächenstruktur
WO1996021427A1 (en) * 1995-01-09 1996-07-18 Atrix Laboratories, Inc. Liquid polymer delivery system
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料

Also Published As

Publication number Publication date
PT884052E (pt) 2004-04-30
US20050013864A1 (en) 2005-01-20
ATE254470T1 (de) 2003-12-15
US6903071B2 (en) 2005-06-07
KR19990067676A (ko) 1999-08-25
CN1207047A (zh) 1999-02-03
US20020168381A1 (en) 2002-11-14
RU2180234C2 (ru) 2002-03-10
AU712445B2 (en) 1999-11-04
HK1018205A1 (en) 1999-12-17
KR100458413B1 (ko) 2005-04-06
EP0884052A4 (en) 1999-05-06
AU712445C (en) 2002-03-28
ES2211993T3 (es) 2004-07-16
DK0884052T3 (da) 2004-03-29
DE69630811D1 (de) 2003-12-24
AU7586996A (en) 1997-06-11
HUP0000411A2 (hu) 2001-04-28
US7238657B2 (en) 2007-07-03
NO982236D0 (no) 1998-05-15
JPH09143093A (ja) 1997-06-03
NZ322188A (en) 2000-10-27
EP0884052A1 (en) 1998-12-16
NO325119B1 (no) 2008-02-04
CA2235400A1 (en) 1997-05-29
CN1165340C (zh) 2004-09-08
HUP0000411A3 (en) 2005-11-28
EP0884052B1 (en) 2003-11-19
DE69630811T2 (de) 2004-06-17
NO982236L (no) 1998-06-26
WO1997018829A1 (fr) 1997-05-29
HU226201B1 (en) 2008-06-30
CA2235400C (en) 2007-12-18

Similar Documents

Publication Publication Date Title
UA63896C2 (en) Morphogenetic material for repairing cartilage and bone and method for treating
Kulinets Biomaterials and their applications in medicine
US6380154B1 (en) Synthetic proteins for in vivo drug delivery and tissue augmentation
FI119816B (fi) Eristetyt DNA-sekvenssit, jotka koodaavat jänteen/nivelsiteen kaltaisen kudoksen muodostumista indusoivaa BMP-12- tai BMP-13-proteiinia, sekä niiden sovellukset
CN109568671B (zh) 一种水凝胶负载细胞的3d骨修复支架及其制备方法
JP2004041236A (ja) 骨形成具
CN112972760A (zh) 一种负载内皮细胞外基质的3d打印骨缺损修复支架及其制备方法
IL259891B1 (en) Organic solvent-free compositions containing conjugates of protein and polymer, and their uses
CN104307040B (zh) 一种组织工程用具控释能力的注射式水凝胶及其应用
JP2001131086A (ja) エンドセリンを含む結合組織修復促進組成物および該組成物の調製におけるエンドセリンの使用
KR100358080B1 (ko) 생리활성물질을 서방화하는 다공성·생분해성 인공장기의제조방법
KR102048914B1 (ko) 콘드로이틴설페이트가 함유된 젤란검 하이드로겔 조성물
RU2195940C2 (ru) Способ регенерации суставного хряща
CN112206307B (zh) 一种可注射的温敏型水凝胶及其制备方法与应用
JP2001122799A (ja) プレイオトロフィンを含む結合組織修復促進組成物および該組成物の調製におけるプレイオトロフィンの使用
CN114805484B (zh) 一种自组装多肽、自组装纳米水凝胶及其应用
ES2625654T3 (es) Un método de producción de componentes nativos, tales como factores de crecimiento o proteínas de la matriz extracelular, mediante cultivo celular de muestras de tejido para la reparación de tejido
WO2019151450A1 (ja) 神経細胞培養材および神経損傷治療剤
Huang et al. Biological activity of self-assembled peptide hydrogel scaffold RADA-RGD and its experimental study of BMP-2 release in vitro
CN114025846A (zh) 用于治疗关节疾病的药物组合物及其制备方法
Ross et al. Multipurpose On‐the‐Spot Peptide‐Based Hydrogels for Skin, Cornea, and Heart Repair
CN116478268A (zh) Bmp2蛋白保护液、bmp2蛋白制剂及其制备方法
CN115287257A (zh) 基于弓形虫外分泌蛋白的成骨诱导分化培养基、制备方法及成骨诱导分化方法
CN100448890C (zh) 来源于mp-52蛋白质的新型蛋白质及其制备方法和用途
RU2269108C2 (ru) Способ ускоренной гистологической проводки трепанобиоптатов костного мозга