HUP0000411A2 - Porc- és csontnövekedést serkentő anyagok - Google Patents

Porc- és csontnövekedést serkentő anyagok

Info

Publication number
HUP0000411A2
HUP0000411A2 HU0000411A HUP0000411A HUP0000411A2 HU P0000411 A2 HUP0000411 A2 HU P0000411A2 HU 0000411 A HU0000411 A HU 0000411A HU P0000411 A HUP0000411 A HU P0000411A HU P0000411 A2 HUP0000411 A2 HU P0000411A2
Authority
HU
Hungary
Prior art keywords
bone
cartilage
poly
morphogenesis
morphogenetic
Prior art date
Application number
HU0000411A
Other languages
English (en)
Inventor
Takcsada Shimura
Satsuki Toriyama
Original Assignee
Hoechst Marion Roussel Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Ltd. filed Critical Hoechst Marion Roussel Ltd.
Publication of HUP0000411A2 publication Critical patent/HUP0000411A2/hu
Publication of HUP0000411A3 publication Critical patent/HUP0000411A3/hu
Publication of HU226201B1 publication Critical patent/HU226201B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable

Abstract

A találmány tárgyát porc és csont morfogenetikus javítását elősegítőanyagok képezik, amelyek alkalmasak csonttörés és csontkárosodáskezelésére. Közelebbről, a találmány tárgyát olyan porc és csontmorfogenetikus javítását elősegítő anyagok képezik, amelyek poli(oxi-etilén)-poli(oxi-propilénglikol)-t és csont morfogenezisét elősegítőfehérjét tartalmaznak, és amelyekben előnyösen a poli(oxi-etilén)-poli(oxi-propilénglikol) alkotóelemként 1500 és 4000 közöttimolekulatömegű polipropilénglikolt, valamint molekulánként mintegy 40-80% arányban etilén-oxidot tartalmaz, és a poli(oxi-etilén)- poli(oxi-propilénglikol) vizes oldatban van jelen és koncentrációja mintegy 10-50%. A találmány szerinti, porc és csont morfogenetikus javításátelősegítő anyag alkalmas porc és csont morfogenezisének kiváltására,anélkül hogy sebészeti műtétre lenne szükség. A találmány szerintiporc és csont morfogenetikus javítását elősegítő anyagra jellemző,hogy a csont morfogenezisét elősegítő fehérjén kívül egy olyanhordozót is tartalmaz, amelyre nagyfokú biabszorpció, a morfogenezistelősegítő fehérjével szembeni nagymértékű affinitás jellemző, valamintaz, hogy képes hőmérsékletfüggő, reverzíbilis szol-gél átmenetre, ígyalkalmas arra, hogy a csonttörés vagy csontkárosodás helyén alkalmazvahelyileg fejtse ki hatását. Ó
HU0000411A 1995-11-17 1996-11-14 Cartilage/bone inducing materials for reparation HU226201B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7322402A JPH09143093A (ja) 1995-11-17 1995-11-17 軟骨・骨誘導性修復用材料
PCT/JP1996/003333 WO1997018829A1 (fr) 1995-11-17 1996-11-14 Materiaux inducteurs d'os/de cartilage en vue de leur reparation

Publications (3)

Publication Number Publication Date
HUP0000411A2 true HUP0000411A2 (hu) 2001-04-28
HUP0000411A3 HUP0000411A3 (en) 2005-11-28
HU226201B1 HU226201B1 (en) 2008-06-30

Family

ID=18143268

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000411A HU226201B1 (en) 1995-11-17 1996-11-14 Cartilage/bone inducing materials for reparation

Country Status (19)

Country Link
US (2) US6903071B2 (hu)
EP (1) EP0884052B1 (hu)
JP (1) JPH09143093A (hu)
KR (1) KR100458413B1 (hu)
CN (1) CN1165340C (hu)
AT (1) ATE254470T1 (hu)
AU (1) AU712445C (hu)
CA (1) CA2235400C (hu)
DE (1) DE69630811T2 (hu)
DK (1) DK0884052T3 (hu)
ES (1) ES2211993T3 (hu)
HK (1) HK1018205A1 (hu)
HU (1) HU226201B1 (hu)
NO (1) NO325119B1 (hu)
NZ (1) NZ322188A (hu)
PT (1) PT884052E (hu)
RU (1) RU2180234C2 (hu)
UA (1) UA63896C2 (hu)
WO (1) WO1997018829A1 (hu)

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JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
CA2280931C (en) † 1997-02-07 2009-05-05 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6309659B1 (en) 1997-09-02 2001-10-30 Gensci Orthobiologics, Inc. Reverse phase connective tissue repair composition
US9616150B2 (en) 1999-10-29 2017-04-11 Children's Hospital Los Angeles Bone hemostasis method and materials
ATE304870T1 (de) * 1999-10-29 2005-10-15 Los Angeles Childrens Hospital Verfahren und material zur hämostase bei knochen
ES2491866T3 (es) 1999-11-15 2014-09-08 Piramal Healthcare (Canada) Limited Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH
US7747332B2 (en) * 2000-05-08 2010-06-29 International Rehabilitative Sciences, Inc. Electrical stimulation combined with a biologic to increase osteogenesis
DK1294414T3 (da) * 2000-06-29 2006-07-24 Biosyntech Canada Inc Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv
JP2002306163A (ja) * 2001-04-11 2002-10-22 Chemo Sero Therapeut Res Inst 大腸菌を宿主とする遺伝子組換えヒトトロンビンの調製方法
KR20040075901A (ko) * 2001-12-21 2004-08-30 아이소티스 오르토바이올로직스, 인크. 말단-캡핑된 폴리알킬렌 글리콜 및 이들 화합물을함유하는 조성물
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
US7994153B2 (en) * 2002-05-20 2011-08-09 Otsuka Pharmaceutical Co., Ltd. Chloasma amelioration composition and dullness amelioration composition
WO2004022120A1 (en) * 2002-09-04 2004-03-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions comprising bone marrow cells, demineralized bone matrix and rtg polymers for use in the induction of bone and cartilage formation
TWI367113B (en) 2003-02-12 2012-07-01 Syncera Inc Random and non-random alkylene oxide polymer alloy compositions
CA2646486A1 (en) * 2006-03-23 2007-09-27 Citagenix Inc. Reverse phase osteoconductive composition
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Also Published As

Publication number Publication date
DK0884052T3 (da) 2004-03-29
CN1207047A (zh) 1999-02-03
KR100458413B1 (ko) 2005-04-06
CA2235400A1 (en) 1997-05-29
DE69630811D1 (de) 2003-12-24
ATE254470T1 (de) 2003-12-15
ES2211993T3 (es) 2004-07-16
HU226201B1 (en) 2008-06-30
AU712445C (en) 2002-03-28
PT884052E (pt) 2004-04-30
US20050013864A1 (en) 2005-01-20
EP0884052A4 (en) 1999-05-06
US7238657B2 (en) 2007-07-03
KR19990067676A (ko) 1999-08-25
DE69630811T2 (de) 2004-06-17
US6903071B2 (en) 2005-06-07
JPH09143093A (ja) 1997-06-03
WO1997018829A1 (fr) 1997-05-29
HK1018205A1 (en) 1999-12-17
CA2235400C (en) 2007-12-18
RU2180234C2 (ru) 2002-03-10
NO982236D0 (no) 1998-05-15
NO982236L (no) 1998-06-26
HUP0000411A3 (en) 2005-11-28
AU7586996A (en) 1997-06-11
EP0884052B1 (en) 2003-11-19
EP0884052A1 (en) 1998-12-16
AU712445B2 (en) 1999-11-04
CN1165340C (zh) 2004-09-08
NO325119B1 (no) 2008-02-04
US20020168381A1 (en) 2002-11-14
UA63896C2 (en) 2004-02-16
NZ322188A (en) 2000-10-27

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