UA62936C2 - N6 heterocyclic substituted adenosine derivatives - Google Patents
N6 heterocyclic substituted adenosine derivatives Download PDFInfo
- Publication number
- UA62936C2 UA62936C2 UA99021148A UA99021148A UA62936C2 UA 62936 C2 UA62936 C2 UA 62936C2 UA 99021148 A UA99021148 A UA 99021148A UA 99021148 A UA99021148 A UA 99021148A UA 62936 C2 UA62936 C2 UA 62936C2
- Authority
- UA
- Ukraine
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- group
- substituted
- lower alkyl
- aryl
- cycloalkyl
- Prior art date
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
- BOTREHHXSQGWTR-UHFFFAOYSA-N oxolane-3-carboxylic acid Chemical compound OC(=O)C1CCOC1 BOTREHHXSQGWTR-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 125000005561 phenanthryl group Chemical group 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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- 238000003825 pressing Methods 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 230000036279 refractory period Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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- 229940124597 therapeutic agent Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08702234 US5789416B1 (en) | 1996-08-27 | 1996-08-27 | N6 mono heterocyclic substituted adenosine derivatives |
PCT/US1997/014724 WO1998008855A2 (en) | 1996-08-27 | 1997-08-20 | N6 heterocyclic substituted adenosine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
UA62936C2 true UA62936C2 (en) | 2004-01-15 |
Family
ID=24820367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA99021148A UA62936C2 (en) | 1996-08-27 | 1997-08-20 | N6 heterocyclic substituted adenosine derivatives |
Country Status (25)
Country | Link |
---|---|
US (1) | US5789416B1 (el) |
EP (3) | EP1081155A3 (el) |
JP (1) | JP3157842B2 (el) |
KR (1) | KR100331775B1 (el) |
CN (1) | CN100363377C (el) |
AT (2) | ATE234323T1 (el) |
AU (1) | AU726597B2 (el) |
BR (1) | BR9711444A (el) |
CA (1) | CA2264155C (el) |
CZ (1) | CZ296855B6 (el) |
DE (2) | DE69719816T2 (el) |
DK (2) | DK0992510T3 (el) |
ES (2) | ES2189330T3 (el) |
GE (1) | GEP20012419B (el) |
GR (1) | GR3036332T3 (el) |
HK (1) | HK1020967A1 (el) |
HU (1) | HU226057B1 (el) |
IL (2) | IL128652A0 (el) |
NO (3) | NO312679B1 (el) |
NZ (3) | NZ334095A (el) |
PL (1) | PL187635B1 (el) |
PT (1) | PT920438E (el) |
TR (2) | TR200202287T2 (el) |
UA (1) | UA62936C2 (el) |
WO (1) | WO1998008855A2 (el) |
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DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
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JP2017514908A (ja) | 2014-05-01 | 2017-06-08 | アールエックスアイ ファーマシューティカルズ コーポレーション | 核酸分子を利用する目の前部における障害の処置のための方法 |
EP3188799B1 (en) | 2014-09-05 | 2022-07-06 | Phio Pharmaceuticals Corp. | Methods for treating aging and skin disorders using nucleic acids targeting tyr or mmp1 |
CA2991598A1 (en) | 2015-07-06 | 2017-01-12 | Rxi Pharmaceuticals Corporation | Nucleic acid molecules targeting superoxide dismutase 1 (sod1) |
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JP2018531037A (ja) | 2015-10-19 | 2018-10-25 | アールエックスアイ ファーマシューティカルズ コーポレーション | 長い非コードrnaを標的とする減少したサイズの自己送達型核酸化合物 |
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-
1996
- 1996-08-27 US US08702234 patent/US5789416B1/en not_active Expired - Lifetime
-
1997
- 1997-08-20 NZ NZ334095A patent/NZ334095A/xx not_active IP Right Cessation
- 1997-08-20 TR TR2002/02287T patent/TR200202287T2/xx unknown
- 1997-08-20 DK DK99119389T patent/DK0992510T3/da active
- 1997-08-20 UA UA99021148A patent/UA62936C2/uk unknown
- 1997-08-20 PT PT97938502T patent/PT920438E/pt unknown
- 1997-08-20 ES ES99119389T patent/ES2189330T3/es not_active Expired - Lifetime
- 1997-08-20 PL PL97331853A patent/PL187635B1/pl not_active IP Right Cessation
- 1997-08-20 EP EP00123879A patent/EP1081155A3/en not_active Withdrawn
- 1997-08-20 CA CA002264155A patent/CA2264155C/en not_active Expired - Fee Related
- 1997-08-20 ES ES97938502T patent/ES2157593T3/es not_active Expired - Lifetime
- 1997-08-20 EP EP99119389A patent/EP0992510B1/en not_active Expired - Lifetime
- 1997-08-20 DE DE69719816T patent/DE69719816T2/de not_active Expired - Lifetime
- 1997-08-20 TR TR1999/00377T patent/TR199900377T2/xx unknown
- 1997-08-20 KR KR1019997001563A patent/KR100331775B1/ko not_active IP Right Cessation
- 1997-08-20 WO PCT/US1997/014724 patent/WO1998008855A2/en active IP Right Grant
- 1997-08-20 NZ NZ505428A patent/NZ505428A/en unknown
- 1997-08-20 AT AT99119389T patent/ATE234323T1/de active
- 1997-08-20 AU AU40809/97A patent/AU726597B2/en not_active Ceased
- 1997-08-20 CN CNB971991790A patent/CN100363377C/zh not_active Expired - Fee Related
- 1997-08-20 BR BR9711444-8A patent/BR9711444A/pt active Search and Examination
- 1997-08-20 JP JP51173698A patent/JP3157842B2/ja not_active Expired - Fee Related
- 1997-08-20 AT AT97938502T patent/ATE202361T1/de active
- 1997-08-20 GE GEAP19974728A patent/GEP20012419B/en unknown
- 1997-08-20 DE DE69705312T patent/DE69705312T2/de not_active Expired - Lifetime
- 1997-08-20 EP EP97938502A patent/EP0920438B1/en not_active Expired - Lifetime
- 1997-08-20 IL IL12865297A patent/IL128652A0/xx active IP Right Grant
- 1997-08-20 CZ CZ0061499A patent/CZ296855B6/cs not_active IP Right Cessation
- 1997-08-20 HU HU0001640A patent/HU226057B1/hu not_active IP Right Cessation
- 1997-08-20 DK DK97938502T patent/DK0920438T3/da active
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1999
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- 1999-02-22 IL IL128652A patent/IL128652A/en not_active IP Right Cessation
- 1999-12-30 HK HK99106191A patent/HK1020967A1/xx not_active IP Right Cessation
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2001
- 2001-06-08 NZ NZ512242A patent/NZ512242A/xx not_active IP Right Cessation
- 2001-08-06 GR GR20010401184T patent/GR3036332T3/el unknown
-
2002
- 2002-02-15 NO NO20020759A patent/NO20020759D0/no not_active Application Discontinuation
- 2002-02-15 NO NO20020758A patent/NO322459B1/no not_active IP Right Cessation
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