UA61955C2 - Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy - Google Patents
Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy Download PDFInfo
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- UA61955C2 UA61955C2 UA99127002A UA99127002A UA61955C2 UA 61955 C2 UA61955 C2 UA 61955C2 UA 99127002 A UA99127002 A UA 99127002A UA 99127002 A UA99127002 A UA 99127002A UA 61955 C2 UA61955 C2 UA 61955C2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001536 pro-arrhythmogenic effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000012501 relaxation of skeletal muscle Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
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- 210000001995 reticulocyte Anatomy 0.000 description 1
- 230000000698 schizophrenic effect Effects 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 229960002101 secretin Drugs 0.000 description 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
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- 230000009528 severe injury Effects 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 229940120904 succinylcholine chloride Drugs 0.000 description 1
- YOEWQQVKRJEPAE-UHFFFAOYSA-L succinylcholine chloride (anhydrous) Chemical compound [Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C YOEWQQVKRJEPAE-UHFFFAOYSA-L 0.000 description 1
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- 230000009044 synergistic interaction Effects 0.000 description 1
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- 210000001550 testis Anatomy 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 229940036248 turpentine Drugs 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 208000001319 vasomotor rhinitis Diseases 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97108384 | 1997-05-23 | ||
| PCT/EP1998/002953 WO1998052973A1 (en) | 1997-05-23 | 1998-05-20 | New bpc peptide salts with organo-protective activity, the process for their preparation and their use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA61955C2 true UA61955C2 (en) | 2003-12-15 |
Family
ID=8226822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99127002A UA61955C2 (en) | 1997-05-23 | 1998-05-20 | Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6288028B1 (cs) |
| EP (1) | EP0983300B1 (cs) |
| JP (1) | JP3492381B2 (cs) |
| KR (1) | KR100488038B1 (cs) |
| CN (1) | CN1166683C (cs) |
| AR (1) | AR011478A1 (cs) |
| AT (1) | ATE277948T1 (cs) |
| AU (1) | AU731317B2 (cs) |
| BG (1) | BG64023B1 (cs) |
| BR (1) | BR9809457B1 (cs) |
| CA (1) | CA2290739C (cs) |
| CZ (1) | CZ299423B6 (cs) |
| DE (1) | DE69826653T2 (cs) |
| DK (1) | DK0983300T3 (cs) |
| EA (1) | EA002058B1 (cs) |
| ES (1) | ES2229507T3 (cs) |
| HU (1) | HU227800B1 (cs) |
| ID (1) | ID23184A (cs) |
| IL (2) | IL132884A0 (cs) |
| NO (1) | NO321126B1 (cs) |
| NZ (1) | NZ501323A (cs) |
| PL (1) | PL193790B1 (cs) |
| PT (1) | PT983300E (cs) |
| RS (1) | RS49733B (cs) |
| SK (1) | SK159599A3 (cs) |
| TR (1) | TR199902866T2 (cs) |
| UA (1) | UA61955C2 (cs) |
| WO (1) | WO1998052973A1 (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4912875B2 (ja) * | 2004-02-27 | 2012-04-11 | 不二製油株式会社 | 癌転移抑制組成物 |
| US8022216B2 (en) * | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| SI24318A (sl) | 2013-03-13 | 2014-09-30 | Diagen D.O.O. | Nove stabilne soli pentadekapeptida, postopek za njihovo pripravo, njihova uporaba za izdelavo farmacevtskih pripravkov in njihova uporaba v terapiji |
| US10350293B2 (en) * | 2016-08-23 | 2019-07-16 | Pharmacotherapia d.o.o. | Compositions and methods for treating symptoms associated with multiple sclerosis |
| MY198425A (en) | 2017-08-24 | 2023-08-29 | Novo Nordisk As | Glp-1 Compositions and uses Thereof |
| MX2022009844A (es) | 2020-02-18 | 2022-09-05 | Novo Nordisk As | Composiciones y usos del peptido similar al glucagon-1 (glp-1). |
| US11065298B1 (en) * | 2020-04-24 | 2021-07-20 | Chanda Zaveri | Compositions and methods for treating or preventing viral infections |
| US20240382565A1 (en) * | 2023-05-15 | 2024-11-21 | Red Mountain Med Spa, LLC | Sublingual semaglutide-bpc 157 combination for weight loss |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6901191A (en) * | 1990-09-11 | 1992-03-30 | Marko Duvnjak | Pharmacologically active substance bpc, the process for its preparation and its use in the therapy |
| DK0572688T3 (da) * | 1992-05-30 | 1997-12-01 | Sikiric Predrag | Peptider, med organ-beskyttende aktivitet, fremgangsmåde til deres fremstilling og deres anvendelse ved terapi |
| RU2116311C1 (ru) | 1992-11-16 | 1998-07-27 | Сикирич Предраг | Пептиды, обладающие органозащитной активностью, фармакологически активная композиция |
-
1998
- 1998-05-20 TR TR1999/02866T patent/TR199902866T2/xx unknown
- 1998-05-20 ES ES98929345T patent/ES2229507T3/es not_active Expired - Lifetime
- 1998-05-20 HU HU0002329A patent/HU227800B1/hu not_active IP Right Cessation
- 1998-05-20 EA EA199901061A patent/EA002058B1/ru not_active IP Right Cessation
- 1998-05-20 AT AT98929345T patent/ATE277948T1/de active
- 1998-05-20 KR KR10-1999-7010862A patent/KR100488038B1/ko not_active Expired - Fee Related
- 1998-05-20 BR BRPI9809457-2A patent/BR9809457B1/pt not_active IP Right Cessation
- 1998-05-20 AU AU79141/98A patent/AU731317B2/en not_active Ceased
- 1998-05-20 SK SK1595-99A patent/SK159599A3/sk unknown
- 1998-05-20 PT PT98929345T patent/PT983300E/pt unknown
- 1998-05-20 US US09/424,414 patent/US6288028B1/en not_active Expired - Lifetime
- 1998-05-20 IL IL13288498A patent/IL132884A0/xx active IP Right Grant
- 1998-05-20 DK DK98929345T patent/DK0983300T3/da active
- 1998-05-20 CA CA002290739A patent/CA2290739C/en not_active Expired - Fee Related
- 1998-05-20 CN CNB988053934A patent/CN1166683C/zh not_active Expired - Fee Related
- 1998-05-20 PL PL98336897A patent/PL193790B1/pl unknown
- 1998-05-20 EP EP98929345A patent/EP0983300B1/en not_active Expired - Lifetime
- 1998-05-20 NZ NZ501323A patent/NZ501323A/en not_active IP Right Cessation
- 1998-05-20 UA UA99127002A patent/UA61955C2/uk unknown
- 1998-05-20 DE DE69826653T patent/DE69826653T2/de not_active Expired - Lifetime
- 1998-05-20 ID IDW991444A patent/ID23184A/id unknown
- 1998-05-20 RS YUP-601/99A patent/RS49733B/sr unknown
- 1998-05-20 CZ CZ0414299A patent/CZ299423B6/cs not_active IP Right Cessation
- 1998-05-20 JP JP54994898A patent/JP3492381B2/ja not_active Expired - Fee Related
- 1998-05-20 WO PCT/EP1998/002953 patent/WO1998052973A1/en active IP Right Grant
- 1998-05-26 AR ARP980102425A patent/AR011478A1/es active IP Right Grant
-
1999
- 1999-11-11 IL IL132884A patent/IL132884A/en not_active IP Right Cessation
- 1999-11-19 NO NO19995692A patent/NO321126B1/no not_active IP Right Cessation
- 1999-11-19 BG BG103905A patent/BG64023B1/bg unknown
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