UA61879C2 - Piperazine-2,5-dione derivatives as resistance modulators to many preparations - Google Patents

Piperazine-2,5-dione derivatives as resistance modulators to many preparations Download PDF

Info

Publication number
UA61879C2
UA61879C2 UA97062956A UA97062956A UA61879C2 UA 61879 C2 UA61879 C2 UA 61879C2 UA 97062956 A UA97062956 A UA 97062956A UA 97062956 A UA97062956 A UA 97062956A UA 61879 C2 UA61879 C2 UA 61879C2
Authority
UA
Ukraine
Prior art keywords
methyl
benzylidene
dioxo
methylbenzamide
piperazinylidene
Prior art date
Application number
UA97062956A
Other languages
English (en)
Ukrainian (uk)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UA61879C2 publication Critical patent/UA61879C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electron Tubes For Measurement (AREA)
UA97062956A 1994-12-23 1995-12-22 Piperazine-2,5-dione derivatives as resistance modulators to many preparations UA61879C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426090.8A GB9426090D0 (en) 1994-12-23 1994-12-23 Pharmaceutical compounds
PCT/GB1995/003029 WO1996020180A1 (en) 1994-12-23 1995-12-22 Piperazine-2,5-dione derivatives as modulators of multidrug resistance

Publications (1)

Publication Number Publication Date
UA61879C2 true UA61879C2 (en) 2003-12-15

Family

ID=10766502

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97062956A UA61879C2 (en) 1994-12-23 1995-12-22 Piperazine-2,5-dione derivatives as resistance modulators to many preparations

Country Status (27)

Country Link
US (1) US5935955A (cs)
EP (1) EP0799210B1 (cs)
JP (1) JPH10511385A (cs)
KR (1) KR100412167B1 (cs)
CN (1) CN1108294C (cs)
AT (1) ATE204569T1 (cs)
AU (1) AU700891B2 (cs)
BG (1) BG63305B1 (cs)
BR (1) BR9510429A (cs)
CA (1) CA2207548A1 (cs)
CZ (1) CZ288935B6 (cs)
DE (1) DE69522342T2 (cs)
DK (1) DK0799210T3 (cs)
ES (1) ES2160726T3 (cs)
FI (1) FI972661A7 (cs)
GB (2) GB9426090D0 (cs)
HU (1) HUT77740A (cs)
IL (1) IL116526A (cs)
MY (1) MY131762A (cs)
NO (1) NO308532B1 (cs)
NZ (1) NZ297849A (cs)
PL (1) PL186851B1 (cs)
PT (1) PT799210E (cs)
SK (1) SK283385B6 (cs)
UA (1) UA61879C2 (cs)
WO (1) WO1996020180A1 (cs)
ZA (1) ZA9510908B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
KR20010085898A (ko) 1998-10-08 2001-09-07 피터 기딩스 도파민 ｄ3 수용체 조절제 (정신병 치료제)로서 유용한테트라히드로벤즈아제핀 유도체
US6828412B1 (en) * 1999-09-03 2004-12-07 School Of Pharmacy, University Of London Degradable polymers
AU7346400A (en) * 1999-09-03 2001-04-10 School Of Pharmacy, University Of London, The Degradable polymers
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU2001288829A1 (en) 2000-09-06 2002-03-22 Ap Pharma, Inc. Degradable polyacetal polymers
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
MXPA04004361A (es) * 2001-11-07 2005-03-31 Pharmacia Corp Metodos para promover la captacion y acumulacion nuclear de poliamidas en celulas eucarioticas.
US8710062B2 (en) * 2011-03-11 2014-04-29 Taipei Medical University Piperazinedione compounds
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
US12139491B2 (en) * 2018-12-27 2024-11-12 Holosmedic Diketopiperazine derivatives as calcium ATPase inhibitor for enhancing anticancer activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001408A1 (en) * 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Anilide derivatives
CA2120760A1 (en) * 1992-08-14 1994-03-03 Tohru Ando Peptide having allergenicity
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
DE69522342D1 (de) 2001-09-27
PL320915A1 (en) 1997-11-10
NO972938L (no) 1997-06-23
DK0799210T3 (da) 2001-10-01
EP0799210B1 (en) 2001-08-22
ZA9510908B (en) 1996-06-24
SK283385B6 (sk) 2003-06-03
GB2311780A (en) 1997-10-08
NO972938D0 (no) 1997-06-23
IL116526A0 (en) 1996-03-31
CZ288935B6 (cs) 2001-09-12
EP0799210A1 (en) 1997-10-08
CA2207548A1 (en) 1996-07-04
AU700891B2 (en) 1999-01-14
CN1108294C (zh) 2003-05-14
FI972661L (fi) 1997-08-22
WO1996020180A1 (en) 1996-07-04
PL186851B1 (pl) 2004-03-31
CZ190297A3 (cs) 1998-01-14
GB2311780B (en) 1999-03-03
CN1176637A (zh) 1998-03-18
NO308532B1 (no) 2000-09-25
ATE204569T1 (de) 2001-09-15
BG101601A (bg) 1998-02-27
BG63305B1 (bg) 2001-09-28
GB9712179D0 (en) 1997-08-13
GB9426090D0 (en) 1995-02-22
HUT77740A (hu) 1998-07-28
BR9510429A (pt) 1998-07-07
IL116526A (en) 1999-11-30
US5935955A (en) 1999-08-10
AU4310296A (en) 1996-07-19
HK1001974A1 (en) 1998-07-24
MY131762A (en) 2007-08-30
SK83597A3 (en) 1998-04-08
PT799210E (pt) 2002-01-30
JPH10511385A (ja) 1998-11-04
ES2160726T3 (es) 2001-11-16
KR100412167B1 (ko) 2004-05-27
DE69522342T2 (de) 2002-01-03
NZ297849A (en) 1999-04-29
FI972661A7 (fi) 1997-08-22
FI972661A0 (fi) 1997-06-19

Similar Documents

Publication Publication Date Title
UA61879C2 (en) Piperazine-2,5-dione derivatives as resistance modulators to many preparations
CN114761003B (zh) 具有雄激素受体降解活性的新型脲类及其用途
KR102499522B1 (ko) 세레브론 단백질의 조절제로서의 치환된 n-(2-(2,6-디옥소피페리딘-3-일)-1,3-디옥소이소인돌린-5-일)아릴설폰아미드 유사체
KR20060037409A (ko) 피페라진 유도체 및 그의 치료제로서의 용도
MX2014007544A (es) Inhibidores de la trayectoria de señalizacion notch y uso de los mismos en el tratamiento de canceres.
HUT77943A (hu) 2,5-Dioxo-piperazin-származékok, eljárás előállításukra és alkalmazásuk, valamint közbenső termékei
WO1991007966A1 (en) Immunosuppressant and process for preparing the same
WO2015116947A1 (en) Itraconazole analogues and methods of use thereof
Akinboye et al. Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines
CA3211378A1 (en) Tetrahydronaphthalene compound, and preparation method therefor and use thereof in medicine
WO2020062883A1 (zh) 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用
WO2022159650A1 (en) HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF eEF1A2
BRPI0911990A2 (pt) compostos de piridina prolinamida e seu uso na terapia
KR20150023880A (ko) 안드로겐 수용체 길항제로서의 ｎ-[4-(퀴놀린-4-일옥시)사이클로헥실(메틸)](헤테로)아릴카복사미드, 그의 제조, 및 의약품으로서의 그의 용도
CN118027003B (zh) 一种protac化合物及其制备方法和作为雌激素受体降解剂的用途
KR20200097301A (ko) 이미다조피리딘 유도체 및 이의 약제로서의 용도
WO1996020179A1 (en) Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
TWI280242B (en) Pharmaceutical compounds
CN116693446A (zh) 苯基脲类衍生物及其医药用途
WO2021254254A1 (zh) 一类基于有机砷的ii型丙酮酸激酶抑制剂及其制备方法和用途
CN107286057A (zh) 间苯二酚类化合物及医药用途
CN118056836A (zh) 取代的氨基嘧啶类大环化合物、其制备方法及其在医药上的应用
CN117843590A (zh) 3-氨基-4-（哌嗪-1-基）苯甲酰胺类衍生物、包含其的药物组合物及其制备方法、应用
WO2021030174A1 (en) Truncated itraconazole analogues and methods of use thereof
TW202532410A (zh) 以四員環結構置換之三級醯胺衍生物