UA41921C2 - Спосіб одержання 7,7-діоксиду-5,6-дигідро-(s)-4-(алкіламіно)-(s)-6-алкіл-4н-тієно[2, 3b]тіопіран-2-сульфонаміду та споріднених сполук - Google Patents

Спосіб одержання 7,7-діоксиду-5,6-дигідро-(s)-4-(алкіламіно)-(s)-6-алкіл-4н-тієно[2, 3b]тіопіран-2-сульфонаміду та споріднених сполук

Info

Publication number
UA41921C2
UA41921C2 UA95094239A UA95094239A UA41921C2 UA 41921 C2 UA41921 C2 UA 41921C2 UA 95094239 A UA95094239 A UA 95094239A UA 95094239 A UA95094239 A UA 95094239A UA 41921 C2 UA41921 C2 UA 41921C2
Authority
UA
Ukraine
Prior art keywords
alkyl
thieno
sulfonamide
alkylamino
dihydro
Prior art date
Application number
UA95094239A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Сохар Пол
Дж. Матр Девід
Дж. Матр Дэвид
Дж. Блеклок Томас
Original Assignee
Мерк Енд Ко, Інк
Мерк энд Ко, Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Енд Ко, Інк, Мерк энд Ко, Инк filed Critical Мерк Енд Ко, Інк
Publication of UA41921C2 publication Critical patent/UA41921C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA95094239A 1993-03-22 1994-03-16 Спосіб одержання 7,7-діоксиду-5,6-дигідро-(s)-4-(алкіламіно)-(s)-6-алкіл-4н-тієно[2, 3b]тіопіран-2-сульфонаміду та споріднених сполук UA41921C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US19588694A 1994-02-10 1994-02-10
PCT/US1994/002852 WO1994021645A1 (en) 1993-03-22 1994-03-16 ENANTIOSELECTIVE SYNTHESIS OF 5,6-DIHYDRO-(S)-4-(ETHYLAMINO)-(S)-6-METHYL-4H-THIENO[2,3-b]THIOPYRAN-2-SULFONAMIDE 7,7-DIOXIDE AND RELATED COMPOUNDS

Publications (1)

Publication Number Publication Date
UA41921C2 true UA41921C2 (uk) 2001-10-15

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95094239A UA41921C2 (uk) 1993-03-22 1994-03-16 Спосіб одержання 7,7-діоксиду-5,6-дигідро-(s)-4-(алкіламіно)-(s)-6-алкіл-4н-тієно[2, 3b]тіопіран-2-сульфонаміду та споріднених сполук

Country Status (28)

Country Link
US (1) US5688968A (OSRAM)
EP (1) EP0617037B1 (OSRAM)
JP (1) JP3273096B2 (OSRAM)
KR (1) KR0157162B1 (OSRAM)
CN (1) CN1046732C (OSRAM)
AT (1) ATE163291T1 (OSRAM)
AU (1) AU673409B2 (OSRAM)
BR (1) BR9406017A (OSRAM)
CA (1) CA2119218C (OSRAM)
CY (1) CY2108B1 (OSRAM)
CZ (1) CZ281390B6 (OSRAM)
DE (1) DE69408550T2 (OSRAM)
DK (1) DK0617037T3 (OSRAM)
ES (1) ES2112482T3 (OSRAM)
FI (1) FI107384B (OSRAM)
GR (1) GR3026178T3 (OSRAM)
HR (1) HRP940182B1 (OSRAM)
HU (1) HU217363B (OSRAM)
NO (1) NO313240B1 (OSRAM)
NZ (1) NZ263092A (OSRAM)
PL (1) PL176373B1 (OSRAM)
RO (1) RO115264B1 (OSRAM)
SI (1) SI9420016B (OSRAM)
SK (1) SK280831B6 (OSRAM)
TW (1) TW265343B (OSRAM)
UA (1) UA41921C2 (OSRAM)
WO (1) WO1994021645A1 (OSRAM)
YU (1) YU48951B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
WO2004089957A1 (en) * 2003-04-07 2004-10-21 Hetero Drugs Limited A novel crystalline form of dorzolamide hydrochloride
MXPA06015274A (es) * 2004-07-09 2007-09-27 Fdc Ltd Un procedimiento mejorado para la preparacion de 5,6-dihidro-4h-4(s)-etilamino-6(s)-metiltieno [2,3-b] tiopiran-2-sulfonamida-7,7-dioxido y sus sales.
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
AU2004326111A1 (en) * 2004-12-28 2006-07-06 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
US20060155132A1 (en) * 2005-01-06 2006-07-13 Kovacs Laszlo Z Method of making dorzolamide hydrochloride
WO2006078731A2 (en) * 2005-01-18 2006-07-27 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
US8263787B2 (en) 2007-05-07 2012-09-11 Cipla Limited Process for preparing dorzolamide
CN103415524B (zh) 2011-03-10 2015-11-25 Zach系统股份公司 不对称还原方法
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
EP3057427B1 (en) * 2013-10-17 2018-07-18 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
CN105636445B (zh) * 2013-10-17 2018-12-07 美国陶氏益农公司 制备杀虫化合物的方法
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
SI9420016A (en) 1996-06-30
AU5787194A (en) 1994-09-29
SK280831B6 (sk) 2000-08-14
YU48951B (sh) 2003-01-31
NO953733L (no) 1995-09-21
PL310633A1 (en) 1995-12-27
HRP940182A2 (en) 1996-08-31
JPH06298767A (ja) 1994-10-25
EP0617037A1 (en) 1994-09-28
GR3026178T3 (en) 1998-05-29
YU13194A (sh) 1997-01-08
SK116995A3 (en) 1997-06-04
HK1009063A1 (en) 1999-05-21
NO313240B1 (no) 2002-09-02
NO953733D0 (no) 1995-09-21
AU673409B2 (en) 1996-11-07
TW265343B (OSRAM) 1995-12-11
FI107384B (fi) 2001-07-31
WO1994021645A1 (en) 1994-09-29
EP0617037B1 (en) 1998-02-18
CN1119866A (zh) 1996-04-03
CZ281390B6 (cs) 1996-09-11
US5688968A (en) 1997-11-18
FI954438L (fi) 1995-09-20
CA2119218A1 (en) 1994-09-23
ATE163291T1 (de) 1998-03-15
DE69408550D1 (de) 1998-03-26
DE69408550T2 (de) 1998-08-27
KR0157162B1 (ko) 1998-11-16
CN1046732C (zh) 1999-11-24
DK0617037T3 (da) 1998-03-16
CZ241895A3 (en) 1996-01-17
RO115264B1 (ro) 1999-12-30
NZ263092A (en) 1997-12-19
FI954438A0 (fi) 1995-09-20
BR9406017A (pt) 1995-12-19
CA2119218C (en) 2000-02-15
PL176373B1 (pl) 1999-05-31
ES2112482T3 (es) 1998-04-01
JP3273096B2 (ja) 2002-04-08
HRP940182B1 (en) 2000-02-29
HU217363B (hu) 2000-01-28
HUT72676A (en) 1996-05-28
HU9502772D0 (en) 1995-11-28
CY2108B1 (en) 2002-04-26
SI9420016B (sl) 2002-12-31

Similar Documents

Publication Publication Date Title
UA41921C2 (uk) Спосіб одержання 7,7-діоксиду-5,6-дигідро-(s)-4-(алкіламіно)-(s)-6-алкіл-4н-тієно[2, 3b]тіопіран-2-сульфонаміду та споріднених сполук
AU8581991A (en) Mercaptoacetylamide derivatives as inhibitors of enkephalinase and ACE, and processes for their production
AU2691488A (en) Pyrimidine derivatives, processes for their production, and herbicidal method and compositions
AU2471788A (en) Pyrimidine derivatives, processes for their production, and herbicidal method and compositions
HUT59558A (en) New 5-chloro-quinoline-8-oxy-alkane-carboxylic acid derivatives, process for producing and utilizing them as antidotum
AU3936095A (en) Novel 2,3-diketopiperazine derivative or salt thereof
SG47520A1 (en) New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
DK0690873T3 (da) Vækstdifferentieringsfaktor-8
FR2691707B1 (fr) Derives de l'acide dithiophosphorique comme additifs de lubrifiants.
IT1237799B (it) Processo microbico per la produzione di antibiotici immunosoppressivi
EP0438261A3 (en) Condensed heterocyclic glutamic acid derivatives, their production and use
AU640194B2 (en) Quinazoline-3-alkanoic acid derivative, salt thereof, and production thereof
FI906407A0 (fi) Menetelmä kestävän teräksen valmistamiseksi
AU1626488A (en) 1,4-dihydropyridine enantiomers
ATE206117T1 (de) Verfahren zur herstellung von pyrimidin-derivaten
ES2008418A6 (es) Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.
HU9200771D0 (en) Process for the production of aryl-1,2,4-triazolyn-5-on derivatives
FR2514761B1 (fr) Nouvelles 1,4-dihydropyridines, utiles notamment comme hypotenseurs
AU1136088A (en) Substituted amine derivatives, their production and use
FI894127L (fi) Menetelmä 2-fosfonobutaani-1,2,4-trikarboksyylihapon ja sen alkalimetallisuolojen valmistamiseksi jatkuvatoimisesti
FR2691708B1 (fr) Derives de l'acide bis-dithiophosphorique comme additifs dans des lubrifiants.
FR2802643B1 (fr) Procede de controle de la qualite d'un article notamment en verre
FI950892L (fi) Entsymaattinen asymmetrinen pelkistysmenetelmä 4-H-tieno-(2,3-6) tiopyraanijohdannaisten tuottamiseksi
AU5651186A (en) Method of production of magnetized seed, seedlings or the like
AU9004591A (en) 1,4-benzothiazine-2-acetic acid derivatives, processes for production thereof