ES2008418A6 - Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo. - Google Patents
Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.Info
- Publication number
- ES2008418A6 ES2008418A6 ES8800226A ES8800226A ES2008418A6 ES 2008418 A6 ES2008418 A6 ES 2008418A6 ES 8800226 A ES8800226 A ES 8800226A ES 8800226 A ES8800226 A ES 8800226A ES 2008418 A6 ES2008418 A6 ES 2008418A6
- Authority
- ES
- Spain
- Prior art keywords
- potassium clavulanate
- novel
- rosettes
- recrystallisation
- crystallisation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE UNA NUEVA FORMA CRISTALINA DEL CLAVULANATO DE POTASIO Y DE COMPOSICIONES DEL MISMO. COMPRENDE HACER QUE PRECIPITE EL CLAVULANATO DE POTASIO (I) DE LA SOLUCION, EN TALES CONDICIONES QUE LA FORMA DE ROSETAS SEA PRECIPITADA ADECUADAMENTE ADICIONANDO UNA SOLUCION DE IONES CLAVULANATO AUN NO-DISOLVENTE PARA EL CLAVULANATO DE POTASIO, EN PRESENCIA DE IONES POTASIO, EN DONDE LA PRECIPITACION SE REALIZA PREFERENTEMENTE A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 15 GC. LAS COMPOSICIONES PUEDEN CONSEGUIRSE OBTENIENDO EL CLAVUNALATO DE POTASIO CRISTALINO EN FORMA DE ROSETAS CRISTALINAS MEZCLADAS O ASOCIADAS CON UN COMPUESTO DE LACTAM ANTIBACTERIANAMENTE ACTIVO. EL PRODUCTO PRESENTA LA UTILIDAD HABITUAL EN EL CAMPO DEL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS EN MAMIFEROS, PRESENTANDO PROPIEDADES MEJORADAS DE ELABORACION, YA QUE EN LA NUEVA CRISTALINA FLUYE CON MAS FACILIDAD Y PUEDE TAMIZARSE MEJOR QUE EL CLAVULANATO DE POTASIO NORMALEN FORMA DE AGUJAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US878187A | 1987-01-29 | 1987-01-29 | |
US7494487A | 1987-07-17 | 1987-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2008418A6 true ES2008418A6 (es) | 1989-07-16 |
Family
ID=26678616
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8800226A Expired ES2008418A6 (es) | 1987-01-29 | 1988-01-27 | Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo. |
ES88300704T Expired - Lifetime ES2074048T3 (es) | 1987-01-29 | 1988-01-27 | Procedimiento para la cristalizacion de clavulanato de potasio. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88300704T Expired - Lifetime ES2074048T3 (es) | 1987-01-29 | 1988-01-27 | Procedimiento para la cristalizacion de clavulanato de potasio. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0277008B1 (es) |
JP (2) | JP2648321B2 (es) |
KR (1) | KR960004535B1 (es) |
AT (1) | AT399154B (es) |
AU (1) | AU620538B2 (es) |
BE (1) | BE1000734A3 (es) |
CA (1) | CA1326486C (es) |
CH (1) | CH677671A5 (es) |
DE (1) | DE3853962T2 (es) |
DK (1) | DK175709B1 (es) |
ES (2) | ES2008418A6 (es) |
FR (1) | FR2610196B1 (es) |
GB (1) | GB2200355B (es) |
GR (1) | GR1000035B (es) |
IE (1) | IE880217L (es) |
IT (1) | IT1227072B (es) |
LU (1) | LU87123A1 (es) |
NZ (1) | NZ223316A (es) |
PT (1) | PT86631B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2435859A (en) * | 1945-06-06 | 1948-02-10 | John E Whitman | Garment hanger |
US2494711A (en) * | 1946-06-28 | 1950-01-17 | Kusher Hyman | Garment hanger |
US3474943A (en) * | 1967-02-21 | 1969-10-28 | Frank Mcbain | Skirt hanger |
SE7805391L (sv) * | 1978-05-11 | 1979-11-12 | Karner & Co Ab | Kledhengare |
AT400033B (de) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SE9401169L (sv) * | 1994-04-08 | 1995-10-09 | Corimed Gmbh | Förfarande för framställning av ett antibekteriellt aktivt ämne samt användning därav |
GB9426261D0 (en) | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
US6414142B1 (en) | 1996-06-13 | 2002-07-02 | Smithkline Beecham Corporation | Process for preparing potassium clavulanate |
TR200102771T2 (tr) * | 1999-04-01 | 2002-04-22 | Dsm N. V. | Kristalleştirme ile elde edilen aglomeralar |
EP1284978B2 (en) | 2000-05-13 | 2008-09-10 | Smithkline Beecham Plc | Process for the purification of a salt of clavulanic acid |
CA2528413A1 (en) * | 2003-06-10 | 2004-12-23 | Taisho Pharmaceutical Co., Ltd. | Radial spherical crystallization product, process for producing the same and dry powder preparation containing the crystallization product |
CN100384853C (zh) * | 2004-05-10 | 2008-04-30 | 河北张药股份有限公司 | 替卡西林钠的合成方法 |
KR102459377B1 (ko) * | 2022-03-18 | 2022-10-28 | 주식회사 에이치투뉴트리션 | 무알콜 단백질 맥주의 제조방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
GB1504425A (en) * | 1975-08-20 | 1978-03-22 | Beecham Group Ltd | Salts of clavulanic acid |
GB2003863B (en) * | 1977-09-01 | 1982-03-31 | Beecham Group Ltd | Chemical process |
EP0026044B1 (en) * | 1979-08-24 | 1983-06-08 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
US4454069A (en) * | 1979-08-24 | 1984-06-12 | Beecham Group Limited | Clavulanic acid salts and their preparation from the tertiary butyl amine salt |
DE3266580D1 (en) * | 1981-12-02 | 1985-10-31 | Beecham Group Plc | Pharmaceutical formulation comprising beta-lactam antibiotics |
FR2586561B1 (fr) * | 1985-09-05 | 1988-05-20 | Rhone Poulenc Sante | Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus |
-
1988
- 1988-01-27 PT PT86631A patent/PT86631B/pt unknown
- 1988-01-27 IE IE880217A patent/IE880217L/xx not_active IP Right Cessation
- 1988-01-27 GB GB8801765A patent/GB2200355B/en not_active Expired - Lifetime
- 1988-01-27 NZ NZ223316A patent/NZ223316A/xx unknown
- 1988-01-27 DK DK198800404A patent/DK175709B1/da not_active IP Right Cessation
- 1988-01-27 ES ES8800226A patent/ES2008418A6/es not_active Expired
- 1988-01-27 DE DE3853962T patent/DE3853962T2/de not_active Expired - Lifetime
- 1988-01-27 ES ES88300704T patent/ES2074048T3/es not_active Expired - Lifetime
- 1988-01-27 GR GR880100031A patent/GR1000035B/el not_active IP Right Cessation
- 1988-01-27 EP EP88300704A patent/EP0277008B1/en not_active Expired - Lifetime
- 1988-01-27 CA CA000557422A patent/CA1326486C/en not_active Expired - Lifetime
- 1988-01-27 AT AT0016388A patent/AT399154B/de not_active IP Right Cessation
- 1988-01-27 IT IT8847572A patent/IT1227072B/it active
- 1988-01-28 CH CH299/88A patent/CH677671A5/de not_active IP Right Cessation
- 1988-01-28 KR KR1019880000765A patent/KR960004535B1/ko not_active IP Right Cessation
- 1988-01-28 AU AU10927/88A patent/AU620538B2/en not_active Expired
- 1988-01-28 BE BE8800098A patent/BE1000734A3/fr not_active IP Right Cessation
- 1988-01-29 FR FR888801033A patent/FR2610196B1/fr not_active Expired - Lifetime
- 1988-01-29 JP JP63021144A patent/JP2648321B2/ja not_active Expired - Lifetime
- 1988-01-29 LU LU87123A patent/LU87123A1/fr unknown
-
1996
- 1996-12-03 JP JP8339027A patent/JP2716966B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BE1000734A3 (fr) | 1989-03-21 |
DE3853962T2 (de) | 1996-02-08 |
DK40488A (da) | 1988-07-30 |
GB2200355B (en) | 1990-08-01 |
CA1326486C (en) | 1994-01-25 |
GR880100031A (en) | 1988-12-16 |
AU1092788A (en) | 1988-08-04 |
KR960004535B1 (ko) | 1996-04-06 |
PT86631B (pt) | 1992-01-31 |
AU620538B2 (en) | 1992-02-20 |
FR2610196B1 (fr) | 1991-06-28 |
PT86631A (pt) | 1988-02-01 |
LU87123A1 (fr) | 1988-05-03 |
IT8847572A0 (it) | 1988-06-27 |
AT399154B (de) | 1995-03-27 |
NZ223316A (en) | 1989-10-27 |
GR1000035B (el) | 1990-03-12 |
FR2610196A1 (fr) | 1988-08-05 |
IT1227072B (it) | 1991-03-14 |
JPS63270687A (ja) | 1988-11-08 |
KR890002166A (ko) | 1989-04-08 |
CH677671A5 (es) | 1991-06-14 |
EP0277008B1 (en) | 1995-06-14 |
EP0277008A1 (en) | 1988-08-03 |
DK175709B1 (da) | 2005-01-31 |
IE880217L (en) | 1988-07-29 |
JP2716966B2 (ja) | 1998-02-18 |
ES2074048T3 (es) | 1995-09-01 |
JPH09169771A (ja) | 1997-06-30 |
ATA16388A (de) | 1994-08-15 |
GB2200355A (en) | 1988-08-03 |
GB8801765D0 (en) | 1988-02-24 |
DK40488D0 (da) | 1988-01-27 |
JP2648321B2 (ja) | 1997-08-27 |
DE3853962D1 (de) | 1995-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20080128 |