UA29393C2 - Похідні [2r, 3r (2'r, 3'r), 6r, 7s, 8s, 9r, 10r]-3-(2', 3'-дигідроксипент-2-іл)-2,6,8,10,12-пентаметил-4, 13-діоксабіцикло[8,2,1]-тридец-12-єн-5-ону, спосіб їх отримання та фармацевтичний засіб, що стимулює дію шлунково-кишкового тракту - Google Patents

Похідні [2r, 3r (2'r, 3'r), 6r, 7s, 8s, 9r, 10r]-3-(2', 3'-дигідроксипент-2-іл)-2,6,8,10,12-пентаметил-4, 13-діоксабіцикло[8,2,1]-тридец-12-єн-5-ону, спосіб їх отримання та фармацевтичний засіб, що стимулює дію шлунково-кишкового тракту

Info

Publication number
UA29393C2
UA29393C2 UA93002699A UA93002699A UA29393C2 UA 29393 C2 UA29393 C2 UA 29393C2 UA 93002699 A UA93002699 A UA 93002699A UA 93002699 A UA93002699 A UA 93002699A UA 29393 C2 UA29393 C2 UA 29393C2
Authority
UA
Ukraine
Prior art keywords
dihydroxypent
tridec
pentamethyl
dioxobicyclo
ene
Prior art date
Application number
UA93002699A
Other languages
English (en)
Russian (ru)
Inventor
Дагмар Хельтє
Дагмар Хельте
Улф Пройшофф
Крістіан Екхоут
Кристиан ЭКХОУТ
Original Assignee
Солвей Фармасьютікалз Гмбх
Солвей Фармасьютикалз Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Солвей Фармасьютікалз Гмбх, Солвей Фармасьютикалз Гмбх filed Critical Солвей Фармасьютікалз Гмбх
Publication of UA29393C2 publication Critical patent/UA29393C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

Даний винахід стосується нових N-заміщених /2R, 3R (2R', 3R'), 6R, 7S, 8S, 9R, 10R/-3-(2;3'-дигідрокcипeнт-2'-іл/-7-/(2,6-дидeoкcи-3-C-мeтил-3-0-d-h-рибoгeксапіранозил/-окси/-9-/ (3,4,6-тридеоксі-3-аміно-В-D-ксилогексапіранозил/-окси/-2,6,8,10,12-пентаметил-4,13-діоксабицикло/8,2,1/-тридец-12-єн-5-он-сполукз мотилінагоністичними властивостями до їхніх солей, продуктів кислотного приєднання, а також фармацевтичних засобів, що містять зазначені сполуки, і способів.
UA93002699A 1992-01-07 1993-04-22 Похідні [2r, 3r (2'r, 3'r), 6r, 7s, 8s, 9r, 10r]-3-(2', 3'-дигідроксипент-2-іл)-2,6,8,10,12-пентаметил-4, 13-діоксабіцикло[8,2,1]-тридец-12-єн-5-ону, спосіб їх отримання та фармацевтичний засіб, що стимулює дію шлунково-кишкового тракту UA29393C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4200145A DE4200145A1 (de) 1992-01-07 1992-01-07 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
UA29393C2 true UA29393C2 (uk) 2000-11-15

Family

ID=6449136

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93002699A UA29393C2 (uk) 1992-01-07 1993-04-22 Похідні [2r, 3r (2'r, 3'r), 6r, 7s, 8s, 9r, 10r]-3-(2', 3'-дигідроксипент-2-іл)-2,6,8,10,12-пентаметил-4, 13-діоксабіцикло[8,2,1]-тридец-12-єн-5-ону, спосіб їх отримання та фармацевтичний засіб, що стимулює дію шлунково-кишкового тракту

Country Status (28)

Country Link
US (1) US5418224A (uk)
EP (1) EP0550895B1 (uk)
JP (1) JP3300084B2 (uk)
KR (1) KR100273937B1 (uk)
CN (1) CN1033646C (uk)
AT (1) ATE155478T1 (uk)
AU (1) AU667699B2 (uk)
CA (1) CA2086811C (uk)
CZ (1) CZ281773B6 (uk)
DE (2) DE4200145A1 (uk)
DK (1) DK0550895T3 (uk)
DZ (1) DZ1652A1 (uk)
ES (1) ES2104808T3 (uk)
FI (1) FI106862B (uk)
GR (1) GR3024859T3 (uk)
HK (1) HK1014003A1 (uk)
HU (2) HU212272B (uk)
IL (1) IL104158A (uk)
LT (1) LT3015B (uk)
LV (1) LV10458B (uk)
MX (1) MX9300045A (uk)
NO (1) NO179586C (uk)
PH (1) PH30098A (uk)
RU (1) RU2107070C1 (uk)
SK (1) SK279251B6 (uk)
TW (1) TW238308B (uk)
UA (1) UA29393C2 (uk)
ZA (1) ZA9339B (uk)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100275A (en) * 1995-10-13 2000-08-08 Neurosearch A/S 8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
CA2247929A1 (en) * 1996-03-01 1997-09-04 Miichiro Arita Processes for the preparation of erythromycin derivatives
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
PT1489090E (pt) * 2000-08-17 2006-05-31 Kitasato Inst Novos derivados de pseudoeritromicina
ATE308537T1 (de) * 2001-05-10 2005-11-15 Solvay Pharm Gmbh Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US20040067896A1 (en) * 2002-07-25 2004-04-08 The Kitasato Institute Novel pseudoerythromycin derivatives
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
BRPI0619556A2 (pt) * 2005-12-08 2011-10-04 Pfizer processo para desmetilação de grupo 3' -dimetil amino de compostos eritromicina
EP2431380A3 (en) 2006-09-11 2013-07-03 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders
RU2422453C2 (ru) * 2006-12-05 2011-06-27 Пфайзер Инк. Полиморфы мотилида
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
TWI662967B (zh) * 2013-03-25 2019-06-21 日商志瑞亞新藥工業股份有限公司 食後期之胃運動亢進劑

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
CA1321581C (en) * 1987-05-26 1993-08-24 Herbert A. Kirst Ring-contracted macrolides
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders

Also Published As

Publication number Publication date
HUT66234A (en) 1994-10-28
CZ341492A3 (en) 1993-07-14
DE4200145A1 (de) 1993-07-08
DE59208710D1 (de) 1997-08-21
SK341492A3 (en) 1995-05-10
CA2086811A1 (en) 1993-07-08
US5418224A (en) 1995-05-23
FI106862B (fi) 2001-04-30
RU2107070C1 (ru) 1998-03-20
FI930051A0 (fi) 1993-01-07
AU3103693A (en) 1993-07-08
ATE155478T1 (de) 1997-08-15
GR3024859T3 (en) 1998-01-30
DK0550895T3 (da) 1997-08-25
KR930016436A (ko) 1993-08-26
EP0550895B1 (de) 1997-07-16
CN1033646C (zh) 1996-12-25
NO930029D0 (no) 1993-01-06
LTIP187A (lt) 1994-03-25
KR100273937B1 (ko) 2000-12-15
ES2104808T3 (es) 1997-10-16
LV10458B (en) 1996-02-20
IL104158A (en) 1997-07-13
HU9204076D0 (en) 1993-04-28
DZ1652A1 (fr) 2002-02-17
JP3300084B2 (ja) 2002-07-08
NO179586B (no) 1996-07-29
IL104158A0 (en) 1993-05-13
CN1075320A (zh) 1993-08-18
NO179586C (no) 1996-11-06
LT3015B (lt) 1994-08-25
TW238308B (uk) 1995-01-11
HU210216A9 (en) 1995-02-28
PH30098A (en) 1996-12-27
CZ281773B6 (cs) 1997-01-15
HU212272B (en) 1996-04-29
LV10458A (lv) 1995-02-20
MX9300045A (es) 1993-12-01
EP0550895A1 (de) 1993-07-14
NO930029L (no) 1993-07-08
CA2086811C (en) 2003-12-09
ZA9339B (en) 1993-08-05
AU667699B2 (en) 1996-04-04
HK1014003A1 (en) 1999-09-17
JPH07247299A (ja) 1995-09-26
FI930051A (fi) 1993-07-08
SK279251B6 (sk) 1998-08-05

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