ES8801659A1 - Un procedimiento para la preparacion de nuevas piranopiridinas. - Google Patents

Un procedimiento para la preparacion de nuevas piranopiridinas.

Info

Publication number
ES8801659A1
ES8801659A1 ES555834A ES555834A ES8801659A1 ES 8801659 A1 ES8801659 A1 ES 8801659A1 ES 555834 A ES555834 A ES 555834A ES 555834 A ES555834 A ES 555834A ES 8801659 A1 ES8801659 A1 ES 8801659A1
Authority
ES
Spain
Prior art keywords
intermediates
preparation
pyrano
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555834A
Other languages
English (en)
Other versions
ES555834A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858514538A external-priority patent/GB8514538D0/en
Priority claimed from GB858527713A external-priority patent/GB8527713D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES555834A0 publication Critical patent/ES555834A0/es
Publication of ES8801659A1 publication Critical patent/ES8801659A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO DE PREPARAR NUEVAS PIRANOPIRIDINAS. CONSISTE EN ACILAR UN COMPUESTO DE FORMULA (II) CON UN AGENTE ACILANTE DE FORMULA (III), EN PRESENCIA DE UN ACEPTOR DE ACIDO TAL COMO ACETATO DE SODIO O UN AGENTE DESHIDRATANTE TAL COMO DICICLOHEXILCARBODIIMIDA, EN UN DISOLVENTE, ENTRE 0JC Y LA TEMPERATURA AMBIENTE; Y CICLAR EL COMPUESTO RESULTANTE EN UN DISOLVENTE INERTE ENTRE 0JC Y LA TEMPERATURA DE REFLUJO PARA OBTENER NUEVAS PIRANOPIRIDINAS DE FORMULA (I), DONDE R1 Y R2 SON H O ALQUILO C 1 A 6; R3 ES H, HIDROXI, ALCOXI C 1 A 6 O ACILOXI C 1 A 7; R4 ES H O JUNTO CON R3 FORMAN UN ENLACE R5 ES H, ALQUILO C 1 A 6 CARBONILO Y OTROS; R6 ES H O ALQUILO C 1 A 6; Y X ES O O S. TIENEN APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTI-HIPERTENSIVA.
ES555834A 1985-06-08 1986-06-06 Un procedimiento para la preparacion de nuevas piranopiridinas. Expired ES8801659A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858514538A GB8514538D0 (en) 1985-06-08 1985-06-08 Active compounds
GB858527713A GB8527713D0 (en) 1985-11-09 1985-11-09 Active compounds

Publications (2)

Publication Number Publication Date
ES555834A0 ES555834A0 (es) 1988-02-16
ES8801659A1 true ES8801659A1 (es) 1988-02-16

Family

ID=26289344

Family Applications (3)

Application Number Title Priority Date Filing Date
ES555834A Expired ES8801659A1 (es) 1985-06-08 1986-06-06 Un procedimiento para la preparacion de nuevas piranopiridinas.
ES557744A Expired ES8802228A1 (es) 1985-06-08 1987-09-16 Un procedimiento para la preparacion de nuevas piranopiridinas
ES557743A Expired ES8802053A1 (es) 1985-06-08 1987-09-16 Un procedimiento para la preparacion de nuevas piranopiridinas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557744A Expired ES8802228A1 (es) 1985-06-08 1987-09-16 Un procedimiento para la preparacion de nuevas piranopiridinas
ES557743A Expired ES8802053A1 (es) 1985-06-08 1987-09-16 Un procedimiento para la preparacion de nuevas piranopiridinas

Country Status (11)

Country Link
US (2) US4812459A (es)
EP (1) EP0205292B1 (es)
JP (1) JPH0784470B2 (es)
AU (1) AU596798B2 (es)
CA (1) CA1301759C (es)
DE (1) DE3682331D1 (es)
DK (1) DK162445C (es)
ES (3) ES8801659A1 (es)
GR (1) GR861484B (es)
NZ (1) NZ216436A (es)
PT (1) PT82728B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613786D0 (en) * 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
EP0301713A3 (en) * 1987-07-07 1990-05-02 Beecham Group Plc Chroman derivatives for treatment of pulmonary hypertension
DE3732146A1 (de) * 1987-09-24 1989-04-06 Merck Patent Gmbh Azachromanderivate
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
GR880100289A (el) * 1988-05-03 1990-03-12 Sandoz Ag Νεες βενζο(β)πυρανες και πυρανοπυριδινες,μεθοδος για την παρασκευη τους και η χρηση τους
US5254557A (en) * 1988-05-09 1993-10-19 Beecham Group P.L.C. Compound and treatment
EP0359537B1 (en) * 1988-09-16 1996-06-26 Beecham Group Plc Benzopyran derivatives with antihypertensive activity
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
US4992435A (en) * 1988-09-23 1991-02-12 Ortho Pharmaceutical Corporation Substituted thienopyrans as antihypertensive agents
GB8822743D0 (en) * 1988-09-28 1988-11-02 Beecham Group Plc Novel compounds
GB8911280D0 (en) * 1989-05-17 1989-07-05 Beecham Group Plc Novel compounds
GB8911949D0 (en) * 1989-05-24 1989-07-12 Beecham Group Plc Novel compounds
US5232938A (en) * 1989-05-24 1993-08-03 Beecham Group P.L.C. Certain 1,2,4-triazole(oxy or amino)benzopyran derivatives having pharmacological activity
US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
CA2015296C (en) * 1989-05-31 2001-08-07 Karnail Atwal Pyranyl cyanoguanidine derivatives
IE63935B1 (en) * 1989-06-27 1995-06-28 Chem Pharm Forsch Gmbh Novel thienopyran derivatives a process for their preparation and their use
GB8916683D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel compounds
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
FR2657872B2 (fr) * 1989-11-06 1992-06-12 Sanofi Sa Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant.
US5185345A (en) * 1989-11-06 1993-02-09 Sanofi 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them
FR2654103B1 (fr) * 1989-11-06 1992-02-21 Sanofi Sa Derives d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques les contenant.
US5061813A (en) * 1990-04-02 1991-10-29 E. R. Squibb & Sons, Inc. Substituted cyanoimino benzopyranes
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5310932A (en) * 1991-04-15 1994-05-10 E. R. Squibb & Sons, Inc. Chromanyl substituted indole potassium channel openers
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5262419A (en) * 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
US5374643A (en) * 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
GR1002276B (el) * 1992-10-08 1996-05-02 Smithkline Beecham P.L.C. Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς.
US5514690A (en) * 1992-11-17 1996-05-07 E. R. Squibb & Sons, Inc. Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
AP360A (en) * 1992-12-04 1994-09-07 Smithkline Beecham Plc Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity.
JPH08505132A (ja) * 1992-12-11 1996-06-04 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 医薬活性を有する二環式化合物
US5393771A (en) * 1993-05-12 1995-02-28 Brisol-Myers Squibb Company 4-substituted benzopyran and related compounds
US5416097A (en) * 1993-05-19 1995-05-16 Berlex Laboratories, Inc. Potassium channel activators/openers
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5401758A (en) * 1993-10-07 1995-03-28 Bristol-Myers Squibb Company Pyridinyl cyanoguanidine compounds
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
GB9411635D0 (en) 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
HUP9701865A3 (en) * 1997-11-06 2000-01-28 Egyt Gyogyszervegyeszeti Gyar Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof
WO2007027780A2 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers
ES2379098T3 (es) 2005-09-01 2012-04-20 Janssen Pharmaceutica Nv Derivados de benzopirano novedosos como abridores del canal de potasio

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
DE3364145D1 (de) * 1982-04-08 1986-07-24 Beecham Group Plc Antihypertensive benzopyranols
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
EP0095316B1 (en) * 1982-05-21 1986-12-03 Beecham Group Plc Pharmaceutically active aminobenzopyrans
DE3364734D1 (en) * 1982-10-19 1986-08-28 Beecham Group Plc Novel chromans and chromenes
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
DE3479726D1 (de) * 1983-05-18 1989-10-19 Beecham Group Plc Benzopyran derivatives.
DK454283A (da) 1983-09-30 1985-03-31 Eternit Fab Dansk As Tagplade, fremgangsmaade til fremstilling af samme, samt taetningsbaand til en saadan tagplade
GB8409745D0 (en) * 1984-04-14 1984-05-23 Beecham Group Plc Active compounds

Also Published As

Publication number Publication date
AU5845786A (en) 1986-12-11
DE3682331D1 (de) 1991-12-12
DK268786D0 (da) 1986-06-06
GR861484B (en) 1986-10-07
PT82728A (en) 1986-07-01
ES8802228A1 (es) 1988-04-16
ES555834A0 (es) 1988-02-16
PT82728B (pt) 1988-12-15
NZ216436A (en) 1990-01-29
DK268786A (da) 1986-12-09
ES557743A0 (es) 1988-03-16
EP0205292A2 (en) 1986-12-17
JPS61293984A (ja) 1986-12-24
ES8802053A1 (es) 1988-03-16
DK162445B (da) 1991-10-28
CA1301759C (en) 1992-05-26
US4812459A (en) 1989-03-14
EP0205292B1 (en) 1991-11-06
JPH0784470B2 (ja) 1995-09-13
DK162445C (da) 1992-03-23
EP0205292A3 (en) 1988-03-09
US4904784A (en) 1990-02-27
ES557744A0 (es) 1988-04-16
AU596798B2 (en) 1990-05-17

Similar Documents

Publication Publication Date Title
ES8801659A1 (es) Un procedimiento para la preparacion de nuevas piranopiridinas.
IL80403A (en) Heterocyclic analogs of mevalonolactone and derivatives thereof,their preparation and pharmaceutical compositions containing them
ES8707210A1 (es) Un procedimiento para la produccion de un compuesto de tiazolidindiona hipoglicemico
IE894048L (en) New therapeutically active compound and a process for its¹preparation
IE56150B1 (en) Novel chromans and chromenes
PT77370A (en) Process for preparing new pyrazolo <3,4-b> piridine derivatives and pharmaceutical preparations containing the same
CA2069608A1 (en) Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
AU6697786A (en) New derivatives of 1-sulphonyl 2-oxo-5-alkoxy pyrrolidine, their preparation process, their use as medicaments and the compositions containing them
AU7725487A (en) New derivatives of indane, the process for their preparation, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
DE3688087T2 (de) Cephemverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
MY129946A (en) Compound with gastric acid inhibitory effect and process for its preparation.
PT86232A (en) Process for preparing a pharmaceutical composition containing a9-substituted guanine
EP0033156A3 (en) 1-phenyl-2-cyclohexene-1-alkylamine derivatives, intermediates and process for their preparation, medicines containing them and their use as pharmaceutically active compounds
GR3002264T3 (en) Decahydroquinoline derivatives, method for their preparation and intermediates thereof, their use as medicaments and their pharmaceutical compositions
AU581855B2 (en) 1-(4'-alkylsulphonylphenyl)-2-amino-1, 3-propanediol n-substituted derivatives
IE891578L (en) Compounds with central analgesic activity, process for their¹preparation and pharmaceutical compositions containing them
ES8201169A1 (es) Un procedimiento para la preparacion de derivados de quina- zolina
HUT63151A (en) Process for producing new benzimidazole-2-sulfonamide and imidazopyuridine-2-sylfonamide derivatives, as well as pharmaceutical compositions comprising same as active ingredient
ES8705463A1 (es) Un procedimiento para la preparacion de 1-metil-4,5-dihi- droorotil-histidil-prolinamida
AU5649286A (en) New derivatives of 4-phenylpropyl indole and their salts, their preparation process, their use as medicaments and the pharmaceutical compositions containing them
IE873212L (en) Medicaments based on derivatives of 3,4-di-phenylpiperidine,¹the use of the derivatives as medicaments, and novel¹3,4-diphenylpiperidine derivatives and a process for the¹preparation therefor
EP0329563A3 (en) Benzocyclohexane and benzocycloheptane derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
AU3071289A (en) New derivatives of 1-arylsulphonyl-2-pyrrolidinone their preparation process and the new intermediates thus obtained, their use as medicaments and the compositions containing them
LTIP1682A (en) Novel 16,17-acetal-substituted derivatives of pregnan-21-oic acid, process for preparing thereof, pharmaceutical preparations containing them
AU4261189A (en) Use of basic nitro-phenyl-dihydropyridine amides as medicaments, new compounds and processes for their preparation via new intermediates

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519