ES8802053A1 - Un procedimiento para la preparacion de nuevas piranopiridinas - Google Patents
Un procedimiento para la preparacion de nuevas piranopiridinasInfo
- Publication number
- ES8802053A1 ES8802053A1 ES557743A ES557743A ES8802053A1 ES 8802053 A1 ES8802053 A1 ES 8802053A1 ES 557743 A ES557743 A ES 557743A ES 557743 A ES557743 A ES 557743A ES 8802053 A1 ES8802053 A1 ES 8802053A1
- Authority
- ES
- Spain
- Prior art keywords
- intermediates
- preparation
- pyrano
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Abstract
LAS PIRANOPIRIDINAS (I), DONDE NO EXCLUSIVAMENTE, R1 Y R2 SON HIDROGENO O ALQUILO C1-6, R3 HIDROXI, R4 HIDROGENO O R3 Y R4 JUNTOS SON UN ENLACE RADICALES5 ES AMINO SUSTITUIDO CON ALQUILO C1-6, R6 ALQUILO C1-6, X OXIGENO O AZUFRE; SE OBTIENEN POR ACILACION DE UN COMPUESTO(II) CON UN COMPUESTO XFCFN.R11, EN CLORURO DE METILENO, A UNA TEMPERATURA MENOR DE 10JC, PREFERIBLEMENTE ENTRE C25 Y C10JC, Y OPCIONALMENTE EN PRESENCIA DE UN CIANATO O TIOCIANATO DE METAL ALCALINO, EN MEDIO ACUOSO METANOLICO ACIDULADO CON ACIDO CLORHIDRICO, TRAS LO CUAL, SI SE DESEA, SE PUEDE PROCEDER A TRANSFORMACIONES VARIAS. SON UTILES EN EL TRATAMIENTO DE LA HIPERTENSION. SE CREE QUE SON ACTIVADORES DEL CANAL KB, POR LO QUE SERIAN UTILES PARA TRATAR AFECCIONES DEL MUSCULO LISO DEL TRACTO GASTROINTESTINAL COMO ULCERAS PEPTICAS, ENTRE OTRAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858514538A GB8514538D0 (en) | 1985-06-08 | 1985-06-08 | Active compounds |
GB858527713A GB8527713D0 (en) | 1985-11-09 | 1985-11-09 | Active compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557743A0 ES557743A0 (es) | 1988-03-16 |
ES8802053A1 true ES8802053A1 (es) | 1988-03-16 |
Family
ID=26289344
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555834A Expired ES8801659A1 (es) | 1985-06-08 | 1986-06-06 | Un procedimiento para la preparacion de nuevas piranopiridinas. |
ES557743A Expired ES8802053A1 (es) | 1985-06-08 | 1987-09-16 | Un procedimiento para la preparacion de nuevas piranopiridinas |
ES557744A Expired ES8802228A1 (es) | 1985-06-08 | 1987-09-16 | Un procedimiento para la preparacion de nuevas piranopiridinas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555834A Expired ES8801659A1 (es) | 1985-06-08 | 1986-06-06 | Un procedimiento para la preparacion de nuevas piranopiridinas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557744A Expired ES8802228A1 (es) | 1985-06-08 | 1987-09-16 | Un procedimiento para la preparacion de nuevas piranopiridinas |
Country Status (11)
Country | Link |
---|---|
US (2) | US4812459A (es) |
EP (1) | EP0205292B1 (es) |
JP (1) | JPH0784470B2 (es) |
AU (1) | AU596798B2 (es) |
CA (1) | CA1301759C (es) |
DE (1) | DE3682331D1 (es) |
DK (1) | DK162445C (es) |
ES (3) | ES8801659A1 (es) |
GR (1) | GR861484B (es) |
NZ (1) | NZ216436A (es) |
PT (1) | PT82728B (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8613786D0 (en) * | 1986-06-06 | 1986-07-09 | Beecham Group Plc | Active compounds |
CH674984A5 (es) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
EP0301713A3 (en) * | 1987-07-07 | 1990-05-02 | Beecham Group Plc | Chroman derivatives for treatment of pulmonary hypertension |
DE3732146A1 (de) * | 1987-09-24 | 1989-04-06 | Merck Patent Gmbh | Azachromanderivate |
GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
GR880100289A (el) * | 1988-05-03 | 1990-03-12 | Sandoz Ag | Νεες βενζο(β)πυρανες και πυρανοπυριδινες,μεθοδος για την παρασκευη τους και η χρηση τους |
US5254557A (en) * | 1988-05-09 | 1993-10-19 | Beecham Group P.L.C. | Compound and treatment |
ES2088895T3 (es) * | 1988-09-16 | 1996-10-01 | Beecham Group Plc | Derivados de benzopirano con actividad antihipertensora. |
US4992435A (en) * | 1988-09-23 | 1991-02-12 | Ortho Pharmaceutical Corporation | Substituted thienopyrans as antihypertensive agents |
NZ230711A (en) * | 1988-09-23 | 1990-10-26 | Ortho Pharma Corp | Substituted thienopyrans as antihypertensive agents |
GB8822743D0 (en) * | 1988-09-28 | 1988-11-02 | Beecham Group Plc | Novel compounds |
GB8911280D0 (en) * | 1989-05-17 | 1989-07-05 | Beecham Group Plc | Novel compounds |
GB8911949D0 (en) * | 1989-05-24 | 1989-07-12 | Beecham Group Plc | Novel compounds |
US5232938A (en) * | 1989-05-24 | 1993-08-03 | Beecham Group P.L.C. | Certain 1,2,4-triazole(oxy or amino)benzopyran derivatives having pharmacological activity |
CA2015296C (en) * | 1989-05-31 | 2001-08-07 | Karnail Atwal | Pyranyl cyanoguanidine derivatives |
US5140031A (en) * | 1989-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Pyranyl cyanoguanidine derivatives |
IE63935B1 (en) * | 1989-06-27 | 1995-06-28 | Chem Pharm Forsch Gmbh | Novel thienopyran derivatives a process for their preparation and their use |
GB8916683D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Novel compounds |
US5254555A (en) * | 1989-10-30 | 1993-10-19 | Beecham Group P.L.C. | Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension |
GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
FR2654103B1 (fr) * | 1989-11-06 | 1992-02-21 | Sanofi Sa | Derives d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques les contenant. |
FR2657872B2 (fr) * | 1989-11-06 | 1992-06-12 | Sanofi Sa | Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant. |
US5185345A (en) * | 1989-11-06 | 1993-02-09 | Sanofi | 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them |
US5061813A (en) * | 1990-04-02 | 1991-10-29 | E. R. Squibb & Sons, Inc. | Substituted cyanoimino benzopyranes |
US5276168A (en) * | 1990-06-18 | 1994-01-04 | E. R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
US5310932A (en) * | 1991-04-15 | 1994-05-10 | E. R. Squibb & Sons, Inc. | Chromanyl substituted indole potassium channel openers |
GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
US5624954A (en) * | 1991-06-13 | 1997-04-29 | Smithkline Beecham P.L.C. | Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity |
US5262419A (en) * | 1992-06-11 | 1993-11-16 | E. R. Squibb & Sons, Inc. | Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator |
US5453421A (en) * | 1992-09-11 | 1995-09-26 | E. R. Squibb & Sons, Inc. | Aryl and heterocyclic substituted propenamide derivatives |
US5374643A (en) * | 1992-09-11 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Aryl urea (thiourea) and cyanoguanidine derivatives |
GR1002276B (el) * | 1992-10-08 | 1996-05-02 | Smithkline Beecham P.L.C. | Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς. |
US5514690A (en) * | 1992-11-17 | 1996-05-07 | E. R. Squibb & Sons, Inc. | Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline |
AP360A (en) * | 1992-12-04 | 1994-09-07 | Smithkline Beecham Plc | Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity. |
KR100326968B1 (ko) * | 1992-12-11 | 2002-07-27 | 스미스클라인비이참피이엘시이 | 약학적 활성을 가진 이환식 화합물 |
US5393771A (en) * | 1993-05-12 | 1995-02-28 | Brisol-Myers Squibb Company | 4-substituted benzopyran and related compounds |
US5416097A (en) * | 1993-05-19 | 1995-05-16 | Berlex Laboratories, Inc. | Potassium channel activators/openers |
US5401758A (en) * | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
GB9411635D0 (en) | 1994-06-10 | 1994-08-03 | Smithkline Beecham Plc | Novel treatment |
US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
HUP9701865A3 (en) * | 1997-11-06 | 2000-01-28 | Egyt Gyogyszervegyeszeti Gyar | Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof |
US7838553B2 (en) | 2005-09-01 | 2010-11-23 | Janssen Pharmaceutica Nv | Benzopyran derivatives as potassium channel openers |
US7812183B2 (en) | 2005-09-01 | 2010-10-12 | Janssen Pharmaceutica Nv | Benzopyran derivatives as potassium channel openers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0076075B1 (en) * | 1981-09-25 | 1986-11-20 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
DE3364145D1 (de) * | 1982-04-08 | 1986-07-24 | Beecham Group Plc | Antihypertensive benzopyranols |
DE3368629D1 (en) * | 1982-04-28 | 1987-02-05 | Beecham Group Plc | Novel chromenes and chromans |
DE3368057D1 (en) | 1982-05-21 | 1987-01-15 | Beecham Group Plc | Pharmaceutically active aminobenzopyrans |
EP0107423B1 (en) * | 1982-10-19 | 1986-07-23 | Beecham Group Plc | Novel chromans and chromenes |
GB8308063D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
GB8308064D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
EP0126311B1 (en) * | 1983-05-18 | 1989-09-13 | Beecham Group Plc | Benzopyran derivatives. |
DE3486354T2 (de) * | 1983-05-18 | 1995-03-30 | Beecham Group Plc | Chroman- und Chromenderivate. |
DK454283A (da) | 1983-09-30 | 1985-03-31 | Eternit Fab Dansk As | Tagplade, fremgangsmaade til fremstilling af samme, samt taetningsbaand til en saadan tagplade |
GB8409745D0 (en) * | 1984-04-14 | 1984-05-23 | Beecham Group Plc | Active compounds |
-
1986
- 1986-05-30 EP EP86304139A patent/EP0205292B1/en not_active Expired - Lifetime
- 1986-05-30 DE DE8686304139T patent/DE3682331D1/de not_active Expired - Fee Related
- 1986-06-06 CA CA000511029A patent/CA1301759C/en not_active Expired - Fee Related
- 1986-06-06 US US06/871,711 patent/US4812459A/en not_active Expired - Fee Related
- 1986-06-06 JP JP61130470A patent/JPH0784470B2/ja not_active Expired - Lifetime
- 1986-06-06 GR GR861484A patent/GR861484B/el unknown
- 1986-06-06 ES ES555834A patent/ES8801659A1/es not_active Expired
- 1986-06-06 NZ NZ216436A patent/NZ216436A/en unknown
- 1986-06-06 DK DK268786A patent/DK162445C/da not_active IP Right Cessation
- 1986-06-06 PT PT82728A patent/PT82728B/pt not_active IP Right Cessation
- 1986-06-06 AU AU58457/86A patent/AU596798B2/en not_active Ceased
-
1987
- 1987-09-16 ES ES557743A patent/ES8802053A1/es not_active Expired
- 1987-09-16 ES ES557744A patent/ES8802228A1/es not_active Expired
-
1989
- 1989-02-23 US US07/314,814 patent/US4904784A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ216436A (en) | 1990-01-29 |
EP0205292B1 (en) | 1991-11-06 |
AU596798B2 (en) | 1990-05-17 |
US4812459A (en) | 1989-03-14 |
DK162445B (da) | 1991-10-28 |
EP0205292A3 (en) | 1988-03-09 |
DK162445C (da) | 1992-03-23 |
CA1301759C (en) | 1992-05-26 |
DK268786D0 (da) | 1986-06-06 |
JPH0784470B2 (ja) | 1995-09-13 |
ES557743A0 (es) | 1988-03-16 |
JPS61293984A (ja) | 1986-12-24 |
ES8802228A1 (es) | 1988-04-16 |
ES557744A0 (es) | 1988-04-16 |
ES555834A0 (es) | 1988-02-16 |
DK268786A (da) | 1986-12-09 |
DE3682331D1 (de) | 1991-12-12 |
PT82728B (pt) | 1988-12-15 |
PT82728A (en) | 1986-07-01 |
GR861484B (en) | 1986-10-07 |
US4904784A (en) | 1990-02-27 |
EP0205292A2 (en) | 1986-12-17 |
AU5845786A (en) | 1986-12-11 |
ES8801659A1 (es) | 1988-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |