UA19756A1 - Спосіб одержаhhя піперазиhілалкіл-3(2h)піридазиhоhів або їх фармацевтичhо прийhятих солей - Google Patents

Спосіб одержаhhя піперазиhілалкіл-3(2h)піридазиhоhів або їх фармацевтичhо прийhятих солей

Info

Publication number
UA19756A1
UA19756A1 UA4742661A UA4742661A UA19756A1 UA 19756 A1 UA19756 A1 UA 19756A1 UA 4742661 A UA4742661 A UA 4742661A UA 4742661 A UA4742661 A UA 4742661A UA 19756 A1 UA19756 A1 UA 19756A1
Authority
UA
Ukraine
Prior art keywords
piperazinyle
pyridazinones
alkyl
preparation
pharmaceutically acceptable
Prior art date
Application number
UA4742661A
Other languages
English (en)
Russian (ru)
Inventor
Блашке Хайнц
Штроісніг Хаймо
Феллієр Харольд
Енценхофер Ріта
Original Assignee
Хафслунд Нікомед Фарма Аг
Хафслунд Никомед Фарма АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хафслунд Нікомед Фарма Аг, Хафслунд Никомед Фарма АГ filed Critical Хафслунд Нікомед Фарма Аг
Publication of UA19756A1 publication Critical patent/UA19756A1/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Винахід належить до способу одержання нових піперазинілалкіл-3(2Н) -піридазинонів. На підставі їх фармакологічних властивостей нові сполуки можна застосовувати в медикаментах при високому кров'яному тиску і при захворюваннях серця.
UA4742661A 1988-12-06 1989-12-05 Спосіб одержаhhя піперазиhілалкіл-3(2h)піридазиhоhів або їх фармацевтичhо прийhятих солей UA19756A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT299188 1988-12-06

Publications (1)

Publication Number Publication Date
UA19756A1 true UA19756A1 (uk) 1997-12-25

Family

ID=3543605

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4742661A UA19756A1 (uk) 1988-12-06 1989-12-05 Спосіб одержаhhя піперазиhілалкіл-3(2h)піридазиhоhів або їх фармацевтичhо прийhятих солей

Country Status (28)

Country Link
US (1) US5034391A (uk)
EP (1) EP0372305B1 (uk)
JP (1) JPH02200676A (uk)
KR (1) KR900009626A (uk)
CN (1) CN1022565C (uk)
AT (1) ATE92487T1 (uk)
AU (1) AU622501B2 (uk)
CA (1) CA2004298A1 (uk)
DD (1) DD290885A5 (uk)
DE (1) DE58905151D1 (uk)
DK (1) DK169102B1 (uk)
ES (1) ES2058449T3 (uk)
FI (1) FI93956C (uk)
GR (1) GR3008659T3 (uk)
HU (1) HU203748B (uk)
IE (1) IE62890B1 (uk)
IL (1) IL92442A0 (uk)
LT (2) LTIP1615A (uk)
LV (1) LV10273B (uk)
MD (2) MD382C2 (uk)
MY (1) MY106282A (uk)
NO (1) NO173441C (uk)
NZ (1) NZ231625A (uk)
PT (1) PT92488B (uk)
RU (2) RU1823874C (uk)
UA (1) UA19756A1 (uk)
YU (1) YU229289A (uk)
ZA (1) ZA899320B (uk)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
KR970002876B1 (ko) * 1990-04-25 1997-03-12 닛산가가꾸고오교 가부시끼가이샤 피리다지논 유도체
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US6960597B2 (en) * 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
HU225955B1 (en) * 2001-07-26 2008-01-28 Egis Gyogyszergyar Nyilvanosan Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HU227237B1 (en) * 2001-09-27 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
EP1470112A1 (en) * 2002-01-18 2004-10-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
US20050176755A1 (en) * 2003-10-31 2005-08-11 Dyatkin Alexey B. Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
BRPI0506676A (pt) * 2004-02-10 2007-05-15 Janssen Phamaceutica N V piridazinona uréias como antagonistas de integrinas alfa4
JP2007522225A (ja) * 2004-02-10 2007-08-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ａ４インテグリン拮抗薬としてのピリダジノン
AU2011213621A1 (en) * 2010-02-08 2012-08-30 Allergan, Inc. Pyridazine derivatives useful as cannabinoid - 2 agonists

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1086238B (de) * 1959-02-03 1960-08-04 Basf Ag Verfahren zur Herstellung von (4, 5)-Dihalogenpyridazonen-(6)
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE755015A (fr) * 1969-08-20 1971-02-01 Byk Gulden Lomberg Chem Fab Piperazinyl-alcoylamino-uraciles substitues par un groupe aryle, leurs ethers et thioethers, ainsi que leur procede de preparation
FR2124164A1 (en) * 1971-02-10 1972-09-22 Ferlux Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
FR2261756A1 (en) * 1974-02-27 1975-09-19 Roussel Uclaf 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity
LU74319A1 (uk) * 1976-02-09 1977-08-19
JPS5742679A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Preparation of phenylpiperazine derivative
JPH0641454B2 (ja) * 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
US4892947A (en) * 1985-04-27 1990-01-09 Nissan Chemical Industries Ltd. 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it
TR22638A (tr) * 1985-07-30 1988-01-29 Nissan Chemical Ind Ltd Piridazinon tuerevleri,bunlarin ve hasarat oeldueruecue bilesiklerin hazirlanmasina mahsus usul
HU195645B (en) * 1985-10-30 1988-06-28 Gyogyszerkutato Intezet Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
US4978665A (en) * 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones

Also Published As

Publication number Publication date
PT92488A (pt) 1990-06-29
NO894856D0 (no) 1989-12-05
FI93956C (fi) 1995-06-26
FI93956B (fi) 1995-03-15
US5034391A (en) 1991-07-23
EP0372305B1 (de) 1993-08-04
ES2058449T3 (es) 1994-11-01
AU622501B2 (en) 1992-04-09
IE62890B1 (en) 1995-03-08
DD290885A5 (de) 1991-06-13
RU1823874C (ru) 1993-06-23
MD382C2 (ro) 1996-06-30
RU2024517C1 (ru) 1994-12-15
ATE92487T1 (de) 1993-08-15
AU4589889A (en) 1990-06-14
CN1043129A (zh) 1990-06-20
CN1022565C (zh) 1993-10-27
YU229289A (en) 1991-10-31
DK611789A (da) 1990-06-07
NO894856L (no) 1990-06-07
MY106282A (en) 1995-04-29
DK611789D0 (da) 1989-12-05
NO173441B (no) 1993-09-06
LTIP1808A (en) 1995-08-25
CA2004298A1 (en) 1990-06-06
KR900009626A (ko) 1990-07-05
LV10273B (en) 1995-04-20
ZA899320B (en) 1991-02-27
LT3945B (en) 1996-05-27
LV10273A (lv) 1994-10-20
MD383C2 (ro) 1996-06-30
IE893721L (en) 1990-06-06
DE58905151D1 (de) 1993-09-09
NO173441C (no) 1993-12-15
PT92488B (pt) 1995-08-09
HU203748B (en) 1991-09-30
DK169102B1 (da) 1994-08-15
NZ231625A (en) 1991-02-26
HUT52094A (en) 1990-06-28
GR3008659T3 (uk) 1993-11-30
JPH02200676A (ja) 1990-08-08
IL92442A0 (en) 1990-08-31
LTIP1615A (en) 1995-07-25
EP0372305A1 (de) 1990-06-13
FI895824A0 (fi) 1989-12-05

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