WO1990005523A3 - Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase - Google Patents

Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase Download PDF

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Publication number
WO1990005523A3
WO1990005523A3 PCT/US1989/004774 US8904774W WO9005523A3 WO 1990005523 A3 WO1990005523 A3 WO 1990005523A3 US 8904774 W US8904774 W US 8904774W WO 9005523 A3 WO9005523 A3 WO 9005523A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenanthrolinedicarboxylate
aminoquinoline
esters
inhibitors
reverse transcriptase
Prior art date
Application number
PCT/US1989/004774
Other languages
French (fr)
Other versions
WO1990005523A2 (en
Inventor
Irene W Althaus
Fritz Reusser
William Gary Tarpley
Louis L Skaletzky
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of WO1990005523A2 publication Critical patent/WO1990005523A2/en
Publication of WO1990005523A3 publication Critical patent/WO1990005523A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This invention relates to a new medical use of some phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as drugs to treat human patients afflicted with a human immunodeficiency virus. The compounds have formulae (IA), (IB), (IC), (ID), where R, R1, R2, R', R'1, R'', R''1, R''2, R3, R4 and X are defined in Claim 1.
PCT/US1989/004774 1988-11-15 1989-10-30 Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase WO1990005523A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US27156788A 1988-11-15 1988-11-15
US271,567 1988-11-15
US27936488A 1988-12-02 1988-12-02
US279,364 1988-12-02
US28744888A 1988-12-20 1988-12-20
US287,448 1988-12-20

Publications (2)

Publication Number Publication Date
WO1990005523A2 WO1990005523A2 (en) 1990-05-31
WO1990005523A3 true WO1990005523A3 (en) 1990-07-12

Family

ID=27402391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/004774 WO1990005523A2 (en) 1988-11-15 1989-10-30 Phenanthrolinedicarboxylate esters, 4-aminoquinoline and isoquinoline derivatives as inhibitors of hiv reverse transcriptase

Country Status (3)

Country Link
AU (1) AU4488989A (en)
CA (1) CA2002414A1 (en)
WO (1) WO1990005523A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3002700B2 (en) * 1990-08-29 2000-01-24 化研生薬株式会社 Anti-AIDS virus agent
AU1580492A (en) * 1991-03-14 1992-10-21 Upjohn Company, The Reissert compounds as anti-hiv agents
AU1746392A (en) * 1991-04-10 1992-11-17 Octamer, Inc. A method for inhibition of retroviral replication
DE4344452A1 (en) * 1993-12-24 1995-06-29 Hoechst Ag Aza-4-iminoquinolines, process for their preparation and their use
AU7453498A (en) 1997-05-30 1998-12-30 Takeda Chemical Industries Ltd. Sulfonamide derivatives, their production and use
AU2298899A (en) 1998-02-05 1999-08-23 Takeda Chemical Industries Ltd. Sulfonamide derivatives, process for producing the same and utilization thereof
KR20180086187A (en) 2015-10-05 2018-07-30 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 Clearance of protein aggregates including phospholipase D and tau, and treatment of protein diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790577A (en) * 1970-10-05 1974-02-05 Ici Ltd Pyridoquinoline dicarboxylic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790577A (en) * 1970-10-05 1974-02-05 Ici Ltd Pyridoquinoline dicarboxylic acid derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 104, no. 11, 17 March 1986,(Columbus, Ohio, US), Z. Szulc et al: "The syntheses and properties of tricyclic azines as potential interferon inducers and antivirus agents", see page 650, abstract 88460z, & Stud. Org. Chem. (Amsterdam) 1984, 18 (Bio-Org. Heterocycl.), 363-6 *

Also Published As

Publication number Publication date
CA2002414A1 (en) 1990-05-15
AU4488989A (en) 1990-06-12
WO1990005523A2 (en) 1990-05-31

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