NO894856L - Fremgangsmaate for fremstilling av nye piperazinylalkyl-3(2h)-pyridazinoner. - Google Patents
Fremgangsmaate for fremstilling av nye piperazinylalkyl-3(2h)-pyridazinoner.Info
- Publication number
- NO894856L NO894856L NO89894856A NO894856A NO894856L NO 894856 L NO894856 L NO 894856L NO 89894856 A NO89894856 A NO 89894856A NO 894856 A NO894856 A NO 894856A NO 894856 L NO894856 L NO 894856L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- unsubstituted
- substituted
- hydrogen
- phenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003836 peripheral circulation Effects 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT299188 | 1988-12-06 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO894856D0 NO894856D0 (no) | 1989-12-05 |
| NO894856L true NO894856L (no) | 1990-06-07 |
| NO173441B NO173441B (no) | 1993-09-06 |
| NO173441C NO173441C (no) | 1993-12-15 |
Family
ID=3543605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO894856A NO173441C (no) | 1988-12-06 | 1989-12-05 | Analogifremgansmaate for fremstilling av nye, terapeutisk aktive piperazinylalkyl-3(2h)-pyridazinoner |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5034391A (no) |
| EP (1) | EP0372305B1 (no) |
| JP (1) | JPH02200676A (no) |
| KR (1) | KR900009626A (no) |
| CN (1) | CN1022565C (no) |
| AT (1) | ATE92487T1 (no) |
| AU (1) | AU622501B2 (no) |
| CA (1) | CA2004298A1 (no) |
| DD (1) | DD290885A5 (no) |
| DE (1) | DE58905151D1 (no) |
| DK (1) | DK169102B1 (no) |
| ES (1) | ES2058449T3 (no) |
| FI (1) | FI93956C (no) |
| GR (1) | GR3008659T3 (no) |
| HU (1) | HU203748B (no) |
| IE (1) | IE62890B1 (no) |
| IL (1) | IL92442A0 (no) |
| LT (2) | LTIP1615A (no) |
| LV (1) | LV10273B (no) |
| MD (2) | MD382C2 (no) |
| MY (1) | MY106282A (no) |
| NO (1) | NO173441C (no) |
| NZ (1) | NZ231625A (no) |
| PT (1) | PT92488B (no) |
| RU (2) | RU1823874C (no) |
| UA (1) | UA19756A1 (no) |
| YU (1) | YU229289A (no) |
| ZA (1) | ZA899320B (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162321A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | 1-naphthyl piperazines useful as 5-HT1A receptor ligands |
| CA2053863C (en) * | 1990-04-25 | 1996-10-29 | Keizo Tanikawa | Pyridazinone derivatives |
| HU214320B (hu) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
| US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| HU225955B1 (en) * | 2001-07-26 | 2008-01-28 | Egis Gyogyszergyar Nyilvanosan | Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| JP2005519895A (ja) * | 2002-01-18 | 2005-07-07 | ファルマシア・コーポレーション | Ｐ３８阻害剤としての置換ピリダジノン |
| HU227592B1 (en) * | 2002-11-13 | 2011-09-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions |
| US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| KR20070004676A (ko) * | 2004-02-10 | 2007-01-09 | 얀센 파마슈티카 엔.브이. | 알파４ 인테그린의 길항제로서의 피리다지논 |
| AR047537A1 (es) * | 2004-02-10 | 2006-01-25 | Janssen Pharmaceutica Nv | Piridazinonaureas como antagonistas de integrinas |
| BR112012019920A2 (pt) * | 2010-02-08 | 2016-04-26 | Allergan Inc | derivados de piridazina úteis como agonístas de canabinoide-2. |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1086238B (de) * | 1959-02-03 | 1960-08-04 | Basf Ag | Verfahren zur Herstellung von (4, 5)-Dihalogenpyridazonen-(6) |
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| BE755015A (fr) * | 1969-08-20 | 1971-02-01 | Byk Gulden Lomberg Chem Fab | Piperazinyl-alcoylamino-uraciles substitues par un groupe aryle, leurs ethers et thioethers, ainsi que leur procede de preparation |
| FR2124164A1 (en) * | 1971-02-10 | 1972-09-22 | Ferlux | Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials |
| DE2334009A1 (de) * | 1973-07-04 | 1975-01-23 | Boehringer Mannheim Gmbh | Purin-derivate sowie verfahren zu ihrer herstellung |
| FR2261756A1 (en) * | 1974-02-27 | 1975-09-19 | Roussel Uclaf | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
| LU74319A1 (no) * | 1976-02-09 | 1977-08-19 | ||
| JPS5742679A (en) * | 1980-08-29 | 1982-03-10 | Otsuka Pharmaceut Co Ltd | Preparation of phenylpiperazine derivative |
| JPH0641454B2 (ja) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| US4892947A (en) * | 1985-04-27 | 1990-01-09 | Nissan Chemical Industries Ltd. | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it |
| YU134686A (en) * | 1985-07-30 | 1988-02-29 | Nissan Chemical Ind Ltd | Process for preparing new derivatives 3-(2h)-pyridazinone |
| HU195645B (en) * | 1985-10-30 | 1988-06-28 | Gyogyszerkutato Intezet | Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same |
| US4859672A (en) * | 1986-10-29 | 1989-08-22 | Rorer Pharmaceutical Corporation | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone |
| US4978665A (en) * | 1987-01-20 | 1990-12-18 | Nissan Chemical Industries Ltd. | 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it |
| GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
-
1989
- 1989-11-21 IE IE372189A patent/IE62890B1/en not_active IP Right Cessation
- 1989-11-23 DE DE8989121681T patent/DE58905151D1/de not_active Expired - Fee Related
- 1989-11-23 EP EP89121681A patent/EP0372305B1/de not_active Expired - Lifetime
- 1989-11-23 ES ES89121681T patent/ES2058449T3/es not_active Expired - Lifetime
- 1989-11-23 AT AT89121681T patent/ATE92487T1/de not_active IP Right Cessation
- 1989-11-24 IL IL92442A patent/IL92442A0/xx not_active IP Right Cessation
- 1989-11-29 MY MYPI89001659A patent/MY106282A/en unknown
- 1989-11-30 US US07/443,166 patent/US5034391A/en not_active Expired - Fee Related
- 1989-11-30 CA CA002004298A patent/CA2004298A1/en not_active Abandoned
- 1989-12-04 PT PT92488A patent/PT92488B/pt not_active IP Right Cessation
- 1989-12-04 KR KR1019890017840A patent/KR900009626A/ko not_active Application Discontinuation
- 1989-12-04 AU AU45898/89A patent/AU622501B2/en not_active Ceased
- 1989-12-04 NZ NZ231625A patent/NZ231625A/xx unknown
- 1989-12-05 DD DD89335270A patent/DD290885A5/de not_active IP Right Cessation
- 1989-12-05 UA UA4742661A patent/UA19756A1/uk unknown
- 1989-12-05 FI FI895824A patent/FI93956C/fi not_active IP Right Cessation
- 1989-12-05 NO NO894856A patent/NO173441C/no unknown
- 1989-12-05 DK DK611789A patent/DK169102B1/da not_active IP Right Cessation
- 1989-12-05 RU SU894742661A patent/RU1823874C/ru active
- 1989-12-05 HU HU896432A patent/HU203748B/hu not_active IP Right Cessation
- 1989-12-05 JP JP1314490A patent/JPH02200676A/ja active Pending
- 1989-12-06 YU YU02292/89A patent/YU229289A/xx unknown
- 1989-12-06 ZA ZA899320A patent/ZA899320B/xx unknown
- 1989-12-06 CN CN89109090A patent/CN1022565C/zh not_active Expired - Fee Related
-
1990
- 1990-12-24 RU SU904831923A patent/RU2024517C1/ru active
-
1993
- 1993-08-05 GR GR930400672T patent/GR3008659T3/el unknown
- 1993-11-12 LV LVP-93-1218A patent/LV10273B/xx unknown
- 1993-12-16 LT LTIP1615A patent/LTIP1615A/xx not_active Application Discontinuation
-
1994
- 1994-01-27 LT LTIP1808A patent/LT3945B/lt not_active IP Right Cessation
- 1994-10-10 MD MD94-0323A patent/MD382C2/ro unknown
- 1994-10-24 MD MD94-0347A patent/MD383C2/ro unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO894856D0 (no) | Fremgangsmaate for fremstilling av nye piperazinylalkyl-3(2h)-pyridazinoner. | |
| HUP0400992A2 (hu) | Karbonsavval helyettesített oxazol-származékok, eljárás előállításukra és PPAR-alfa- és -gamma-aktivátorként való alkalmazásuk diabétesz kezelésére felhasználható gyógyszerek készítésére | |
| NO159091C (no) | Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive xantinderivater. | |
| DZ1694A1 (fr) | "n-(2-Aminoethyl)-benzothialozones". | |
| NO975094L (no) | Vinylpyrrolidoncefalosporinderivater | |
| NO170274C (no) | Analogifremgangsmaate for fremstilling av nye terapeutisk virksomme benzhydryloksyetylpiperidin-derivater | |
| NO162821C (no) | Fremgangsmaate for fremstilling av terapeutisk aktive furo-pyridinderivater. | |
| HUP0300177A2 (hu) | Szívszélhűdés ellen alkalmazható piridazinil-fenil-hidrazon-származékok és ezeket tartalmazó gyógyszerkészítmények | |
| DK0699198T3 (da) | N-benzoylmethyl-substituerede paroxetinderivater | |
| NO890691D0 (no) | Fremgangsmaate for fremstilling av nye basiske substituerte 5-halogen-tienoisotiazol-3(2h)-on-1,1-dioksider og farmasoeytiske preparater derav. | |
| IE40514L (en) | Amphetamine derivatives | |
| MXPA01009768A (es) | Analogos de fenoxazina utiles como inhibidores de la agregacion amiloide y para el tratamiento de la enfermedad de alzheimer y las enfermedades relacionadas con la amiloidosis. | |
| ES8101045A1 (es) | Procedimiento para la preparacion de derivados de acidos pi-rrolidinilsulfamoilbenzoicos sustituidos | |
| FI861328A (fi) | Nya 1,2-benzioxazol-3-yl- och 1,2-benzisotiazol-3-yl-derivat. | |
| NO831040L (no) | Enantiomerer av substituerte fenylazacykloalkaner og fremgangsmaate for deres fremstilling | |
| HUP0401251A2 (hu) | Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok sói, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények | |
| TH919A (th) | การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน |