HUP0401251A2 - Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok sói, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények - Google Patents

Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok sói, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények

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Publication number
HUP0401251A2
HUP0401251A2 HU0401251A HUP0401251A HUP0401251A2 HU P0401251 A2 HUP0401251 A2 HU P0401251A2 HU 0401251 A HU0401251 A HU 0401251A HU P0401251 A HUP0401251 A HU P0401251A HU P0401251 A2 HUP0401251 A2 HU P0401251A2
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Hungary
Prior art keywords
optionally substituted
group
salts
substituted alkyl
carboxylic acid
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HU0401251A
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English (en)
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Corinna Sundermann
Michael Przewosny
Werner Günter Englberger
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GRÜNENTHAL GmbH,
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Publication of HUP0401251A2 publication Critical patent/HUP0401251A2/hu

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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Találmány (I) általános képletű helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok sóira, e vegyületekelőállítására, gyógyszerek előállítására történő felhasználására,valamint a fenti sókat tartalmazó gyógyszerekre vonatkozik. A fentivegyületek különböző fájdalom kezelésére alkalmasak. A képletben Rl ésR2 együtt adott esetben helyettesített -(CH2)n- (ahol n értéke 3-10) -CH=CH-CH2-, -CH2-CH=CH-, -CH=CH-CH2-CH2-, -CH2-CH2-CH=CH-, -CH2-CH=CH-CH2-, -CH2-CH=CH-CH2-CH2-, -CH2-CH2-CH=CH-CH2-, -CH2-CH2-CH=CH-CH2-CH2-, -O-CH2-CH2-, -CH2-CH2-O-, -O-CH2-CH2-CH2-, -CH2-CH2-CH2-O-, -CH2-O-CH2-, CH2-CH2-O-CH2-, -CH2-O-CH2-CH2-, (A), (B), (C), (D), (E), (F), (G), (H) vagy (I) képletűcsoportot képez (ahol X jelentése oxigén- vagy kénatom); R3 jelentésehidrogénatom; adott esetben helyettesített alkil-, alkenil- vagyalkinilcsoport; adott esetben helyettesített cikloalkilcsoport,illetve egy megfelelő heterociklus; adott esetben helyettesítettalkil-aril- vagy alkil-heteroaril-csoport; adott esetbenhelyettesített aril- vagy heteroarilcsoport; R4 jelentése R4a vagyZR4a ; R5, R6, R7 és R8 jelentése egymástól függetlenül H, F, Cl, Br,I, CN, NO2; adott esetben helyettesített alkil-, alkenil- vagyalkinilcsoport; OR14, OC(O)R14, OC(S)R14, C(O)R14, C(O)OR14, C(S)R14,C(S)OR14, SR14, S(O)R14 illetve S(O)2R14 ; NR15R16, NR15C(O)R16,C(NR15)NR16R17, NR15C(S)R16, C(S)NR15R16 vagy C(S)NR15NR16R17 vagyS(O2)NR15R16 ; vagy R5 és R6, R6 és R7 vagy R7 és R8 együtt =CR18-CH=CH-CH= vagy =CH-CRl8=CH-CH= képletű csoportot képez; vagy R1jelentése adott esetben helyettesített alkilcsoport; adott esetbenhelyettesített cikloalkilcsoport, illetve egy megfelelő heterociklus;R2 jelentése hidrogénatom; adott esetben helyettesített alkilcsoport;adott esetben helyettesített fenilcsoport; R3 jelentése hidrogénatom;adott esetben helyettesített alkil-, alkenil- vagy alkinilcsoport;adott esetben helyettesített cikloalkilcsoport, illetve egy megfelelőheterociklus; és R4-R8 jelentése a fenti. Ó
HU0401251A 2001-08-03 2002-08-05 Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok sói, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények HUP0401251A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10137488A DE10137488A1 (de) 2001-08-03 2001-08-03 Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
PCT/EP2002/008729 WO2003013530A2 (de) 2001-08-03 2002-08-05 Salze substituierter 1,2,3,4,-tetrahydrochinolin-2-carbonsaurederivate als nmda-antagonisten

Publications (1)

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HUP0401251A2 true HUP0401251A2 (hu) 2004-10-28

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HU0401251A HUP0401251A2 (hu) 2001-08-03 2002-08-05 Helyettesített 1,2,3,4-tetrahidrokinolin-2-karbonsav-származékok sói, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények

Country Status (18)

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US (1) US20040224969A1 (hu)
EP (1) EP1411947A2 (hu)
JP (1) JP2005501839A (hu)
KR (1) KR20040043177A (hu)
CN (1) CN1561215A (hu)
BR (1) BR0211733A (hu)
CA (1) CA2456103A1 (hu)
CO (1) CO5550424A2 (hu)
DE (1) DE10137488A1 (hu)
EC (1) ECSP044969A (hu)
HU (1) HUP0401251A2 (hu)
IL (1) IL160162A0 (hu)
MX (1) MXPA04000952A (hu)
NO (1) NO20040423L (hu)
PL (1) PL369502A1 (hu)
RU (1) RU2004106531A (hu)
WO (1) WO2003013530A2 (hu)
ZA (1) ZA200401724B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301320D0 (sv) * 2003-05-06 2003-05-06 Astrazeneca Ab Positive modulators of nicotinic acetylcholine receptors
WO2009073550A2 (en) * 2007-11-30 2009-06-11 Maxthera, Inc. Substituted tetrahydroquinolines as antibacterial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017584A (en) * 1984-12-20 1991-05-21 Sterling Drug Inc. Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
ATE147732T1 (de) * 1989-03-08 1997-02-15 Merck Sharp & Dohme Tetrahydroquinolin-derivate, verwendbar bei neurodegenerativen krankheiten
AU8191998A (en) * 1997-02-04 1998-08-25 Trega Biosciences, Inc. 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate

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JP2005501839A (ja) 2005-01-20
RU2004106531A (ru) 2005-07-27
IL160162A0 (en) 2004-07-25
ECSP044969A (es) 2004-03-23
WO2003013530A3 (de) 2003-09-25
BR0211733A (pt) 2004-09-21
ZA200401724B (en) 2005-02-01
KR20040043177A (ko) 2004-05-22
MXPA04000952A (es) 2004-04-20
WO2003013530A2 (de) 2003-02-20
PL369502A1 (en) 2005-04-18
CA2456103A1 (en) 2003-02-20
DE10137488A1 (de) 2003-02-20
EP1411947A2 (de) 2004-04-28
CO5550424A2 (es) 2005-08-31
CN1561215A (zh) 2005-01-05
NO20040423L (no) 2004-03-08
US20040224969A1 (en) 2004-11-11

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