NO20063675L - Acylaminotiazolderlvater, fremstillingsmater og anvendelse derav I terapeutika - Google Patents
Acylaminotiazolderlvater, fremstillingsmater og anvendelse derav I terapeutikaInfo
- Publication number
- NO20063675L NO20063675L NO20063675A NO20063675A NO20063675L NO 20063675 L NO20063675 L NO 20063675L NO 20063675 A NO20063675 A NO 20063675A NO 20063675 A NO20063675 A NO 20063675A NO 20063675 L NO20063675 L NO 20063675L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- alkyl
- alkoxy
- cycloalkyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Det beskrives en forbindelse med den generelle formel (I) der: R1 betyr enten en eventuell substituert C1-C6-alkyl eller C3-C7-cykloalkyl, tiofen, benzotiofen, pyridinyl, furanyl eller eventuelt substituert fenyl; R2 og R'2 uavhengig av hverandre betyr hydrogen, halogen, hydroksy, C1-C3-alkoksy, C1-C3-alkyl, C3-C7-cykloalkyl, O-C(O)-C1-C6-alkyl, eller R2 og R'2 sammen danner en oksogruppe; R3 er hydrogen, C1-C6-alkyl som eventuelt er substituert med hydroksy, C1-C6-cykloalkyl eller C1-C3-alkoksy; en av R4 eller R5 betyr en gruppe (Z) og den andre betyr en -C(X)R6-gruppe; G betyr en enkeltbinding eller en -CH2-gruppe; Y betyr en enkeltbinding, oksygen, svovel, eventuelt substituert C1-C4-alkylen eller -N(W)-; A og B uavhengig av hverandre betyr hydrogen, halogen, hydroksy, C1-C3-alkyl, C1-C3-alkoksy, trifluormetyl, trifluormetoksy eller -O-CHF2; X betyr O eller S; R6 betyr en eventuelt substituert Ci-C6-alkoksy, hydroksy eller -NR7R8; og R7 og R8 uavhengig av hverandre betyr enten hydrogen, eventuelt substituert C1-C6-alkyl, eventuelt substituert C3-C7-cykloalkyl, C1-C6-alkoksy eller fenyl som eventuelt er substituert; eller R7 og R8 sammen med nitrogenatomet hvortil de er bundet danner en aziridin-, azetidin-, pyrrolidin-, piperidin-, morfolin- eller benzopiperidinring. Oppfinnelsens forbindelser kan ha form av en base, et syreaddisjonssalt eller et hydrat. Videre beskrives forbindelsenes anvendelse i terapeutika.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400387A FR2865206B1 (fr) | 2004-01-16 | 2004-01-16 | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| FR0408115A FR2873370B1 (fr) | 2004-07-22 | 2004-07-22 | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| PCT/FR2005/000032 WO2005073226A1 (fr) | 2004-01-16 | 2005-01-07 | Derives d’acylaminothiazole, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063675L true NO20063675L (no) | 2006-10-16 |
Family
ID=34828645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063675A NO20063675L (no) | 2004-01-16 | 2006-08-15 | Acylaminotiazolderlvater, fremstillingsmater og anvendelse derav I terapeutika |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7582664B2 (no) |
| EP (1) | EP1709041A1 (no) |
| JP (1) | JP2007517840A (no) |
| AR (1) | AR047387A1 (no) |
| AU (1) | AU2005209442B2 (no) |
| BR (1) | BRPI0506880A (no) |
| CA (1) | CA2551142A1 (no) |
| HK (1) | HK1104542A1 (no) |
| IL (1) | IL176701A (no) |
| MA (1) | MA28233A1 (no) |
| NO (1) | NO20063675L (no) |
| NZ (1) | NZ548531A (no) |
| RU (1) | RU2401262C2 (no) |
| TW (1) | TWI340642B (no) |
| WO (1) | WO2005073226A1 (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514566B2 (en) * | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
| JP2010533715A (ja) | 2007-07-17 | 2010-10-28 | アムジエン・インコーポレーテツド | 複素環系ｐｋｂ調節剤 |
| CA2693473A1 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL334516A1 (en) * | 1996-11-22 | 2000-02-28 | Elan Pharm Inc | N-(aryl/heteroaryl/alkylacetyl)amino cid amides, pharmaceutic agent containing them and method of inhibiting eduction and/or synthesis of beta-amyloid peptide using such compounds |
| AU6229699A (en) * | 1998-10-26 | 2000-05-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-amyloid formation inhibitors |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
| FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| WO2004033439A1 (en) * | 2002-10-09 | 2004-04-22 | Pfizer Products Inc. | Thiazole compounds for the treatment of neurodegenerative disorders |
| PT1709018E (pt) * | 2004-01-16 | 2011-10-24 | Sanofi Sa | Derivados de acilaminotiazole e sua aplicação como inibidores |
-
2005
- 2005-01-07 CA CA002551142A patent/CA2551142A1/fr not_active Abandoned
- 2005-01-07 JP JP2006548342A patent/JP2007517840A/ja not_active Ceased
- 2005-01-07 BR BRPI0506880-0A patent/BRPI0506880A/pt not_active IP Right Cessation
- 2005-01-07 WO PCT/FR2005/000032 patent/WO2005073226A1/fr active Application Filing
- 2005-01-07 EP EP05717380A patent/EP1709041A1/fr not_active Withdrawn
- 2005-01-07 RU RU2006129642/04A patent/RU2401262C2/ru not_active IP Right Cessation
- 2005-01-07 AU AU2005209442A patent/AU2005209442B2/en not_active Ceased
- 2005-01-07 NZ NZ548531A patent/NZ548531A/en unknown
- 2005-01-14 TW TW094101173A patent/TWI340642B/zh not_active IP Right Cessation
- 2005-01-14 AR ARP050100129A patent/AR047387A1/es unknown
-
2006
- 2006-06-19 MA MA29119A patent/MA28233A1/fr unknown
- 2006-07-04 IL IL176701A patent/IL176701A/en not_active IP Right Cessation
- 2006-07-07 US US11/456,123 patent/US7582664B2/en not_active Expired - Fee Related
- 2006-08-15 NO NO20063675A patent/NO20063675L/no not_active Application Discontinuation
-
2007
- 2007-09-06 HK HK07109706.9A patent/HK1104542A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0506880A (pt) | 2007-06-26 |
| WO2005073226A1 (fr) | 2005-08-11 |
| RU2006129642A (ru) | 2008-02-27 |
| IL176701A (en) | 2012-01-31 |
| US20060293365A1 (en) | 2006-12-28 |
| IL176701A0 (en) | 2006-10-31 |
| CA2551142A1 (fr) | 2005-08-11 |
| MA28233A1 (fr) | 2006-10-02 |
| HK1104542A1 (en) | 2008-01-18 |
| NZ548531A (en) | 2010-01-29 |
| RU2401262C2 (ru) | 2010-10-10 |
| TW200533345A (en) | 2005-10-16 |
| TWI340642B (en) | 2011-04-21 |
| US7582664B2 (en) | 2009-09-01 |
| JP2007517840A (ja) | 2007-07-05 |
| AU2005209442B2 (en) | 2011-03-31 |
| EP1709041A1 (fr) | 2006-10-11 |
| AU2005209442A1 (en) | 2005-08-11 |
| AR047387A1 (es) | 2006-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |